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All Journal Universa Medicina The International Journal of Medical Science and Health Research
Goenarjo, Roman Ardian
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Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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The effects of Hibiscus sabdariffa Linn. on the levels of FGF21 and AMPK in the Heart of Diabetic Mice Amelia, Rossa; Goenarjo, Roman Ardian; Kartinah, Neng Tine
The International Journal of Medical Science and Health Research Vol. 3 No. 2 (2024): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/eedvat70

Abstract

Background : Diabetes Mellitus (DM) is a metabolic disorder characterized by pancreatic cell dysfunction and insulin resistance. Fibroblast Growth Factor 21 (FGF21) is thought to have a cardioprotective role. Through FGF21 signaling, AMP-activated protein kinase (AMPK) activity reduces apoptosis, inflammation, hypertrophy, and fibrosis in the heart. Hibiscus sabdariffa Linn. (HSL) contains flavonoids that have hypoglycemic effects and are anti-inflammatory and antioxidant-active. This study aims to assess the effect of HSL on FGF21 and AMPK levels in the heart of diabetic mice models. Methods : An experimental study using Deutschland Denken Yoken (DDY) mice aged eight weeks were divided into four groups: Control, DM Control, HSL 200, and HSL 400. In the DM control, HSL 200, and HSL 400 groups, diabetes was induced by giving a High Fat Diet(HFD) and STZ 40mg/kgbb. The HSL 200 group was given HSL 200mg/kgBB supplementation for three weeks, and the HSL 400 group was given HSL 400 mg/kgBB supplementation for three weeks. FGF21 and AMPK levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Results : There was no significant difference between FGF21 and AMPK levels between the control and DM control groups. FGF21 and AMPK levels in the HSL 400 group were higher than in the control, DM control, and HSL 200 groups. Conclusions : These findings suggest that HSL supplementation at specific doses can potentially increase the activation of FGF 21 and AMPK signaling in the heart of diabetic mice models.
Myosin heavy chain as biomarker in the prevention of sarcopenia Sari, Desy Nofita; Goenarjo, Roman Ardian; Sianipar, Imelda Rosalyn; Lim, Chin Leong
Universa Medicina Vol. 45 No. 1 (2026): Aheaf Of Print
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2026.v45.%p

Abstract

Sarcopenia, or the age-related loss of skeletal muscle mass and function, can reduce total muscle contractile capacity and increase the likelihood of physical disability in older adults. The loss of muscle mass and contractile performance is generally thought to be multifactorial, with as possible contributing factor an age-related shift in the expressed amounts of myosin heavy chain (MyHC) isoforms. The composition of adult human skeletal muscle consists of a mixture of three distinct MyHC isoforms (I, IIA, and IIX). This literature review aimed to explore studies focused on the signs of sarcopenia, the early detection of initial symptoms, and awareness among the aging population. We aimed to understand the molecular changes in muscle fibers as people age and to help inform the early intervention approach to prevent sarcopenia. The literature search was conducted in several databases between 2020 to 2025, including PubMed, ScienceDirect, and SpringerLink. The search terms consisted of “sarcopenia”, “muscle mass”, “early detection”, and “myosin heavy chain”. Inclusion criteria included original full-text English-language studies on the cellular and molecular physiology of sarcopenia. Molecular changes in myosin heavy chain vary across different age groups, suggesting the potential for early detection of muscle aging. The review is limited by the variability in the definition and measurement of sarcopenia across different studies, which may affect the generalizability of the findings. This review highlights the potential significance of identification and sarcopenia management in elderly individuals. The findings would be helpful for clinicians, researchers, and policymakers to improve elderly care and quality of life.
Co-Authors Imelda Rosalyn Sianipar Jalma, Monica Dwi Lim, Chin Leong Naibaho, Fitri Boru Neng Tine Kartinah Almuktabar Nurul Paramita Rossa Amelia, Rossa Santoso, Dewi Irawati Soeria