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All Journal journal of internal medicine Berkala Ilmu Kesehatan Kulit dan Kelamin The Indonesian Biomedical Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Respirasi (JR) Majalah Biomorfologi (Biomorphology Journal)
Deasy Fetarayani
Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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ASOSIASI ANTARA POLUSI UDARA DENGAN IgE TOTAL SERUM DAN TES FAAL PARU PADA POLISI LALU LINTAS Fahimi, Mukti; Dharma S, Bayu; Fetarayani, Deasy; Baskoro, Ari; Soegiarto, Gatot; Effendi, Chairul
journal of internal medicine Vol. 13, No. 1 Januari 2012
Publisher : journal of internal medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.192 KB)

Abstract

Ambient air pollution often associated with allergic diseases and impaired respiratory function. Total serum IgE levels was  one  of  the  diagnostic  tools  to  establish  an  allergic  diseases while  lung  function  test was  standard  examination to establish alteration in lung function. Trafc police ofcers were often assigned on the highway is one of the mostvulnerable population against exposure to air pollution. Aim of this study isto know the association between air pollution on total serum IgE levels and lung function in trafc police ofcers compared to staff police ofcer as control.This is anobservational analysis study with cross sectional design.There were 60 police ofcers as a subject, divided in two groups.Thirty subjects as exposured groups and 30 subjects as control group. Air pollution was measured by Pollutant StandardIndex (PSI)/ Indeks Standar Pencemar Udara (ISPU) method. Independent  t-test and Mann-Whitney  test were used  to analyze differences between variabel. Spearman test was used to analyze correlation and strength between variabel.There were no signicant differences in total IgE serum levels between groups (p = 0.301). There were signicant differencesin FEV1 (%p) (p = 0.015), FVC (%p) (p = 0.000) and spyrometry result (p = 0.001). There was no signicant differencein FEV1/FVC ratio (p = 0.573). There were negative weak association between air polution and FEV1 (%p) (r = -0.298;p=0.021) and between air pollution and spyrometry result (r = -0.380; p = 0.003). There was negative moderate associationbetween air pollution and FVC (%p) (r = -0.409; p = 0.001). There was no association between air pollution and FEV1/FVC ratio (r = 0.058; p = 0.662). There was signicant association between air pollution and impaired respiratory functionbut there was no association between air pollution and total serum IgE levels.
The role of gut microbiota in health and diseases Deasy Fetarayani; Handoko Hariyono; Gatot Soegiarto
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.5846

Abstract

ABSTRACTABSTRACTMicrobiota contributes a crucial part in the human hosts' health and actively provides to the emergence of various diseases. The optimal composition of healthy intestinal microbiota varies from person to person. The more various and abundant of the microbiota, the greater their resistance to outside hazards. Colonization of the microbiota in the human body starts after delivery and develops continuously from infant to adult. The largest microbial colony is constructed in the lower part of the adult human digestive tract. The composition of the human intestinal microbiota alters promptly during the beginning of life and is steady. It has been described the close relationship among dysbiosis of the intestinal microbiota with intestinal and non-intestinal diseases. Nevertheless, it is uncertain whether dysbiosis is the culprit of the disease or only as a result of the disease. Human microbiota's role must be investigated more deeply so that later it can be developed for the prevention, diagnosis of disease, and more effective treatment strategies in the future. In this minireview, we will describe the development of the gut microbiota, its interaction with our bodily systems and defense, the multiple causes of dysbiosis, and its impact on several metabolic in inflammatory diseases in humans. With this insight, it is hoped that we can be more cautious about using antibiotics, avoid things that lead to dysbiosis, and handle diseases more holistically, putting the balance of the microbiota into account. Keywords:  human, microbiota, gastrointestinal tract, dysbiosis, health and diseaseCorresponding author: deasyfetarayani@gmail.com
Profil Pasien Urtikaria Aulia Rafikasari; Deasy Fetarayani; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 3 (2019): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (363.607 KB) | DOI: 10.20473/bikk.V31.3.2019.122-127

Abstract

Latar Belakang: Sebanyak 15-20% manusia pernah mengalami episode urtikaria satu kali selama hidupnya. Urtikaria adalah erupsi pada kulit, berwarna merah, berbatas tegas, dan memutih bila ditekan. Prevalensi urtikaria di dunia berkisar antara 0,3%-11,3% tergantung besar populasi yang diteliti. Tujuan: Mengevaluasi profil dan gambaran umum pasien baru urtikaria. Metode: Penelitian ini dilakukan di Instalasi Rawat Jalan Ilmu Kesehatan Kulit dan Kelamin dan Ilmu Penyakit Dalam RSUD Dr. Soetomo Surabaya periode 2015-2017. Metode yang digunakan adalah deskriptif retrospektif dengan mengevaluasi rekam medis pasien berupa umur, jenis kelamin, klasifikasi International Classification of Diseases (ICD) urtikaria, durasi urtikaria, dan pengobatan. Hasil: Didapatkan 463 pasien urtikaria. Pasien didominasi oleh rentang umur antara 12-25 tahun. Diagnosis terbanyak adalah urtikaria alergi sebanyak 36% pada tahun 2015, 34% tahun 2016, dan meningkat menjadi 40% pada tahun 2017. Pengobatan yang paling sering dilakukan adalah golongan obat antihistamin H1 generasi kedua. Kombinasi antihistamin H1 dan H2 juga masih banyak digunakan untuk terapi urtikaria. Simpulan: Pasien urtikaria di RSUD Dr. Soetomo tidak mengalami banyak perubahan bila dibandingkan dengan data profil urtikaria yang dilakukan tahun sebelumnya. Pengobatan urtikaria yang dilakukan kurang sesuai dengan guideline urtikaria terbaru tahun 2014.
Contact Dermatitis in Tertiary Hospital: A 2-year Retrospective Study Efenina Ginting; Damayanti Damayanti; Deasy Fetarayani; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 2 (2021): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.2.2021.88-92

Abstract

Background: Contact dermatitis (CD) is a skin inflammatory caused by allergen or irritant that generates public health impact. CD is classified into two types, based on its etiological perspective, namely allergic contact dermatitis (ACD) due to a hypersensitivity type IV reaction and irritant contact dermatitis (ICD), which is a non-immunological reaction. Purpose: To determine the profile of CD patients at Dermatology and Venereology Outpatients Unit of Dr. Soetomo General Academic Hospital Surabaya in January 2018 – December 2019. Methods: A retrospective study by observation and recording data. The results of the data recap were then processed using Microsoft Excel to obtain conclusions.  Result: The results obtained were ACD (61.9%) and ICD (38.1%), aged 26-45 years (32.7%), female (79.3%). The most frequent occupation was housewives (25.3%), followed by private employees (24.5%). The most suspected causative substance was cosmetic (47.7%). The most common skin disease history was food allergy (11%), followed by drug allergy (2.8%), and atopic dermatitis (2.3%). The most frequent manifestation was acute (69.8%), with the most clinical presentation was erythematous macules (35%). Most therapies were given in combination (73.6%), with antihistamines (61%) and topical corticosteroids (49.2%) were the most prescription drug. Conclusion: ACD was more common than ICD, mostly in a female, dominated in the 26-45 years old. Housewife was the most occupational. Cosmetic was the most suspected causative substance. Food allergy was the most skin disease history. Acute was the most frequent manifestation. Erythematous macules were the most clinical presentation. Antihistamine and corticosteroid are the most common drug in combination therapy.
Exclusive Breastfeeding Duration and Allergic Asthma Severity in Children Aida Fahira Rachma; Anang Endaryanto; Deasy Fetarayani; Retno Asih Setyoningrum
Jurnal Respirasi Vol. 7 No. 3 (2021): September 2021
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.837 KB) | DOI: 10.20473/jr.v7-I.3.2021.106-113

Abstract

Introduction: Asthma is a disease marked by bronchial hyperresponsivity. It is commonly seen in children and often affects their quality of life. Many factors affect asthma, including breastfeeding. Bioactive and immunological components of maternal milk have a protective effect on allergic asthma. However, some studies denied this, stating that it had no significant association to asthma. This study aimed to analyze the correlation between breastfeeding duration and the severity of allergic asthma described by the frequency of asthma attacks, sleep disorder, and activity limitation.Methods: This analytic observational study used a cross sectional approach. The subjects were pediatric outpatients aged 1 – 5 years old with allergic asthma at Pediatric Clinic of Dr. Soetomo General Hospital Surabaya and Private Pediatric Clinic from September 2019 to July 2020. Subjects were assessed based on the history of exclusive breastfeeding duration, frequency of asthma attacks, sleep disorder, and activity limitation through an interview using questionnaire.Results: Through the data obtained from 62 respondents, duration of exclusive breastfeeding showed no significant relation to the frequency of asthma attack (rs = -0.227, p = 0.076), sleep disorder (rs = -0.214, p = 0.095), and activity limitation (rs = -0.055, p = 0.672).Conclusion: There was no correlation between the duration of exclusive breastfeeding and the frequency of asthma attack, sleep disorder, and activity limitation.
FEATURES OF THE CLINICAL MANIFESTATIONS OF AUTOIMMUNE OPTIC NEUROPATHY IN MULTIPLE SCLEROSIS ON CORTICOSTEROID THERAPY Dalia Sharliz Raihana; Lukisiari Agustini; Deasy Fetarayani
Majalah Biomorfologi Vol. 34 No. 2 (2024): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v34i2.2024.123-133

Abstract

Highlights Intravenous corticosteroid treatment followed by oral clinical treatment can reduce the incidence of post-treatment optic neuritis recurrenc Visual acquisition increases at one-month post-treatment.   Abstract Background: The clinical picture of autoimmune optic neuropathy, known as neuritis, is strongly influenced by the unique structure of the human anterior visual pathway. The central nervous system autoimmune is related to multiple sclerosis (MS). Optic neuropathy is an injury that frequently results in acute inflammatory damage. Objective: This study aimed to determine the clinical manifestations of autoimmune optic neuropathy in multiple sclerosis and identify diseases with appropriate corticosteroid therapy using systematic review methods. Material and Method: This study used a systematic review method to analyze topic-related kinds of literature on  Scopus, PubMed, and Google Scholar databases. The literature screening process was carried out based on the PRISMA 2020 guidelines. Result: Regarding the post-treatment recurrence rate of optic neuritis, the use of intravenous corticosteroids alone and intravenous corticosteroid followed by oral administration may clinically reduce the incidence of recurrence in the patients compared those receiving placebo and oral administration. This suggests that intravenous corticosteroid followed by oral corticosteroid treatment is effective in helping to reduce the incidence of recurring optic neuritis. Conclusion: Intravenous corticosteroid treatment followed by oral administration may clinically reduce the incidence of post-treatment recurrence of optic neuritis in multiple sclerosis (MS) patients.
Lactiplantibacillus plantarum IS-10506 Enhances Tight Junction Integrity in Bronchial Epithelium: An Experimental Study Fetarayani, Deasy; Soegiarto, Gatot; Surono, Ingrid Suryanti; Endaryanto, Anang; Athiyyah, Alpha Fardah; Hernaningsih, Yetti; Fauziah, Dyah; Sudiana, I Ketut; Utomo, Budi; Prakoeswa, Cita Rosita Sigit
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2995

Abstract

BACKGROUND: Airway epithelium constitutes the initial structural defense against inhaled allergens, with its integrity primarily maintained through the formation of tight junctions (TJ) consisting of claudins, occludins, and zonula occludens (ZO). Currently, the effects of probiotics on airway TJ remain unclear. Therefore, this study was conducted to explore the impact of Lactiplantibacillus plantarum IS-10506, a native probiotic from Indonesia, on bronchial epithelial TJ in a mouse model of allergic airway inflammation.METHODS: Twenty-four BALB/c mice were randomly assigned to three groups: negative control, positive control subjected to Dermatophagoides pteryonissinus (Der p) sensitization and challenge, and treatment group exposed to Der p and administered L. plantarum IS-10506 since one week before sensitization up to three weeks after. The expression levels of claudin-18, occludin, and ZO-1 were investigated through immunohistochemistry analysis and quantified based on the immunoreactive score (IRS). RESULTS: The results of this study demonstrated that L. plantarum IS-10506 significantly enhanced the expressions of claudin-18, occludin, and ZO-1 (p<0.05).CONCLUSION: These findings underscore the probiotic's role in fortifying the integrity of airway TJ.KEYWORDS: allergic inflammation, probiotic Lactiplantibacillus plantarum, immunology, respiratory system, tight junction, occludin, claudin, zonula occludens
Co-Authors Afif Nurul Hidayati Aida Fahira Rachma Alpha Fardah Athiyyah Anang Endaryanto Ari Baskoro Aulia Rafikasari Bayu Dharma S Budi Utomo Chairul Effendi Cita Rosita Sigit Prakoeswa Dalia Sharliz Raihana Damayanti Damayanti DYAH FAUZIAH, DYAH Efenina Ginting Gatot Soegiarto Handoko Hariyono INGRID SURYANTI SURONO Lukisiari Agustini Mukti Fahimi Retno Asih Setyoningrum S.Pd. M Kes I Ketut Sudiana . Trisniartami Setyaningrum Yetti Hernaningsih