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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Hardjoeno Hardjoeno
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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KADAR FIBRIN MONOMER DAN UKURAN INFARK DI STROK ISKEMIK AKUT Ani Kartini; Mansyur Arif; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.470

Abstract

Coagulation activation and thrombosis frequently exist in ischemic stroke, thrombus formation can be detected early by the presence of fibrin monomer. The purpose of this study was to know the correlation of fibrin monomer level with cerebral infarct size in acute ischemic stroke patients. This was a cross sectional study with a total of 39 samples. The fibrin monomer level was determined by immunoturbidimetry method using STA-Compact and the measurement of the infarct size was done by CT scan of the head using Broderick formula. The results of this study showed that the median level of fibrin monomer in acute ischemic stroke with nonlacunar infarct type and lacunar infarct type were 14.46 μg/mL and 4.29 μg/mL, respectively. Mann-Whitney test showed there was a significant difference of fibrin monomer levels between nonlacunar infarct type and the lacunar type, p=0.000. The cut-off point analysis result of the fibrin monomer level was 5.96 μg/mL with a sensitivity of 88.9% and specificity of 76.4%, respectively. Spearman correlation test showed that fibrin monomer level was positively correlated with cerebral infarct volume in acute ischemic stroke (r=0.56, p=0.000). Based on this study, it can be concluded that fibrin monomer level can be used as a marker to predict the type of cerebral infarct and volume of acute ischemic stroke as well.
ANALISIS TEMUAN BASIL TAHAN ASAM PADA SPUTUM CARA LANGSUNG DAN SEDIAAN KONSENTRASI PADA SUSPEK TUBERKULOSIS Elisabeth Frida; S. Ibrahim; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 2 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i2.844

Abstract

Tuberculosis is still an important health problem in Indonesia, being the third place in the world. The diagnosis could be done bydirect microscopic method of slides stained with Ziehl Neelsen. The finding of AFB could be improved by decontaminating the specimensto provide a concentrated sample. To analyze the findings of AFB through microscopy and concentrated smear methods, comparing ofeach to bacteriological culture. Diagnosis was done on 148 patients during May to September 2005, using microscopic method (directmicroscopy and concentrated smear) and culture. Analysis of results was done by using SPSS for Window v. 11.5. Of the 148 specimens,15 (10.1%) and 55 (37.2%) positive AFB were found in direct microscopy and concentrated smears respectively. The sensitivities indirect microscopy and concentrated smears were 22% and 64.8%, while the specificities were 96.8% and 78.7%, positive predictivevalues (PPV) were 80% and 63.6%, negative predictive values (NPV) 68.4% and 79.5%, accuracy values were 69.5% and 73.6%. Thespecificity and PPV were higher in direct microscopic method, while positive value, sensitivity, NPV and accuracy value were higher indecontamination, concentrated sample method. Concentrated sample method will increase the accuracy of the finding of Ziehl NeelsenstainedAFB so that this method could be assumed better for use.
NILAI SMALL DENSE LDL REMAJA DAN KAITANNYA DENGAN LIPID LAINNYA Nurahami Nurahmi; S Aprianti; M. Arif; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 1 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i1.892

Abstract

In Indonesia, coronary heart disease (CHD) as the cause of death is still the highest in number. It is estimated that the numberof deaths is about 535 per 100.000 population. Atherosclerosis represents the main risk factor which could be predicted through thepresence of small dense LDL (sdLDL) in youngsters. To determine the value of sdLDL in youngsters and its correlation with other lipids,a study was conducted cross sectionally in Makassar, from January to August 2006, on 125 youngsters aged 15 to 19 years. Their totalcholesterol, HDL, LDL, TG and ApoB was determined and sdLDL was derived from calculation of LDL/apoB ≤ 1.2. 69 (55.20%) patientsshowed sdLDL value and 56 (44.8%) patients did not show sdLDL value. Statistical calculation showed a significant correlation betweensdLDL and HDL level (p = 0.001), sdLDL and TG level (p = 0.003), and sdLDL and ApoB level (p = 0.036). Percentage of sdLDL valuewas higher in youngsters aged 15 to 19. This proves that the process of atherosclerosis happened early at a young age. Showed by theexistence of sdLDL and therefore sdLDL could be used as a predictor of atherosclerosis which can be prevented if detected earlier.
NILAI RUJUKAN HEMATOLOGI PADA ORANG DEWASA SEHAT BERDASARKAN SYSMEX XT-1800i T Esa; S Aprianti; M Arif; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 3 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i3.875

Abstract

The reference values of laboratory tests are affected by factors such as instruments and methods of tests, which are always beingdeveloped. For these reasons, each laboratory is recommended to determine their own reference values. To determine the reference valuesof complete blood count in healthy adult people, and compare them to the reference values which is taken from the references. A crosssectional study was conducted on 200 healthy adult people, aged 18-60 years, selected during blood donation. The eight haematologicalparameters were estimated using Sysmex Xt-1800i at Dr.Wahidin Sudirohusodo Hospital. The data were analyzed statistically by SPSS11.5 programs. The reference values of leukocyte, erythrocyte, haemoglobin, hematocrit, MCV, MCH, MCHC and platelet were: 4400 to10000 /µL; %:4.2–6.2 × 106/µL; &:3.8–5.5 × 106/µL; %:12.5–17.3 g/dL; &:11.8–15.4 g/dL; %:38.1–50.4 %; &:31.1–49.7 %; 80,1to 94,3 fL, 25,9–31,9 pg, 31,4–35,2 g/dL, and %:171.2–405.1 × 103/µL; &:191.8–441.5 × 103/µL, respectively. Significant differenceswere observed in the MCH and platelet values (p< 0,005). The values found in this study were similar to the reference value commonlyused in our laboratory, except for the MCH value which was lower and the platelet value which was higher..
PROFIL LIPID PENDERITA DIABETES MELLITUS TIPE 2 P S Josten; Mutmainnah Mutmainnah; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 1 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i1.894

Abstract

Prevalence of type 2 diabetes mellitus (DM) tends to increasing worldwide. The main cause of death in type 2 DM is coronaryheart disease (CHD) and its mortality rate can increase 2 to 4 times compared to non-diabetics. One of the risk factors in CHD isdyslipidemia. To know the lipid profile based on age and gender and to assess the relation of total cholesterol, LDL, HDL, and TG levelto age. Descriptive retrospective study in patients with type 2 DM who are 45 years old and over. From 100 Type 2 DM patients, in theDepartment of Internal Medicine, Dr. Wahidin Sudirohusodo Hospital, Makassar, period of June to December 2005, the largest age groupwith dyslipidemia was > 59 years old, with increase LDL level, 32.73% in males and 46.67% in females. There was a significant relationbetween the in crease of TG (p = 0.03) and the decrease of HDL (p = 0.02) with age. Dyslipidemia in type 2 DM patients at age group> 59 years old was shown by an increase in LDL level. The increase of TG and decrease of HDL level were significant in all age groups.Restriction of this study was not to check the antilipidemic medicine used. Early dyslipidemia of Type 2 DM should be known by lipidfraction determination and further dyslipidemia study should be conducted to predict the risk of CHD.
POLA DAN SENSITIVITAS KUMAN DI PENDERITA INFEKSI SALURAN KEMIH Samirah Samirah; Darwati Darwati; Windarwati Windarwati; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 3 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i3.869

Abstract

The bacterial and sensitivity pattern towards antimicrobials on urinary tract infections (UTI) patients are very important to beknown by clinicians to get a successful treatment. The bacterial and sensitivity pattern towards antimicrobials will be changed in differentplace and time, so that those should be analyzed routinely. To evaluate the bacterial and antimicrobials resistance pattern on urinarytract infections patients. A retrospective study on 220 urinary samples in January until December 2004 at Clinical Microbiology subunit of Dr.Wahidin Sudirohusodo hospital . Of 99 samples of UTI, Prevalence of UTI in woman (54.5%) were higher than man (45.5%).Most of sample (28 samples) were found in 0 to 15 years group. The most bacteries in urine were Escherichia coli (39.4%) and Klebsiella(26.3%). Amikacin was sensitive to all bacteries, while amoxicilin and ampicilin were resistance. Prevalence of UTI in women werehigher than in men. Incidens of UTI was highest in children group. The most bacteries in urine samples were Escherichia coli. Amikacinwas sensitive to all bacteries, while Amoxicilin and Ampicilin were resistance.
KADAR b-hCG PENDERITA MOLA HIDATIDOSA SEBELUM DAN SESUDAH KURETASE Syafii Syafii; S Aprianti; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 1 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i1.877

Abstract

Hydatiform mole is an important disease, with a high incidence, many risk factors, and equity spreading. To know and compareb-hCG levels among patients with hydatiform mole before and after curretage was investigated. A retrospective study from January2002 to December 2005 at Dr. Wahidin Sudirohusodo Public Hospital was performed comprising b-hCG levels of hydatiform molepatients before and after curettage. b-hCG level (Elisa’s method) were grouped by age of pregnancy. Among 72 patients, 43 patients withhydatiform mole were found. At trimester I among 10 patients (23.3%), b-hCG level was higher 3 (7.0%), normally 4 (9.3%) and lower3 (7.0%). At trimester II, among 33 patients (76.7%), b-hCG level was higher 12 (27.9%), normal 13 (30.2%) and lower 3 (7.0%).After curretage, b-hCG level was decreased in 35 (81.4%), and increased in 7 (16.3%). Diagnosis of hydatiform mole was establishedin 36 (83.7%) and Gestational Trophoblastic Tumours (GTT) 7 (16.3%). Patients with hydatiform mole had the highest incidence intrimester II with normal b-hCG level and b-hCG level decreased after curretage.
NILAI TROPONIN T (cTnT) PENDERITA SINDROM KORONER AKUT (SKA) R A Nawawi; Fitriani Fitriani; B Rusli; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 3 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i3.872

Abstract

Acute Coronary Syndrome (ACS) is an emergency cardiac condition manifested by chest pain or other symptoms as the result ofischemic myocardium. Myocardial damage can be detected by Creatine Kinase MB (CK-MB), Lactate Dehydrogenase (LDH) and cTnTtests. CTnT can be used as criteria of therapy determination. The combination of CK-MB and cTnT are the most effective tests if theearly myocardium damage is unknown, to evaluate cTnT, CK-MB, and LDH values in patients with Acute Coronary Syndrome (ACS) atWahidin Sudirohusodo Hospital, Makassar. Secondary data were collected from the medical records (from March to July 2005 period)at Wahidin Sudirohusodo Hospital, Makassar. Chi-square and Spearman correlation were carried out to analyze the collected data. Theinvestigators found 90 patients with ACS consisted of 57 males (63.33%) and 33 females (36.67%). The highest cTnT Value of 0.1 to2.0 ng/ml was found in 39 patients (43.33%), 30 females (52.63%). Significant correlation showed by Chi-square test between IMAEKG and cTnT values (p < 0.05). Spearman correlation test demonstrated significant correlation between cTnT value and CK-MB andLDH (p = 0.001). Most cTnT values were found in the male patients with ACS, aged 60 to 69 years and significantly correlated withIMA’s ECG, CK-MB and LDH.
POLA KUMAN BERDASARKAN SPESIMEN DAN SENSITIVITAS TERHADAP ANTIMIKROBA Rostina Rostina; B Rusli; M Arief; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 1 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i1.890

Abstract

High prevalence of infectious diseases in Indonesia lead to the use of uncontrollable anti microbial treatment with less concern todrug resistance, marked with fewer requests for sensitivity testing. This leads to irrational anti microbial treatment and increasing drugresistance. With unsupported condition for using a sensitivity test prior to anti microbial treatment, a common guide for choosing ananti microbial agent for infection of specific organ system is needed. A descriptive study of retrospectively collected data of sensitivity testresults was done on 841 spesimens from sources of infected organs in Wahidin Sudirohusodo Hospital of Makassar during 2005–2006periods. Objectives of this study are to know the microbial pattern of specific organ infection (represented by microbes of the specimens),antimicrobial sensitivity pattern of the microorganisms, and whether there is shifting of the pattern within a 1 year period. Shiftingof microbial patterns during 2005–2006 period was found. Klebsiella aeroginosa, Enterobacter agglomerans, Alkaligenes faecalis andEscherichia coli were the most frequent micro organisms found from spesimens examined. Most of antimicrobial drugs commonlyused were found effective to most of micro organisms, while amikacin, cefepime, gentamycin, sulbactam, tobramycin, vancomycin andmeropene were still sensitive enough to the majority of the infectious agents.
Co-Authors A. Nikmawati Amraini Afiah Ani Kartini AT. Lopa B Rusli B. Rusli D. Irwadi Darwati, Darwati Didi Irwadi Elisabeth Frida Fitriani Fitriani Ismawati Amin M Arief M Arif M. Arif Mansyur Arif Mutmainnah Mutmainnah N Sennang AN N. Ibrahim Nurahami Nurahmi R A Nawawi RDN Pakasi Rostina Rostina S Aprianti S Josten S. Ibrahim Samirah Samirah Sriwati Atjo Suci Aprianti Sulina Y. Wibawa Syafii Syafii T Esa Uleng Bahrun Windarwati Windarwati