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All Journal Sari Pediatri Paediatrica Indonesiana Majalah Kedokteran Nusantara The Journal Of Medical School

Atan Baas Sinuhaji, Atan Baas

Department Of Child Health, University Of North Sumatera Medical School, Medan

Author-ID : 3453858

Health Professions Medicine & Pharmacology

Published : 29 Documents Claim Missing Document

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Hepatitis Akibat Penyakit Sistemik Dedy Gumilang Daulay; Supriatmo Supriatmo; Atan Baas Sinuhaji
Sari Pediatri Vol 8, No 4 (2007)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp8.4.2007.294-8

Hati merupakan organ parenkim terbesar yang sering terlibat akibat penyakit sistemik.Pada beberapa penyakit sistemik, hati dapat lebih bertahan dibanding organ tubuhlainnya. Dalam mengevaluasi pasien dengan disfungsi dan penyakit sistemik, klinisiharus dapat membedakan apakah gangguan hati yang terjadi akibat penyakit sistemik,akibat obat yang digunakan dalam terapi penyakit sistemik tersebut ataupun bersamaandengan penyakit hati primer

Lactobacillus probiotics for treating functional dyspepsia in children Tuty Ahyani; Supriatmo Supriatmo; Melda Deliana; Ade Rachmat Yudiyanto; Atan Baas Sinuhaji
Paediatrica Indonesiana Vol 56 No 1 (2016): January 2016
Publisher : Indonesian Pediatric Society

Background Functional dyspepsia is a common gastrointestinal disorder in school-aged children, though, there is no reliable treatment. Probiotics are live microorganisms administered in adequate amounts to confer beneficial health effects on the host. Although definitive evidence is lacking, several studies have found probiotics to be effective for relieving symptoms of dyspepsia, particularly abdominal pain and bloating.Objective To determine the efficacy of lactobacillus probiotics for treating functional dyspepsia in children.Method A double-blind, randomized controlled trial was done from April to June 2012 in five schools in the Pakpak Bharat Regency, North Sumatera. A total of 116 children who fulfilled the Rome III criteria for functional dyspepsia were randomized into 2 groups to receive either lactobacillus probiotics or placebo for 2 weeks. All patients received a diary to record symptoms and frequency of pain daily. The primary outcome for treatment was defined to be no pain at the end of the intervention.Results The probiotics and placebo groups were not significantly different in recovery from functional dyspepsia (29.3% vs. 13.8%, respectively; P=0.432). However, compared to the placebo group, the probiotics group had significantly reduced frequency of pain (P=0.0001), but no significant differences in pain severity (P=0.08) or pain duration (P 0.091).Conclusion There are no significant differences in recovery from functional dyspepsia, pain severity, or pain duration between the probiotics and placebo groups. However, the probiotics group has significantly reduced frequency of pain compared to that of the placebo group.

The role of glucomannan fiber in childhood functional constipation Indiana Aulia; Supriatmo Supriatmo; Emil Azlin; Atan Baas Sinuhaji
Paediatrica Indonesiana Vol 56 No 2 (2016): March 2016
Publisher : Indonesian Pediatric Society

its most common type is functional constipation. The dietary fiber may be useful in childhood functional constipation management, but unfortunately the role of fiber in functional constipation is still less developed.Objective To determine the role of glucomannan in treatment of childhood functional constipation.Methods A crossover randomized controlled trial (RCT) was done from May until July 2012 in a boarding school in Medan, North Sumatera. The subjects were children with functional constipation aged 7 to 12 years. Subjects were randomised into two group receiving glucomannan fiber as polysaccharide gel (group A) and maltodextrin as placebo (group B) with each dose of 100 mg/kg/day (maximum of 5 g/day) diluted in 50 ml water/500 mg for 4 weeks, then after a wash out period we did the crossover of the two groups. Frequency and consistency of stools were recorded into diary sheet for 4 and 8 weeks of treatment. Functional constipation has been diagnosed based on Rome III criteria. Data was analyzed using independent T-test and Chi-square test.Results A total of 36 subjects were eligible with each group consisting of 18 subjects and mean of weight of 25 kg. We found significant difference in stool frequency, treated on glucomannan with P= 0.002 before and P = 0.0001 after the wash out period. For stool consistency, we found difference while treated on glucomannan 9/18 (P= 0.034) in 4 weeks before and 11/18 (P = 0.008) in 4 weeks after the wash out period.Conclusion Glucomannan has significant effect to improve functional constipation especially in 4 weeks treatment.

Selenium and functional constipation in children Marlina Tanjung; Supriatmo Supriatmo; Melda Deliana; Ade Rachmat Yudiyanto; Atan Baas Sinuhaji
Paediatrica Indonesiana Vol 56 No 2 (2016): March 2016
Publisher : Indonesian Pediatric Society

Background Constipation is a common problem in children, with approximately 90 to 95% of constipation cases having functional constipation. Oxidative stress may be a causative factor in gastrointestinal diseases, alleved by intervention with antioxidants. Selenium is an essential trace element and acts as a cofactor of gluthathione peroxidase, which protects membranes from oxidative damage.Objective To determine the effect of selenium on functional constipation in children.Methods We conducted a single-blind, randomized clinical trial from November to December 2012 at the Al-Kautsar Al-Akbar Islamic Boarding School in Medan, North Sumatra. Subjects were children aged 12 to 17 years with functional constipation, diagnosed according to the ROME III criteria. Patients were randomly allocated into either the selenium group (n=57) or the placebo group (n=57). Subjects were clinically evaluated for frequency of defecation, stool consistency, severity of abdominal pain, and side effects during the 2 weeks of treatment (days 7 and 14) and 1 week after treatment had stopped (day 21).Results A total of 114 subjects were eligible to participate. The average frequency of defecation observed on day 14 was 1.5 (SD 0.75) days per defecation (P=0.0001) in the selenium group and 2.4 (0.84) days per defecation in the placebo group, a statistically significant difference (P=0.0001). There was no significant difference in frequency of defecation on the 7th day of treatment. But after day 7, there were significant differences between the groups at days 14 and 21. Normal stool consistency was found in 45 subjects (78.9%) on day 7 and in 57 subjects (100%) on day 14 of treatment in the selenium group, significantly more than those in the placebo group (P<0.05). In placebo group, normal stool consistency was found in 27 subject (47.4%) with (P=0.001) on day 7 and in 38 subject (66.7%) on day 14 of treatment (P=0.0001). On day 14, the selenium group had significantly more subjects without pain than the placebo group [47 subjects (82.5%) vs. 10 subjects (17.5%), respectively (P=0.0001)]. Severity of abdominal pain after 14th day of treatment is without pain 47 subject (82.5%) and mild pain 10 subject (17.5%) (P=0.0001). We found no side effects of selenium treatment in our subjects.Conclusion Selenium is effective in improving clinically functional constipation, in terms of increased frequency of defecation, normalization of stool consistency, and less severe abdominal pain.

Selenium for acute watery diarrhea in children Meiviliani Sinaga; Supriatmo Supriatmo; Rita Evalina; Ade Rachmat Yudiyanto; Atan Baas Sinuhaji
Paediatrica Indonesiana Vol 56 No 3 (2016): May 2016
Publisher : Indonesian Pediatric Society

Background Acute watery diarrhea remains a major health problem affecting infants and children in developing countries. Selenium deficiency may be a risk factor for diarrhea and vice versa. Few studies have been conducted on the effectiveness of selenium for the treatment of diarrhea in children.Objective To determine the effectiveness of selenium in reducing the severity of acute watery diarrhea in children.Methods A single-blind, randomized clinical trial was done in children with acute watery diarrhea, aged six months to two years, and who visited the community health center in Simalungun from May to August 2012. Children were randomized into either the selenium or placebo (maltodextrin) group. We monitored diarrheal frequency, stool consistency, and duration of diarrhea. Mann-Whitney, Fisherâ€™s, and Kolmogorov-Smirnov tests were used to compare the two groups.Results Sixty-five children were recruited into the study, of whom 36 children received selenium and 29 children received a placebo. The selenium group had significantly lower frequency of diarrhea (bouts per day) than the placebo group on days 2, 3, and 4 after treatment onset [day 2: 3.5 vs. 4.1, respectively (P=0.016); day 3: 2.7 vs. 3.4, respectively (P=0.002); day 4: 2.1 vs. 2.8, respectively (P<0.001)]. On day 2, stool consistency had significantly improved in the selenium group compared to the placebo group (P=0.034). In addition, the median duration of diarrhea was significantly lower in the selenium group than in the placebo group (60 vs. 72 hours, respectively; P=0.001). Median recovery time from the the first day of diarrhea was also significantly lower in the selenium group than in the placebo group (108 vs. 120 hours, respectively; P=0.009).Conclusion In children with acute watery diarrhea, those treated with selenium have decreased frequency of diarrhea, improved stool consistency, as well as shorter duration of diarrhea and recovery time than those treated with a placebo. [Paediatr Indones. 2016;56:139-43.].

Oral versus rectal laxatives for functional constipation in child Wiji Joko Pranoto; Supriatmo Supriatmo; Melda Deliana; Atan Baas Sinuhaji
Paediatrica Indonesiana Vol 56 No 3 (2016): May 2016
Publisher : Indonesian Pediatric Society

Background Functional constipation is a common childhood condition. Benefits of oral and rectal laxatives in terms of recovery and recurrence in children with functional constipation are still controversial.Objective To compare the effectiveness of oral and rectal laxatives in terms of recovery and recurrence in children with functional constipation.Methods Children aged 8 to 17 years who met the Rome III criteria for functional constipation were enrolled in this open randomised trial. Data was collected through questionnaires, interviews, and physical examinations. The participants were randomly assigned to receive stimulant laxatives (5 mg bisacodyl) either orally for three consecutive days or rectally in a single dose. Subjects kept daily defecation records for 7 days, and were followed up on days 14, 21, 28, 35, and 42. Comparisons of defecation patterns and recurrence of constipation between groups were assessed using Chi-square test.Results Of 99 subjects, 46 children (5 boys, 41 girls) received oral laxatives (group I) and 45 children (8 boys, 37 girls) received rectal laxatives (group II). Four children in each group dropped out. Baseline characteristics are comparable between the groups. Rate of recovery in the first 7 days was higher in the oral compared to rectal groups [84.8% versus 73.3%, respectively, but this was not statistically sininficant (P=0.278)]. In the second week, the recurrence of constipation was significantly higher in the rectal (57.5%) than in the oral laxative group (42.5%) (P=0.026).Conclusion Although recovery tends to occur more with oral compared to rectal laxative agents, the difference was not statistically significant. Higher recurrence in the second week after treatment occurred with rectal laxative agent. [Paediatr Indones. 2016;56:162-6.].

Effect of lansoprazole on quality of life in adolescents with recurrent abdominal pain Sri Yanti Harahap; Selvi Nafianti; Sri Sofyani; Supriatmo Supriatmo; Atan Baas Sinuhaji
Paediatrica Indonesiana Vol 53 No 2 (2013): March 2013
Publisher : Indonesian Pediatric Society

Background Recurrent abdominal pain (RAP) is one of the mostcommon complaints in adolescents. Treatment for RAP dependson the etiology. Lansoprazole has been shown to be effective ongastroesophageal reflux disease (GERD), but further study isneeded to assess the effects of lansoprazole on RAP.Objective To assess quality of life (QoL) of RAP patients whoreceived lansoprazole compared to placebo treatment.Methods This randomized, clinical trial was conducted in theSecanggang District, Lan gkat Regency, North Sumatera, fromAugust to October 2009. Patients who met the Apley criteria forRAP diagnosis were enrolled in the study. Subj ects were dividedinto two groups: those who received 30 mg lansoprazole daily andthose who received placebo, for 14 days. Quality oflife was assessedusing the Pediatrics Quality of Life (PedsQL) version 4.0 beforeadministration oflansoprazole/placebo and reassessed 30 days aftertreatment. Efficacy of treatment was assessed by comparing theQoL before and after treatment in the two groups.Results A total of 98 adolescents, aged 12 - 18 years, wereenrolled in the study and divided into two groups: lansoprazoleand placebo. There was no significant difference QoL in physicalhealth (mean differences 95%CI -109.19 to 1.02; P=0.054),emotional health (mean differences 95%CI -29.26 to 45.48;P=0.666), social functioning (mean differences 95%CI -42.91to 31.69; P=0.766), and sch ool functioning (mean differences95%CI -56.97 to 24.32; P= 0.430), before and after treatmentin the two groups.Conclusion There is no significant difference in QoL between thetwo groups of adolescents with RAP before and after lansoprazoletreatment.

Functional constipation and posture in defecation Fahrul Azmi Tanjung; Supriatmo Supriatmo; Atan Baas Sinuhaji; Hakimi Hakimi
Paediatrica Indonesiana Vol 53 No 2 (2013): March 2013
Publisher : Indonesian Pediatric Society

Background Functional constipation is often a consequence ofhabitual bowel elimination while sitting on common toilet seats.A considerable proportion of the population with n ormal bowelmovement frequency has difficulty emptying their bowels. Theprincipal cause of this problem may be the obstructive nature ofthe rectoanal angle and its relationship to the posture normallyused in defecation.Objective To assess the relationship between functional constipationwith the posture (sitting vs squatting) during defecationin children.Methods We conducted a cross-sectional study in November2010. Participants aged 12- 15 years were selected consecutivelyfrom a junior high school in Medan . Parents and children filledquestionnaires and were interviewed. Functional constipation wasassessed based on the Rome III criteria.Results Sixty-five students enrolled in the study. There was nostatistically significant diffe rences in subjects' characteristics.T here was a significant correlation between functional constipationwith posture during defecation in children (RR= 0.06, 95%CI0.02 to 0.25; P=0.0001). Functional constipation was more likelyoccured in children with sitting (12/20) th an squatting posture(4/45) during defecation.Conclusion We found th at posture in defecation is correlatedto functional con stipation in children.

Zinc therapy for different causes of diarrhea Hafaz Zakky Abdillah; Supriatmo Supriatmo; Melda Deliana; Selvi Nafianti; Atan Baas Sinuhaji
Paediatrica Indonesiana Vol 53 No 6 (2013): November 2013
Publisher : Indonesian Pediatric Society

Background The incidence of diarrhea in Indonesia has declinedin the past five years. In spite of the increasing number of studieson the treatment for acute diarrhea, especially the use of zinc,it is not known if bacterial vs. non-bacterial etiology makes adifference in the reduction of severity of acute diarrhea in childrenon zinc therapy.Objective To assess the effect of zinc therapy in reducing theseverity of acute bacterial and non-bacterial diarrhea.Methods We performed a cross-sectional study in the SecanggangDistrict, Lan gkat Regen cy of North Sumat era, from Augustto November 2009 in children aged 2 months to 14 years .Microscopic stool examination s were undertaken to separatesubjects into the acute bacterial or non-bacterial diarrhea groups.Both groups received 10 mg/day ofzinc sulphate for subjects aged<6 months or 20 mg/day for those aged 2:6 months for 10 days.Measurement of disease severity was based on the frequency ofdiarrhea (times/day) and the duration of diarrhea (hours) afterinitial drug consumption . We performed indepen dent T test forstatistical an alysis.Results Sixty-two children participated in this study, with 31children in the acute bacterial group, and the remainder in thenon-bacterial group. There were no significant differences betweenthe two gro ups in frequency of diarrhea (2 .61 vs 2.70 times/day,respectively, P=0.27) or in duration of diarrhea (63.39 vs 66.68hours, respectively, P= 0.06) .Conclusion Zinc is not more effective in reducing the severityof acute bacterial diarrhea compared to non-bacterial diarrhea inchildren.

Effect of vitamin A on severity of acute diarrhea in children Marlisye Marpaung; Supriatmo Supriatmo; Atan Baas Sinuhaji
Paediatrica Indonesiana Vol 53 No 3 (2013): May 2013
Publisher : Indonesian Pediatric Society

Background Vitamin A deficiency may increase the risk or bea cause of diarrhea. Many studies have been conducted on theefficacy of vitamin A in the management of acute diarrhea, butthe outcomes remain inconclusive.Objective To determine the effectiveness of vitamin A in reducingthe severity of acute diarrhea in children.Methods We performed a singleô€ˆblindô€ˆrandomized controlledtrial in the Secanggang District, Langkat Regency, North ofSumatera, from August 2009 to January 2010 in children aged6 months to 5 years, who had diarrheas. Subjects were dividedinto two groups. Group 1 received a single dose of vitamin A(100,000 IU for subjects aged 6 to 11 month old or with bodyweights :s 10 kg, or 200,000 IU for subjects aged 2: 12 month oldor with body weights> 10 kg). Group 2 received a single doseof placebo. The establishment of severity was based on changesin diarrheal frequency, stool consistency, volume and durationof diarrhea after treatment. We performed independent Tô€ˆtestand Chi square tests for statistical analyses. The study was anintentionô€ˆtoô€ˆtreat analysis.Results We enrolled 120 children who were randomized intotwo groups of 60 subjects each. Group 1, received vitamin Aand group 2 received a placebo. The results showed significantdifferences between the two groups in stool volume starting onthe first day (95%CI 192.30 to 3237.51; Pô€‰O.OOI), as well asdiarrheal frequency (P=O.OOl) and stool consistency (P=O.OOl)on the second day observation and duration of diarrhea followingtreatment (95%CI - 40.60 to - 25.79; Pô€‰O.OOI;).Conclusions Vitamin A supplementation is effective in reducingthe severity of acute diarrhea in children under five years of age.[Paediatr lndones. 2013;53:125-31.]

Co-Authors A. H. Soetanto A. H. Sutanto A. H. Sutanto A. H. Sutanto, A. H. Ade Amelia Ade Rachmat Yudiyanto Ade Rachmat Yudiyanto Ade Rachmat Yudiyanto Ade Rachmat Yudiyanto Ade Rachmat Yudiyanto Ade Saifan Surya Ali Antoni Arizal Arizal Armelia Moesri Asrul Asrul Berlian Hasibuan Berlian Hasibuan Bugis Mardina Lubis Charles Darwin Siregar, Charles Darwin Dedy Gumilang Daulay Emil Azlin Fahrul Azmi Tanjung Fera Luna Nasution Guslihan Dasa Tjipta Gustina Lubis Hafaz Zakky Abdillah Hakimi Hakimi Hakimi Hakimi Herlina Loka Indiana Aulia Indra Mustawa Indra Mustawa Indra Tamboen Irfan Abdullah Johnwan Usman Johnwan Usman Lubis, Azwan Hakmi M. Iqbal Manihar D. Marbun Marlina Tanjung Marlisye Marpaung Meiviliani Sinaga Melda Deliana Melda Deliana Melda Deliana Melda Deliana Melda Deliana Muhammad Ali Muhammad Hatta Muhazar Muhazar Natasha Yuwanita Reni Suryanty Rita Evalina Sari Leyli Harahap Selvi Nafianti Selvi Nafianti Selvi Nafianti Sri Sofyani Sri Sulastri Sri Yanti Harahap Supriatmo dr Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Taheng Sebayang Tiangsa Sembiring Tm. Thaib Tuty Ahyani Tyahaya Bangun Wahyu Ningsih Lestari Wiji Joko Pranoto Yosodiharjo, Asmui

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