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All Journal Borneo Journal Of Pharmascientech Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Hayatus Sa`adah
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Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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KARAKTERISASI PARAMETER SPESIFIK DAN PARAMETER NON SPESIFIK AKAR KUNING (Fibraurea tinctoria) Supomo Supomo; Hayatus Sa`adah; Eka Siswanto Syamsul; Kintoko Kintoko; Hardi Astuti Witasari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 2 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (611.786 KB) | DOI: 10.36387/jiis.v5i2.592

Abstract

One of the secondary metabolites from yellow root (Fibraurea tinctoria) that has the potential to be developed as medicine is berberine. Alkaloid class compounds are reported to have antimicrobial, anti-diarrheal, intestinal parasite infection inhibitors, antihypertensives, anti-tumor, anti-inflammatory, hepatoprotective, antimalarial and anticancer properties. In the development of natural ingredients as medicine, it is necessary to standardize simplicia and extracts The research objective was to determine the characterization of specific and non-specific parameters of yellow root plants. This research is an experimental research. The object of research used yellow roots obtained from KDKT Samboja, Kutai Kartanegara district, East Kalimantan Province. Samples were made of simplicia which were extracted using the maceration method with 70% ethanol solvent. The results of the extraction were carried out by characterization including: macroscopic, microscopic, water content, water-soluble extract, ethanol-soluble extract, ash content, and acid-insoluble ash, then phytochemical screening was carried out. Data were analyzed using descriptive methods. The results of macroscopic characterization of yellow root simplicia powder were Liana with a length of 10-20 m, with round stems, bark grayish brown, coarse, 2-7 cm in diameter and bright yellow powder color. The simplicia powder microscopy found stone cell fragments and tracheal fragments. Characterization of simplicia powder, water content of 67.3%, ethanol soluble extract content of 6.69%, water soluble extract content of 8.05%, ash content of 7.37%, acid insoluble ash content of 0.37%. The results of the identification of the chemical compound group were positive for containing chemical compounds in the form of alkaloids, flavonoids and saponins.
PENGARUH METODE EKSTRAKSI TERHADAP KADAR FLAVONOID EKSTRAK ETANOL UMBI BAWANG DAYAK (Eleutherine palmifolia(L.)Merr) DENGAN METODE SPEKTROFOTOMETRI Hayatus Sa`adah; Henny Nurhasnawati; Vivi Permatasari
BORNEO JOURNAL OF PHARMASCIENTECH Vol 1 No 1 (2017): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bawang dayak (Eleutherine palmifolia (L.) Merr) merupakan salah satu tumbuhan berkhasiat yang mempunyai aktifitas sebagai antioksidan. Salah satu senyawa aktif yang terdapat dalam ekstrak etanol umbi bawang dayak yang merupakan senyawa flavonoid. Optimasi pembuatan ekstrak perlu dilakukan untuk mendapatkan kandungan zat aktif yang tinggi. Optimasi pembuatan ekstrak salah satunya adalah metode ekstraksi. Penelitian merupakan penelitian eksperimental dengan objek penelitian adalah kadar flavonoid dari umbi bawang dayak. Penelitian dilakukan untuk membandingkan hasil metode ekstraksi yaitu metode maserasi dan sokletasi dengan menggunakan pelarut yang sama. Kadar flavonoid diuji menggunakan metode spektrofotometri berdasarkan pembentukan senyawa kompleks aluminium klorida, dengan standar baku kuersetin. Data dianalisis dengan uji statistik independent T-Test menggunakan SPSS versi 20. Hasil penelitian menunjukkan kadar flavonoid rata-rata pada metode ekstraksi maserasi sebesar 1,09% lebih besar daripada metode ekstraksi sokletasi sebesar 0,81%. Hasil uji statistik menunjukkan nilai sig 0,005 lebih kecil dari 0,05 dengan taraf kepercayaan 95%, yang berarti bahwa terdapat perbedaan signifikan antara kadar flavonoid metode ekstraksi maserasi dan sokletasi.
FORMULASI SEDIAAN TABLET EKSTRAK AKAR KUNING (Fibraurea tinctoria Lour.) SEBAGAI ANTIDIABETES Hayatus Sa`adah; Supomo Supomo; Eka Siswanto; Kintoko Kintoko; Hardi Astuti Witasari
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.484

Abstract

There are many plants that have the potential to be developed into anti-diabetic herbal medicine. One of them is yellow root (Fibraurea tinctoria Lour.) that contains chemical compounds including alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids. Its known that the administration of ethanolic extract of yellow root at doses of 50, 100 and 200 mg/kg BW can reduce blood glucose levels of rats with induced with alloxan. To increase the use of yellow root in food medicine, preparations were developed by formulating the extract in tablet dosage form. In this study, tablets were made with three formulas with different fillers, namely Avicel PH 101 and pregelatinized starch. The research was conducted experimentally using three formulas with varying concentrations of fillers with a ratio between Avicel PH 101 and and pregelatinized starch, namely formula I (1:0), formula II (0.5:0,5) and formula III (0:1). Furthermore, evaluation of granules which includes evaluation of flow time, angle of repose, compressibility, mass density and moisture content. The granules were compressed and evaluated for tablets including evaluation of weight uniformity, hardness, friability and tablet disintegration time. Based on the results of the study, it can be concluded that the variation of the filler did not affect the physical properties of the yellow root extract granules, but did affect the physical properties of the tablets. The results showed that the tablet that met all the requirements for the physical properties of the yellow root extract tablet was formula II with a combination of Avicel PH 101 and Pregelatinized Starch as fillers.
Co-Authors Eka Siswanto Eka Siswanto Syamsul Hardi Astuti Witasari Hardi Astuti Witasari Henny Nurhasnawati Kintoko Kintoko Supomo Supomo Vivi Permatasari