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All Journal Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Prosiding International Conference on Sustainable Innovation (ICoSI)
Damayanti Damayanti
Departement Of Dermatology And Venereology, Faculty Of Medicine, Universitas Airlangga, Surabaya
Religion Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health

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Profile of Psoriasis Vulgaris Patients Treated with Methotrexate at Dr. Soetomo Hospital, Surabaya, 2017–2018 Damayanti Damayanti; Karina Dyahtantri Pratiwi; Wisnu Triadi Nugroho
Jurnal Berkala Epidemiologi Vol. 9 No. 1 (2021): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V9I12021.70-78

Abstract

Background: Psoriasis Vulgaris is a chronic inflammatory skin disease that affects patients’ quality of life. Methotrexate is the first-line and most effective systemic therapy in psoriasis vulgaris management. Purpose: The aim of this study was to evaluate clinical improvement after methotrexate therapy and any adverse effects of methotrexate therapy in psoriasis vulgaris management. Methods: The data for this descriptive, retrospective study were retrieved from the medical records of 22 psoriasis vulgaris patients who were treated with methotrexate therapy between January 2017 and June 2018 in the Child Kemuning Ward (IRNA), Dr. Soetomo General Hospital in Surabaya, East Java. Results: Data for a total of 22 subjects were collected for this study. The majority of the subjects were in the age group 25–59, and the average age was 40.50±17.20. Good clinical improvement (decrease in the body surface area of the lesion) was found in all patients. The adverse effects of methotrexate were evaluated based on the elevation of liver and renal function test levels. An elevation of aspartate aminotransferase levels was found in 11 patients, and an elevation in alanine aminotransferase levels was found in 13 patients. Elevated blood urea nitrogen levels were found in eight patients, and elevated serum creatinine levels were found in four patients. Conclusion: Methotrexate is an effective treatment for severe psoriasis vulgaris management when administered with careful selection and regular monitoring of patients. Application of methotrexate therapy in accordance with the guidelines remains suitable for psoriasis vulgaris management with vigilance regarding methotrexate’s adverse effects.
Penuaan Kulit: Patofisiologi dan Manifestasi Klinis Ahmad Zahruddin; Damayanti Damayanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 3 (2018): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (553.722 KB) | DOI: 10.20473/bikk.V30.3.2018.208-215

Abstract

Latar belakang: Proses penuaan kulit merupakan proses fisiologis yang tidak dapat dihindari. Kulit merupakan bagian tubuh yang paling sering terpapar oleh faktor-faktor luar terutama radiasi sinar ultraviolet, dan karena terlihat oleh orang lain sehingga akan memengaruhi kehidupan sosial individu. Tujuan: Mengetahui patofisiologi dan manifestasi klinis penuaan kulit. Telaah Kepustakaan: Penuaan kulit yang terjadi pada seorang individu merupakan gabungan dari penuaan kulit intrinsik dan penuaan kulit ekstrinsik. Penuaan kulit intrinsik merupakan proses alami yang terjadi seiring bertambahnya usia, dipengaruhi oleh ras, jenis kelamin, gen, hormon, dan sebagainya, sedangkan penuaan kulit ekstrinsik dipengaruhi oleh berbagai faktor dari lingkungan, seperti gaya hidup, polusi, serta terutama paparan sinar ultraviolet (photoaging). Kedua proses penuaan tersebut akan menyebabkan peningkatan produksi radikal bebas, kerusakan sel, penurunan sintesis matriks ekstraseluler, serta peningkatan aktivitas enzim yang mendegradasi kolagen. Simpulan: Dasar patofisiologi penuaan kulit terutama disebabkan oleh peningkatan radikal bebas, akibat pertambahan usia maupun paparan sinar ultraviolet, sehingga menyebabkan kerusakan sel dan jaringan pada lapisan-lapisan dan adneksa kulit yang akan tampak sebagai manifestasi klinis penuaan kulit.
Skin Aging and Basic Skin Care in Elderly Damayanti Damayanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.693 KB) | DOI: 10.20473/bikk.V29.1.2017.73-80

Abstract

Background: In the last few decades, the world population of older adults is increasing significantly. One-fifth of the global population will be more than 65 years old by the year 2050. Of interest is those 85 years old and older has the fastest growing segmen of population. Since the human population is living longer, chronic disease including skin disease and skin aging problems, will be more prevalence. Purpose: To review the pathogenesis and clinical manifestation of skin aging, and to review basic skin care in elderly. Reviews: Skin aging is caused by endogen and extrinsic factors. Skin aging divided into intrinsic (chronologic) skin aging and extrinsic photoaging. The elderly population, that has rapidly increase, needs for basic skin care in order to delay skin aging process.  Basic skin care consist of cleansing, hidrating, replenishing, and protection. Photoprotection, such as avoiding midday sun, using photoprotective clothes, hat, sunglasses, and administration of sunscreen, has important role in preventing skin damage. Conclusion: Good visible aging process can be delayed by preventive skin care to reach successful aging, which has good physical health, good mental health and adaptive psychosocial functioning, so that older person can live a happy, health and  active life.
Severe Cutaneous Adverse Drug Reaction Damayanti Damayanti; Sylvia Anggraeni; Cita Rosita SP; Marsudi Hutomo; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.379 KB) | DOI: 10.20473/bikk.V29.2.2017.151-157

Abstract

Background: Cutaneous adverse drug eruption (CADR) are frequently found. A systematic review showed, the incidence of severe CADR (SCADR) ranging from 0-8%. Few studies have assessed the severe form of CADR, which has high mortality rate. The epidemiological study was needed to show the profile of SCADR, especially in the setting of general hospital. Purpose: To evaluate clinical and epidemiological profile of SCADR in Dermatology and Venereology Ward Dr. Soetomo Hospital Surabaya. Methods: All SCADR patients in the period of January 2015–January 2016 was evaluated clinically and epidemiologically. Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic reaction (DRESS) cases were included in the study. Results: There were 14 patients in this study, consist of 10 SJS cases (71.4%), 2 TEN patients, and 2 AGEP patients. The highest frequency of age group was 25-29 years old (57.1%). Man to woman ratio was 3:4. The most common offending drug was paracetamol (50%), followed by amoxicillin (28.6%). Antibiotic was the highest frequent offending drug-group (64.3%), followed by antipiretics (50%). In this study, all patients got systemic corticosteroid and the mortality was 0%. Conclusion: The most common type of SCADR was SJS. The most common offending drug was paracetamol, and antibiotic was the highest frequent offending drug-group. Systemic corticosteroid therapy showed good result in severe CADR management.
Konsep Patomekanisme Erupsi Obat Terkini Damayanti Damayanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 3 (2019): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (59.79 KB) | DOI: 10.20473/bikk.V31.3.2019.136-141

Abstract

Latar Belakang: Erupsi obat terjadi sekitar 30-45% dari adverse drug reaction (ADR) dengan peningkatan angka kejadian di negara berkembang sebesar 2-5 %. Erupsi obat dapat menimbulkan angka morbiditas dan mortalitas yang tinggi sehingga diperlukan pemahaman mengenai patomekanisme erupsi obat, yang akan bermanfaat pada pencegahan dan penatalaksanaannya. Tujuan: Memahami perkembangan terkini konsep patomekanisme erupsi obat. Telaah Kepustakaan: Erupsi obat merupakan respons yang tidak diinginkan terhadap pemberian obat dengan dosis normal pada manusia. Angka kejadian ADR di rumah sakit adalah 6,5% dengan  bentuk terbanyak berupa erupsi obat dengan lesi pada kulit. Konsep patomekanisme pada erupsi obat terus berkembang. Obat dapat menstimulasi sistem imun dengan membentuk hapten-carrier complex, yaitu pada konsep hapten-prohapten. Obat juga dapat menstimulasi sistem imun melalui sifat farmakologisnya, melalui ikatan nonkovalen dengan reseptor imun, yaitu T cell receptor (TCR) atau human leukocyte antigen (HLA), yang terdapat pada p-i concept (pharmacologic interaction). Ikatan obat pada molekul HLA dapat mempunyai 2 akibat. Bila obat dapat memodifikasi molekul HLA, akan terbentuk peptida yang berbeda (altered peptide model). Walaupun demikian, perubahan peptida tidak diperlukan untuk membuat peptide-HLA complex bersifat imunogenik; bila obat berikatan dengan HLA, maka gabungan dari altered  HLA dan peptida normal dapat bersifat imunogenik dan menstimulasi sel T (altered pHLA model). Selain itu, konsep patomekanisme erupsi obat berdasarkan dasar genetik (keterkaitan dengan HLA) dapat bermanfaat pada pembuatan data dasar genetika. Simpulan: Perkembangan konsep patomekanisme erupsi obat dapat menjadi dasar pada perkembangan pencegahan serta penatalaksanaannya.
Sifilis Sekunder pada Pasien HIV: Laporan Kasus Dyatiara Devy Rahadiyanti; Damayanti Damayanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 2 (2018): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (518.592 KB) | DOI: 10.20473/bikk.V30.2.2018.178-184

Abstract

Latar Belakang: Sifilis merupakan penyakit menular seksual yang disebabkan oleh mikroorganisme Treponema pallidum. Infeksi Human Immunodeficiency Virus (HIV) dapat terjadi bersamaan dan saling mempengaruhi. Kasus: Pria, 33 tahun dengan keluhan bercak-bercak merah di badan, kedua tangan dan kaki sejak 1 bulan, tidak nyeri ataupun gatal. Awalnya bercak merah timbul di tangan kemudian menyebar ke bagian tubuh lainnya. Pasien memiliki riwayat luka di kelamin yang sembuh sendiri 3 bulan sebelumnya. Pemeriksaan fisik ditemukan makula eritematosa multipel batas jelas, diameter 0,5-1 cm, beberapa tertutup skuama tipis. Pasien telah didiagnosis HIV sejak 1 tahun yang lalu dan mendapatkan antiretroviral (ARV) secara rutin. Titer serologi Venereal Disease Research Laboratory (VDRL) 1:128 dan Treponema pallidum Hemagglutination Assay (TPHA) 1:1280. Pasien diberikan terapi penisilin G 2,4 juta intramuskular dosis tunggal. Kasus ini menunjukkan adanya fluktuasi nilai tes serologis pada bulan keenam dan ke sembilan. Penatalaksanaan: Diagnosis sifilis ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan pemeriksaan laboratoris. Terapi sifilis sekunder adalah benzathine penisilin G 2,4 juta unit intramuskular dosis tunggal. Diperlukan waktu lebih lama pada terapi pasien sifilis dengan HIV dan follow up tes serologis lebih lanjut masih dibutuhkan hingga 24 bulan. Simpulan: Hasil tes serologis nontreponemal (dapat tinggi, rendah, atau berfluktuasi) dapat ditemui pada pasien sifilis dengan HIV. Kesesuaian antara gambaran klinis, diagnosis, dan strategi manajemen pada pasien sifilis dengan HIV harus dikenali oleh seorang klinisi.
Profil Psoriasis Vulgaris di RSUD Dr. Soetomo Surabaya: Studi Retropektif Karina Dyahtantri Pratiwi; Damayanti Damayanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 3 (2018): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (659.118 KB) | DOI: 10.20473/bikk.V30.3.2018.248-254

Abstract

Latar belakang: Psoriasis vulgaris adalah penyakit kulit inflamasi kronis yang ditandai dengan plak merah berbatas tegas tertutup skuama tebal sebagai akibat dari gangguan proliferasi dan diferensiasi epidermis.  Sifat kronis dari psoriasis vulgaris sangat mempengaruhi kualitas hidup pasien. Profil pasien psoriasis vulgaris diperlukan untuk mengevaluasi morbiditas akibat psoriasis vulgaris, sehingga dapat meningkatkan mutu pelayanan. Tujuan: Mengevaluasi profil pasien psoriasis vulgaris meningkatkan mutu pelayanan terhadap pasien. Metode: Studi retrospektif dari data rekam medis pasien psoriasis vulgaris yang dirawat di Instalasi Rawat Inap (IRNA) Kemuning I dan II Kulit dan Kelamin RSUD Dr. Soetomo Surabaya selama periode 1 Januari 2016 sampai 31 Desember 2017. Hasil: Sebanyak 36 pasien psoriasis vulgaris didapatkan dari pengamatan selama 2 tahun. Faktor pencetus kekambuhan lesi terbanyak adalah fokal infeksi gigi pada 30,6% pasien. Luas lesi >30% Body Surface Area (BSA) terdapat pada 55,6% pasien. Terapi sistemik yang diberikan berupa metotreksat (55,6%) dan siklosporin (25%); sedangkan 19,4% tidak diberikan terapi sistemik terkait kontraindikasi individual. Kesimpulan: Diagnosis psoriasis vulgaris ditegakkan berdasarkan anamnesis dan gejala klinis, didukung dengan hasil histopatologi. Terapi sistemik berupa metotreksat atau siklosporin, disertai dengan terapi topikal dan terapi suportif, memberikan hasil perbaikan skor PASI 50% - 75% pada 58,3% pasien.
Clinicoepidemiological Profile of Severe Cutaneous Adverse Drug Reaction: A Retrospective Study Damayanti Damayanti; Menul Ayu Umborowati; Sylvia Anggraeni; Cita Rosita Sigit Prakoeswa; Marsudi Hutomo; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 1 (2019): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2926.113 KB) | DOI: 10.20473/bikk.V31.1.2019.1-6

Abstract

Background: Drug eruption were varied from mild to severe reaction. Few studies have assessed the severe cutaneous adverse drug reaction (SCADR), especially in the setting of general hospital. Purpose: To evaluate clinicoepidemiological profile of SCADR at Dermatology and Venereology Ward Dr. Soetomo Hospital, Surabaya, Indonesia. Methods: All SCADR patients at Dr. Soetomo Hospital, Surabaya, Indonesia in the period of January 2016 – June 2017 was evaluated. Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), Acute Generalized Exanthematous Pustulosis (AGEP), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) and exfoliative dermatitis cases were included in the study. Results: There were 24 patients in this study, consisted of 11 SJS cases, 1 TEN case, 2 SJS/TEN-overlap cases, 10 exfoliative dermatitis cases. The mean of latent period between drug intake and onset of symptoms was 15.8 days. The most common offending drug was mefenamic acid (20.9%), followed by cefadroxil and phenytoin (each 16.7%). Antibiotics was the highest frequent offending drug-groups (62.5%), followed by non-steroid anti-inflammatory drugs (NSAIDs). Prompt withdrawal of the offending drugs, systemic corticosteroid, and supported therapy were given to all patients, which gave good results in 21/24 patients (87.5%). Conclusion: Antibiotics were the most common offending drug-groups. SCADR might give high mortality rate, but early diagnosis, prompt withdrawal of the suspected drugs, closed monitoring to evaluate complications can improve the prognosis of SCADR.
Skin Test for Cutaneous Adverse Drug Reactions Yusuf Wibisono; Damayanti Damayanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.62-69

Abstract

Background: The incidence of drug eruptions is increasing during the last few years due to a large number of new medications. Early detection of the causative agent and the prevention from exposure are crucial managements in terms of drug eruption, mainly to prevent its recurrence. Objective: To understand skin test as a diagnostic modality in drug eruption, which includes skin patch test, skin prick test, and intradermal test. Literature review: Drug eruption is a form of skin eruption triggered by the use of medications, topical or systemic, in the right dose and indication. The manifestation can vary from maculopapular, urticaria, pustular, and bullous eruption; from the most nonsignificant to a life-threatening reaction. A diagnostic procedure is critical to discover the type of drugs that cause the eruption, i.e., skin test, specific IgE measurement, histamine-release test, and provocation test. Skin test is the first choice in the diagnostic process as it is simple, easy, practical and has high sensitivity and specificity. Conclusion: Skin test is one of the many available diagnostic tools.  However, both false positive and false negative results might still arise. The experts are currently attempting to come up with more accurate and practical tests to aid the diagnostic of drug eruption, thus preventing its occurrence.
The Concordance of Three Diagnostic Test for Malassezia folliculitis using Potassium Hydroxide 20% + Blue-Black Parker Ink, May Grunwald Giemsa, and Potassium Hydroxide 10% + Chicago Sky Blue Dyatiara Devy Rahadiyanti; Evy Ervianti; Damayanti Damayanti; Dwi Murtiastutik; Sawitri Sawitri; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.33-39

Abstract

Background: Malassezia folliculitis is a pilosebaceous follicular infection disease caused by Malassezia species. There are many misdiagnosed Malassezia folliculitis cases, causing the maladministration of therapy. A routine diagnostic test performed for Malassezia folliculitis cases is the identification of fungal elements (spore) with a microscope using potassium hydroxide, but it has several weaknesses. Purpose: To evaluate the suitability of Malassezia folliculitis diagnostic test using Potassium Hydroxide 20% + Blue-Black Parker Ink, May Grunwald Giemsa, and Potassium Hydroxide 10% + Chicago Sky Blue. Methods: Analytic observational study conducted in the Dermatomycology Division of Dermatology and Venereology outpatient clinic, Dr. Soetomo General Hospital Surabaya. The samples were thirty patients with clinical features of Malassezia folliculitis. The research material was obtained from the body as many as three pieces of papulomoluscoid lesion extracted. The material obtained was then divided into three glass objects for Potassium Hydroxide 20% + Blue-Black Parker Ink, May Grunwald Giemsa, and Potassium Hydroxide 10% + Chicago Sky Blue staining. Result: The identification of spores using Potassium Hydroxide 20% + Blue-Black Parker Ink was 90%, May Grunwald Giemsa was 90%, and Potassium Hydroxide 10% + Chicago Sky Blue was 93% with a value of κ=0.348 and p=0.051. The diagnostic values of May Grunwald Giemsa and Potassium Hydroxide 10% + Chicago Sky Blue were 96.6% sensitivity, 33.3% specificity, 92.9% Positive Predictive Value, and 50 % Negative Predictive Value. Conclusions: There was no significant concordance between May Grunwald Giemsa and Potassium Hydroxide 10% + Chicago Sky Blue with Potassium Hydroxide 20% + Blue-Black Parker Ink in establishing the diagnosis of Malassezia folliculitis. Potassium Hydroxide 20% + Blue-Black Parker Ink is still needed as a routine examination in cases with clinical features of Malassezia folliculitis.
Co-Authors Afif Nurul Hidayati Ahmad Zahruddin Anang Endaryanto Anggraeni, Sylvia As'ad Naufal Bella Ayu Paramitha Bernadya Yogatri Anjuwita Budi Utomo Cita Rosita Sigit Prakoeswa Cita Rosita SP Deasy Fetarayani Diah Mira Indramaya Dwi Murtiastutik Dyah Ayu Pitasari Dyatiara Devy Rahadiyanti Dyatiara Devy Rahadiyanti Efenina Ginting Esti Hendradi Evy Ervianti Fatimah, Nurmawati Febriyana, Nining Hari Sukanto, Hari I Gusti Ayu Indah Ardani Irwadi, Irfiansyah Iskandar Zulkarnain Iskandar Zulkarnain Karina Dyahtantri Pratiwi Karina Dyahtantri Pratiwi KUSUMASTUTI, ETTY HARY Linda Astari, Linda M. Yulianto Listiawan Marsudi Hutomo Marsudi Hutomo Maya Wardiana Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati Pepy Dwi Endraswari, Pepy Dwi Rahmadewi Rahmadewi Riyana Noor Oktaviyanti Samsriyaningsih Handayani Sawitri Sawitri Tasya Wikassa Trisniartami Setyaningrum William Andrew Isaac Wisnu Triadi Nugroho Wisnu Triadi Nugroho Wisnu Triadi Nugroho Yasmin Adzra Nabila Yusuf Wibisono Zsa Zsa Ollyvia