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All Journal Medical Journal of Indonesia The Indonesian Biomedical Journal eJournal Kedokteran Indonesia Indonesian Journal of Biomedicine and Clinical Sciences
Nurul Paramita
Department Of Physiology, Faculty Of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta 10430
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Does VEGF concentration in pre-eclamptic serum induce sVCAM-1 production in endothelial cell culture? Subakir, Sri B.; Paramita, Nurul; Wardhani, Ika; Wiria, Metta S.; Soeradi, Oentoeng
Medical Journal of Indonesia Vol 14, No 1 (2005): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.512 KB) | DOI: 10.13181/mji.v14i1.163

Abstract

Serum concentrations of VEGF (Vascular Endothelial Growth Factor) are elevated in preeclampsia. In addition to inducing mitosis and increase permeability of endothelial cells, VEGF was reported to activate endothelial cells to produce cell adhesion molecules. Cell adhesion molecules play an important role in the inflammation process by inducing adherence of leukocytes in blood stream to the endothelial cells. The aim of this study is to investigate the effect of VEGF in serum from preeclamptic patients on sVCAM-1 (soluble vascular adhesion molecules-1) production in endothelial cell culture. Twelve sera from women with preeclampsia and 11 from women with normal pregnancy (controls) in 20% concentration were added to human umbilical vein endothelial cell culture (HUVEC) and incubated for 24 hours. All subjects have agreed to participate in this study and signed the informed consent form. sVCAM-1 concentration in the supernatant was measured by ELISA. VEGF concentration tends to be higher in preeclamptic serum than control, but the difference is not stastitically significant. The production of sVCAM-1 by endothelial cells exposed to preeclamptic serum was significantly higher than the production by endothelial cells exposed to serum from control (p<0.05). No correlation was found between the difference in VEGF concentrations in preeclamptic and control sera, and sVCAM-1 production by endothelial cell culture. (Med J Indones 2005; 14: 3-6)Keywords: endothelial cell, preeclampsia, VCAM, VEGF
Environmental Enrichment and Aerobic Exercise Enhances Spatial Memory and Synaptophysin Expression in Rats Diah Ayu Aguspa Dita; Nurul Paramita; Ria Kodariah; Neng Tine Kartinah
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.945

Abstract

BACKGROUND: Exposure to environmental enrichment has a positive effect on brain function, including improved cognition. Environmental enrichment has many aspects, including social interactions, object stimulations, and physical activities. Exercise and environmental enrichment can be considered to improve cognitive function with different underlying mechanisms. This study aims to compare the effects of environmental enrichment and aerobic exercise at both synaptic and whole-organism levels using synapyophysin as a measure of synaptic physiology and spatial memory as a measure of cognitive function.METHODS: A six-week in vivo experimental study on 15, 6-month old male Wistar rats randomly divided into three groups (n=5): aerobic group (A), enriched environment group (EE), and enriched with an aerobic or combined group (EEA). All rats were tested four times in the Water-E maze (WEM) task at weeks 0, 2, 4, and 6 of the study. We used immunohistochemistry to determine the synaptophysin expression in hippocampal CA1 region.RESULTS: Based on synaptophysin immunostaining, there were higher optical density scores for synaptophysin in hippocampal CA1 region following EEA, but there were no statistically significant differences between groups (ANOVA test, p>0.05). The spatial memory test showed there were significantly reduced travel time and total errors from the 2nd and 4th weeks in the EEA group, respectively (p<0.05).CONCLUSION: The combination of enriched environment and aerobic exercise seems to rapidly improve spatial memory and enhances the presynaptic protein, synaptophysin in hippocampal CA1 region.KEYWORDS: aerobic exercise, environmental enrichment, spatial memory, synaptophysin, Water-E maze
Peran HIIT dan MICT terhadap Kadar Angiotensin II, Ekspresi Fibronektin, dan Gambaran Histologis Aorta pada Model Tikus Hipertensi Induksi NOS Inhibitor Naibaho, Fitri Boru; Santoso, Dewi Irawati Soeria; Paramita, Nurul; Jalma, Monica Dwi; Goenarjo, Roman Ardian; Sianipar, Imelda Rosalyn
eJournal Kedokteran Indonesia Vol. 12 No. 2 (2024): Vol. 12 No. 2 - Agustus 2024
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

Salah satu mekanisme adaptif terhadap hipertensi adalah perubahan struktur pembuluh darah, sehingga perubahan tekanan darah berhubungan dengan perubahan struktur aorta. High-Intensity Interval Training (HIIT) dan Moderate-Intensity Continuous Training (MICT) berperan menurunkan hipertensi dan memperbaiki kerusakan pembuluh darah. Tujuan penelitian ini ialah untuk mengetahui perbandingan HIIT dan MICT terhadap kadar angiotensin dan fibronektin tikus hipertensi yang diinduksi N(gamma)-nitro-L-arginine methyl ester (L-NAME) dengan desain penelitian eksperimental. Penelitian ini dilakukan di empat Laboratorium di lingkungan Fakultas Kedokteran Universitas Indonesia pada bulan Maret 2023–Januari 2024. Penelitian ini menggunakan 24 ekor tikus putih jantan galur Wistar (Rattus Novergicus) usia 10–13  minggu dengan berat 220–300 g di awal penelitian. Tikus dibagi menjadi empat kelompok yaitu: tikus kontrol, tikus yang diberi L-NAME secara oral selama 5 minggu, tikus L-NAME yang diberi perlakuan HIIT dan kelompok tikus L-NAME yang diberi perlakuan MICT. Penelitian awal menunjukkan tikus HIIT mengalami penurunan berat badan yang bermakna  dibandingkan kontrol. Pada tikus yang diinduksi L-Name, tekanan darah  meningkat dibandingkan kelompok kontrol. Setelah perlakuan 5 minggu,tekanan darah pada kelompok L-NAME, HIIT dan MICT menurun tidak bermakna  dibandingkan dengan kontrol.  Kadar angiotensin II pada kelompok HIIT menunjukkan penurunan tekanan darah secara bermakna  dibandingkan MICT dan HIIT secara bermakna  lebih berperan dalam menurunkan kadar fibronektin dibandingkan MICT. Disimpulkan induksi L-NAME dapat menyebabkan hipertensi dan HIIT dapat  menurunkan berat badan, kadar angiotensin II, dan kadar fibronektin dibandingkan MICT. HIIT lebih berperan menurunkan risiko hipertensi dibandingkan MICT.
Effect of Hibiscus sabdariffa Linn. on the development of atherosclerosis in diabetes mellitus: a rapid review Fakhrul Gamal Putra; Nurul Paramita; Dewi Irawati Soeria Santoso
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.19981

Abstract

Atherosclerosis is closely linked to disturbances in lipid metabolism and chronic inflammation. In diabetes mellitus (DM), hyperglycemia exacerbates atherosclerosis by inducing structural changes in blood vessel endothelium through chronic inflammation triggered by oxidized low-density lipoprotein (OxLDL) formation. Inflammation plays a major role in atherosclerosis pathogenesis, with OxLDL, nuclear factor kappa B (NFkB), intercellular adhesion molecule-1 s(ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) being crucial players in this process. Hibiscus (Hibiscus sabdariffa Linn.) a medicinal plant rich in polyphenols, is believed to have a role to prevent atherosclerosis development through its antioxidant activity, inhibiting vascular smooth muscle cell (VSMC) proliferation, and modulating inflammation pathways. This review explores the potential of hibiscus to prevent atherosclerosis development in DM, focusing on its phytochemical compounds and their impact on oxidative stress, hyperlipidemia, and inflammation pathways. The review highlights the importance of targeting VSMC proliferation, migration, and inflammatory responses mediated by ICAM-1 and VCAM-1 to attenuate atherosclerosis progression. Hibiscus shows promise as a natural treatment for atherosclerosis, but further research is still needed to fully understand its mechanisms and therapeutic potential.
Co-Authors Diah Ayu Aguspa Dita Fakhrul Gamal Putra Goenarjo, Roman Ardian Ika Wardhani Imelda Rosalyn Sianipar Jalma, Monica Dwi Metta S. Wiria Naibaho, Fitri Boru Neng Tine Kartinah Almuktabar Oentoeng Soeradi Ria Kodariah Santoso, Dewi Irawati Soeria Sri B. Subakir