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All Journal Lantanida Journal JIPI (Jurnal IPA dan Pembelajaran IPA)
Saaid, Mardiana
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Physics

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Experimental and Computational Studies on the Antiglaucoma Effects of Kelulut Honey (Heterotrigona itama) from Aceh in Rats (Rattus norvegicus) Erlidawati*, Erlidawati; Rizarullah, Rizarullah; Mustika, Chessy Rima; Awlanur, Cut; Fazli, Rahmad Rizki; Saaid, Mardiana
Jurnal IPA & Pembelajaran IPA Vol 9, No 2 (2025): JUNE 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jipi.v9i2.45131

Abstract

This study aimed to evaluate the efficacy of kelulut (H. itama) honey as an antiglaucoma agent in rats. Kelulut honey diluted to a concentration of 400 ppm using distilled water was prepared for chemical and biological analysis. Secondary metabolites in the extracts were identified by phytochemical methods and antioxidant activity was evaluated by DPPH method. In vivo test was conducted on R. novergicus rats that had been treated with intraocular pressure with 5 treatment groups and 5 repetitions for the antiglaucoma test. In addition, in silico studies were also conducted using apigenin, cathecin, luteolin, naringenin and taxifolin against Rho Kinase protein. The results showed that kelulut honey extract has been confirmed to contain alkaloid, flavonoid, and flavone compound classes. The extract was also confirmed to have antioxidant activity with an IC50 value of 6.2 ppm against 5.4 ppm ascorbic acid. The findings showed that kelulut honey has efficacy as antiglaucoma in rats. The secondary metabolites in this honey, especially alkaloids, flavonoids, and flavones, showed high antioxidant activity (50). At a dose of 40 ppm, kelulut honey was showed to reduce intraocular pressure (IOP) by 46.56% in the right eye and 55.15% in the left eye of rats. This effect is comparable to the use of 2% pilocarpine. In silico study showed that all tested compounds have good binding affinity to protein targets, with promising key interactions. Therefore, kelulut honey was potentially a natural candidate for the development of antiglaucoma therapeutics.
EKSPLORASI, ISOLASI, DAN MORFOLOGI MIKROBA DARI GUA LEUNTIE, LHOONG, SERTA UJI PRELIMINARY POTENSIAL MICP (MICROBIALLY INDUCED CALCIUM CARBONATE PRECIPITATION) Fazli, Rahmad Rizki; Taufiq, Luthfi Chaliqi; Zahra, Mimi; Jwita, Nova Elsa; Erlidawati, Erlidawati; Saaid, Mardiana
Lantanida Journal Vol 14 No 1 (2026): January-June 2026
Publisher : UIN AR-RANIRY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/lj.v14i1.34801

Abstract

 Aceh province has interesting natural landscapes. Forests, seas, mountains and caves are very complete in decorating the natural landscape of Aceh. One of the famous caves is Leuntie Cave which is located in Lhoong, Aceh Besar. The structure of Leuntie Cave is very unique because it consists of cave walls made of rock and the floor layered with sea sand. The mouth of Leuntie Cave is located not far from the sea, only about 200 m from the shoreline which affects the humidity of the cave. High humidity level allows Leuntie Cave to be a potential and unique microbial habitat for isolation. This study used an experimental research method with the initial stage of exploration of Leuntiee Cave for sampling of soil and cave wall rocks, followed by isolation and screening of bacterial growth and obtained five bacterial isolates with codes BGL-1 to BGL-5. Microbial morphological identification was carried out by observing bacterial colonies and gram staining tests. Preliminary urea agar base test to see the potential in precipitating calcium carbonate (CaCO3) by producing the urease enzyme. The results of this study obtained two Leuntiee Cave bacterial isolates BGL-1 and BGL-3 which were positive for producing the urease enzyme and could be selected as MICP bio-agent candidates.
Co-Authors Awlanur, Cut Erlidawati Erlidawati Erlidawati*, Erlidawati Fazli, Rahmad Rizki Jwita, Nova Elsa Mustika, Chessy Rima Rizarullah, Rizarullah Taufiq, Luthfi Chaliqi Zahra, Mimi