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All Journal Pharmaciana: Jurnal Kefarmasian JCPS (Journal of Current Pharmaceutical Sciences) Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Al-'Adad: Jurnal Tadris Matematika Jurnal Ilmiah Multidisiplin Ilmu Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan

Kintoko Kintoko

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Author-ID : 3413762

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Public Health Other

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Articles

KARAKTERISASI PARAMETER SPESIFIK DAN PARAMETER NON SPESIFIK AKAR KUNING (Fibraurea tinctoria) Supomo Supomo; Hayatus Sa`adah; Eka Siswanto Syamsul; Kintoko Kintoko; Hardi Astuti Witasari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 2 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

One of the secondary metabolites from yellow root (Fibraurea tinctoria) that has the potential to be developed as medicine is berberine. Alkaloid class compounds are reported to have antimicrobial, anti-diarrheal, intestinal parasite infection inhibitors, antihypertensives, anti-tumor, anti-inflammatory, hepatoprotective, antimalarial and anticancer properties. In the development of natural ingredients as medicine, it is necessary to standardize simplicia and extracts The research objective was to determine the characterization of specific and non-specific parameters of yellow root plants. This research is an experimental research. The object of research used yellow roots obtained from KDKT Samboja, Kutai Kartanegara district, East Kalimantan Province. Samples were made of simplicia which were extracted using the maceration method with 70% ethanol solvent. The results of the extraction were carried out by characterization including: macroscopic, microscopic, water content, water-soluble extract, ethanol-soluble extract, ash content, and acid-insoluble ash, then phytochemical screening was carried out. Data were analyzed using descriptive methods. The results of macroscopic characterization of yellow root simplicia powder were Liana with a length of 10-20 m, with round stems, bark grayish brown, coarse, 2-7 cm in diameter and bright yellow powder color. The simplicia powder microscopy found stone cell fragments and tracheal fragments. Characterization of simplicia powder, water content of 67.3%, ethanol soluble extract content of 6.69%, water soluble extract content of 8.05%, ash content of 7.37%, acid insoluble ash content of 0.37%. The results of the identification of the chemical compound group were positive for containing chemical compounds in the form of alkaloids, flavonoids and saponins.

Farmasi EFEK RAMUAN OBAT TRADISIONAL (BATRA) KALIPUTIH JAWA TENGAH, TERHADAP KOLESTEROL, TRIGLISERIDA DAN HDL TIKUS SPRAGUE DAWLEY YANG DIINDUKSI STREPTOZOTOSIN Urmatul Waznah; Nurkhasanah Nurkhasanah; Kintoko Kintoko; Djati Wulan Kusumo
JCPS (Journal of Current Pharmaceutical Sciences) Vol 3 No 1 (2019): September 2019
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417.224 KB)

ABSTRAK Ramuan Batra asli Kaliputih adalah ramuan tradisional yang secara empiris berkhasiat untuk mengobati penyakit diabetes dengan komplikasi gagal ginjal yang terdiri dari tumbuhan obat yaitu, daun keji beling, daun kumis kucing, biji kopi arabika mentah, tunas bambu kuning, cokol tebu ireng, ganyong merah, rimpang temulawak, rimpang kunir putih, rimpang kunyit, buah belimbing wuluh dan srintil hutan. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian Ramuan Batra terhadap kadar kolesterol, trigliserid dan HDL. Penelitian ini menggunakan 30 ekor tikus jantan galur Sprague Dawley yang diinduksi dengan Streptozotosin (dosis 40 mg/dl) secara intra peritonial dengan dosis tunggal. Pemberian ramuan dilakukan selama 15 hari sesuai dengan terapi yang dilakukan oleh Batra kepada pasien. Parameter yang diamati meliputi kadar kolesterol, trigiserid dan HDL menggunakan metode enzimatik–kalorimetri secara CHOD–PAP. Hasil Pengukuran kadar kolesterol dan trigliserida menunjukan penurunan dibandingkan kontrol negatif pada dosis 36 mL/kg BB dan dosis 54 mL/kg BB untuk kolesterol dan dosis 18 mL/kg BB, 36 mL/kg BB 54 mL/kg BB untuk trigliserida.Sedangkan pemeriksaan terhadap kadar HDL menunjukkan kenaikan dibandingkan kontrol negatif pada dosis 18 mL/kg BB, 36 mL/kg BB , 54 mL/kg BB. Sehingga ramuan Batra pada ketiga dosis,mampu menurunkan kadar kolesterol, trigliserida dan meningkatkan HDL. Kata kunci : Ramuan Batra Kaliputih, kolesterol, trigliserida, HDL

Studi In Vivo Efektivitas Gel Ekstrak Etanol Daun Binahong (Anredera cordifolia (Tenore) Steen) Sebagai Penyembuh Luka Diabetes Kintoko Kintoko; Novitasari, P.R. Novitasari, P.R.
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 3 (2016): Spesial Issue of Mulawarman Pharmaceuticals Conference Proceeding (Prosiding Semnas T
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Diabetes Melitus (DM) merupakan penyakit yang ditandai dengan meningkatnya kadar gula darah yang dapat menyebabkan berkembangnya bakteri dan menimbulkan berbagai komplikasi, seperti ulkus diabetik. Gel ekstrak etanol daun binahong (Anredera cordifolia (Tenore) Steen) yang mengandung saponin, alkaloid, tanin, steroid, triterpenoid, flavonoid dan asam askorbat dapat sebagai penyembuh luka melalui mekanisme antibakteri. Tujuan dari penelitian ini adalah mengetahui konsentrasi ekstrak etanol daun binahong pada proses penyembuhan luka diabetik serta mengetahui gambaran sel radang polimorfonuklear netrofil dan reepitelisasinya secara histologi. Penelitian ini menggunakan tikus jantan putih galur Wistar berjumlah 25 ekor yang dibagi dalam 5 kelompok, yaitu kontrol negatif, kontrol positif, kontrol normal, perlakuan gel ekstrak etanol daun binahong; konsentrasi 10% dan 30%, kemudian dilakukan pengamatan terhadap gambaran histopatologi kulit tikus yang sebelumnya telah diinduksi aloksan agar mengalami diabetes dan diamati pada hari ke-16 dan hari ke-23. Hasil pengamatan histopatologi kulit tikus diperoleh data berkurangnya sel radang polimirfonuklear netrofil dan terbentuknya reepitelisasi setelah diberi gel pada konsentrasi 30%. Dari hasil penelitian, disimpulkan bahwa pemberian gel ekstrak etanol daun binahong berefek signifikan pada penyembuhan luka diabetik.

HUBUNGAN KEMANDIRIAN BELAJAR DENGAN KEMAMPUAN BERPIKIR KRITIS SISWA KELAS VIII SMP NEGERI 2 GAMPING Siti Suprihatiningsih; Richatul Asmah; Kintoko Kintoko
Bahasa Indonesia Vol 2 No 1 (2023)
Publisher : IAIN Pontianak

Penelitian ini bertujuan untuk mengetahui: (1) Apakah ada hubungan kemandirian belajar dengan keterampilan berpikir kritis siswa kelas VIII SMP Negeri 2 Gamping, (2) Seberapa besar hubungan antara kemandirian belajar dengan keterampilan berpikir kritis siswa kelas VIII SMP Negeri 2 Gamping. Penelitian ini merupakan penelitian kuantitatif korelasional. Populasi dalam penelitian ini adalah siswa kelas VIII dengan sampel sebanyak 30 siswa. Dipilih dengan teknik random sampling. Instrumen penelitian berupa angket dan tes. Teknik analisis data, uji validitas dan uji reliabilitas. Uji prasyarat berupa uji normalitas dan uji linieritas. Uji hipotesis menggunakan uji-t dengan taraf signifikansi 0,05. Teknik analisis data dalam penelitian ini menggunakan korelasi Product Moment. Berdasarkan hasil analisis data penelitian diketahui bahwa: (1) terdapat hubungan yang positif dan signifikan antara kemandirian belajar dengan keterampilan berpikir kritis siswa kelas VIII SMP Negeri 2 Gamping. Hal ini terlihat dari nilai sig. (2-tailed) sebesar 0,000 < 0,05 dan nilai Pearson Correlation sebesar 0,643 > 0,361. Selain itu dapat dilihat dari nilai hitung (4,446) > t tabel (2,048) (2) bahwa hubungan antara kemandirian belajar dengan keterampilan berpikir kritis siswa kelas VIII SMP Negeri 2 Gamping cukup kuat dengan persentase sebesar 41,4%. Kemampuan berpikir kritis sebesar 41,4% ditentukan oleh kemandirian belajar. Hal ini terlihat dari nilai koefisien determinasi dengan R square sebesar 0,414.

Combination of Spirulina platensis powder and Stichopus variegatus powder against Bcl2 expression in the hippocampus of dementia Rats Lisa Agustina Botutihe; Rizka Safira; Sapto Yuliani; Kintoko Kintoko
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.26205

Spirulina (Spirulina platensis) and golden sea cucumber (Stichopus variegatus) are known to have antioxidant activity that has the potential to prevent neurodegeneration disease. The aim of this study was to examine the effect of the combination of spirulina and golden sea cucumber on Bcl2 gene expression in pyramidal hippocampus cells of trimethyltin-induced dementia (TMT) rats. The study used Sprague Dawley rats which were divided into 6 groups, namely the normal control group (CMC-Na and NaCl 0.9%), pain control (CMC-Na and TMT), positive control (citicoline dose 200 mg / kg and TMT) and test control injected with TMT and given a combination of spirulina and golden sea cucumber dose 200 mg/KgBB with three ratios namely 3: 1, 1: 1 and 1: 3. Extract and citicoline were given on day 1 to day 28, while TMT injection was given a single dose of 8 mg/KgBB on day 8. On the 36th day the rats were sacrificed, brains were removed and the right hemispherium cerebri was fed to 10% formalin in pbs. After 6 days the hippocampus was separated for immunohistochemical observation. The test result data was statistically analyzed with a one-way ANOVA test then followed by post hoc tukey to see the differences between groups. Results showed the combination of spirulina and golden sea cucumber can increase the expression of the Bcl2 gene in the hippocampus. The combination of spirulina and golden sea cucumber (ST1: 3) dose of 200 mg / kg body weight was able to increase hippocampus Bcl2 expression with the number of Bcl2 cell expression almost the same as citicoline in both CA1 and CA2-CA3 regions.

EFEKTIVITAS MUSIK KLASIK DALAM MENGURANGI KECEMASAN MATEMATIKA MURID Deny Hadi Siswanto; Kintoko Kintoko; Tarso Tarso
Jurnal Ilmiah Multidisiplin Ilmu Vol. 2 No. 2 (2025): April : Jurnal Ilmiah Multidisiplin Ilmu (JIMI)
Publisher : CV. Denasya Smart Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69714/t476vs25

Mathematics is often considered a difficult subject and a source of anxiety for many students, a phenomenon known as math anxiety. This anxiety negatively affects students' conceptual understanding, learning motivation, and academic performance. One strategy that can be implemented to reduce math anxiety is the use of classical music. Classical music is known to have a relaxing effect that can reduce stress, enhance focus, and create a more comfortable and conducive learning environment. This study aims to examine the effectiveness of classical music in reducing math anxiety among 11th-grade students at Muhammadiyah Mlati senior high school (28 students) through an experimental approach. The research employs a quasi-experimental design using a pretest-posttest control group method, where students' anxiety levels are measured before and after the intervention with classical music. The findings of this study are expected to provide new insights into the role of music in improving the quality of mathematics learning and serve as a foundation for developing more innovative and holistic teaching strategies. Integrating classical music into mathematics instruction is not only an innovation but also a strategic step in creating a more supportive and enjoyable learning environment. This approach allows students to learn with greater confidence, better understand mathematical concepts, and achieve optimal learning outcomes

Fostering Pancasila Awareness: Youth Dialogue to Counter the Threat of Global Radicalism Muhammad Yusuf Rambe; Deny Hadi Siswanto; Helena Anggraeni Putri; Kintoko Kintoko
Jurnal Ilmiah Multidisiplin Ilmu Vol. 2 No. 2 (2025): April : Jurnal Ilmiah Multidisiplin Ilmu (JIMI)
Publisher : CV. Denasya Smart Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69714/773zb791

The primary objective of this activity was to enhance students' understanding of the critical importance of instilling and practicing the values of Pancasila as a means to confront the growing threat of radicalism in the era of globalization. This event was conducted at Muhammadiyah Seyegan Vocational School and engaged 25 twelfth-grade students in a dynamic and interactive dialogue session. The program featured a knowledgeable resource person who delivered an in-depth presentation on a specific theme, which was followed by an engaging discussion to explore and reflect upon the key points shared. The outcomes of the dialogue revealed that the values embedded within Pancasila are not only foundational but also remain highly relevant and applicable in addressing contemporary challenges. This initiative sought to provide students with a clearer understanding of Pancasila as a comprehensive national worldview, a philosophical cornerstone of Indonesia, and a guiding principle for governance and citizenship. Beyond theoretical understanding, the activity encouraged participants to internalize Pancasila's principles in their daily interactions and decisions, fostering a commitment to embody these values in their personal lives, within their families, in community settings, and in their contributions to national and state affairs. Through this approach, the program aimed to cultivate a sense of responsibility and pride in upholding Pancasila as a unifying and protective force against radicalism

DEVELOPMENT OF A MATHEMATICS MODULE ON INFINITE LIMITS OF ALGEBRAIC FUNCTIONS TO ENHANCE STUDENTS’ CRITICAL THINKING SKILLS Deny Hadi Siswanto; Kintoko Kintoko; Tarso Tarso; Rohmanur Mala; Rif'an Efendi
Jurnal Ilmiah Multidisiplin Ilmu Vol. 2 No. 3 (2025): Juni : Jurnal Ilmiah Multidisiplin Ilmu (JIMI)
Publisher : CV. Denasya Smart Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69714/7a0ppg56

This study aims to develop a mathematics module on the infinite limit material of algebraic functions to improve critical thinking skills of phase-F students at SMA Muhammadiyah 1 Sleman. The study used the ADDIE development model which includes five stages: Analysis, Design, Development, Implementation, and Evaluation. Data were collected through material and media expert validation questionnaires, student response questionnaires, and pretest and posttest tests. The validation results showed that the module was classified as very valid, with an average score of 71 from material experts and 103 from media experts. The student response questionnaire produced a practicality score of 72.6, indicating that the module was practical to use. The effectiveness test was carried out using the normality test and paired sample t-test using SPSS-25, which showed a significant increase (p <0.05) in student learning outcomes. The average pretest score of 58.22 increased to 84.27 in the posttest, with an n-Gain value of 0.64 which is classified as moderate. This module also improved scores on all indicators of students' critical thinking. Thus, the developed e-module is declared valid, practical, and effective in improving students' conceptual understanding and critical thinking skills

PSYCHOLOGICAL DETERMINANTS OF MATHEMATICS ACHIEVEMENT: EXAMINING THE ROLES OF SELF-CONFIDENCE, ACADEMIC RESILIENCE, AND LEARNING DISCIPLINE Deny Hadi Siswanto; Kintoko Kintoko; M.M. Endang Susetyawati; Muhammad Yusuf Rambe
Jurnal Ilmiah Multidisiplin Ilmu Vol. 2 No. 5 (2025): Oktober : Jurnal Ilmiah Multidisiplin Ilmu (JIMI)
Publisher : CV. Denasya Smart Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69714/grxtz057

This study aims to analyze the influence of self-confidence, academic resilience, and learning discipline on students' mathematics learning outcomes. The research method used is quantitative with an ex post facto design, because the research variables have existed naturally without manipulation. The study was conducted in July 2025 with a population of all students of SMK Muhammadiyah Mlati and a sample of 150 students selected through a simple random sampling technique. The data collection instrument was a 5-point Likert scale questionnaire on the variables of self-confidence (X1), academic resilience (X2), learning discipline (X3), and mathematics achievement (Y). Before being used, the instrument was tested for validity and reliability. Data were analyzed using prerequisite tests (normality, multicollinearity, heteroscedasticity, and linearity) and multiple regression using SPSS-25. The results showed that self-confidence, academic resilience, and learning discipline had a significant effect both simultaneously and partially on mathematics learning outcomes. Simultaneously, the three variables contributed 21.4% to learning outcomes, while the rest was influenced by other factors. Self-confidence increases students' courage to face challenges, academic resilience helps students survive difficulties, and learning discipline supports learning consistency

FORMULASI SEDIAAN TABLET EKSTRAK AKAR KUNING (Fibraurea tinctoria Lour.) SEBAGAI ANTIDIABETES Hayatus Sa`adah; Supomo Supomo; Eka Siswanto; Kintoko Kintoko; Hardi Astuti Witasari
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.484

There are many plants that have the potential to be developed into anti-diabetic herbal medicine. One of them is yellow root (Fibraurea tinctoria Lour.) that contains chemical compounds including alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids. Its known that the administration of ethanolic extract of yellow root at doses of 50, 100 and 200 mg/kg BW can reduce blood glucose levels of rats with induced with alloxan. To increase the use of yellow root in food medicine, preparations were developed by formulating the extract in tablet dosage form. In this study, tablets were made with three formulas with different fillers, namely Avicel PH 101 and pregelatinized starch. The research was conducted experimentally using three formulas with varying concentrations of fillers with a ratio between Avicel PH 101 and and pregelatinized starch, namely formula I (1:0), formula II (0.5:0,5) and formula III (0:1). Furthermore, evaluation of granules which includes evaluation of flow time, angle of repose, compressibility, mass density and moisture content. The granules were compressed and evaluated for tablets including evaluation of weight uniformity, hardness, friability and tablet disintegration time. Based on the results of the study, it can be concluded that the variation of the filler did not affect the physical properties of the yellow root extract granules, but did affect the physical properties of the tablets. The results showed that the tablet that met all the requirements for the physical properties of the yellow root extract tablet was formula II with a combination of Avicel PH 101 and Pregelatinized Starch as fillers.

Co-Authors Deny Hadi Siswanto Eka Siswanto Eka Siswanto Syamsul Hardi Astuti Witasari Hardi Astuti Witasari Hayatus Sa`adah Helena Anggraeni Putri Kusumo, Djati Wulan Lisa Agustina Botutihe M.M. Endang Susetyawati Muhammad Yusuf Rambe Novitasari, P.R. Novitasari, P.R. Nurkhasanah Nurkhasanah Richatul Asmah Rif'an Efendi Rizka Safira Rohmanur Mala Sapto Yuliani Siti Suprihatiningsih Supomo Supomo Tarso Tarso Urmatul Waznah

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