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All Journal Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Oto Rhino Laryngologica Indonesiana Ina Kidney Biomolecular and Health Science Journal CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL CRJIM (Clinical and Research Journal in Internal Medicine)
Nunuk Mardiana, Nunuk
Division Of Nephrology – Hypertension, Department Of Internal Medicine, Dr.Soetomo Hospital, Faculty Of Medicine, Airlangga University – Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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HEPATITIS C VIRUS INFECTION IN HEMODIALYSIS PATIENTS: COMPARISON OF THE SURABAYA DIALYSIS CENTER AND JUNTENDO UNIVERSITY HOSPITAL DIALYSIS CENTRE santoso, djoko; pranawa, pranawa; Yogiantoro, Moh.; Widodo, Widodo; Wardana, Aditia; Mardiana, Nunuk; Mohani, Chandra Irwanadi; soewanto, soewanto; Shou, Ichiyu; Maeda, Kunimi; Hamada, chieko; Fukui, Mitsumine; Horikoshi, Satoshi; Tomino, Yasuhiko
Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 3 (2010)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (441.735 KB) | DOI: 10.20473/ijtid.v1i3.2183

Abstract

Hepatitis C virus infection is highly prevalence in chronic hemodialysis (HD) patients. The present study will compare prevalence of HCV positive population in difference countries where there are great contrasts in and diversity of care available to patients who have end stage renal disease. All serum samples of the 100 patients were tested for HCV antibodies, using third-generation enzyme immunoassay. The prevalence of anti-HCV was correlated with a history of blood transfusion and with duration of hemodialysis. HCV prevalences were 88% of Surabaya group and 6% of Juntendo Group, respectively. In Surabaya Group, prevalence of HCV positive was high and the risk factors are not only those of the Juntendo Group, but also a combination of poor living conditions, frequent blood transfusions, and lack of adherence. Much needs to be studied about the role of universal screening and effective techniques for primary prevention in Surabaya Group
C-reactive Protein and Hepcidin in Non-Dialysis Chronic Kidney Disease Putera, Edward Muliawan; Widodo, Widodo; Mardiana, Nunuk
Indonesian Journal of Tropical and Infectious Disease Vol. 8 No. 3 (2020)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i3.12226

Abstract

Complications such as anemia and its clinical consequences arise as chronic kidney diseases progress,. One renal anemia pathophysiology is a disruption of iron metabolism, regulated by the main iron exporter hormone, hepcidin. Chronic kidney disease patients were constantly in an inflammatory state, represented by an increased in C-reactive protein. This inflammatory state would facilitate the liver to secrete hepcidin, which would subsequently follow a decrease of iron circulation, thus resulting in functional iron deficiency. Both acute phase reactants which used thoroughly as markers in tropical and infectious diseases, had their own roles in chronic kidney disease. The correlation of c-reactive protein and hepcidin in chronic kidney disease patients was still controversial. To analyse the relationship between c-reactive protein and hepcidin in non-dialysis chronic kidney disease patients. We conducted an observational cross-sectional study with 40 non-dialysis chronic kidney disease patients who met the inclusion and exclusion criteria. Patients were enrolled with consecutive sampling and were examined for serum c-reactive protein and hepcidin levels.A total of forty subjects (67.5% male with mean age of 50.23 ± 1.04 years) were eligible for enrolment in this study. The most comorbid factor was hypertension (62.5%). The common stage for chronic kidney disease was stage 3 (40%). The mean hemoglobin value was 10.74 ± 0.36 g/dL, mean blood urea nitrogen was 39.98 ± 29.59 mg/dL, and serum creatinine of 4.12 ± 3.39 mg/dL. Mean serum c-reactive protein levels were 3.52 ± 5.13 mg/l. Mean hepcidin level were 94,03 ± 95,39 ng/ml. Serum C-reactive protein levels correlated positively (r=0.487) and significantly (p-value=0.001) with serum hepcidin value. C-reactive protein and hepcidin was significantly correlated in non-dialysis chronic kidney disease patients. 
Association between Albuminuria and Serum Phosphate Levels in Non-Dialysis Stage 3-5 Chronic Kidney Disease Patients Harfonso, Ernesto Everald Baibelino; Mardiana, Nunuk; Atika
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 2 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i2.49184

Abstract

Introduction: Chronic kidney disease (CKD) remains a global burden and catastrophic disease as about 697.5 million people suffering from it in 2017. About 42% of CKD mortality in Indonesia is related to cardiovascular complications. Hyperphosphatemia, a manifestation of chronic kidney disease-mineral bone disorder, could increase the risk of cardiovascular mortality. Albuminuria has been proven to inhibit the compensatory mechanisms for hyperphosphatemia, thereby aggravating this condition. This study was conducted to analyze the association between albuminuria and serum phosphate levels among CKD patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.Methods: This cross-sectional study used medical records of 129 non-dialysis stage 3-5 CKD patients at the outpatient clinic of Dr. Soetomo General Academic Hospital from March-November 2021. Descriptive analysis was performed on albuminuria, serum phosphate, age, sex, body mass index, comorbid, blood chemistry tests, and CKD stages data. Correlational analysis was conducted using the Spearman Rank test on albuminuria and serum phosphate levels.Results: The majority of the subjects in this study were male (55.81%); mean age was 55.21±11.99 years; mean BMI was 22.39±2.27 kg/m2; hypertension was found in 65.89% of the patients; mean eGFR was 25.01±16.1 ml/min/1.73 m2 and dominated by CKD stage 3-5. The distribution of albuminuria grade was dominated by heavy albuminuria (>300 mg/g) and the mean serum phosphate level was 4.81±1.9 mg/dl. Spearman Rank analysis found a significant positive correlation with weak association strength (p<0.001; rs=0.277) between albuminuria and serum phosphate levels.Conclusion: There was a significant positive correlation with weak association strength between albuminuria and serum phosphate levels.  
Co-Authors Aditia Wardana, Aditia Aditiawardana Aditiawardana, Aditiawardana Alfarika Rosmalia Ardityo R Ardhany, Ardityo R Artaria Tjempakasari, Artaria atika Caesar Ayudi Chandra Irwanadi Chandra Irwanadi Chandra Irwanadi Mohani, Chandra Irwanadi Chandra Irwanadi, Chandra chieko Hamada, chieko Dana Pramudya Djoko Santoso DYAH FAUZIAH, DYAH Fauzia N Liani Hadiati Setyorini Harfonso, Ernesto Everald Baibelino Ichiyu Shou, Ichiyu Jahidi, Savero Mizan Kunimi Maeda, Kunimi M Thaha, M Mahrumi Dewi Tri Utami Makhmudyah Indri Cahyani ManikRetno Wahyunitisari Mega Kahdina Mitsumine Fukui, Mitsumine MOCHAMMAD THAHA Moh. Yogiantoro, Moh. Nurwidda, Arvi Dian Prasetia Nyilo Purnami P Pranawa Pranawa Pranawa pranawa pranawa, pranawa Putera, Edward Muliawan Rebekah Setiabudi, Rebekah Rusdi Zakki Aminy Sabrina Izzattisselim Sambodo, Shella Violita Satoshi Horikoshi, Satoshi soewanto soewanto, soewanto Suryantoro, Satriyo Dwi Tenta Hartian Hendyatama Tri P Asmarawati, Tri P Wardhani, Indrayuni Lukitra Widodo Widodo Widodo Widodo Yasuhiko Tomino, Yasuhiko