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All Journal Majalah Kedokteran Bandung Indonesian Journal of Kidney and Hypertension
Dwi Lestari Partiningrum
Staf Pengajar Bagian Ilmu Penyakit Dalam FK UNDIP / RSUP Dr. Kariadi Semarang
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Vitamin D Insufficiency with Elevated ADMA and hs-CRP: A Single-center Study of Chronic Kidney Disease Patients Undergoing Hemodialysis Lusito, Lusito; Lestariningsih, Lestariningsih; Partiningrum, Dwi Lestari; Chasani, Shofa; Arwanto, Arwedi; Nurani, Ayudyah; Makarim, Fadhli Rizal
Indonesian Journal of Kidney and Hypertension Vol 1 No 2 (2024): Volume 1 No. 2, August 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i2.134

Abstract

Background: Vitamin D deficiency is a common issue among patients with chronic kidney disease (CKD) due to its ability to convert vitamin D into the active form of calcitriol, which is crucial for controlling cell inflammation. Low vitamin D levels are associated with increased inflammation and higher levels of biomarkers such as c-reactive protein and asymmetric dimethylarginine as an endogenous inhibitor of nitric oxide synthase. Those two combined become a specific marker for cardiovascular diseases, which become one of the common causes of CKD mortality. Objective: This study examines the correlation between vitamin D insufficiency, elevated high-sensitivity c-reactive protein, and asymmetric dimethylarginine in CKD patients receiving hemodialysis. Methods: This study used a cross-sectional design of CKD patients receiving hemodialysis in Dr. Kariadi Central General Hospital, Semarang, Indonesia, in November 2021. Thirty-six patients were randomly enrolled after meeting inclusion and exclusion criteria. Primary outcomes of Vitamin D, hs-CRP, and ADMA were measured from patients’ blood after hemodialysis. A statistical analysis of Pearson's correlation was used for primary outcomes. Results: No significant difference was found in the patient's baseline characteristics. A significant correlation between vitamin D and ADMA has been found; however, no correlation between vitamin D and hs-CRP has been found Conclusion: Vitamin D deficiency is correlated with elevated ADMA, indicative of endothelial dysfunction.
Correlation Between Pre-Transplant Anemia and Mortality After Kidney Transplantation in Diabetic and Non-Diabetic Patients Partiningrum, Dwi Lestari; Putra, Nusa Purnawan; Lestariningsih, Lestariningsih
Majalah Kedokteran Bandung Vol 48, No 1 (2026)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v58.4397

Abstract

Anemia is an established risk factor for mortality and graft failure among kidney transplant recipients, particularly those with diabetes mellitus; however, the combined effects of these conditions remains poorly understood. Regular anemia evaluation is important for patients with End-Stage Kidney Disease (ESKD), especially after transplantation. This retrospective study aimed to analyze 40 kidney transplant recipients with anemia to investigate the correlation between pre-transplant anemia and post-transplant mortality in diabetic and non-diabetic patients at Dr. Kariadi National General Hospital between 2014 and 2020. Data on patient demographics and comorbidities, as well as laboratory data were collected and analyzed. The mean patient age was 41.9±12.4 years, with male constituted 52.5%. The average pre-transplant hemoglobin and serum creatinine levels were 9.4±1.4 mg/dL and 12.4±18.9 g/dL, respectively. Diabetes mellitus was present in 12.5% of patients. Overall, the one-year and three-year post-transplant mortality rates were 20% and 22.5%, respectively. One-year post-transplant mortality occurred in 80% of diabetic patients and 11.4% of non-diabetic patients (p=0.003). At three years, mortality reached 80% in diabetic patients and 14.3% in non-diabetic patients (p=0.006). Pre-transplant anemia significantly increases the risk of post-transplant mortality, especially among diabetic patients, highlighting the need for optimal anemia management before kidney transplantation to enhance long-term patient outcomes.
Co-Authors Arwanto, Arwedi Lestariningsih Lestariningsih Lusito, Lusito Makarim, Fadhli Rizal Nurani, Ayudyah Putra, Nusa Purnawan Shofa Chasani