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All Journal Paediatrica Indonesiana Majalah Kedokteran Nusantara The Journal Of Medical School Cermin Dunia Kedokteran
Fera Wahyuni
Departments Of Child Health, University Of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North Sumatera
Health Professions Medicine & Pharmacology Public Health

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Hemoglobin level and cardiothoracic ratio in children with chronic severe anemia Fera Wahyuni; Muhammad Ali; Bidasari Lubis; Netty D. Lubuis; Tina Christina Tobing
Paediatrica Indonesiana Vol 51 No 5 (2011): September 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi51.5.2011.262-5

Abstract

Background Chronic severe anemia is known to increase cardiac output when the hemoglobin levels are < 7 g/dL for more than three months. Chronic severe anemia is also associated with a high incidence of cardiac enlargement and congestive heart failure.Objective To determine the relationship between hemoglobin level and cardiothoracic ratio in children with chronic severe anemia.Methods We conducted a cross-sectional study in Haji Adam Malik Hospital, Medan, Indonesia from October to December 2009. Subjects had chronic severe anemia and were aged 1 to 15 years. Hematological data was collected at the beginning of the study. The heart was considered enlarged if the cardiothoracic ratio (CTR) was greater than 50% (0.50) by chest roentgenogram. We used simple linear regression to analyze the relationship between hemoglobin and CTR values.Results Thirty subjects enrolled in our study. Their mean age was 115.7 months (SD 56.95). Hemoglobin levels ranged from 2.1 to 6.9 g/dL. The mean hemoglobin level and duration of anemia were 4.71 g/dL (SD 1.48) and 3.9 months (SD 0.70), respectively. Heart enlargement was observed in 23 patients (76.6%). The CTR ranged from 0.52 to 0.69, with a mean of 0.54 (SD 0.06). We found a significant correlation between CTR and hemoglobin levels with Pearson’s correlation coefficient, (r) = - 0.612 and P = 0.001.Conclusion Low hemoglobin levels significantly correlated with high CTR values in children with chronic severe anemia. [Paediatr Indones. 2011;51:262-5].
Correlation between hemoglobin level and left ventricular systolic functions and dimensions in children with chronic severe anemia Erlina Masniari Napitupulu; Fera Wahyuni; Tina Christina L. Tobing; Muhammad Ali; Bidasari Lubis
Paediatrica Indonesiana Vol 51 No 2 (2011): March 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi51.2.2011.79-83

Abstract

Background Chronic severe anemia is a connnon disease. Cardiac output may increase when the hemoglobin (Hb) level decreases to < 7 g/dL for 3 months or more. Alteration of left ventricular (LV) function occurs frequently in children 'With chronic severe anemia, in the {onn of concentric LV hypertrophy, LV dilatation with or v.ithout LV hypertrophy, or systolic dysfunction. Objective To examine the correlation between Hb level and alteration of LV systolic function in children with chronic severe anemia. Methods We conducted a cross-sectional study in Adam Malik Hospital from October to December 2009. Subjects were chronic severely anemic children. Left ventricular systolic function (ejection fraction/EF, fractional shortening/FS) and dimensions (left ventricular end diastolic diameter/LVEDD and left ventricular end systolic diameter/LVESD) were measured using Hitachi EUB 5500 echocardiography unit. Univariate analysis  and Pearson correlation were performed.Results Thirty children were enrolled in the study. The mean of age was 113.5 months (SD 53.24). Hb values ranged from 2.1 to 6.9 g/dL with mean value of 4.6 g/dL (SD 1.44). Mean duration of anemia was 3.9 months (SD 0.70). Chronic severe anemia was not associated \\lith decreased LV systolic function [EF 62.2% (SD 9.16), r =0.296, P=0.112; FS 33.8% (SD 7.26), r =0.115, P=0.545], nor LV dimension changes [LVEDD 40.2 mm (SD 6.85), r = -0.192, P=0.308; LVESD 26.2 mm (SD 4.98), r=-0.266, P=0.156]. Conclusion There was no correlation between Hb level in chronically anemic children and changes in LV systolic function or dimension.
Terapi antibiotika empiris pada neonatus Muchtar Kusuma Hayatullah; Guslihan Dasa Tjipta; Pertin Sianturi; Emil Azlin; Bugis Mardina Lubis; Syamsidah dr; Fera Wahyuni
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 2 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.074 KB)

Abstract

Neonatal sepsis is a clinical syndrome with symptoms of systemic infection and followed by bacteremia in the first month of life. Antibotic initial therapy empirically is often given concomittantly awaiting the results of blood cultures in neonates with suspected sepsis. The recommended initial treatment in general is a combination of ampicillin and aminoglycoside (gentamicin). Alternative to aminoglycosides is the third-generation cephalosporins (eg cefotaxime). This regimen was found safe and effective by appropriate duration of therapy. This therapy should be evaluated every 48 hours with a lingering risk of therapy associated with increased risk of necrotizing enterocolitis and death.Keyword : antibotic initial, Neonatal sepsis
Analisis Gas Darah dan Laktat Darah Tali Pusat sebagai Parameter Metabolik pada Asfiksia Perinatal Fitri Parinda Sitanggang; Bugis Mardina Lubis; Yazid Dimyati; Guslihan Dasa Tjipta; Beby Syofiani; Pertin Sianturi; Syamsidah Lubis; Fera Wahyuni
Cermin Dunia Kedokteran Vol 46, No 9 (2019): Neuropati
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i9.437

Abstract

Asfiksia masih merupakan salah satu penyebab utama kematian neonatus per tahun. Skor Apgar dapat memberikan informasi vitalitas neonatus namun memiliki beberapa keterbatasan. Asfiksia perinatal dapat muncul dari berbagai risiko intrapartum dan postpartum yang mengakibatkan terhentinya pertukaran gas pada fetus. Metabolisme anaerob akan menyebabkan akumulasi laktat dan penurunan pH. Analisis asam-basa dan laktat darah tali pusat dapat memberikan penilaian objektif terhadap status metabolik neonatus.Asphyxia still remain a major causes of neonatal death per year. Apgar score provides information on neonatal vitality but has several limitations. Perinatal asphyxia can arise from a variety of intrapartum and postpartum risks which result in cessation of gas exchange. Anaerobic metabolism will cause lactate accumulation and pH decrease. Analysis of acid-base and lactate in cord blood can provide an objective assessment of the metabolic status of the neonate. 
Co-Authors Beby Syofiani Bidasari Lubis Bugis Mardina Lubis Bugis Mardina Lubis Emil Azlin Erlina Masniari Napitupulu Fitri Parinda Sitanggang Guslihan D Tjipta Guslihan Dasa Tjipta Muchtar Kusuma Hayatullah Muhammad Ali Muhammad Ali Netty D. Lubuis Pertin Sianturi Pertin Sianturi Syamsidah dr Syamsidah Lubis Tina Christina Tobing Yazid Dimyati