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All Journal Sari Pediatri Paediatrica Indonesiana Majalah Kedokteran Nusantara The Journal Of Medical School
Atan Baas Sinuhaji, Atan Baas
Department Of Child Health, University Of North Sumatera Medical School, Medan
Health Professions Medicine & Pharmacology

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Oral erythromycin for treatment of gastrointestinal dysmotility in premature infants Armelia Moesri; Bugis Mardina Lubis; Asrul Asrul; Atan Baas Sinuhaji; Guslihan Dasa Tjipta
Paediatrica Indonesiana Vol 47 No 5 (2007): September 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (206.252 KB) | DOI: 10.14238/pi47.5.2007.234-7

Abstract

Background Functional immaturity of gastrointestinal (GI)motility predisposes preterm infants to feeding intolerance.Erythromycin as a prokinetic agent has been given to preterminfants for the management of non-obstructive GI dysmotility.Objective To evaluate the efficacy of oral erythromycin for thetreatment of GI dysmotility in preterm infants.Methods A randomized controlled clinical trial was done at AdamMalik Hospital and Pirngadi Hospital, Medan, between October2004 – March 2005. Fifty preterm infants with feeding intolerancewere randomly assigned to either receive oral erythromycin (12.5mg/kg, every 6 hours) or placebo for 7 days. Improved tolerancefor enteral feedings was evaluated by the amount of gastric residuebefore feeding.Results On the sixth day, there was a significant difference in theamount of residue from gastric residue between the oralerythromycin group and placebo group (mean 21.7 and 29.4;P<0.05) and so were results on the seventh day (mean 14.1 and26.9; P<0.05).Conclusion Oral erythromycin reduces the amount of gastricresidue before feed in premature infants.
Obesity and functional constipation in children Natasha Yuwanita; Atan Baas Sinuhaji; Tiangsa Sembiring; Supriatmo Supriatmo; Ade Rachmat Yudiyanto
Paediatrica Indonesiana Vol 58 No 1 (2018): January 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.628 KB) | DOI: 10.14238/pi58.1.2018.1-4

Abstract

Background Functional constipation is a common pediatric problem in both developed and developing countries. In the past two decades, the prevalence of obesity has increased worldwide. Obesity itself leads to many health problems, including functional constipation. Studies correlating obesity to functional constipation have thus far mostly originated from developed countries. Objective To assess for a possible correlation between obesity and functional constipation in children in a developing country. Methods This cross-sectional study was conducted in Al-Mukhlisin Islamic Boarding School, Batu Bara District, North Sumatera Province, Indonesia, between July and August 2015. The subjects were 150 students aged 12 to 17 years. Questionnaires were used to determine functional constipation and filled by direct interview. Obesity was determined by body mass index. Data were analyzed using Chi-square test. Results Of 150 children, 49 had functional constipation; and 18 of the 49 were obese. The mean age of children with constipation was 14.7 (SD 1.07) years (95%CI 14.1 to 14.7) and their mean body weight was 53.8 (SD 15.10) kg (95%CI 49.4 to 58.1). The prevalence for functional constipation in obese children was  58% There was a statistically significant correlation between obesity and functional constipation (prevalence ratio=4; 95%CI 1.72 to 8.94; P=0.001), indicating that obese children had 4 times higher risk of having functional constipation. Conclusion There is a significant correlation between obesity and functional constipation in children.
Folic acid and acute diarrhea in children Ade Amelia; Atan Baas Sinuhaji; Supriatmo Supriatmo
Paediatrica Indonesiana Vol 54 No 5 (2014): September 2014
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (117.517 KB) | DOI: 10.14238/pi54.5.2014.273-9

Abstract

Background Diarrhea has been a health problem in childrenunder five year old. Although the mortality caused by acutediarrhea has fallen worldwide, the mortality has increased indeveloping countries, such as Indonesia.Objective To assess the effect of folic acid in reducing the severityof acute diarrhea in children.Methods This study was a single-blind, randomized control trialin children with diarrhea aged six months to five years at a localgoverrnent clinic in the Secanggang District, Langkat Regency,North Sumatera Province from August 2009 until January20 10. Subjects were recruited by con secutive sampling thenrandomized into two groups. Of the 112 children who participated,56 children received oral fo lic acid and 56 children receivedplacebo, 1 capsule per day for five days. The statistical analysesused were the independent T-test and Chi square test with 95%confidence intervals (95% CI) and P values < 0.05 consideredto be statistically significant.Results There were significant differences between the fo lic acidand placebo groups with regards to stool consistency (P=0.02),diarrheal volume on the second day [ 14 7 .52 vs. 303 .21 mL,respectively, (P=0.001)], frequency of diarrhea on the third day[1.9 vs 2.8 episodes, respectively, (P= 0.001)], duration of initialtreatment to recovery [91.3 vs. 117 .9 hours, respectively, (P =0.001) and the total duration between initial symptoms andrecovery (123.6 vs . 147.4 hours, respectively, (P = 0.001)].Conclusion Oral folic acid is clinically beneficial for reducing theseverity of acute diarrh ea in children under five year old.
Efficacy of fructooligosaccharide versus placebo for treatment of acute diarrhea in children: A double-blind randomized clinical trial Reni Suryanty; Supriatmo Supriatmo; Berlian Hasibuan; Atan Baas Sinuhaji
Paediatrica Indonesiana Vol 45 No 2 (2005): March 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.2.2005.65-8

Abstract

Objective To compare the efficacy of fructooligosaccharide (FOS)versus placebo in pediatric patients with acute diarrhea with re-gard to duration and frequency of diarrhea and the volume andconsistency of the stools.Methods This double-blind randomized clinical trial was carriedout from July to November 2003 in the pediatric intensive careunit, outpatient clinic, and pediatric ward of Adam Malik Hospitaland Pirngadi Hospital, Medan. Subjects were children and infantsaged 4 to 24 months suffering from acute diarrhea without dehy-dration or with mild to moderate dehydration whose parents gaveconsent. Children included in this trial received tablets of either600 mg FOS or 761 mg fructulin as placebo. Patients with mild tomoderate dehydration were initially rehydrated according to theWHO protocol. Afterwards, 10 tablets of FOS or placebo were givento each subject to be taken twice daily. In subjects without dehy-dration, the tablets were given by their parents. Daily follow-upwas performed, in which body weight, temperature, duration andfrequency of diarrhea, and the volume and consistency of stoolswere recorded. For outpatients, home visits were made.Results Out of 142 children who met inclusion criteria, 135 com-pleted the study. These consisted of 68 children in the FOS groupand 67 in the placebo group. Subjects were mostly <12 months ofage (57.0%), male (57.8%), and moderately malnourished (34.1%).There was no statistically significant difference between both groupsin the duration and frequency of diarrhea and the volume and con-sistency of stools (P>0.05).Conclusion There is no effect of the administration of FOS assupplemental therapy on the duration and frequency of diarrheaand on the volume and consistency of stools in children with acutediarrhea
Lansoprazole for recurrent abdominal pain in adolescents Ade Saifan Surya; Selvi Nafianti; Melda Deliana; Supriatmo Supriatmo; Atan Baas Sinuhaji
Paediatrica Indonesiana Vol 51 No 4 (2011): July 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi51.4.2011.234-40

Abstract

Background Recurrent abdominal pain is common among adolescents. School absenteeism and lower quality of life are associated with severity of symptoms. Lansoprazole has been used to treat recurrent abdominal pain.Objective To investigate the effectiveness of lansoprazole as a treatment for recurrent abdominal pain in adolescents.Methods We conducted a randomized, double-blind, controlled trial from August 2009 to October 2009. Adolescents suffering recurrent abdominal pain were eligible for the study. Simple randomization was done to divide subjects into two groups. Groups received 30 mg of lansoprazole or placebo, once a day for 14 days. Before treatment, we performed laboratory and physical examinations. Pain frequency was measured in number of abdominal pain episodes per month. Duration was measured in minutes and pain intensity was measured by a pain rating scale. Drug efficacy was measured before, during and after intervention. Data was analyzed using Mann-Whitney U-test and t-test.Results One hundred sixteen recurrent abdominal pain patients were randomized into two groups of 58 patients. There were no statistically significant differences in pain frequency before and after treatment for either the lansoprazole group or the placebo group (P=0.083, 95%CI, -0.033 to 0.021 and P=0.096, 95%CI -0.376 to 0.031, respectively). In addition, there were no significant differences in frequency, duration, and degree of abdominal pain at baseline and after 1, 2 and 3 months of treatment between the two groups.Conclusion Lansoprazole was not more effective than the placebo for treatment of recurrent abdominal pain among adolescents.
Comparison of zinc-probiotic combination therapy to zinc therapy alone in reducing the severity of acute diarrhea Muhammad Hatta; Supriatmo Supriatmo; Muhammad Ali; Atan Baas Sinuhaji; Berlian Hasibuan; Fera Luna Nasution
Paediatrica Indonesiana Vol 51 No 1 (2011): January 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi51.1.2011.1-6

Abstract

Background Although the incidence of diarrhea in Indonesia has declined in the last five years, the mortality rate in children under five years old is still high. Therefore, appropriate and comprehensive management of diarrhea is essential. There have been many studies on the role of zinc therapy and probiotic therapy in reducing the severity of acute diarrhea, but not many studies have compared the use of a combination of the two therapies tozinc therapy alone.Objective To compare the efficacy of zinc-probiotic combination therapy to zinc alone in reducing the severity of acute diarrhea.Methods We conducted a randomized, open-label, controlled trial from July 2009 to January 2010 in Adam Malik Hospital and Pirngadi Hospital, Medan. Children aged between 1 month and 5 years who met the criteria were divided into two groups. Group I received zinc sulphate (aged <6 months: 10 mg/day; aged 2:6 months: 20 mg/day) combined with heat-killed Lactobacillus acidophilus (3x101O CFU/day) for 10 days. Group II received only zinc sulphate at the same dosage as group I. Measurement of disease severity was based on the frequency of diarrhea (times/day) and the duration of diarrhea (hours) after initial drug consumption.Results Eighty subjects were enrolled, randomised, and divided equally into two groups. 40 children received zinc-probiotic in combination (group I) and the remainder (group II) received zinc alone. We observed significant differences in frequency of diarrhea (2.1 vs 3.1 times/day, P=0.001, 95%CI -1.62 to -0.49), and duration of diarrhea (52.1 vs. 72.6 hours, P=0.00l, 95%CI -30.91 to -10.18) in the two groups.Conclusion Combination of zinc-probiotic therapy was more effective in reducing the severity of acute diarrhea than zinc therapy alone in children under five years of age.
Effectiveness of amitriptyline for treating functional dyspepsia in adolescents Indra Mustawa; Supriatmo Supriatmo; Hakimi Hakimi; Atan Baas Sinuhaji
Paediatrica Indonesiana Vol 56 No 5 (2016): September 2016
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.899 KB) | DOI: 10.14238/pi56.5.2016.262-6

Abstract

Background Functional dyspepsia is common among adolescents. Pain reduces children’s quality of life, psychosocial functioning, and school attendance. Amitriptyline is assumed to be one of the alternative treatments in functional dyspepsia.Objective To investigate the effectiveness of amytriptyline as a treatment  for  functional dyspepsia in adolescents.Methods We conducted a randomized, single-blind, controlled trial from January to March 2011 in junior and senior high school students in Dobo City, Aru Island District, Maluku Province. Adolescents suffering from functional dyspepsia and who fulfilled the inclusion criteria were eligible for the study. Subjects were randomized into two groups. Each group received 10 mg (for body weight < 35 kg) or 20 mg (for body weight ≥ 35 kg) amitriptyline or placebo once per day for 28 days. Pain frequency was measured in terms of abdominal pain episodes per month, and duration was measured in minutes. Data were analyzed using t-test.Results Eighty-eight students participated in this study: the amitriptyline group (43 subjects) and the placebo group (45 subjects). There were no statistically significant differences between the amitriptyline and placebo groups in frequency (P=0.777; 95%CI -0.846 to 1.129) or duration (P=0.728) of abdominal pain after treatment.Conclusion  Amitriptyline is not more effective than placebo for treating functional dyspepsia in adolescents.  
Bowel Habits in Children Sri Sulastri; M. Iqbal; Johnwan Usman; Atan Baas Sinuhaji; A. H. Sutanto
Paediatrica Indonesiana Vol 35 No 1-2 (1995): January - February 1995
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.743 KB) | DOI: 10.14238/pi35.1-2.1995.41-6

Abstract

A cross sectional study of the bowel habits of 119 children (aged 2 years or less) was performed at PTP VIII, North Sumatera. The study was carried out on Desember 18 and 19, 1992, using questionnaire. Mean frequency of defecation was 1.2 times/day (± 0.49) and median volume of defecation was 25 mL/day. Out of 119 children, 9 children were on fluid diet, the mean frequency of defecation was 1.5 times/day (± 0.71) and the median volume of defecation was 5 mL/day. Eighty-eight children who were on fluid diet plus solid diet had a mean frequency of defecation 1.1 times/day (± 0.48) and median volume of defecation was 25 mL/day. Twenty two children who received solid diets had a mean frequency of defecation of 1.2 times/day (± 0.35) and median volume of defecation was 57.5 mL/day. The volume of defecation in children who received solid_diets was higher than children who bad not received solid diets (p < 0.05). There was a positive corelation between age and stool volume (r=0.4; p < 0.05).
Steatocrit Value in New-Born Babies Johnwan Usman; Irfan Abdullah; Muhazar Muhazar; Atan Baas Sinuhaji; A. H. Sutanto
Paediatrica Indonesiana Vol 35 No 7-8 (1995): July - August 1995
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi35.7-8.1995.190-3

Abstract

A prospective study on steatocrit value in full-term or preterm newborn babies of~ 2 days of age in Dr. Pimgadi Hospital, Medan is reported. This study was conducted from December 7, 1992, to February 7, 1993; there were 72 newborn babies (37 males and 35 females). The body weight was> 2500 gin 60 babies and s. 2500 gin 12 babies. The median steatocrit value in babies with body weight of> 2500 g was 9%, and it was 32% in babies less than 2500 g of body weight. The proportion of babies with > 25% steatocrit value was larger in babies less than 2500 g than that in 2500 g by the diet patterns of breast milk, breast milk and milk formula, milk formula. The proportion of babies with < 25% steatocrit value was higher in babies with body weight of< 2500 g than that in babies > 2500 g for those who had either breast milk, breast milk and milk formula or milk formula. There was significant difference (p<0,05) in the steatocrit levels between babies with the body weight of > 2500 g and those who had body weight of ≤ 2500 g.
Parents' Knowledge on Diarrhea in a Plantation Area Arizal Arizal; Ali Antoni; Sari Leyli Harahap; Atan Baas Sinuhaji; A. H. Sutanto
Paediatrica Indonesiana Vol 34 No 5-6 (1994): May - June 1994
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (404.244 KB) | DOI: 10.14238/pi34.5-6.1994.149-53

Abstract

The parents' knowledge on diarrhea was evaluated by a cross sectional study in Balirnbingan plantation PTP Vlll Kabupaten Simalungunon December 18-19, 1992. The study was conducted by providing questionnaires to 216 parents of infants and children with diarrhea. Most parents (97.2%) knew that diarrhea was a disease, wbile six of them (2.SOA>) thought that diarrhea was not a disease but was associated with the increase level of intelligence or teeth eruption. Seventy-five percent of parents thought that fluid and electrolyte ought to be given to children with diarrhea, and 16.5 % thought to give anti-diarrheal drugs or traditional medicaments. Fluid and electrolytes were given as an initial treatment for diarrhea by most of the parents (69%). Eight per cent of parents gave diarrheal drugs and 12% used traditional medicaments. They got oral electrolyte solution (OES) from the health workers (63.3%) or from the dispensaries or drug stores (36.7%). Most of the parents (53.7%) thought that OES was useful to stop diarrhea. Only 30.3% knew that OES was used as the substitute of fluid loss, 16% thought it was to cure for stomach ache. As many as 57.4% parents knew diarrhea as an infectious disease and 57.4 % knew how to prevent it. Most of them knew that environmental sanitation could prevent the disease (23.3%). Food and beverages were known as vehicle of infections by 37.5% parents.
Co-Authors A. H. Soetanto A. H. Sutanto A. H. Sutanto A. H. Sutanto, A. H. Ade Amelia Ade Rachmat Yudiyanto Ade Rachmat Yudiyanto Ade Rachmat Yudiyanto Ade Rachmat Yudiyanto Ade Rachmat Yudiyanto Ade Saifan Surya Ali Antoni Arizal Arizal Armelia Moesri Asrul Asrul Berlian Hasibuan Berlian Hasibuan Bugis Mardina Lubis Charles Darwin Siregar, Charles Darwin Dedy Gumilang Daulay Emil Azlin Fahrul Azmi Tanjung Fera Luna Nasution Guslihan Dasa Tjipta Gustina Lubis Hafaz Zakky Abdillah Hakimi Hakimi Hakimi Hakimi Herlina Loka Indiana Aulia Indra Mustawa Indra Mustawa Indra Tamboen Irfan Abdullah Johnwan Usman Johnwan Usman Lubis, Azwan Hakmi M. Iqbal Manihar D. Marbun Marlina Tanjung Marlisye Marpaung Meiviliani Sinaga Melda Deliana Melda Deliana Melda Deliana Melda Deliana Melda Deliana Muhammad Ali Muhammad Hatta Muhazar Muhazar Natasha Yuwanita Reni Suryanty Rita Evalina Sari Leyli Harahap Selvi Nafianti Selvi Nafianti Selvi Nafianti Sri Sofyani Sri Sulastri Sri Yanti Harahap Supriatmo dr Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Supriatmo Taheng Sebayang Tiangsa Sembiring Tm. Thaib Tuty Ahyani Tyahaya Bangun Wahyu Ningsih Lestari Wiji Joko Pranoto Yosodiharjo, Asmui