Claim Missing Document
Check
Articles

Found 17 Documents
Search

Anthropometry-based Body Fat Percentage Predicts High hs-CRP in Chronic Kidney Disease Patients Mochammad Thaha; Maulana Antiyan Empitu; Ika Nindya Kadariswantiningsih; Cahyo Wibisono Nugroho; Nurina Hasanatuludhhiyah; Haerani Rasyid; Zaky El Hakim; Maulana Muhtadin Suryansyah; Rieza Rizqi Alda; Mohammad Yusuf Alsagaff; Mochammad Amin; Djoko Santoso; Yusuke Suzuki
The Indonesian Biomedical Journal Vol 10, No 2 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i2.397

Abstract

BACKGROUND: Obesity is an important cardiovascular risk factor and associated with low grade inflammation in chronic kidney disease (CKD) patients. This study aims to assess the association between body fat with serum high sensitivity C-reactive protein (hs-CRP) level in CKD patients.METHODS: A cross-sectional study was performed in 71 CKD patients. Anthropometric measurements included body weight, height, body mass index (BMI), body fat percentage (BFP), skinfold thickness (SKF) of triceps and biceps were performed by trained physician. BFP was calculated using Kwok’s Formula and hs-CRP was measured by Particle enhanced Turbidimetry.RESULTS: The averaged BMI of our subjects was 25.8±4.4. There was no significant difference in BMI between pre-dialysis and hemodialysis CKD patients. Positive correlation was found between BFP and hs-CRP (r=0.266; p<0.05), while there was no significant correlation between BMI and hs-CRP.CONCLUSION: Body fat percentage was associated with hs-CRP. Hence, it will be more beneficial to assess nutritional status in CKD using BFP rather than BMI alone since it was demonstrated to correlate with hs-CRP in our studyKEYWORDS: CKD, obesity, inflammation, body fat, hs-CRP
Could Complete Blood Count Parameters and Non-fasting Cholesterol Profile Describe Inflammation and Oxidative Stress in Chronic Kidney Disease? Ika Nindya Kadariswantiningsih; Mochammad Thaha; Cahyo Wibisono Nugroho; Berliana Hamidah; Haerani Rasyid; Zaky El Hakim; Maulana Muhtadin Suryansyah; Mohammad Yusuf Alsagaff; Djoko Santoso; Maulana Antiyan Empitu; Yusuke Suzuki
The Indonesian Biomedical Journal Vol 10, No 3 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i3.451

Abstract

BACKGROUND: Establishment of inexpensive clinical laboratory tests to evaluate inflammation and oxidative stress is urgently needed in the limited resources settings. This study aims to investigate the potential of complete blood count (CBC) parameters and non-fasting cholesterol profile parameters to describe inflammation and oxidative stress in chronic kidney disease (CKD) patients.METHODS: Measurement of CBC, non-fasting cholesterol profile, high sensitivity C-reactive protein (hs-CRP) and malondialdehyde (MDA) were performed in 71 CKD patients grouped into hemodialysis (HD) and non-hemodialysis (non-HD). Correlation analysis were performed to assess the potential of CBC and cholesterol profile to describe the level of hs-CRP and MDA.RESULTS: In the HD group, total cholesterol was moderately associated with hs-CRP while total cholesterol/HDL-C ratio, monocyte/HDL-C ratio, monocyte/LDL-C ratio, neutrophil/HDL-C ratio, neutrophil/LDL-C ratio, platelet/HDL-C ratio and platelet/LDL-C ratio were strongly associated with hs-CRP. In the non-HD group,only neutrophil/total cholesterol ratio and platelet/total cholesterol ratio that were associated with hs-CRP. Total cholesterol, monocyte/LDL-C ratio, neutrophil/LDL-C ratio and platelet/LDL-C ratio were moderately associated with MDA while total cholesterol/HDL-C ratio, monocyte/HDL-C ratio, neutrophil/HDL-C ratio and platelet/HDL-C ratio were strongly associated respectively with MDA in HD group. In the non-HD group, total cholesterol/HDL-C ratio, neutrophil/HDL-C ratio and platelet/HDL-C ratio were moderately associated with MDA in non-HD group while monocyte/HDL-C ratio was weakly associated with MDA.CONCLUSION: Some CBC parameters and non-fasting cholesterol profile such as cholesterol/HDL-C, monocyte/HDL-C, neutrophil/HDL-C and platelet/HDL-C ratio showed a potential to describe the inflammation and stress oxidative markers, given some strong associations with the level of hs-CRP and MDA. Further study is needed to assess whether this parameter represent long-term prognostic value among CKD patients.KEYWORDS: inflammation, oxidative stress, CRP, MDA, TAC, 8-OHdG, CBC, cholesterol
Correlations between Total Antioxidant Capacity and 8-Hydroxydeoxyguanosine with Carotid-Femoral Pulse Wave Velocity in Chronic Kidney Disease Mochammad Yusuf Alsagaff; Budi Susetyo Pikir; Mochammad Thaha; Hendri Susilo
The Indonesian Biomedical Journal Vol 12, No 3 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i3.1241

Abstract

BACKGROUND: Chronic kidney disease (CKD) is often associated with an increased risk of cardiovascular disease. Cardiovascular disease in CKD can be affected by oxidative stress and inflammation. The oxidative stress can affect arterial stiffness, especially in patients with CKD, which will increase the risk of cardiovascular disease. This study aimed to explain the correlation between total antioxidant capacity (TAC) and 8-hydroxydeoxyguanosine (8-OHdG) with carotid-femoral pulse wave velocity (cf-PWV) in patients with CKD.METHODS: Forty-three CKD patients was included in this cross-sectional study. TAC was measured from serum samples by colorimetric method and 8-OHDG was measured from urine by enzyme-linked immunoassay method. cf-PWV was measured by Doppler ultrasound as a diagnostic tool for arterial stiffness.RESULTS: Significant correlations were found between age, estimated glomerular filtration rate (e-GFR), Hemoglobin A1C (HbA1C), serum creatinine, cystatin-C, and severity of CKD with urinary 8-OHdG levels. Serum creatinine, cystatin-C, severity of CKD, age, high-density lipoprotein (HDL), e-GFR, and HbA1C also had significant correlations with serum TAC levels. Other significant correlations between e-GFR, HbA1C, serum creatinine, cystatin-C, and severity of CKD with cf-PWV were also obtained. A significant negative correlation was obtained between serum TAC and cf-PWV with moderate levels of correlation coefficient (r=-0.504).CONCLUSION: There was a negative correlation between TAC and cf-PWV, but there was no significant correlation between 8-OHdG and cf-PWV in patients with CKD.KEYWORDS: chronic kidney disease, total antioxidant capacity, 8-hydroxydeoxyguanosine, carotid-femoral pulse wave velocity
Determiner of Poor Sleep Quality in Chronic Kidney Disease Patients Links to Elevated Diastolic Blood Pressure, hs-CRP, and Blood-count-based Inflammatory Predictors Maulana Antiyan Empitu; Ika Nindya Kadariswantiningsih; Mochammad Thaha; Cahyo Wibisono Nugroho; Eka Arum Cahyaning Putri; Zaky El Hakim; Maulana Muhtadin Suryansyah; Rieza Rizqi Alda; Mohammad Yusuf Alsagaff; Mochammad Amin; Djoko Santoso; Yusuke Suzuki
The Indonesian Biomedical Journal Vol 11, No 1 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i1.452

Abstract

BACKGROUND: Sleep deprivation is strongly associated with cardiovascular disease (CVD) via sympathetic overstimulation and systemic inflammation in general population. However, the significance of poor sleep quality in chronic kidney disease (CKD) is still underexplored.METHODS: This study assessed the sleep quality of 39 with non-dialysis CKD (ND CKD) patients and 25 hemodialysis CKD (HD CKD) patients using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Poor sleeper was defined as individual with PSQI > 5.RESULTS: The prevalence of poor sleeper (30% vs. 60%, p=0.029) and the cummulative PSQI (ND CKD 4.5±4.4, HD CKD 8±6, p=0.038) are different between ND CKD and HD CKD groups. Among the ND CKD, there are association between short sleep duration (< 5 hours per day) with elevated diastolic blood pressure groups (r=0.421, p<0.05); habitual sleep efficiency with platelet-to-lymphocyte ratio (r= 0.532, p<0.0001); daytime dysfunction with increased hs-CRP (r=0.345, p=0.032) and neutrophil-to-lymphocyte ratio (r=0.320, p=0.046). In HD CKD group, a requirement to use sleep medication was associated with elevated highsensitivity C-reactive protein (hs-CRP) level (r=0.434, p=0.030) and decreased monocyte-to-lymphocyte ratio (r=- 0.410, p=0.042); daytime dysfunction was associated with serum hs-CRP (r=0.452, p=0.023).CONCLUSION: This study revealed that some features of poor sleep quality in CKD patients including low sleep efficiency, daytime dysfunction and requirement to use sleep medication were associated with increased diastolic blood pressure, hs-CRP and blood-count-based inflammatory predictors. Thus, this finding prompt to pay closer attention to sleep complaints in the management of CVD risk factors in CKD patients.KEYWORDS: sleep quality, chronic kidney disease, blood pressure, inflammation
Comparison of High-sensitivity C-reactive Protein Level between Chronic Kidney Disease Stages Mochammad Thaha; Tri Asih Imroati; Aditia Wardana; Widodo Widodo; Pranawa Pranawa; chandra irwanadi
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1125.644 KB) | DOI: 10.20473/bhsj.v1i1.8226

Abstract

ABSTRACTAim : This research is to evaluate the hs-CRP level comparison between CKD stages in Dr. Soetomo General Hospital Surabaya.Methods: An analytic observational cross-sectional study, evaluating the differences of hs-CRP level between CKD stages in 72 patients (mean age 55.49±7.62 years, the ratio between male:female was 1:1.48, mean BMI 24.18±3.64 kg/m2, 36.11% diabetics, 43.05% on ACEI/ARB, 29.16% on statin), recruited from Nephrology Outpatient Clinic, Dr Soetomo General Hospital, Surabaya, from January to May 2014. The stages were stratified  according to the MDRD formula.Results: The mean hs-CRP of  CKD stage 3 was 2.29±2.86, stage 4 was 2.48 ± 2.19, and non-dialysis stage 5 was 2.09 ± 2.54. The analysis using Kruskal-Wallis test showed no significant differences among patients with  CKD stage 3, stage 4, and non-dialysis stage 5 (median 1.25 vs 1.80 vs 1.05 mg/L; p=0.430). No significant differences of the serum hs-CRP level were detected between diabetics and non diabetics in stage 3, 4, and non-dialysis stage 5  (p=0.673 vs 0.666 vs 0.138); between patients with and without ACEI/ARB treatment (p=0.610 vs 0.649 vs 0.671); and between patients with and without statin treatment (p=0.852 vs 0.341 vs 0.309).Conclusion: The elevation of serum hs-CRP level can not indicate the decline of kidney function, but it still needs further investigations.
VARIABILITAS TEKANAN DARAH INTRADIALISIS PASIEN PENYAKIT GINJAL KRONIS DENGAN HEMODIALISIS BERKELANJUTAN Maulana Muhtadin Suryansyah; Mochammad Thaha; Budiono Budiono
Majalah Biomorfologi Vol. 29 No. 1 (2019): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.275 KB) | DOI: 10.20473/mbiom.v29i1.2019.7-12

Abstract

Background: Various of studies report there was a link between changes in blood pressure during hemodialysis and the level of patient’s morbidity and mortality. Higher amount of mortality was found in groups of patients who have lower or higher blood pressure. Thus it is important to know the variability of blood pressure during hemodialysis. Objective: This study aims to determine blood pressure variability, namely systolic blood pressure and diastolic blood pressure during hemodialysis and determine the significance of changes in every hour of measurement. Material and method: The design of this study used a cross-sectional method with a total sample of 15 patients who have been diagnosed with Chronic Kidney Disease (CKD) and have been ungergone hemodialysis stably in the last 3 months. The data obtained were processed using paired T-Test and Wilcoxon test. Result: There was no significant difference in systolic blood pressure between hourly systolic blood pressure and a tendency to increase the mean systolic blood pressure during hemodialysis. In diastolic blood pressure, there was a difference between the mean diastole 3 and diastole 4, p = 0.007 (<0.05), while in other observation there were no significant differences. In the mean of diastolic blood pressure, there was a tendency to increase. Conclusion: During the hemodialysis process systolic blood pressure did not show a significant difference between the mean hours. In diastolic blood pressure, there was a significant difference between diastole 3 and diastole 4.
COMPARISON OF TOTAL ANTIOXIDANT CAPACITY (TAC)’S PATIENTS OF CHRONIC KIDNEY DISEASE UNDERGOING HEMODIALYSIS AND NON-HEMODIALYSIS Zaky Firmawan El-Hakim; Mochammad Thaha; Yetti Hernaningsih
Majalah Biomorfologi Vol. 30 No. 2 (2020): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v30i2.2020.52-58

Abstract

Background: Total antioxidant capacity (TAC) is one of the biomarkers to determine a person's health condition through antioxidant and oxidant activity or oxidative stress so that it can help in determining the therapy needed. However, currently, TAC levels in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) and non-hemodialysis (non-HD) are still controversial, so further research is needed. Objective: To analyze the comparison of TAC in HD and non-HD CKD patient. Materials and Methods: This was an analytical cross-sectional study with clinical observation in CKD patient. A total of 71 CKD patients consisting of 28 CKD HD patients and 43 non-HD CKD patients were enrolled in this study. Data about the characteristics of the subjects were taken using the anamnesis method, while data about TAC were taken using the colorimetric method with COBAS C-501 0837-19 series and 0835-13 series to measure TAC levels in the serum of CKD patients. The data that has been obtained were analyzed using independent sample t-tests. Results: TAC levels were significantly higher in CKD patients undergoing HD compared to non-HD CKD patients (p <0.05). There are data on albumin as an antioxidant and MDA as an oxidative stress biomarker that affects TAC levels. Conclusion: TAC levels found to be higher in hemodialysis CKD patient compared to non-hemodialysis CKD patient.
Peran Resiliensi, Positive Social Relationships, dan Health Belief terhadap Kesejahteraan Emosi Pasien Hemodialisis Nur Istiqomah; M. Noor Rochman Hadjam; Kwartarini Wahyu Yuniarti; Ira Paramastri; Mochammad Thaha
Personifikasi: Jurnal Ilmu Psikologi Vol 13, No 1 (2022)
Publisher : Universitas Trunojoyo Madura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21107/personifikasi.v13i1.13958

Abstract

Individu didiagnosis dengan penyakit ginjal stadium akhir dan harus menjalani perawatan hemodialisis memiliki implikasi bahwa menjadi tergantung pada pengobatan seumur hidup. Sejumlah studi melaporkan pasien hemodialisis mengalami beban simtom dan terganggunya well-being akibat penyakit maupun perawatan hemodialisis. Penelitian ini bertujuan untuk menguji peran resiliensi, positive social relationships, dan health belief terhadap emotional well-being pasien hemodialisis. Subjek penelitian yaitu pasien penyakit ginjal stadium akhir yang menjalani hemodialisis secara rutin di Instalasi Hemodialisis RSU Dr. Soetomo, Surabaya yang dipilih melalui purposive sampling, artinya dipilih berdasarkan pertimbangan kriteria tertentu dan kesediaan berpartisipasi. Penelitian ini melibatkan pasien hemodialisis sejumlah 55 orang terdiri dari 34 laki-laki dan 21 perempuan, berusia 26 – 60 tahun. Menggunakan metode kuantitatif dengan melakukan survei, pengumpulan data dilakukan menggunakan lima Skala yakni Scale of Positive and Negative Experience (SPANE) dan Satisfaction with Life Scale (SWLS), 10-Item Connor-Davidson Resilience Scale (10-Item CD-RISC), Medical Outcomes Study Social Support Survey (MOS-SSS), dan Skala Health Belief. Analisis data dilakukan dengan analisis statistik uji regresi ganda. Hasil uji regresi ganda menunjukkan bahwa hipotesis ditolak, artinya resiliensi, positive social relationships, dan health belief secara simultan tidak dapat memprediksi emotional well-being pasien hemodialisis (F = 2,363, p 0,05). Secara parsial, berdasarkan nilai t diketahui hanya resiliensi memberi kontribusi signifikan terhadap emotional well-being (t = 2,342, p 0,05), sementara positive social relationships dan health belief masing-masing memberi kontribusi tidak signifikan terhadap emotional well-being. Penelitian berikutnya diharapkan dapat membantu meningkatkan coping resources yakni resiliensi yang bermanfaat mendorong perkembangan emosi positif, serta dapat membantu memberi edukasi terkait penyakit ginjal dan hemodialisis sehingga pasien memiliki pemahaman, respon permasalahan, dan belief yang lebih positif.Kata kunci: emotional well-being, pasien hemodialisis
Correlation of Serum Nitric Oxide and Urine Malondialdehyde Levels in Non-Hemodialysis Chronic Kidney Disease Patients Dinda Dwi Purwati; Arifa Mustika; Lukman Hakim; Mochammad Thaha
Molecular and Cellular Biomedical Sciences Vol 6, No 1 (2022)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v6i1.226

Abstract

Background: In 2017, about 1.2 million people died because of Chronic Kidney Disease (CKD). Patients with CKD are known to have increased levels of oxidative stress which leads to decrease in NO production. NO is a highly reactive signaling molecule and a major determinant of vascular homeostasis. Thus, the decreased NO can be a risk factor for the development of atherosclerosis and increased cardiovascular risk. Meanwhile, Malondialdehyde (MDA) is known as excellent biomarker for oxidative stress. This study aims to determine the correlation of serum total nitric oxide (NO) and urine MDA levels in non-hemodialysis CKD patients.Materials and Methods: This study was an observational clinical study with a cross sectional design. Fourty-nine CKD subjects were selected by consecutive sampling. The samples for laboratory tests were collected from urine. MDA concentration was measured using the High-Performance Liquid Chromatography (HPLC) kit. NO concentration was measured with Griess reaction method and Total Nitric Oxide Parameter kit. The data were analyzed using the Statistic Package for Social Science (SPPS) software version 16.Results: The data showed significant negative correlations between MDA with NO (r=-0.294; p=0.041).Conclusion: There was a correlation between serum total NO and urine MDA levels in non-hemodialysis CKD patients.Keywords: chronic kidney disease, malondialdehyde, nitric oxide, non-hemodialysis
Kidney-Pulmonary Crosstalk from Pathophysiological Perspective Sharifa Audi Salsabila; Alfian Nur Rosyid; Maulana Antiyan Empitu; Ika Nindya Kadariswantiningsih; Satriyo Dwi Suryantoro; Mutiara Rizki Haryati; Mochammad Thaha; Yusuke Suzuki
Jurnal Respirasi Vol. 8 No. 1 (2022): January 2022
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.477 KB) | DOI: 10.20473/jr.v8-I.1.2022.44-51

Abstract

Lungs and kidneys are distant organs which are functionally related in physiological and pathological contexts. Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are common complications in acute kidney injury (AKI) or acute-on-chronic kidney disease. On the other hand, there is a considerable risk of AKI in respiratory diseases such as ARDS and chronic obstructive pulmonary disease (COPD). From a pathophysiological point of view, the kidney-lung crosstalk involves interdependency in the regulation of fluid hemodynamic, acid-base and electrolyte balance, and carbon dioxide partial pressure. Aside from the closely related function, the crosstalk may also occur by non-classical mechanisms such as through activation of systemic inflammation, excessive cytokine release, and the formation of auto-antibody which targets both kidneys and lungs. This review discussed several disease mechanisms by which kidney and lungs affect each other or are simultaneously affected by pathological processes. Particularly, this review discussed some specific mechanisms in lungs and kidneys, such as how hypoxemia and hypercapnia induced by ARDS may reduce kidney function and how distance injury on kidney may affect the development of non-cardiogenic edema lungs.
Co-Authors Aditia Wardana Alisia Y Putri, Alisia Y Arifa Mustika Artaria Tjempakasari, Artaria Berliana Hamidah Budi Susetyo Pikir Budiono Budiono Cahyo Wibisono Nugroho chandra irwanadi David Setyo Budi Dinda Dwi Purwati Djoko Santoso Eka Arum Cahyaning Putri Haerani Rasyid Haerani Rasyid HAK HOTTA Hakim, Arief Rakhman Hendri Susilo I Gde Raka Widiana Ika Nindya Kadariswantiningsih Ira Paramastri Juniastuti Juniastuti Kwartarini Wahyu Yuniarti Laurentius Andre Lukman Hakim M. Amin M. Noor Rochman Hadjam MARIA INGE LUSIDA Maulana Antiyan Empitu Maulana Muhtadin Suryansyah Maulana Muhtadin Suryansyah Maulana Muhtadin Suryansyah MOCHAMAD AMIN Mochamad Yusuf Alsagaff Mochammad Amin Mochammad Yusuf Alsagaff Mochammad Yusuf, Mochammad Moh. Yogiantoro, Moh. Mohammad Yusuf Alsagaff Mohammad Yusuf Alsagaff Multazam, Chaq ECZ. Mutiara Rizki Haryati Nunuk Mardiana, Nunuk Nur Istiqomah Nurina Hasanatuludhhiyah Nurwidda, Arvi Dian Prasetia Pakpahan, Cennikon Pranawa Pranawa Priyo Budi Purwono Puling, Imke MDR. Putri Aliya Ahadini Ramadhan, Roy N. Rampengan, Derren DCH. Retno Handajani Rieza Rizqi Alda Rieza Rizqi Alda Rosyid, Alfian Nur Saphira, Diva Sharifa Audi Salsabila Soebroto, Heroe SOETJIPTO . Suryantoro, Satriyo Suryantoro, Satriyo Dwi TAKAKO UTSUMI Tjandra, Kevin C. Tri Asih Imroati Wenny P Nilamsari, Wenny P WENNY PUTRI NILAMSARI, WENNY PUTRI Widipriyatama, Gabriel Rio Widodo Widodo Widodo Widodo Willyanto, Sebastian E. Wungu, Citrawati Dyah Kencono Yasuhiko Tomino, Yasuhiko Yetti Hernaningsih YOSHIHIKO YANO YOSHITAKE HAYASHI Yusuke Suzuki Yusuke Suzuki Yusuke Suzuki Zaky El Hakim Zaky El Hakim Zaky Firmawan El-Hakim