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FACTORS THAT HAVE PROGNOSTIC VALUES IN THE MANAGEMENT OF NASOPHARYNGEAL CARCINOMA PATIENTS Chandra Kangga; Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3454

Introduction: The survival rate of Nasopharyngeal carcinoma (NPC) patients is influenced by several prognostic factors, Such aspatient factors, tumor factors and therapeutic interventions carried out as well as the quality of care. Tumor factors in the form of spread of local invasion, regional lymphatic involvementand metastasis that is reflected in the TNM stage (Tumor, Nodule and Metastatic) are the most important prognostic factors of NPC. Objective: To determine the Prognostic factors that effectedsurvival rate of nasopharyngeal carcinoma patients. Material and methods: Analytic observational studywith particular design of survival analysis. Data was taken from medical records and then performed survival analysis on the studiedfactors. Sample of this studywas all patients who were first diagnosed NPC From January 2013 until December 2013 and meetinclusion and exclusion criteria is52 patients. Results:From 52 patients in the fifth year, 50% died and 50% survive. Survival was worse in the 30-39 year age group (30.8%), male sex (47.2%), Stage IV (44.4%), T4 size (40%), N1 size (23,1%), Distant metastases (40%), WHO type III (48.5%), chemoradiation (48.9%). In multivariate analysis, it was found that the variables that most influenced the survival of NPC patients based on p <0.05 and based on hazard ratio strength were T-size, N-size categories and Metastasis with 95% CI. Conclusion: Prognostic factors that affect the survival of NPC patients in RSUP. Dr. Mohammad Hoesin Palembang is a category of size T, N, and Metastasis.

VISUAL IMPAIRMENT IN NASOPHARYNGEAL CARCINOMA Apryanza Akbar; Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3504

Introduction: he most common complaint in almost half of nasopharyngeal carcinoma (NPC) patients is a lump in the neck. Neurological symptoms occur less frequently, whereas blindness occurs in only less than one percent of cases. Case report: A 47-year-old male had complained about headache, nasal voice, and blindness in the right eye since a month ago. An examination found a mass in the right nasal cavity, right neck lymph nodes enlargement, damage to the right oculomotor (III), trochlear (IV), and abducens (VI) nerve, and right optic nerve (II). On funduscopy, the right macular reflex decreased. On CT scan there was a right nasopharyngeal mass extending to intracranial and right intraorbital spaces. Conclusion: There was a direct infiltration of NPC into surrounding and intracranial structures. Unilateral blindness might be caused by expansion to middle cerebral fossa and orbita. It could also be caused by optic nerve compression from surrounding tumor tissue.

Carboplatin and Docetaxel Chemotherapy in Nasopharyngeal Carcinoma: A Case Report Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 3 No. 01 (2021): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v3i01.5725

Introduction: Nasopharyngeal Carcinoma (NPC) is a squamous cell malignant tumor that usually occurs in the lateral wall of the nasopharynx near the area of the eustachian tube. NPC is often found in southern Asia. In head and neck areas, NPC is one of the top five malignant which has the highest frequency tumours in Indonesia. Case report: We reported a case of a 57-year-old man with complaints of obstruction in both noses, accompanied by headache. Based on medical history, physical and Radiology examination, we concluded that he was diagnosed with Nasopharyngeal Carcinoma WHO II Stage III (T3N0M0). Histopathology revealed a differentiated non keratinizing squamous cell carcinoma in the nasopharynx. Six cycles of carboplatin and docetaxel regimen as an induction chemotherapy were planned for this patient. The patient then performed a nasoendoscopy followed by nasopharyngeal CT scan evaluation and showed a good response after Chemotherapy. Conclusion: Carboplatin and docetaxel chemotherapy management in this patient was given according to the management of nasopharyngeal carcinoma and has given a good response to the patient

Audiometry Finding in Nasopharyngeal Carcinoma Patients in ENT-HN Department of Mohammad Hoesin General Hospital Palembang 1 June 2016-1 June 2020 Denny Satria Utama; Sella Vanessa Lie
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 3 No. 02 (2021): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v3i02.6321

Introduction: Nasopharyngeal Carcinoma (NPC) is a type of epithelial carcinoma that arises from the nasopharynx mucosal lining that usually develops in the fossa of Rosenmüller. One of NPC’s initial signs is hearing loss. Objective: This study aims to determine the audiometry of patients with nasopharyngeal carcinoma in the ENT-HN department of Mohammad Hoesin General Hospital Palembang 1 June 2016-1 June 2020. Methods: This research is a descriptive observational study with cross-sectional study design using medical records of patients with nasopharyngeal carcinoma at Mohammad Hoesin General Hospital Palembang 1 June 2016 – 1 June 2020 who met the inclusion criteria. Results: From 48 samples, 42 samples (87,5%) were male, and 14 samples (29,2%) were included in the age range of 47-52 years. There were 18 samples (37,5%) suffering from a moderate degree of deafness. NPC patients mostly had conductive hearing loss (72,9%). Most of the sample suffered from bilateral hearing loss (75%). The majority of NPC patients had already been in stage IV (70,8%). It was found that NPC patients with stage IV suffered the most from conductive hearing loss (79,4%). Conclusion: NPC patients from 1 June 2016 – 1 June 2020 at ENT-HN Department of Mohammad Hoesin General Hospital Palembang were mostly male with an age range of 47-52 years who suffered from bilateral moderate conductive hearing loss and had already been in stage IV. It was found that most patients with stage IV of NPC had conductive hearing loss

Risk Factors Associated with Chemotherapy Response in Nasopharyngeal Carcinoma: A Cross-Sectional Study from a Tertiary Referral Center in Indonesia Valencia, Valencia; Utama, Denny Satria; Widyasari, Fiona
Sriwijaya Journal of Medicine Vol. 8 No. 2 (2025): Vol 8, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i2.309

Nasopharyngeal carcinoma (NPC) is a type of cancer commonly found in the head and neck, with the highest incidence in Asia. This study aims to analyze the influence of risk factors on chemotherapy response in NPC patients at Dr. M. Hoesin Hospital Palembang. The sample consisted of 65 NPC patients who underwent chemotherapy during the 2022–2023 period, selected using consecutive sampling. The variables studied include age, gender, histopathological classification, cancer stage, body mass index (BMI), and comorbidities. Chemotherapy response, as the dependent variable, was assessed using the RECIST (Response Evaluation Criteria in Solid Tumors) criteria. Data were collected from patient medical records and analyzed using SPSS software with univariate, bivariate (Chi-Squared test), and multivariate (multinomial logistic regression) analysis. The results showed that comorbidities were significantly associated with chemotherapy response, while age, gender, stage, histopathological classification, and BMI did not show significant relationships. Multivariate analysis indicated that age 30-50 years and stage IVA tended to influence chemotherapy response, although it did not reach statistical significance. In conclusion, managing comorbidities is an important factor in the success of chemotherapy in NPC patients, and this study suggests the need for a more holistic approach to treatment by considering other risk factors that may influence therapy outcomes.

Relationship between CD-8 Expression to Treatment Response in Nasopharyngeal Carcinoma Patient After Neoadjuvant Chemotherapy in Dr. Mohammad Hoesin Hospital Palembang Utama, Denny Satria; Eriza; Belly Sutopo Wijaya; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.455

Background. Nasopharyngeal carcinoma (NPC) is the most common malignancy in head and neck in Indonesia with 19,943 new cases in 2020 resulting 13,399 deaths. Lymphocytes are cells that play a role in the anti-cancer immune response, especially CD-8 T-cells. Neoadjuvant chemotherapy is chemotherapy given before radiotherapy that aims to kill primary tumors and micrometastasis tumors. This study aims to find out the relationship of CD-8 expression to treatment response in NPC undergoing neoadjuvant chemotherapy at Dr. Mohammad Hoesin Hospital Palembang. Methods. This study is an analytical observational research study on a retrospective cohort basis. Data collection from medical records using total sampling in 15 patients pilot study of NPC patients undergoing neoadjuvant chemotherapy and conducted CD-8 examination at ORLHNS polyclinic Dr. Mohammad Hoesin Hospital Palembang from December 2018 to December 2019 that met the criteria of inclusion and exclusion. Results. From 15 samples, the average CD-8 test result before neoadjuvant chemotherapy was 24.54 ng/μL and after neoadjuvant chemotherapy was 193.56 ng/μL. There was a tendency to increase the average CD-8 from before to after completion of neoadjuvan chemotherapy with a statistically significant difference of p =0.001. ROC analysis found CD-8 cut off points is 23.76 ng/μL with an area below the curve is 0.667. There were no significant relationships between CD-8 to performance status and treatment response with p values of 0.289 and 0.219, respectively. Conclusions. There was a significant change between CD-8 before neoadjuvant chemotherapy and after neoadjuvant chemotherapy with increased CD-8 tendencies and trends from before to after 6 series neoadjuvant chemotherapy with CD-8 cut off points is 23.76 ng/μL. In this study there has not been a significant relationships between CD-8 to performance status and treatment response in NPC patients undergoing neoadjuvant chemotherapy.

Relationship between CD-8 Expression to Treatment Response in Nasopharyngeal Carcinoma Patient After Neoadjuvant Chemotherapy in Dr. Mohammad Hoesin Hospital Palembang Utama, Denny Satria; Eriza; Belly Sutopo Wijaya; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.455

Background. Nasopharyngeal carcinoma (NPC) is the most common malignancy in head and neck in Indonesia with 19,943 new cases in 2020 resulting 13,399 deaths. Lymphocytes are cells that play a role in the anti-cancer immune response, especially CD-8 T-cells. Neoadjuvant chemotherapy is chemotherapy given before radiotherapy that aims to kill primary tumors and micrometastasis tumors. This study aims to find out the relationship of CD-8 expression to treatment response in NPC undergoing neoadjuvant chemotherapy at Dr. Mohammad Hoesin Hospital Palembang. Methods. This study is an analytical observational research study on a retrospective cohort basis. Data collection from medical records using total sampling in 15 patients pilot study of NPC patients undergoing neoadjuvant chemotherapy and conducted CD-8 examination at ORLHNS polyclinic Dr. Mohammad Hoesin Hospital Palembang from December 2018 to December 2019 that met the criteria of inclusion and exclusion. Results. From 15 samples, the average CD-8 test result before neoadjuvant chemotherapy was 24.54 ng/μL and after neoadjuvant chemotherapy was 193.56 ng/μL. There was a tendency to increase the average CD-8 from before to after completion of neoadjuvan chemotherapy with a statistically significant difference of p =0.001. ROC analysis found CD-8 cut off points is 23.76 ng/μL with an area below the curve is 0.667. There were no significant relationships between CD-8 to performance status and treatment response with p values of 0.289 and 0.219, respectively. Conclusions. There was a significant change between CD-8 before neoadjuvant chemotherapy and after neoadjuvant chemotherapy with increased CD-8 tendencies and trends from before to after 6 series neoadjuvant chemotherapy with CD-8 cut off points is 23.76 ng/μL. In this study there has not been a significant relationships between CD-8 to performance status and treatment response in NPC patients undergoing neoadjuvant chemotherapy.

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