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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Majalah Obat Tradisional Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology JI-KES (Jurnal Ilmu Kesehatan) Jurnal Jamu Indonesia Jurnal Kajian Ilmiah Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Journal of Food and Pharmaceutical Sciences Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan JI-KES (Jurnal Ilmu Kesehatan)

Hardi Astuti Witasari

Universitas Ahmad Dahlan Yogyakarta

Author-ID : 419451

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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PENGARUH DIABETES MELLITUS TERHADAP RESISTENSI ASPIRIN PADA PASIEN STROKE ISKEMIK DI RUMAH SAKIT BETHESDA YOGYAKARTA Hardi Astuti Witasari; Rizaldy Taslim Pinzon; Erna Kristin
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The secondary prevention of ischemic stroke can be implemented by giving aspirin.However, some cases of aspirin resistance have been found. The purpose of this study was toexamine the influence of diabetes mellitus on the risk of aspirin resistance in ischemic strokepatients at Bethesda Hospital Yogyakarta. This study was using a nested case-control studydesign. The Cases group was subjects who resistance to aspirin therapy. The control group wassubjects who response to aspirin therapy. The factors that affect the incidence of aspirinresistance were analyzed by bivariate analysis chi square test. The proportion of diabetesmellitus in resistant group was bigger than the aspirin responsive group. Its odds ratio (OR) was1.605 (95% CI, 0.641 to 4.017) (p=0.155). Conclusion: Ischemic stroke patients at BethesdaHospital Yogyakarta with diabetes mellitus were not proved to have a bigger risk of aspirinresistance than the patients without diabetes mellitus.

Optimizing Formula of Fast Disintegrating Tablet of Belimbing Wuluh Leaf Extract with Crospovidone and Croscarmellose Sodium as Superdisintegrant Citra Ariani Edityaningrum; Tantri Sofia Fauziah; Zainab Zainab; Hardi Astuti Witasari
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Averrhoa bilimbi L. leaves can be used as an antidiabetic in the presence of flavonoid. Antidiabetic drugs were widely consumed by elderly patients who often had difficulty in consuming conventional tablets. Research in developing formulations of an antidiabetic drug that is capable of rapid disintegration and quickly dissolves when placed on the tounge is necessary, therefore it is formulated in fast disintegrating tablet dosage forms. The research aimed to formulate FDT of ethanol extract of Averrhoa bilimbi L. leaves with variation of superdisintegrant crospovidone and croscarmellose sodium. Fast disintegrating tablet of Averrhoa bilimbi L. leaves extract was manufactured by direct compression. Furthermore, the tablet was evaluated with physical properties and the results were analyzed using Design expert 10.1.3 program to bring in simplex lattice design (SLD) equation to get the optimum formula. Data which had been obtained was then analyzed byone sample test with confidence interval 95%. Based on the research results, the combinations of crospovidone and croscarmellose sodium was able to reduce the response of physical properties such as weight variation, hardness, friability, disintegration time, and wetting time. The optimum formula consist of 6.8 mg crospovidone and 12.2 mg croscarmellose sodium which resulted in 4.41 kg of hardness response, 0.59% of friability, 11.21 seconds of wetting time, and 3,85 seconds of disintegration time. Analysis of one sample t-test showed that there was no significant difference between the parameter values predicted results with the results of the research, so it can be concluded that SLD equation can be used to develop a formula that gives optimum parameters of FDT.

Formulation and Antifungal Activity of Piper betle L. Leaf Extract in Emulsion Gels Against Candida albicans Widyasari Putranti; Chairisty Asterina; Hardi Astuti Witasari
Majalah Obat Tradisional Vol 26, No 1 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.53257

Candidiasis is the most common fungal infection in humans and is a form of primary and secondary infections of C. albicans. Betel (Piper betle L.) leaf extract has been reported to exhibit efficacious antifungal effects against C. albicans. Emulsion gels, a type of topical dosage form, can deliver hydrophilic and hydrophobic drugs and perform multiple and controlled releases. This research aimed to determine the antifungal activity and physical properties of emulsion gels formulated from betel leaf extract. The dried betel leaves were extracted by maceration with alcohol 95%. Then, with different concentrations (1, 2, and 4%), the extract was formulated into emulsion gels. These dosage forms were later subjected to antifungal activity testing against C. albicans using the cup plate diffusion method that involved Mycoral Cream® for comparison. In this test, the intensity of the activity was determined by measuring the diameter of the formed inhibition zone. The second test evaluated the physical characteristics of the dosage forms, including organoleptic properties, pH, adhesion, dispersion, and viscosity. These data were analyzed using the Mann-Whitney method, and the conclusion was withdrawn from describing the results quantitatively. The reaction yield of the extraction was 9.702%. The analysis results showed that emulsion gels containing 1, 2, and 4% of betel leaf extract created zones of inhibition with diameters of 5.3 ± 0.29, 6.2 ± 0.29, and 10.2 ± 0.41 mm, respectively. As for the physical properties, they differed in pH (6.39 ± 0.120, 6.17 ± 0.132, 5.66 ± 0.123), spreadability (1.849 ± 0.45, 1.816 ± 0.051, 1.771 ± 0.092 g.cm.s-1), adhesion (110 ± 10.8, 126.3 ± 8.5, 142.7 ± 13.50 seconds), and viscosity (2640.35, 1992.95, 2162.12 cps), respectively. The betel leaf emulsion gels exhibited antifungal activity against C. albicans (p <0.05) and met the physical requirements of semi-solid dosage forms.

KARAKTERISASI PARAMETER SPESIFIK DAN PARAMETER NON SPESIFIK AKAR KUNING (Fibraurea tinctoria) Supomo Supomo; Hayatus Sa`adah; Eka Siswanto Syamsul; Kintoko Kintoko; Hardi Astuti Witasari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 2 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

One of the secondary metabolites from yellow root (Fibraurea tinctoria) that has the potential to be developed as medicine is berberine. Alkaloid class compounds are reported to have antimicrobial, anti-diarrheal, intestinal parasite infection inhibitors, antihypertensives, anti-tumor, anti-inflammatory, hepatoprotective, antimalarial and anticancer properties. In the development of natural ingredients as medicine, it is necessary to standardize simplicia and extracts The research objective was to determine the characterization of specific and non-specific parameters of yellow root plants. This research is an experimental research. The object of research used yellow roots obtained from KDKT Samboja, Kutai Kartanegara district, East Kalimantan Province. Samples were made of simplicia which were extracted using the maceration method with 70% ethanol solvent. The results of the extraction were carried out by characterization including: macroscopic, microscopic, water content, water-soluble extract, ethanol-soluble extract, ash content, and acid-insoluble ash, then phytochemical screening was carried out. Data were analyzed using descriptive methods. The results of macroscopic characterization of yellow root simplicia powder were Liana with a length of 10-20 m, with round stems, bark grayish brown, coarse, 2-7 cm in diameter and bright yellow powder color. The simplicia powder microscopy found stone cell fragments and tracheal fragments. Characterization of simplicia powder, water content of 67.3%, ethanol soluble extract content of 6.69%, water soluble extract content of 8.05%, ash content of 7.37%, acid insoluble ash content of 0.37%. The results of the identification of the chemical compound group were positive for containing chemical compounds in the form of alkaloids, flavonoids and saponins.

Uji Aktivitas Antibakteri EkstrakEtanol dan Fraksi Batang Kuning (Fibraurea Tinctoria Lour) terhadap Bakteri Escherichia coli dan Staphylococcus aureus Lusi Mardika Ariyanti; Supomo Supomo; Hayatus Sa’adah; Eka Siswanto Syamsul; Kintoko Kintoko; Hardi Astuti Witasari
JI-KES (Jurnal Ilmu Kesehatan) Vol 5, No 2 (2022): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : STIKes Hafshawaty Pesantren Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v5i2.323

Abstrak Akar kuning (Fibraurea tinctoria Lour) merupakan tumbuhan khas yang dapat dijumpai di Kalimantan serta biasa dimanfaatkan oleh masyarakat setempat sebagai obat gatal, penyakit kuning dan diare. Salah satu senyawa kimia yang terkandung dalam akar kuning adalah berberin yang berpotensi memiliki khasiat sebagai antidiabetes, antivirus, antibakteri dan antiinflamasi. Penelitian ini bertujuan untuk mengetahui potensi tumbuhan Akar Kuning (Fibraurea tinctoria Lour.) sebagai antibakteri terhadap bakteri Escherichia coli dan Staphylococcus aureus dengan menggunakan metode disc diffusion. Ekstrak etanol difraksinasi dengan menggunakan pelarut n-heksan dan etilasetat, ekstrak dan fraksi yang telah didapat ditimbang dengan konsentrasi 2,5%, 5% dan 10%. Kontrol positif yang digunakan yaitu amoxicillin dan DMSO sebagai kontrol negatif. Hasil penelitian menunjukkan bahwa ektrak etanol dan fraksi akar kuning (Fibraurea tinctoria Lour.) memiliki potensi untuk menghambat pertumbuhan bakteri. Aktivitas zona hambat terbesar yang terbentuk pada ekstrak etanol yaitu pada konsentrasi 10% dengan diameter zona hambat 9,18 mm terhadap bakteri Escherichia coli dan 12,16 mm terhadap bakteri Staphylococcus aureus sedangkan fraksi batang akar kuning yang memiliki aktivitas antibakteri paling kuat terhadap bakteri Escherichia coli dan Staphylococcus aureus yaitu fraksi sisa. Staphylococcus aureus memiliki sensitifitas lebih tinggi terhadap akar kuning (Fibraurea tinctoria Lour) dari pada bakteri Escherichia coli. Kata kunci : antibakteri, akar kuning, berberin, Fibraurea tinctoria Lour. Abstract Akar kuning (Fibraurea tinctoria Lour.) is typically plant that can be found in Kalimantan usually used by local people as itch medicine, jaundice and diarrhea. Berberin, one of the chemical compounds contained in the akar kuning, berberin has the potential to act as an anti-diabetic, antiviral, antibacterial, and anti-inflammatory. This study aimed to determine the activity of akar kuning as an antibacterial against Escherichia coli and Staphylococcus aureus using the disc diffusion method. Ethanol extract are fractionated using n-Heksan and Etilasetat solvents, the obtained of extract and fraction are weighed to 2,5%, 5% and 10%. Positive control antibacterial used amoxicillin and DMSO as negative control. The results showed that ethanol extracts and fraction of akar kuning (Fibraurea tinctoria Lour.) are have potential to inhibited bacteria growth. The highest antibacterial activity that showed at 10% concentration of ethanol extract with diameter inhibition is 9,18 mm to Escherichia coli and 12,16 mm to Staphylococcus aureus while the fraction of akar kuning which has the stronger antibacterial activity to Escherichia coli and Staphylococcus aureus is the rest fraction. Staphylococcus aureus were more susceptible to akar kuning (Fibraurea tinctoria Lour.) extract and fraction than Escherichia coli.Keywords: antibacterial, akar kuning, berberin, Fibraurea tinctoria Lour

Bioassay-Guided Extraction Komponen Aktif Daun Sirih Merah (Piper crocatum Ruiz & Pav) Sebagai Antioksidan Hardi Astuti Witasari; Sukanya Dej-adisay
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 3 (2016): Spesial Issue of Mulawarman Pharmaceuticals Conference Proceeding (Prosiding Semnas T
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Antioksidan bertindak sebagai fungsi pertahanan yang melindungi dari kerusakan oksidatif. Antioksidan juga mempunyai kemampuan mengganti dan memperbaiki bagian yang mengalami kerusakan. Sirih merah (Piper crocatum Ruiz & Pav) adalah tanaman yang memiliki kemampuan antioksidan untuk menghambat oksidasi asam lemak dan mengurangi radikal bebas. Tujuan penelitian ini adalah untuk meneliti fraksi polar, semipolar atau nonpolar yang paling aktif sebagai antioksidan dari ekstrak etanol daun sirih merah (Piper crocatum Ruiz & Pav). Penelitian dilakukan dengan tahapan persiapan simplisia, pembuatan ekstrak etanol daun sirih merah, pembuatan fraksi n-Heksana, etilasetat dan fraksi air, uji aktivitas antioksidan ekstrak etanol, fraksi n-Heksana, fraksi etil asetat, dan fraksi etanol-air dengan metode DPPH, analisis Kromatografi Lapis Tipis (KLT) ekstrak dan fraksi yang aktif sebagai antioksidan Penelitian dilakukan pada bulan Juli sampai Oktober 2015 di laboratorium fakultas farmasi Universitas Ahmad Dahlan dan Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Prince Songkla University, Thailand. Pada hasil uji antioksidan dengan metode DPPH dihasilkan bahwa nilai ES 50 dari ekstrak adalah 51,93 ± 2,51, fraksi heksan 210,69 ± 1,73, fraksi etil asetat 58,20 ± 1,41, dan fraksi metanol air 47,62 ± 0,27. Pada uji ini digunakan quersetin sebagai pembanding yang mempunyai nilai ES 50 sebesar 10,72 ± 0,71. Kesimpulan dari penelitian ini adalah fraksi etanol-air mempunyai nilai ES 50 paling kecil dibandingkan faraksi lain dan ekstraknya.

Effect of aspirin resistance with dyslipidemia against VerifyNOW® measurement in Bethesda hospital Yogyakarta Hardi astuti witasari; Rizaldy Taslim Pinzon; Erna Kristin
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 2, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss2.art2

Background: Aspirin is first line drug of choice to prevent ischemic stroke. However, some cases are found occuring of aspirin resistance. Objective: This study was to examine the effect of dyslipidemia on the risk of antiplatelet resistance with VerifyNOW ® at Bethesda Hospital Yogyakarta. Method: This research was observational analysis using a nested casecontrol study design. The subjects were ischemic stroke patients who underwent tests of platelet function by VerifyNOW® (Accumetrics, San Diego, CA, USA). The Case group was ischemic stroke patients who has history of aspirin resistance. The control group was ischemic stroke patients who response on aspirin therapy. Both groups were analyzed and compared to the state of dyslipidemia. Results: Bivariate analysis on the incidence of aspirin resistance indicate that dyslipidemia had OR = 0.979 (95% CI; 0.378 to 2.531), p = 0.572. Hypercholesterolemia had OR = 0,909 (CI 95%; 0,377-2,190) p = 0,500; hypertrigliceride had OR = 0,838 (CI 95%; 0,331-2,119) p = 0,409; abnormal HDL had OR = 1,468 (CI 95% 0,564-3,817) p = 0,238; abnormal LDL had OR = 0,937 (CI 95% 0,374-2,345) p = 0,500. Patient factors such as age >55 years (p = 0.168) and female gender (p = 0.226) showed a nonsignificant results. Conclusion: Ischemic stroke patients at Bethesda Hospital Yogyakarta who had dyslipidemia were not evident to have a greater risk of aspirin resistance than ischemic stroke patients who did not undergo dyslipidemia.

Characterization and The Effects Analysis of Purple-fleshed Sweet Potato Extract (Ipomoea batatas [L.]) Administration on Triglyceride Concentration and Pancreatic Histopathology Profiles of Triton X-100-induced Hyperlipidemia in Rats Kintoko; Hardi Astuti Witasari; Rizky Nurdhillah; Tsania Taskia Nabila
Jurnal Jamu Indonesia Vol. 7 No. 2 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i2.258

Hypertriglyceridemia occurs when the triglyceride levels are increasing from the normal (>150 mg/dL) and it causes pancreatitis at a dose of more than 885 mg/dL. The triglyceride-lowering medicines consumption has several side effects on various organ systems. The plant-based medicine (phytomedicine) alternatives have been observed as the synthetic medicine substitution. Purple-fleshed sweet potato (Ipomoea batatas [L.]) contains anthocyanin that has proven to carry out the antioxidant mechanism and the capability to be used as anti-hypertriglyceridemia. This study aims to identify the activity of purple-fleshed sweet potato extracts on triglyceride levels and the histopathological profile of rats' pancreas-induced Triton X-100. Twenty-five male Wistar rats of week 8th were divided into five groups. The normal (N) group was treated with saline solution, and the treatment (T) groups were a single dose of 100 mg/kg of body weight (BW) Triton X-100 and purple-fleshed sweet potato extracts of 175 (T1); 350 (T2); and 700 (T3) mg/kg BW, while the negative (C-) control group was mere induced by a single-dose Triton X-100 of 100 mg/kg BW. The blood serum was isolated and the pre-and post-test was subsequent conducted. The triglyceride serum levels and histopathological data were analyzed by the Kolmogorov-Smirnov normality test and Kruskal-Wallis post-test statistical analysis. The results showed that Triton X-100-induced treatment could significantly increase the triglyceride levels compared to the normal group (P<0.05). The purple-fleshed sweet potato extracts started to lower the triglyceride level at a dose of 700 mg/kg BW (51.83 ±19.15(%)). The extract doses of 175 and 350 mg/kg BW could not reduce the triglyceride level significantly (3.03±2.77 and 5.63±4.24 (%), respectively). A dose of 700 mg/kg BW did not damage the exocrine gland and Langerhans islet of hyperlipidemia rat pancreas treated by Triton X-100.

Components Analysis of Bioactive Essential Oil Combinations (Lavender, Lemon, and Cinnamon) by Gas Chromatography-Mass Spectrometry and their Activities against In Vitro Photoaging on Hairless Rat Dorsal Skin Hardi Astuti Witasari; Kintoko Kintoko; Warsi Warsi; Salsabila Ramadhan; Nadiya Utari; Tsania Taskia Nabila
Majalah Obat Tradisional Vol 27, No 2 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.74197

The essential oil of lavender, lemon, and cinnamon (LaLC) combination is rich in antioxidants and potentially be used as an anti-wrinkle and strengthens the collagen tissue. Ultraviolet B (UVB) radiation is a free radical source that accelerates the aging process and reduces collagen production. This study aims to characterize the chemical components of each oil and determine the best combination as an anti-wrinkle substance. The test was conducted on twenty-four Wistar male rats (Mus musculus) that were divided into six experimental groups consisting of the normal (N), control (C), vehicle control (V), first treatment (T1), second treatment (T2), and third treatment (T3) groups. Each sample was rubbed upon, and the UVB irradiation was administered frequently to each subject. The embedded skin specimen was analyzed using a digital-capable microscope. Data were analyzed through the Kolmogorov-Smirnov normality test, one-way analysis of variance (ANOVA), and the post-hoc Tukey's Honest Significant Difference test. Lavender, lemon, and cinnamon essential oils contained each most significant component, which was linalool (41.46% peak area), dl limonene (44.74% peak area), and 2-propenal, 3-phenyl- (CAS) (53.89% peak area), respectively according to the Gas Chromatography-Mass Spectrometry (GC-MS) analysis. The T1 showed the best score of all parameters and did not show significant significance compared to the N group. In conclusion, the 1:1:3 combination of LaLC is better in preventing in vitro photoaging than other treatment groups.

Ethnomedicine Study on Medicinal Plants in Nanggulan District, Kulon Progo Regency Kintoko, Kintoko; Saputri, Ginanjar Zukhruf; Novitasari, Putri Rachma; Desmayanti, Astri; Witasari, Hardi Astuti; Ranti, Imaniar; Yulianto, Yulianto; Febriansah, Rifki; Widyaningrum, Rachmawati; Utami, Febri; Setiyawati, Fitri Indah
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.14189

Despite the advancements in conventional medicine, medicinal plants continue to play an important role in treating different human ailments, particularly in developing nations. This is based on locals' knowledge of medicinal plants for treating various ailments. Ethnomedicine is a branch of research investigating society's local wisdom for maintaining its health. According to diverse field studies, 40 different varieties of plants have been discovered that the native inhabitants of Kulon Progo Regency think are medicinal. The purpose of this research was to identify therapeutic herbs used by the Kulon Progo population. Traditional healers and members of the Kulon Progo village were interviewed as part of this study. The ethnomedicine data was analyzed using Use Value (UV), Frequency of Citation (FC), and Plant Part Value (PPV). The analytical results suggest that turmeric (0.78), galangal (0.67), and ginger (0.67) are the most important plants to society. Rhizomes (38.10%) and leaves (34.52) are the most commonly employed plant parts for medicinal purposes. Boiling it (47.06%) produces herbal medication from the plant extract.

Co-Authors Ariyanti, Lusi Mardika Chairisty Asterina Citra Ariani Edityaningrum, Citra Desmayanti, Astri Eka Siswanto Syamsul Erna Kristin Hayatus Sa`adah Hayatus Sa`adah, Hayatus Hayatus Sa’adah Hutari, Andri Ilmia, Nisrien Kintoko Kintoko Kintoko Kintoko Kintoko Kintoko, Kintoko Lusi Mardika Ariyanti Mustofa Ahda Nadiya Utari Novitasari, Putri Rachma Nurkhasanah Mahfudh Rangkuti, Ahmad Faizal Ranti, Imaniar Rifki Febriansah Rizaldy Pinzon Rizaldy Taslim Pinzon Rizaldy Taslim Pinzon Rizky Nurdhillah Saâ€™adah, Hayatus Salsabila Ramadhan Santoso, Blegoh Iwan Saputri, Ginanjar Zukhruf Setiyawati, Fitri Indah Siswanto, Eka Suhendra Suhendra Sukanya Dej-adisay Supomo Supomo Supomo Supomo Supomo Supomo Tantri Sofia Fauziah Tsania Taskia Nabila Tsania Taskia Nabila Utami, Febri Warsi Warsi Widyaningrum, Rachmawati Widyasari Putranti Yulianto Yulianto Zainab Zainab

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