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All Journal Althea Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) The International Journal of Medical Science and Health Research
Goenarjo, Roman Ardian
Department Of Medical Physiology And Biophysics, Faculty Of Medicine, Universitas Indonesia, Jakarta, Indonesia/Center For Sport And Exercise Studies (SES), IMERI, Faculty Of Medicine, Universitas Indonesia, Jakarta, Indonesia
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The effects of Hibiscus sabdariffa Linn. on the levels of FGF21 and AMPK in the Heart of Diabetic Mice Amelia, Rossa; Goenarjo, Roman Ardian; Kartinah, Neng Tine
The International Journal of Medical Science and Health Research Vol. 3 No. 2 (2024): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/eedvat70

Abstract

Background : Diabetes Mellitus (DM) is a metabolic disorder characterized by pancreatic cell dysfunction and insulin resistance. Fibroblast Growth Factor 21 (FGF21) is thought to have a cardioprotective role. Through FGF21 signaling, AMP-activated protein kinase (AMPK) activity reduces apoptosis, inflammation, hypertrophy, and fibrosis in the heart. Hibiscus sabdariffa Linn. (HSL) contains flavonoids that have hypoglycemic effects and are anti-inflammatory and antioxidant-active. This study aims to assess the effect of HSL on FGF21 and AMPK levels in the heart of diabetic mice models. Methods : An experimental study using Deutschland Denken Yoken (DDY) mice aged eight weeks were divided into four groups: Control, DM Control, HSL 200, and HSL 400. In the DM control, HSL 200, and HSL 400 groups, diabetes was induced by giving a High Fat Diet(HFD) and STZ 40mg/kgbb. The HSL 200 group was given HSL 200mg/kgBB supplementation for three weeks, and the HSL 400 group was given HSL 400 mg/kgBB supplementation for three weeks. FGF21 and AMPK levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Results : There was no significant difference between FGF21 and AMPK levels between the control and DM control groups. FGF21 and AMPK levels in the HSL 400 group were higher than in the control, DM control, and HSL 200 groups. Conclusions : These findings suggest that HSL supplementation at specific doses can potentially increase the activation of FGF 21 and AMPK signaling in the heart of diabetic mice models.
The Effect of High-Intensity Interval Training on Interleukin-6 Levels in Hypertensive Individuals: A Systematic Review and Meta-Analysis Ainnaya Natin Ristanti; Roman Ardian Goenarjo
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1296

Abstract

Background: High-intensity interval training (HIIT) has emerged as a time-efficient exercise modality with potential benefits for hypertensive individuals. Interleukin-6 (IL-6), a cytokine with both pro- and anti-inflammatory properties, has been implicated in the development and progression of hypertension. This meta-analysis aimed to investigate the effect of HIIT on IL-6 levels in hypertensive individuals. Methods: A systematic search of electronic databases (PubMed, Scopus, Web of Science) was conducted to identify relevant studies published between 2013 and 2024. Studies were included if they met the following criteria: (1) randomized controlled trials; (2) included hypertensive participants; (3) compared HIIT to a control group (no exercise or moderate-intensity continuous training); (4) measured circulating IL-6 levels; and (5) provided sufficient data for meta-analysis. Data were extracted and pooled using a random-effects model. Results: Seven studies met the inclusion criteria, comprising a total of 328 participants. The meta-analysis revealed a significant decrease in IL-6 levels following HIIT compared to the control group (standardized mean difference [SMD] = -1.27, 95% confidence interval [CI] = (-1.81 to -0.73, p = 0.002). Subgroup analysis showed that HIIT interventions lasting ≥ 8 weeks were associated with a greater reduction in IL-6 levels compared to shorter interventions. Conclusion: HIIT appears to be an effective exercise modality for reducing IL-6 levels in hypertensive individuals. This finding suggests that HIIT may have anti-inflammatory effects and could be a valuable non-pharmacological strategy for managing hypertension.
One Minute Stair Step Test in Predicting VO2 max among Healthy Young Adults Lisna Anisa Fitriana; Upik Rahmi; Setiawan Setiawan; Lucky Angkawijaya Roring; Hamidie Ronald Daniel Ray; Roman Ardian Goenarjo; Zulkarnain Jaafar; Farida Murtiani
Althea Medical Journal Vol 13, No 2 (2026)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v13n2.4662

Abstract

Background: Cardiovascular risk factors such as hypercholesterolemia and hypertension, are increasing among Indonesian young adults despite their apparently healthy status. Valid field methods for assessing VO₂max, a key indicator of cardiorespiratory fitness, are needed for large-scale screening. This study validated the one-minute stair step test (OMSST) against the Bruce treadmill protocol as the reference standard. Methods: This cross-sectional study included 51 healthy males (20.41±0.57 years, BMI 22.52±3.28 kg/m²) in Bandung, Indonesia. VO₂max was measured using the Bruce protocol and estimated using the OMSST (40-cm step, 30 steps/min). Anthropometrics variables, heart rate recovery at 60 seconds (HRR60), and multiple regression variables (age, height, weight, and HRR60) were analyzed using paired t-tests, correlations, and Bland-Altman plots. Results: The mean VO₂max estimated using the OMSST (50.91±3.29 mL/kg/min) closely matched that measured Bruce protocol (49.75±3.61 mL/kg/min; p=0.091), with a small positive bias (1.16 mL/kg/min) and 95% limits of agreement within acceptable bounds. A strong correlation (r=0.85, p<0.001) confirmed validity. HRR60 (91.12±15.10 bpm) significantly predicted VO₂max.Conclusion: OMSST is a valid, simple, low-cost field surrogate for laboratory VO₂max testing in young males, ideal for middle-income settings. Future studies should assess diverse populations and longitudinal reliability.
PROTECTIVE EFFECTS OF HIBISCUS SABDARIFFA LINN EXTRACT ON OXIDATIVE STRESS AND COLLAGEN DEPOSITION IN D-GALACTOSE-INDUCED SKELETAL MUSCLE AGING IN RATS Gabriella E.O Andrianti; Nurul Paramita; Roman Ardian Goenarjo; Imelda Rosalyn Sianipar
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 6 No. 5 (2026): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.21282013

Abstract

Background: The aging process in skeletal muscle is often triggered by chronic oxidative stress that impacts extracellular matrix remodeling in the form of fibrosis and decreased motor function. Hibiscus sabdariffa Linn. (HSL) extract is known to be rich in polyphenol and anthocyanin compounds that have the potential as antioxidant agents. Objective: This study aims to analyze the potential of HSL intervention in regulating gastrocnemius muscle aging in an old rat model accelerated with D-galactose, reviewed from molecular, histopathological and functional aspects. Methods: A total of 18 rats were divided into three groups (n=6): Young Normal Group (NM), D-galactose aging acceleration Group (Ap), and D-galactose + HSL Group (ApH). Aging induction was carried out using D-galactose at a dose of 200 mg/KgBW, daily for 8 weeks orally via tube. HSL supplementation was mixed in drinking water at a dose of 400 mg/KgBW daily for 8 weeks. The parameters tested included serum Malondialdehyde (MDA) levels, MMP-9 levels in muscle tissue, limb muscle grip strength, and the percentage of collagen deposition in histopathology preparations. Results: MDA levels and MMP-9 enzyme activity in the Ap group were higher than the NM group (P < 0.001). The percentage of gastrocnemius muscle tissue collagen in the Ap group was lower than the NM group (P < 0.05). No differences were found in muscle grip strength between the Ap group and the NM group. MDA and MMP-9 levels in the ApH group given HSL supplementation were not significantly different from the NM group (P > 0.05). The percentage of gastrocnemius muscle tissue collagen in the ApH group was also not significantly different from the NM group (P > 0.05). Conclusion: Supplementation of HSL extract in the accelerated aging group was able to suppress MDA levels, reduce MMP-9 levels, and maintain the percentage of gastrocnemius muscle tissue collagen. Hibiscus sabdariffa Linn. extract proven to be effective in inhibiting the aging process of gastrocnemius muscle through the mechanism of lipid peroxidation chain cleavage and prevention of fibrotic remodeling, which contributes to the maintenance of the mechanical functional capacity of the muscle.
Co-Authors Ainnaya Natin Ristanti Farida Murtiani Gabriella E.O Andrianti Hamidie Ronald Daniel Ray Imelda Rosalyn Sianipar Jalma, Monica Dwi Lisna Anisa Fitriana Lucky Angkawijaya Roring Naibaho, Fitri Boru Neng Tine Kartinah Almuktabar Nurul Paramita Rossa Amelia, Rossa Santoso, Dewi Irawati Soeria Setiawan Setiawan Upik Rahmi Zulkarnain Jaafar