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All Journal Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Journal of Health Sciences Biomolecular and Health Science Journal Indian Journal of Forensic Medicine & Toxicology
Arthur Pohan Kawilarang
Departemen Mikrobiologi Fakultas Kedokteran Universitas Airlangga/Rumah Sakit Umum Daerah Dr. Soetomo Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Antibacterial Activity Test of Jatropha multifida L. sap against Staphylococcus aureus and Methicillin Resistant Staphylococcus aureus (MRSA) in vitro Anastassya Yuniar Setyo Putri; Marijam Purwanta; DantiNur Indiastuti; Arthur Pohan Kawilarang
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15611

Abstract

Background: Jatropha multifida L. is a plant that commonly used as a traditional treatment espesciallyfor wounds. It has been proven that its sap had an antibacterial activity against Staphylococcus aureus.Staphylococcus aureus has developed resistant strains named MRSA (Methicillin-Resistant Staphylococcusaureus). Due to this resistance development, hopefully the sap of Jatropha multifida L. can also performedits antibacterial activity against MRSA. Objective: To determine the antibacterial activity of the sap ofJatropha multifida L. against Staphylococcus aureus and MRSA. Methods: A well-diffusion method wasperformed on several concentration: 100%, 50%, 25%, 12.5%, and 6.25%. From this method, the diameterof the inhibition zone produced by the sap was measured. Results: The average of inhibition zone diameterwere 11.29 - 16.00 mm for Staphylococcus aureus and the bigger zone 12.15 - 17.61 mm for MRSA.Conclusion:Jatropha multifida L. had antibacterial activity against Staphylococcus aureus and MRSA. Thisplant showed higher antibacterial activity on MRSA than Staphylococcus aureus.
Patient Profile Of Tinea Corporis In Dr. Soetomo General Hospital, Surabaya From 2014 To 2015 Novita Oktaviana; Arthur Pohan Kawilarang; Damayanti -
Jurnal Berkala Epidemiologi Vol. 6 No. 3 (2018): Jurnal Berkala Epidemiologi
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (520.871 KB) | DOI: 10.20473/jbe.V6I32018.200-208

Abstract

Background: The prevalence of dermatophytosis in Indonesia reach 52% of all fungal infections and is dominated by tinea corporis. Purpose: This study aimed to describe the clinical profile of tinea corporis patients in the Outpatient Unit of Dermatology and Venereology, Dr. Soetomo General Hospital, Surabaya. Methods: This study was a descriptive study with a case series method from patient medical records in the mycology division of the Outpatient Unit of Dermatology and Venereology, Dr. Soetomo General Hospital, Surabaya from January 1, 2014 to December 31, 2015 with 339 samples. Results: This study showed that tinea corporis patients were dominated by women counting for 113 patients in 2014 and 84 in 2015. Tinea corporal patients were dominated by the post-puberty age group between 40 and 50 years. Tinea cruris is the most common comorbid infection in this case. There were 85.25% of patients who showed positive results for hyphae structure, 72.57% of patients showed negative results for blastospore structure, and 64.31% of patients showed negative results for examination of Wood’s lamp. There were 100 patients in 2014 and 86 patients in 2015 who received oral griseofulvin pharmacological therapy and 86.30% of these patients showed improvement in results after two weeks of treatment. Conclusion: Tinea corporis mostly attacks women and post-puberty age groups with tinea cruris as the most comorbid infections. The characteristic of tinea corporis could be shown as positive result for hyphae and negative for blastospore through the KOH test, and oral Griseofulvin is the most pharmacological therapy used for treatment
Profil Pasien Baru Kandidiasis Apriliana Puspitasari; Arthur Pohan Kawilarang; Evy Ervianty; Abu Rohiman
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 1 (2019): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (7611.725 KB) | DOI: 10.20473/bikk.V31.1.2019.24-34

Abstract

Latar Belakang: Kandidiasis adalah infeksi jamur yang bersifat oportunistik yang disebabkan oleh Candida sp. Prevalensi kandidiasis di Indonesia sekitar 20-25%, dapat menyerang rambut, kulit, kuku, selaput lendir, dan organ lain seperti mulut dan kerongkongan, namun informasi tentang faktor dan karakteristik risikonya masih terbatas. Tujuan: Mengevaluasi gambaran dan karakteristik pasien baru kandidiasis. Metode: Penelitian deskriptif retrospektif yang dilakukan dengan mengevaluasi rekam medis pasien kandidiasis di Divisi Mikologi URJ Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya tahun 2013-2016. Hasil: Dalam kurun waktu tahun 2013-2016 didapatkan 298 pasien baru. Jenis kandidiasis terbanyak adalah kandidiasis intertriginosa (50,5%). Distribusi jenis kelamin yang paling banyak adalah perempuan (62,4%) dengan usia terbanyak 45-64 tahun (31,5%). Penyakit penyerta terbanyak adalah diabetes melitus. Keluhan utama terbanyak berupa gatal dengan efloresensi berupa satelit papul. Hasil laboratorium 30,2% positif untuk blastospora dan blastospora+hifa, dengan hasil kultur berupa Candida sp. Simpulan: Kandidiasis sering ditemukan dan jumlah kejadian setiap tahun berfluktuasi di Divisi Mikologi Unit Rawat Jalan Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya.
Cat Contact as A Risk Factor for Tinea Capitis Infection Evy Ervianti; Addia Salsabila; Yuri Widia; Arthur Pohan Kawilarang
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.1-4

Abstract

Background: Tinea capitis (TC) is common infection caused by dermatophytes on the scalp. Cat contact is one of the TC risk factors. Microsporum canis is the most abundant fungi in cats and humans as a zoophilic infection. Cats and carrier cats can infect humans, mostly children. Purpose: To evaluate cat contact as a risk factor for TC patients at the Dermatology and Venereology Outpatients Unit of Dr. Soetomo General Academic Hospital Surabaya in January 2017 - December 2018. Methods: A retrospective study by observation and recording data. The results obtained as a result of the data recap were then processed using tabulation to obtain conclusions. Result: The results obtained from TC cases in 2017 and 2018 are 20 patients. The results were cat contact in 9 patients (45%), aged > 5 years (55,6%), male (55,6%), and lived in Surabaya (88,9%), hair loss (88,9%), crust (100%), M. canis in culture (55,6%), Grey patch type (55,6%), combination of oral Griseofulvin and Ketoconazole 2% scalp solution (88,9%), and patients’ follow up (44,4%). Discussion: More people keeping cats will increase the risk of being infected with feline dermatophytosis. Combination therapy is the best treatment for M. canis. It is important to educate parents to be careful with pet cats that can become carriers. Conclusion: Cat contact was positive in almost half patients, mostly in a male and > 5 years old. The most common signs and symptoms were crust and hair loss, and grey patch.
Antibacterial Activity Test of Red Ginger Extract (Zingiber officinale var. Rubrum) Against Streptococcus pyogenes In vitro Samira Assegaf; Arthur Pohan Kawilarang; Retno Handajani
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19130

Abstract

Introduction: Red ginger (Zingiber officinale var. rubrum) is known as an antibacterial agent. Streptococcus pyogenes is the most common bacterial cause of pharyngitis in children and adults. Over the years, antibiotic resistance case is increasing. Therefore, further research of other substances to find an bactericidal or bacteriostatic agent is needed. The aim of this study is to determine the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of Z. officinale var. rubrum against S. pyogenes. Methods: Serial dilution test of red ginger extract in Mueller hinton broth (8 concentrations of red ginger extract : 80%, 40%, 20%, 10%, 5%, 2,5%, 1,25%, and 0,625%) and positive control (1 ml bacterial suspension in Mueller hinton broth) was used to determine MIC. MBC was determined by culturing solutions from the previous dilution test into blood agar plate.lResults: MIC of red ginger extract against S. pyogenes could not be determined because the color of red ginger extract affected the turbidity of the dilution test result. MBC of red ginger extract against S. pyogenes was at concentration 20% of red ginger extract.Conclusion: Z. officinale var. rubrum showed antibacterial activity against S. pyogenes.
Kesesuaian Pemeriksaan jamur antara pewarnaan periodic acid schiff(PAS) dan KOH pada flour albus ibu hamil di RSUD dr Soetomo Surabaya Shinta arya; Arthur pohan kawilarang
Jurnal Ilmiah Kesehatan Vol 13 No 01 (2020): Jurnal Ilmiah Kesehatan (Journal of Health Science)
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.429 KB) | DOI: 10.33086/jhs.v13i01.1342

Abstract

Background: Candidiasis vaginalis is a form of vaginal infection by Candida spp, estimated to occur in women of childbearing age in 70-75% of the cases. Clinical history, symptoms and laboratory examinations are very important to diagnose candidiasis vaginalis. Vaginal discharge examination can be done by direct or wet, and culture examination. Microscopic examination can be used to prove the existence of yeast form of Candida. This method is simple, can be applied in clinical microbiology laboratory with limited resources and is considered effective because it is cheap and results are obtained in a short time compared to culture. Detection of fungi by Periodic Acid Schiff (PAS) staining is visually better than KOH. The aim of this study is to analyze the concordance between Periodic Acid Schiff (PAS) staining and KOH method for fungal detection in flour albus from pregnant women. Method: This research is a descriptive observational study to figure out the suitability of Periodic Acid Schiff (PAS) staining and KOH method for fungal detection in flour albus from pregnant women with cross sectional approach. Samples were collected in the form of 30 vaginal discharge specimens taken from pregnant women and sent to the Clinical Microbiology Laboratory Dr. Soetomo Surabaya. The study was conducted in July - August 2019. Result: There was a significant difference in fungal detection between Periodic Acid Schiff (PAS) staining (56.7%, 17 samples) and 20% KOH method (6 samples) out of 30 samples (p=0.017). The concordance between Periodic Acid Schiff (PAS) staining and KOH method for fungal detection in flour albus from pregnant women is low (Kappa=0.321). Conclusion: Periodic Acid Schiff (PAS) staining detects more fungi when compared to KOH, and therefore is considered as a better method. Keywords: Flour albus, pregnancy, Periodic Acid Schiff (PAS), KOH.
The Prevalence and Success Factor of Ibuprofen and Paracetamol Administration for Neonates with Patent Ductus Arteriosus at RSUD Dr. Soetomo Rodia Amanata Rofiq; I Ketut Alit Utamayasa; Nurina Hasanatuludhhiyah; Arthur Pohan Kawilarang
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 3 (2022): Indian Journal of Forensic Medicine and Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i3.18303

Abstract

Background: Four thousand neonates with Persisten Ductus Arteriosus every year in Indonesia. There are twotreatment options to treat Persistent Ductus Arteriosus, they are surgery and pharmacological therapy. Ibuprofenand paracetamol can be used as pharmacological therapy for Persistent Ductus Arteriosus with minimal sideeffects.Objective: To analyze the prevalence and success factors in giving ibuprofen and paracetamol in neonates withpersistent ductus arteriosus.Method: This research is an observational analytic research with cross-sectional method. The determination of theresearch sample uses a total sampling technique by taking all members of the population in accordance with theconditionsfrom January, 2016 to March , 2020. Bivariate analysis was perform using the Spearman rank test with95% confidence interval (α=0.05).Result: From 51 samples that met the inclusion criterias, it was found that the most criterias were male (66.67%),normal birth weight (60.78%), aterm (76.48%), moderate defect size before being administrated pharmacologicaltherapy (47.06%), pharmacological therapy using paracetamol (88.24%), atrial septal defect in the cardiaccomorbidities category (21.74%) and hyperbilirubinemia in the non-cardiac comorbidities category (13.04%). Themajority of lumen defects in neonates were closed completely after being administrated pharmacological therapy(72.55%). Statistical test results of spearman rank showed that no significant relationship between birth weightand pharmacological therapy in RSUD Dr. Soetomo. There was a significant relationship between gestation andpharmacological therapy (p = 0.000; r = -0.495; r2 = 0.237, 95% CI). There was a significant relationship between thesize of the ductus arteriosus defect before therapy and pharmacological therapy (p = 0.001; r = -0.435; r2 = 0.211,95% CI). Conclusion: The success factors in administrating ibuprofen and paracetamol for neonates with persistent ductusarteriosus in RSUD dr. Soetomo from January 1, 2016 to March 3, 2020 were affected by gestation period and sizeof the ductus arteriosus defect prior to pharmacological therapy.
Comparative evaluation between KOH and PAS stain of fungal examination result on lung Tuberculosis patients’ sputum with positive Ziehl-Neelsen stain Ratna Kusumawati; Eddy Bagus Wasito; Arthur Pohan Kawilarang; Eko Budi Koendhori
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 7 No 2 (2023): Journal Qanun Medika Vol 07 No 02
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v7i2.18606

Abstract

Mycosis is often misdiagnosed as Tuberculosis (TB) with negative sputum smear results or Tuberculosis recurrent. In the last two-decade, mycosis increases dramatically as HIV and immunocompromised incidence rates increased. Even though, the prevalence data of mycosis in TB patient is less researched, the identification using KOH often give a false negative result. To compare the result of fungal identification using KOH and PAS staining. This study is observational analytical using a cross-sectional design with 29 TB samples that have been diagnosed with Ziehl-Neelsen (ZN) stain positive in RSUD Dr. Soetomo. The sputum of every sample was colored with KOH and PAS and observed by the researcher and microbiology analyst. The results of this study were 22 sputa identified with Candida sp positive and 12 sputa with non-Candida positive using KOH staining. Meanwhile, using PAS staining, there were 25 sputa identified as Candida sp positive and 22 sputa as non-Candida positive. The congruency test between KOH and PAS has a fair result for both identifying Candida sp (κ = 0.298; significance = 0.069) and non-Candida (κ = 0.240; significance = 0.095). The identification of candida and non-candida in TB patients using KOH and PAS has a fair congruency result. The PAS staining has better identification results both in identifying candida and non-candida rather than KOH staining. 
Co-Authors Abu Rohiman Addia Salsabila Anastassya Yuniar Setyo Putri Apriliana Puspitasari Damayanti - Eddy Bagus Wasito Eko Budi Koendhori, Eko Budi Evy Ervianti Evy Ervianty Indiastuti, Danti Nur Novita Oktaviana Nurina Hasanatuludhhiyah Purwanta, Marijam Ratna Kusumawati Retno Handajani Rodia Amanata Rofiq Samira Assegaf Shinta arya Yuri Widia, Yuri