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All Journal Journal of Science and Applicative Technology Jurnal Pengabdian Kepada Masyarakat Radisi
Tirta Setiawan
Institut Teknologi Sumatera
Agriculture, Biological Sciences & Forestry Humanities Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Materials Science & Nanotechnology Mechanical Engineering Social Sciences

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Predicting Multi-Epitope Peptide Cancer Vaccine from Novel TAA Topo48 Tirta Setiawan; Rizarullah Rizarullah
Journal of Science and Applicative Technology Vol 5 No 1 (2021): Journal of Science and Applicative Technology June Chapter
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/jsat.v5i1.349

Abstract

Cancer is one of the most lethal diseases. Recently, cancer immunotherapy has a tremendous achievement in cancer treatment. A certain number of cancer based epitope vaccines with different moiety have been discovered. In japan, several clinical tests of cancer based epitope vaccine derived from tumor associated antigens (TAAs) are now ongoing or have recently been completed. a novel of TAAs potentially as cancer vaccine have been retrieved from a fragment weighed 48kDa derived from human DNA-topoisomerase 1 (TOP1) called Topo48. Therefore, it is still critical to discover a derived Topo48 epitope based cancer vaccine. Immuno-informatics considered as a methods noted to have better accuracy to design promising vaccine candidates. Here, continuous and discontinuous B-cell epitopes following with CTL epitopes and their docking interaction to major histocompatibility complex (MHC) class I Human Leukocyte Antigens (HLA)- A0201 were predicted. Kolaskar-Tongaonkar’s, Emini’s, Karpus-Schulz’s, and Parker’s methods were used to predict continuous B-cell epitopes while ElliPro was used for prediction of discontinued B-cell epitopes. Those considered methods marked to have better accuracy to design promising vaccine candidates. Similarly, CTL epitopes was also predicted by using NetCTL server and the best candidates were further investigated their binding affinity by mean of PEP-FOLD3, PatchDock rigid-body docking server, and FireDock server. Total 27 continuous epitopes and 7 discontinuous B-cell epitopes were predicted. In the other hand, 9 peptides were predicted as CTL epitopes. Whereas, three predicted CTL epitope in range 263MLDHEYTTK27, 755AIDMADEDY763, 715ALGTSKLNY724) exhibited good interactions to HLA-A0201. Moreover, we also found residues His266, Thr270, Ala755, Tyr723, Thr718, Ser719, Lys720 from Topo48 and residues Thr163, Asp757, His70, Glu63 from HLA- A0201 were indicated to be antigenic. Ultimately, our proposed continuous/discontinuous B-cell epitopes, and also CTL epitopes can be potential vaccines for cancer immunotherapy.
Pelatihan Penerapan Sistem Integrasi Data Kependudukan Sederhana (SIDaKS) Di Kecamatan Kota Agung Timur Tanggamus Dani Al Mahkya; Fery Widhiatmoko; Dian Anggraini; Tirta Setiawan; Febri Dwi Irawati; Meida Cahyo Untoro
Jurnal Pengabdian kepada Masyarakat Radisi Vol 2 No 1 (2022): April
Publisher : Yayasan Kajian Riset dan Pengembangan RADISI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55266/pkmradisi.v2i1.68

Abstract

System-based data recording is indispensable in all fields, including government agencies. One of the important points in data recording is system integration. Data integration has the advantage of making the flow of organizational information better. One of the problems that arise in this Community Service activity partner is the unavailability of a population data integration system from each village/village to the sub-district. This activity aims to conduct training, mentoring and demonstration of the proposed integration system. The solution that will be offered is to conduct training and socialization related to population data management and integration. This training and socialization will use Ms. Excel and Google Sheet in the process. The method used in implementing community service activities is training and mentoring as well as demonstrations related to the Implementation of the Simple Population Data Integration System (SIDaKS) in Kota Agung Timur District, Tanggamus. The training was carried out in the East Kota Agung District hall, Tanggamus. Participants who attended the activity were representatives of each village/village in the Kota Agung Timur District. There are several steps taken to support the implementation of activities. The activity took place smoothly in accordance with the applicable health protocol. And it will be held on September 30, 2021 at the Kota Agung Timur , Tanggamus
Co-Authors Dani Al Mahkya Dian Anggraini Fery Widhiatmoko Irawati, Febri Dwi Rizarullah, Rizarullah Untoro, Meida Cahyo