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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin
Damayanti Damayanti
Departement Of Dermatology And Venereology, Faculty Of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya
Immunology & microbiology Public Health

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Antifungal Activity of Rosmarinus Officinalis Essential Oil and Nystatin on Store Isolate of Candida species from HIV/AIDS Patients with Oral Candidiasis Bernadya Yogatri Anjuwita; Iskandar Zulkarnain; Muhammad Yulianto Listiawan; Evy Ervianti; Rahmadewi Rahmadewi; Pepy Dwi Endraswari; Damayanti Damayanti; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.167-173

Abstract

Background: Oral candidiasis is caused by the mycotic activity of Candida albicans present in the oral cavity, and it is one of the most common opportunistic infections found in patients with Human Immunodeficiency Virus (HIV)/acquired immune deficiency syndrome (AIDS). The growing resistance and side effects to common antifungal drugs have promoted herbal essential oils as antifungal agents in recent years. In this study, essential oils (EO) of Rosmarinus officinalis (Lamiaceae) were examined for in vitro antifungal activ­ity against Candida species. Purpose: To evaluate the antifungal activity of essential oils of Rosmarinus officinalis (Lamiaceae) and nystatin using the microdilution technique by determining the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) of Candida spesies. Methods: This was an experimental laboratory study with a post-test-only design conducted in Dr. Soetomo General Academic Teaching Hospital, Surabaya. Forty isolates consisted of twenty isolates of Candida albicans and twenty isolates of Candida non-albicans were collected. The isolates were tested for antifungal activity using the microdilution on 96-well plates. Result: There was a significant difference from the results of the MIC concentration of rosemary essential 100% to 6.25% microdilution method between nystatin and rosemary essential oil (p < 0.05). Conclusion: The antifungal activity of rosemary essential oil was better than nystatin that the lowest MIC value, which was 6.25%, has been obtained the microdilution method. The minimum fungicidal concentration of rosemary essential oil was 25%, while the minimum fungicidal concentration nystatin was higher than 100%.
The Effect of Lifestyle on Skin Aging Yasmin Adzra Nabila; Damayanti Damayanti; Samsriyaningsih Handayani; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 2 (2021): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.2.2021.110-115

Abstract

Background: Skin aging is a natural process, and it has many causes. Skin aging can be a result of a process of deterioration of the skin structure and a decrease in normal skin function. As much as 97% of skin aging factors is extrinsic, while the remaining 3% of the factors is intrinsic. Extrinsic factors are closely related to lifestyle; therefore it is necessary to further investigate the effects of lifestyle on skin aging. Skin aging may not have a direct correlation to mortality but the process of aging itself can lead to depression, demoralization, and shame at the extreme to the point of accepting the changes that occur with age. This shows that aging plays an important role in decreasing the quality of human life and youth well-being index, especially in women. Purpose: To determine the effects of lifestyle on skin aging. Methods: This was a case-control study. A case means a person with heavy aging, and control means an individual with mild aging. The data were obtained from medical records and anamneses. Data on lifestyle were collected through interviews with open-ended questions. Subjects who met the inclusion criteria were shortlisted, and their skins were examined as per the Glogau scale. Result: Multivariate test results showed significant results on the variable UV light exposure (p = 0.017), use of sunscreen (p = 0.002), use of anti-aging cream (p = 0.036), and Vitamin D (p = 0.040) against skin aging. Meanwhile, other variables showed no significant results. Conclusion: Lifestyle has an important role in the occurrence of skin aging. However, an in-depth research is needed to determine how many external factors affect skin aging.
The Profiles of Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) Patients in Tertiary Hospital William Andrew Isaac; Damayanti Damayanti; Nurmawati Fatimah; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 2 (2021): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.2.2021.116-122

Abstract

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe eruptive skin reactions that can cause death. The incidence of SJS and TEN cases in the United States is 1.5–9.6 per 1,000,000 per year. Drugs are the primary etiology of SJS and TEN. Some drugs are at high risk and used frequently. The SJS and TEN mortality rates were relatively high, with SJS 4.8%, SJS / TEN overlap 19.8%, and TEN 14.8%. In Indonesia, there are lack of studies on the SJS and TEN. This study is needed to determine the epidemiological profile of SJS and TEN. Purpose: This study aimed to describe SJS and TEN patients' profiles. Methods: Drug-induced SJS and TEN cases from January 2016 to December 2019 were evaluated from the medical records patients' profile, incidence, suspected drugs, risk factors, and comorbidities of SJS and TEN were described. Result: There were 28 SJS and TEN patients, comprising of 24 SJS patients (85.7%), 3 TEN patients (10.7%), and 1 SJS overlapping TEN patients (3.5%). The most common suspected drugs were paracetamol (22.2%), carbamazepine (20.4%), cefadroxil (8.8%), and ciprofloxacin (8.8%). Women (53.5%) experienced more severe drug eruptions than men (46.4%). The largest age group was 25–44 years (35.7%). Most comorbidities were epilepsy (21%), diabetes (15.7%), hypertension (15.7%), and stroke (15.7%). Conclusion: The most common manifestation was SJS with paracetamol as the most common suspected drug, followed by carbamazepine.
Risk Factor Profile and Quality of Life of Psoriasis Vulgaris As'ad Naufal; Damayanti Damayanti; Etty Hary Kusumastuti; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 2 (2021): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.2.2021.129-134

Abstract

Background: Psoriasis is an autoimmune human skin disease. It is a chronic and recurrent lesion characterized by erythema patches with well-defined borders with rough, multi-layered, and transparent scales with a significant negative impact on patients' quality of life. Several risk factors for psoriasis can decrease patient’ quality of life. Purpose: To determine the risk factor profile and quality of life of psoriasis patients at the dermatology and venereology outpatient clinic at Dr. Soetomo General Academic Hospital Surabaya.  Methods: This was a cross-sectional study involving new and control psoriasis patients. Their risk factors were evaluated using questionnaires, and their quality of life was measured using the DLQI questionnaires. The data was collected at the Dermatology and Venereology outpatient unit Dr. Soetomo General Academic Hospital Surabaya. Result: Of the 24 patients, the biggest risk factor for psoriasis patients was trauma/ Koebner phenomenon, as reported in 15 patients (62.5%), and 11 patients’ (45.8%) quality of life was affected. Conclusion: Trauma was the largest risk factor for psoriasis, and psoriasis has significantly affected patient’ quality of life.
Contact Dermatitis in Tertiary Hospital: A 2-year Retrospective Study Efenina Ginting; Damayanti Damayanti; Deasy Fetarayani; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 2 (2021): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.2.2021.88-92

Abstract

Background: Contact dermatitis (CD) is a skin inflammatory caused by allergen or irritant that generates public health impact. CD is classified into two types, based on its etiological perspective, namely allergic contact dermatitis (ACD) due to a hypersensitivity type IV reaction and irritant contact dermatitis (ICD), which is a non-immunological reaction. Purpose: To determine the profile of CD patients at Dermatology and Venereology Outpatients Unit of Dr. Soetomo General Academic Hospital Surabaya in January 2018 – December 2019. Methods: A retrospective study by observation and recording data. The results of the data recap were then processed using Microsoft Excel to obtain conclusions.  Result: The results obtained were ACD (61.9%) and ICD (38.1%), aged 26-45 years (32.7%), female (79.3%). The most frequent occupation was housewives (25.3%), followed by private employees (24.5%). The most suspected causative substance was cosmetic (47.7%). The most common skin disease history was food allergy (11%), followed by drug allergy (2.8%), and atopic dermatitis (2.3%). The most frequent manifestation was acute (69.8%), with the most clinical presentation was erythematous macules (35%). Most therapies were given in combination (73.6%), with antihistamines (61%) and topical corticosteroids (49.2%) were the most prescription drug. Conclusion: ACD was more common than ICD, mostly in a female, dominated in the 26-45 years old. Housewife was the most occupational. Cosmetic was the most suspected causative substance. Food allergy was the most skin disease history. Acute was the most frequent manifestation. Erythematous macules were the most clinical presentation. Antihistamine and corticosteroid are the most common drug in combination therapy.
Co-Authors Afif Nurul Hidayati As'ad Naufal Bernadya Yogatri Anjuwita Deasy Fetarayani Dwi Murtiastutik Efenina Ginting Evy Ervianti Fatimah, Nurmawati Iskandar Zulkarnain KUSUMASTUTI, ETTY HARY M. Yulianto Listiawan Pepy Dwi Endraswari, Pepy Dwi Rahmadewi Rahmadewi Samsriyaningsih Handayani Trisniartami Setyaningrum William Andrew Isaac Yasmin Adzra Nabila