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All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia Jurnal Abdi Insani Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Journal Pharmasci (Journal of Pharmacy and Science)
Rahmad Aji Prasetya
Akademi Farmasi Surabaya, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Physics Public Health

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Pengaruh Lama Waktu Pengadukan Terhadap Pengikatan Impuritis untuk Meningkatkan Kadar NaCl Pada Garam Rakyat Astuti, Rika Puji; Yulianti, Cicik Herlina; Prasetya, Rahmad Aji
Journal of Pharmacy and Science Vol. 1 No. 1 (2016): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v1i1.46

Abstract

ABSTRAKGaram dapat didefinisikan sebagai suatu kumpulan senyawa kimia yang bagian utamanya adalah Natrium Chlorida (NaCl) dengan zat-zat pengotor terdiri dari MgCl2, MgSO4, CaSO4, dan lain-lain. Dalam penelitian ini digunakan sampel garam rakyat dari Pasar Larangan Sidoarjo yang memiliki kualitas dibawah standar, dengan kadar NaCl 81,88% b/b. Oleh karena itu, diperlukan pemurnian garam dengan menggunakan metode rekristalisasi. Penelitian ini dilakukan untuk mengetahui pengaruh lama waktu pengadukan (15, 30, dan 45menit) terhadap penambahan beberapa senyawa kimia, seperti natrium hidroksida (NaOH), natrium karbonat (Na2CO3) dan barium klorida (BaCl2) untuk mengurangi ion polutan (Ca2+, Mg2+ dan SO42-). Sehingga kadar NaCl dalam garam rakyat akan meningkat. Kadar NaCl dihitung sebelum dan setelah diberi perlakuan dengan menggunakan metode titrasi argentometri. Hasil penelitian menunjukkan bahwa kadar NaCl tertinggi diperoleh pada rekristalisasi dengan lama waktu pengadukan 45 menit, dengan kadar 98,86% b/b. Kemurnian ini sesuai untuk memenuhi tuntutan kebutuhan masyarakat dan industri.Kata Kunci: Garam Rakyat, Kadar NaCl, Lama Waktu PengadukanABSTRACTSalt can be defined as chemical compounds which the main substance is Sodium Chloride (NaCl) with impurity substances consist of MgCl2, MgSO4, CaSO4, etc. This study used public salt from Larangan Market Sidoarjo which has sub-standard quality, and the concentration of NaCl is about 81,88%b/b. Hence, salt purification is needed using recrystallization method. This study was conducted to determine the influence of stirring time (15, 30, and 45 minutes) of the addition of several chemical compounds, such as sodium hydroxide (NaOH), sodiumcarbonate (Na2CO3) and barium chloride (BaCl2) in order to reduce the pollutant ions (Ca2+, Mg2+ and SO42-). Eventually the percentage of NaCl concentration in public salt will increase. NaCl concentration was calculated before and after treatment was using argentometry titration. The results shows that the highest NaCl concentration is obtained at recrystallization with stirring time 45 minutes, concentration 98,86% b/b. This purity suitable to meet the needs of society and industry demands.Keywords: Stirring Time, The Concentration Of NaCl, Public Salt.
Profil Penurunan Tekanan Darah pada Terapi Obat Antihipertensi Golongan CCB Dihidropiridin Antara Amlodipin Dibandingkan Nifedipin Oral Osmotik (Studi Dilakukan di Poli Penyakit Dalam RS Bhayangkara Porong) Ulfa, Ninik Mas; Prasetya, Rahmad Aji; Adelia, Lailatul
Journal of Pharmacy and Science Vol. 3 No. 1 (2018): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v3i1.72

Abstract

ABSTRAKHipertensi adalah suatu peningkatan tekanan darah sistolik dan diastolik yang tidak normal. Tujuan dari penelitian ini adalah untuk mengetahui profil penurunan tekanan darah pada terapi obat antihipertensi yaituAmlodipin dibandingkan Nifedipin Oros dan untuk mengetahui prevalensi efek samping obat. Penelitian ini bersifat observasional. Pengamatan berdasarkan perubahan tekanan darah pre, selama terapi, dan post terapi obat antihipertensi selama 4 bulan terapi. Hasil penelitian tekanan darah pada terapi Amlodipin menunjukkan bahwa mayoritas tekanan darah pre adalah pada kategori hipertensi stage II yaitu 13 pasien (92,86%), setelah 1-2 bulan terapi, tekanan darah mencapai kategori hipertensi stage I, setelah 3 bulan terapi mencapai kategori pre hipertensi, dan pada 4 bulan terapi (tekanan darah post) mayoritas tekanan darah pasien pada kategori pre hipertensi yaitu 13 pasien (92,86%). Sedangkan pada terapi Nifedipin Oros, tekanan darah pasien pada kategori hipertensi stage II yaitu 14 pasien (100,00%), setelah 1-3 bulan terapi, tekanan darah mencapai kategori hipertensi stage I, dan pada 4 bulan terapi (tekanan darah post) mayoritas pasien hipertensi pada kategori pre hipertensi yaitu 13 pasien (92,86%). Berdasarkan analisis statistika deskriptif menunjukkan pola grafik yang sama pada kedua kelompok terapi. Hasil penelitian efek samping obat yaitu hipotensi postural berupa pusing/nyeri kepala dan mual menunjukkan bahwa pada kelompok terapi Amlodipin terdapat 1 pasien (7,14%)yang mengalami efek samping hipotensi postural. Sedangkan pada Nifedipin Oros tidak terdapat pasien yang mengalami efek samping obat. Ini menunjukkan bahwa Amlodipin dan Nifedipin Oros memiliki efek samping obat yang ringan.Kata kunci: Amlodipin, Nifedipin Oros, Profil Tekanan Darah, Hipertensi. ABSTRACTHypertension is a medical situation in which sistolic and diastolic blood pressure is high. This research intended to know, first, the reduction of blood pressure toward antihypertensive medicine such as Amlodipin compare with Nifedipin Oros. Second, to know the prevalence of side effect of the medicines. This study wasobservational research. Observation was based on the changes of “pre” blood pressure, during therapy, and “post” therapy of antihypertensive medicines within 4 months therapy. The result of blood pressure study toward Amlodipin treatment showed that “pre” blood pressure was dominated by hypertensive stage II with 13 patients (92,86%). Furthermore, after 1-2 month therapy, the blood pressure attained to hypertensive stage I. In3 month therapy, the blood pressure reach pre hypertensive category. Moreover, after 4 moth therapy (“post” blood pressure), was dominated by pre hypertensive patients with 13 patients (92,86%). Nevertheless, inNifedipin Oros therapy, most of blood pressure was in the hypertensive stage II ie 14 patients (100,00%). Furthermore, after 1-3 months therapy, the blood pressure attained to hypertensive stage I, then in 4 mothstherapy (“post” blood pressure), was dominated by pre hypertensive patients with 13 patients (92,86%). Based on descriptive statistical analysis showed similar trend in both treatment groups chart. The result of side effects observation was postural hypotension (with signed of headache) and nausea only showed in the Amlodipin therapy, ie 1 patients (7,14%) who got postural hypotension. This showed that Amlodipin and Nifedipin had mild side effects.Key Words: Amlodipin, Nifedipin Oros, Blood pressure profile, Hypertension
Korelasi Kadar Serum Vitamin D terhadap Derajat Keparahan Penyakit Infeksi Covid-19: Sebuah Literatur Review Devyani D. Wulansari; Indi R. Tsani; Rahmad A. Prasetya
Jurnal Farmasi Klinik Indonesia Vol 11, No 2 (2022)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2022.11.2.174

Abstract

Dalam beberapa tahun terakhir, penyakit infeksi yang disebabkan oleh virus menjadi salah satu masalah terbesar bagi kesehatan global, termasuk infeksi coronavirus disease 2019 (Covid-19). Covid-19 merupakan penyakit yang disebabkan oleh severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Paparan virus SARS-CoV-2 pada tubuh akan menimbulkan respon dari sistem imun dan akan berdampak pada reaksi inflamasi yang dapat merusak jaringan. Hiperinflamasi (cytokine storm) pada infeksi Covid-19 dapat menyebabkan risiko keparahan infeksi yang dapat berujung pada kematian. Salah satu cara untuk menurunkan risiko ini yakni dengan memberikan vitamin D sebagai imunomodulator. Artikel ini bertujuan untuk memberikan gambaran tentang efek imunomodulator yang dimiliki vitamin D dalam menanggulangi infeksi Covid-19. Literatur review ini dilakukan dengan pencarian literatur melalui beberapa basis data seperti PUBMED dan Science Direct dengan kata kunci “Covid-19”, “immunomodulator”, dan “vitamin D”. Dari 9 artikel yang didapatkan setelah melalui tahapan skrining, 5 artikel merupakan studi retrospektif atau observasional untuk melihat hubungan antara kadar serum vitamin D dan tingkat keparahan pasien dengan infeksi Covid-19, sedangkan 5 artikel lainnya merupakan uji klinis untuk melihat efek suplementasi vitamin D pada pasien Covid-19. Hasil penelitian menunjukkan bahwa konsentrasi serum vitamin D yang tinggi berhubungan dengan rendahnya konsentrasi sitokin pro-inflamasi sehingga dapat mengurangi kejadian infeksi saluran pernapasan akut dan keparahan penyakit akibat infeksi virus Covid-19. Selain itu, vitamin D, khususnya vitamin D3 berpotensi sebagai imunomodulator pada infeksi virus Covid-19 dengan menurunkan sitokin pro-inflamasi sehingga menurunkan risiko keparahan infeksi.Kata kunci: Covid-19, imunomodulator, SARS CoV-2, vitamin D Correlation between Serum Level of Vitamin D and Covid-19 Infection Severity: A Literature ReviewAbstractIn recent years, infectious diseases caused by viruses have become one of the biggest global health problems, including coronavirus disease 2019 (Covid-19) infection. Covid-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can induce immune responses and inflammatory reactions, thereby leading to the damage of tissues. Hyperinflammation due to cytokine storm in infected patients increases the risk of severe infection and death. Vitamin D can also reduce the severity of infections because it acts as an immunomodulator. Therefore, this study aimed to determine the immunomodulatory effect of vitamin D on Covid-19 infections. A total of nine articles were collected using literature searching on several databases, such as PUBMED and Science Direct with the keywords of “Covid-19”, “immunomodulator”, and “vitamin D”. Five of them were observational or retrospective studies, which determined the correlation between serum concentration of vitamin D and Covid-19 infection severity. Meanwhile, another four articles were random clinical trials testing the effect of the drugs’s supplementation on infected people. The results showed that high levels of serum vitamin D can cause low concentrations of pro-inflammatory cytokines, which reduces the incidence of acute respiratory infections and the severity of the viral infection. Furthermore, vitamin D, specifically D3, has the potential to act as an immunomodulator in Covid-19 by reducing pro-inflammatory cytokines, thereby reducing the risk of severity.Keywords: Covid-19, immunomodulator, SARS CoV-2, vitamin D
In vivo nephroprotective effect of herbal plants towards gentamicin-induced nephrotoxicity: A literature review Erlyn Dwi Cahyani; Rahmad Aji Prasetya; Izzatul Ma'rifah; Deby Nanda Tri Widia; Tiara Sri Dewi; Sulfa Putri
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art17

Abstract

Background: Gentamicin can cause nephrotoxicity due to accumulation in proximal tubules then triggering free radicals generation that damage the nephrons. In response, our body produces endogenous antioxidants. However, extensive formation of free radicals requires exogenous antioxidants which can be obtained from herbal plants to compensate. Thus, rigorous preclinical and clinical studies are needed to prove the efficacy of medicinal plants that protect the kidneys from gentamicin nephrotoxicity. Objective: This review article provides a scientific overview of the herbal plants’ nephroprotective activity towards gentamicin induction in vivo. Method: A literature search through ScienceDirect database in July 2022 using the keywords “kidney damage”, “herbal plants”, and “gentamicin” resulted in 12 articles to be reviewed. Results: We found 12 herbal plants proven to reverse the declining kidney function. We observed significant attenuation in elevated Blood Urea Nitrogen (BUN) and/or creatinine levels in subject animals receiving herbal plants compared to the gentamicin-induced group. This nephroprotective effect is due to the content of several compounds such as flavonoids, polyphenols, and tannins. Although each plant contains different compounds, all of them have antioxidant activity that inhibits oxidation in nephrons due to gentamicin induction. Conclusion: The antioxidant compounds contained in herbal plants have the potential to prevent or treat nephrotoxicity due to gentamicin usage.
PENGEMBANGAN MODUL KESEHATAN REPRODUKSI BERBASIS POSITIVE YOUTH DEVELOPMENT FRAMEWORK PADA POSYANDU REMAJA Bani Bacan Hacantya Yudanagara; Rahmad Aji Prasetya; Aphrodita Cahya Buwana; Putu Vidyastitha Wiguna
Jurnal Abdi Insani Vol 10 No 3 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i3.1020

Abstract

Risky sexual behavior is common among teenagers in Tosari, Pasuruan, and is caused by lack of access to reproductive health knowledge. Data from primary health care stated that 60% of mothers who had children under five married at too-young age of 15-19 years. However, Tosari has an active and routine Youth Integrated Health Post or Posyandu Remaja (PR). PR is a community-based youth health service that can potentially increase access to reproductive health services for youth around PR. During the development period, youth needs to prevent risks, including risky sexual behavior, as described in the Positive Youth Development (PYD) framework. Therefore, a reproductive health education modul was developed using the PYD framework. Modul was delivered to PR cadres and members in Tosari using modules compiled through literature studies and assessments from experts and stakeholders. After that, attitudes and knowledge were measured through pre-test and post-test. The results showed a significant change in knowledge and attitudes among participants after following the education program (p < 0.001, effect size 0.649). This module and educational model are expected to improve and help youths to face challenges during the development period so that risky sexual behavior can be avoided.
Formulasi dan Evaluasi Likuid Vape tanpa Nikotin dengan Kandungan Minyak Atsiri Pepermin (Mentha spicata), Jeruk (Citrus reticulata) dan Lavender (Lavandula angustifolia) Rahmad Aji Prasetya; Hilya Nur Imtihani
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 5 No 01 (2023): HERCLIPS VOL 05 NO 1
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v5i01.6380

Abstract

Hasil Riset Kesehatan Dasar (Riskesdas) pada tahun 2018 menyatakan bahwa perokok di Indonesia mencapai lebih dari seperempat jumlah penduduk (28,9%). Dari seluruh perokok tersebut, proporsi pengguna rokok elektrik sebesar 2,8%, dengan pengguna terbanyak pada kelompok usia 10-19 tahun. Saat ini sudah banyak produk cairan vape dengan kandungan nikotin lebih dari 12 mg bahkan sampai 30 mg yang berpotensi menimbulkan kecanduan karena adanya interaksi antara nikotin dengan reseptor kolinergik di otak. Oleh karena itu, penelitian ini bertujuan untuk membuat formulasi cairan vape tanpa nikotin yang mengandung essential oil (EO) pepermin, jeruk dan lavender, serta melakukan evaluasi kualitas dengan parameter homogenitas, viskositas, kompatibilitas dengan alat hisap vape (mods atau pods) dan tingkat akseptabilitas. Hasil penelitian menunjukkan bahwa semua formula likuid vape tanpa nikotin yang dikembangkan telah memenuhi aspek homogenitas dan kompatibilitas. Tingkat kekentalan atau viskositas terukur lebih tinggi dari produk yang ada di pasaran, namun tidak mengurangi kemudahan penggunaan serta akseptabilitas yang diuji pada beberapa volunteer yang sebelumnya telah menggunakan vape. Berdasarkan uji penerimaan, likuid dengan kandungan EO tunggal lavender kurang disukai karena menimbulkan rasa pahit yang kurang nyaman. Selain itu, penggunaan kombinasi tiga EO yakni pepermin, jeruk, dan lavender paling disukai volunteer karena kompleksitas rasa dan aroma yang ditimbulkan.
EDUKASI KESEHATAN MENGENAI PENYAKIT DAN KEPATUHAN MINUM OBAT HIPERTENSI DAN DIABETES PADA LANSIA DI WILAYAH MANUKAN LOR SURABAYA Rahmad Aji Prasetya; Fitria Abbas Thalib; Bani Bacan Hacantya Yudanagara
Jurnal Abdi Insani Vol 10 No 4 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i4.1163

Abstract

The prevalence of hypertension and diabetes among the elderly in East Java reached 63.2% and 21.6%, respectively, making these significant health problems. Controlling these diseases depends on drug adherence, which is also influenced by the patient's level of knowledge. Therefore, a health education program is needed to increase the elderly's knowledge regarding hypertension and diabetes as well as drug adherence. In addition, this program also provides education about the use of curcuma (Curcuma xanthorriza) and cinnamon (Cinnamomum verum) as nutraceutical products. This activity was held for two days at the Manukan Lor Culinary Tourism Center, attended by 25 participants aged 48-81 years; there were 4 men (16%) and 21 women (84%). The material presented on the first day included symptoms, signs, and complications of hypertension and diabetes, lifestyle influence, and drug adherence. Meanwhile, on the second day, there was a presentation and demonstration of making nutraceutical products from ginger and cinnamon. A questionnaire is filled out before and after the presentation to assess the success of education activities. The statistical analysis results showed that this health education activity significantly increased (p=0.002) participants' knowledge regarding hypertension and diabetes mellitus. It was also found that knowledge about medication adherence and lifestyle changes like exercise and low-carbohydrate foods still need improvement.
Nicotine-free vape liquids containing essential oils of peppermint, lavender, and tangerine: safety and efficacy profiles Prasetya, Rahmad Aji; Arifiyana, Djamilah; Syulthoni, Zain Budi
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.30005

Abstract

Despite low nicotine levels, cigarettes and vape liquids can cause addiction, which makes quitting smoking difficult owing to withdrawal syndrome. Hence, we created a nicotine-free liquid vape using essential oils (EOs) like peppermint (Mentha piperita), lavender (Lavandula latifolia), and tangerine (Citrus reticulata) to substitute the nicotine in inducing relaxation without addiction. Thus, this study aimed to examine (1) the safety profile of this nicotine-free liquid vape by observing chemical characteristics using gas chromatography-mass spectrometry (GC-MS) and (2) its efficacy in reducing short-term anxiety in healthy volunteers who had previously used nicotine vape. The most complicated vape liquid formula (F4), containing propylene glycol, vegetable glycerin, with those three EOs, was injected into GC-MS, and the mass spectra were compared to the Wiley mass spectral library to identify the compound name. For the efficacy test, subjects who met inclusion criteria and fulfilled informed consent were randomly assigned to five groups (four groups received test liquids formula (F1-F4) while one group received placebo). Before and after using the vape liquid, subjects were asked to complete the State-Trait Anxiety Inventory (STAI) questionnaire to assess its anxiety-reduction effects. The result showed that nicotine-free vape liquids containing three EOs did not show any foreign substances that had never been encountered before, which means our product is safer than nicotine-containing vape liquids. This safety was also supported by all study subjects who did not report any adverse effects. The efficacy test showed that subjects who used vape liquids with essential oils (F1-F4) experienced a significant decrease in heart rate and systolic blood pressure. At the same time, 50% had a lower post-test STAI score, indicating a decrease in anxiety, although it was not statistically significant.
Co-Authors Adelia, Lailatul Aphrodita Cahya Buwana Astuti, Rika Puji Bani Bacan Hacantya Yudanagara Cicik Herlina Yulianti Deby Nanda Tri Widia Devyani D. Wulansari Djamilah Arifiyana Erlyn Dwi Cahyani Fitria Abbas Thalib Hilya Nur Imtihani Indi R. Tsani Izzatul Ma'rifah Putu Vidyastitha Wiguna Sulfa Putri Syulthoni, Zain Budi Tiara Sri Dewi Ulfa, Ninik Mas