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All Journal The Indonesian Biomedical Journal Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Indonesian Journal of Biomedicine and Clinical Sciences
Nurul Paramita
Department Of Physiology, Faculty Of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta 10430
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Environmental Enrichment and Aerobic Exercise Enhances Spatial Memory and Synaptophysin Expression in Rats Diah Ayu Aguspa Dita; Nurul Paramita; Ria Kodariah; Neng Tine Kartinah
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.945

Abstract

BACKGROUND: Exposure to environmental enrichment has a positive effect on brain function, including improved cognition. Environmental enrichment has many aspects, including social interactions, object stimulations, and physical activities. Exercise and environmental enrichment can be considered to improve cognitive function with different underlying mechanisms. This study aims to compare the effects of environmental enrichment and aerobic exercise at both synaptic and whole-organism levels using synapyophysin as a measure of synaptic physiology and spatial memory as a measure of cognitive function.METHODS: A six-week in vivo experimental study on 15, 6-month old male Wistar rats randomly divided into three groups (n=5): aerobic group (A), enriched environment group (EE), and enriched with an aerobic or combined group (EEA). All rats were tested four times in the Water-E maze (WEM) task at weeks 0, 2, 4, and 6 of the study. We used immunohistochemistry to determine the synaptophysin expression in hippocampal CA1 region.RESULTS: Based on synaptophysin immunostaining, there were higher optical density scores for synaptophysin in hippocampal CA1 region following EEA, but there were no statistically significant differences between groups (ANOVA test, p>0.05). The spatial memory test showed there were significantly reduced travel time and total errors from the 2nd and 4th weeks in the EEA group, respectively (p<0.05).CONCLUSION: The combination of enriched environment and aerobic exercise seems to rapidly improve spatial memory and enhances the presynaptic protein, synaptophysin in hippocampal CA1 region.KEYWORDS: aerobic exercise, environmental enrichment, spatial memory, synaptophysin, Water-E maze
Effect of Hibiscus sabdariffa Linn. on the development of atherosclerosis in diabetes mellitus: a rapid review Fakhrul Gamal Putra; Nurul Paramita; Dewi Irawati Soeria Santoso
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.19981

Abstract

Atherosclerosis is closely linked to disturbances in lipid metabolism and chronic inflammation. In diabetes mellitus (DM), hyperglycemia exacerbates atherosclerosis by inducing structural changes in blood vessel endothelium through chronic inflammation triggered by oxidized low-density lipoprotein (OxLDL) formation. Inflammation plays a major role in atherosclerosis pathogenesis, with OxLDL, nuclear factor kappa B (NFkB), intercellular adhesion molecule-1 s(ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) being crucial players in this process. Hibiscus (Hibiscus sabdariffa Linn.) a medicinal plant rich in polyphenols, is believed to have a role to prevent atherosclerosis development through its antioxidant activity, inhibiting vascular smooth muscle cell (VSMC) proliferation, and modulating inflammation pathways. This review explores the potential of hibiscus to prevent atherosclerosis development in DM, focusing on its phytochemical compounds and their impact on oxidative stress, hyperlipidemia, and inflammation pathways. The review highlights the importance of targeting VSMC proliferation, migration, and inflammatory responses mediated by ICAM-1 and VCAM-1 to attenuate atherosclerosis progression. Hibiscus shows promise as a natural treatment for atherosclerosis, but further research is still needed to fully understand its mechanisms and therapeutic potential.
PROTECTIVE EFFECTS OF HIBISCUS SABDARIFFA LINN EXTRACT ON OXIDATIVE STRESS AND COLLAGEN DEPOSITION IN D-GALACTOSE-INDUCED SKELETAL MUSCLE AGING IN RATS Gabriella E.O Andrianti; Nurul Paramita; Roman Ardian Goenarjo; Imelda Rosalyn Sianipar
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 6 No. 5 (2026): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.21282013

Abstract

Background: The aging process in skeletal muscle is often triggered by chronic oxidative stress that impacts extracellular matrix remodeling in the form of fibrosis and decreased motor function. Hibiscus sabdariffa Linn. (HSL) extract is known to be rich in polyphenol and anthocyanin compounds that have the potential as antioxidant agents. Objective: This study aims to analyze the potential of HSL intervention in regulating gastrocnemius muscle aging in an old rat model accelerated with D-galactose, reviewed from molecular, histopathological and functional aspects. Methods: A total of 18 rats were divided into three groups (n=6): Young Normal Group (NM), D-galactose aging acceleration Group (Ap), and D-galactose + HSL Group (ApH). Aging induction was carried out using D-galactose at a dose of 200 mg/KgBW, daily for 8 weeks orally via tube. HSL supplementation was mixed in drinking water at a dose of 400 mg/KgBW daily for 8 weeks. The parameters tested included serum Malondialdehyde (MDA) levels, MMP-9 levels in muscle tissue, limb muscle grip strength, and the percentage of collagen deposition in histopathology preparations. Results: MDA levels and MMP-9 enzyme activity in the Ap group were higher than the NM group (P < 0.001). The percentage of gastrocnemius muscle tissue collagen in the Ap group was lower than the NM group (P < 0.05). No differences were found in muscle grip strength between the Ap group and the NM group. MDA and MMP-9 levels in the ApH group given HSL supplementation were not significantly different from the NM group (P > 0.05). The percentage of gastrocnemius muscle tissue collagen in the ApH group was also not significantly different from the NM group (P > 0.05). Conclusion: Supplementation of HSL extract in the accelerated aging group was able to suppress MDA levels, reduce MMP-9 levels, and maintain the percentage of gastrocnemius muscle tissue collagen. Hibiscus sabdariffa Linn. extract proven to be effective in inhibiting the aging process of gastrocnemius muscle through the mechanism of lipid peroxidation chain cleavage and prevention of fibrotic remodeling, which contributes to the maintenance of the mechanical functional capacity of the muscle.
Co-Authors Diah Ayu Aguspa Dita Fakhrul Gamal Putra Gabriella E.O Andrianti Goenarjo, Roman Ardian Ika Wardhani Imelda Rosalyn Sianipar Jalma, Monica Dwi Metta S. Wiria Naibaho, Fitri Boru Neng Tine Kartinah Almuktabar Oentoeng Soeradi Ria Kodariah Santoso, Dewi Irawati Soeria Sri B. Subakir