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All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia Jurnal Abdi Insani Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) PROFICIO: Jurnal Pengabdian Masyarakat
Rahmad Aji Prasetya
Akademi Farmasi Surabaya, Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Korelasi Kadar Serum Vitamin D terhadap Derajat Keparahan Penyakit Infeksi Covid-19: Sebuah Literatur Review Devyani D. Wulansari; Indi R. Tsani; Rahmad A. Prasetya
Jurnal Farmasi Klinik Indonesia Vol 11, No 2 (2022)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2022.11.2.174

Abstract

Dalam beberapa tahun terakhir, penyakit infeksi yang disebabkan oleh virus menjadi salah satu masalah terbesar bagi kesehatan global, termasuk infeksi coronavirus disease 2019 (Covid-19). Covid-19 merupakan penyakit yang disebabkan oleh severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Paparan virus SARS-CoV-2 pada tubuh akan menimbulkan respon dari sistem imun dan akan berdampak pada reaksi inflamasi yang dapat merusak jaringan. Hiperinflamasi (cytokine storm) pada infeksi Covid-19 dapat menyebabkan risiko keparahan infeksi yang dapat berujung pada kematian. Salah satu cara untuk menurunkan risiko ini yakni dengan memberikan vitamin D sebagai imunomodulator. Artikel ini bertujuan untuk memberikan gambaran tentang efek imunomodulator yang dimiliki vitamin D dalam menanggulangi infeksi Covid-19. Literatur review ini dilakukan dengan pencarian literatur melalui beberapa basis data seperti PUBMED dan Science Direct dengan kata kunci “Covid-19”, “immunomodulator”, dan “vitamin D”. Dari 9 artikel yang didapatkan setelah melalui tahapan skrining, 5 artikel merupakan studi retrospektif atau observasional untuk melihat hubungan antara kadar serum vitamin D dan tingkat keparahan pasien dengan infeksi Covid-19, sedangkan 5 artikel lainnya merupakan uji klinis untuk melihat efek suplementasi vitamin D pada pasien Covid-19. Hasil penelitian menunjukkan bahwa konsentrasi serum vitamin D yang tinggi berhubungan dengan rendahnya konsentrasi sitokin pro-inflamasi sehingga dapat mengurangi kejadian infeksi saluran pernapasan akut dan keparahan penyakit akibat infeksi virus Covid-19. Selain itu, vitamin D, khususnya vitamin D3 berpotensi sebagai imunomodulator pada infeksi virus Covid-19 dengan menurunkan sitokin pro-inflamasi sehingga menurunkan risiko keparahan infeksi.Kata kunci: Covid-19, imunomodulator, SARS CoV-2, vitamin D Correlation between Serum Level of Vitamin D and Covid-19 Infection Severity: A Literature ReviewAbstractIn recent years, infectious diseases caused by viruses have become one of the biggest global health problems, including coronavirus disease 2019 (Covid-19) infection. Covid-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can induce immune responses and inflammatory reactions, thereby leading to the damage of tissues. Hyperinflammation due to cytokine storm in infected patients increases the risk of severe infection and death. Vitamin D can also reduce the severity of infections because it acts as an immunomodulator. Therefore, this study aimed to determine the immunomodulatory effect of vitamin D on Covid-19 infections. A total of nine articles were collected using literature searching on several databases, such as PUBMED and Science Direct with the keywords of “Covid-19”, “immunomodulator”, and “vitamin D”. Five of them were observational or retrospective studies, which determined the correlation between serum concentration of vitamin D and Covid-19 infection severity. Meanwhile, another four articles were random clinical trials testing the effect of the drugs’s supplementation on infected people. The results showed that high levels of serum vitamin D can cause low concentrations of pro-inflammatory cytokines, which reduces the incidence of acute respiratory infections and the severity of the viral infection. Furthermore, vitamin D, specifically D3, has the potential to act as an immunomodulator in Covid-19 by reducing pro-inflammatory cytokines, thereby reducing the risk of severity.Keywords: Covid-19, immunomodulator, SARS CoV-2, vitamin D
In vivo nephroprotective effect of herbal plants towards gentamicin-induced nephrotoxicity: A literature review Erlyn Dwi Cahyani; Rahmad Aji Prasetya; Izzatul Ma'rifah; Deby Nanda Tri Widia; Tiara Sri Dewi; Sulfa Putri
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art17

Abstract

Background: Gentamicin can cause nephrotoxicity due to accumulation in proximal tubules then triggering free radicals generation that damage the nephrons. In response, our body produces endogenous antioxidants. However, extensive formation of free radicals requires exogenous antioxidants which can be obtained from herbal plants to compensate. Thus, rigorous preclinical and clinical studies are needed to prove the efficacy of medicinal plants that protect the kidneys from gentamicin nephrotoxicity. Objective: This review article provides a scientific overview of the herbal plants’ nephroprotective activity towards gentamicin induction in vivo. Method: A literature search through ScienceDirect database in July 2022 using the keywords “kidney damage”, “herbal plants”, and “gentamicin” resulted in 12 articles to be reviewed. Results: We found 12 herbal plants proven to reverse the declining kidney function. We observed significant attenuation in elevated Blood Urea Nitrogen (BUN) and/or creatinine levels in subject animals receiving herbal plants compared to the gentamicin-induced group. This nephroprotective effect is due to the content of several compounds such as flavonoids, polyphenols, and tannins. Although each plant contains different compounds, all of them have antioxidant activity that inhibits oxidation in nephrons due to gentamicin induction. Conclusion: The antioxidant compounds contained in herbal plants have the potential to prevent or treat nephrotoxicity due to gentamicin usage.
PENGEMBANGAN MODUL KESEHATAN REPRODUKSI BERBASIS POSITIVE YOUTH DEVELOPMENT FRAMEWORK PADA POSYANDU REMAJA Bani Bacan Hacantya Yudanagara; Rahmad Aji Prasetya; Aphrodita Cahya Buwana; Putu Vidyastitha Wiguna
Jurnal Abdi Insani Vol 10 No 3 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i3.1020

Abstract

Risky sexual behavior is common among teenagers in Tosari, Pasuruan, and is caused by lack of access to reproductive health knowledge. Data from primary health care stated that 60% of mothers who had children under five married at too-young age of 15-19 years. However, Tosari has an active and routine Youth Integrated Health Post or Posyandu Remaja (PR). PR is a community-based youth health service that can potentially increase access to reproductive health services for youth around PR. During the development period, youth needs to prevent risks, including risky sexual behavior, as described in the Positive Youth Development (PYD) framework. Therefore, a reproductive health education modul was developed using the PYD framework. Modul was delivered to PR cadres and members in Tosari using modules compiled through literature studies and assessments from experts and stakeholders. After that, attitudes and knowledge were measured through pre-test and post-test. The results showed a significant change in knowledge and attitudes among participants after following the education program (p < 0.001, effect size 0.649). This module and educational model are expected to improve and help youths to face challenges during the development period so that risky sexual behavior can be avoided.
Formulasi dan Evaluasi Likuid Vape tanpa Nikotin dengan Kandungan Minyak Atsiri Pepermin (Mentha spicata), Jeruk (Citrus reticulata) dan Lavender (Lavandula angustifolia) Rahmad Aji Prasetya; Hilya Nur Imtihani
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 5 No 01 (2023): HERCLIPS VOL 05 NO 1
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v5i01.6380

Abstract

Hasil Riset Kesehatan Dasar (Riskesdas) pada tahun 2018 menyatakan bahwa perokok di Indonesia mencapai lebih dari seperempat jumlah penduduk (28,9%). Dari seluruh perokok tersebut, proporsi pengguna rokok elektrik sebesar 2,8%, dengan pengguna terbanyak pada kelompok usia 10-19 tahun. Saat ini sudah banyak produk cairan vape dengan kandungan nikotin lebih dari 12 mg bahkan sampai 30 mg yang berpotensi menimbulkan kecanduan karena adanya interaksi antara nikotin dengan reseptor kolinergik di otak. Oleh karena itu, penelitian ini bertujuan untuk membuat formulasi cairan vape tanpa nikotin yang mengandung essential oil (EO) pepermin, jeruk dan lavender, serta melakukan evaluasi kualitas dengan parameter homogenitas, viskositas, kompatibilitas dengan alat hisap vape (mods atau pods) dan tingkat akseptabilitas. Hasil penelitian menunjukkan bahwa semua formula likuid vape tanpa nikotin yang dikembangkan telah memenuhi aspek homogenitas dan kompatibilitas. Tingkat kekentalan atau viskositas terukur lebih tinggi dari produk yang ada di pasaran, namun tidak mengurangi kemudahan penggunaan serta akseptabilitas yang diuji pada beberapa volunteer yang sebelumnya telah menggunakan vape. Berdasarkan uji penerimaan, likuid dengan kandungan EO tunggal lavender kurang disukai karena menimbulkan rasa pahit yang kurang nyaman. Selain itu, penggunaan kombinasi tiga EO yakni pepermin, jeruk, dan lavender paling disukai volunteer karena kompleksitas rasa dan aroma yang ditimbulkan.
EDUKASI KESEHATAN MENGENAI PENYAKIT DAN KEPATUHAN MINUM OBAT HIPERTENSI DAN DIABETES PADA LANSIA DI WILAYAH MANUKAN LOR SURABAYA Rahmad Aji Prasetya; Fitria Abbas Thalib; Bani Bacan Hacantya Yudanagara
Jurnal Abdi Insani Vol 10 No 4 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i4.1163

Abstract

The prevalence of hypertension and diabetes among the elderly in East Java reached 63.2% and 21.6%, respectively, making these significant health problems. Controlling these diseases depends on drug adherence, which is also influenced by the patient's level of knowledge. Therefore, a health education program is needed to increase the elderly's knowledge regarding hypertension and diabetes as well as drug adherence. In addition, this program also provides education about the use of curcuma (Curcuma xanthorriza) and cinnamon (Cinnamomum verum) as nutraceutical products. This activity was held for two days at the Manukan Lor Culinary Tourism Center, attended by 25 participants aged 48-81 years; there were 4 men (16%) and 21 women (84%). The material presented on the first day included symptoms, signs, and complications of hypertension and diabetes, lifestyle influence, and drug adherence. Meanwhile, on the second day, there was a presentation and demonstration of making nutraceutical products from ginger and cinnamon. A questionnaire is filled out before and after the presentation to assess the success of education activities. The statistical analysis results showed that this health education activity significantly increased (p=0.002) participants' knowledge regarding hypertension and diabetes mellitus. It was also found that knowledge about medication adherence and lifestyle changes like exercise and low-carbohydrate foods still need improvement.
Nicotine-free vape liquids containing essential oils of peppermint, lavender, and tangerine: safety and efficacy profiles Prasetya, Rahmad Aji; Arifiyana, Djamilah; Syulthoni, Zain Budi
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.30005

Abstract

Despite low nicotine levels, cigarettes and vape liquids can cause addiction, which makes quitting smoking difficult owing to withdrawal syndrome. Hence, we created a nicotine-free liquid vape using essential oils (EOs) like peppermint (Mentha piperita), lavender (Lavandula latifolia), and tangerine (Citrus reticulata) to substitute the nicotine in inducing relaxation without addiction. Thus, this study aimed to examine (1) the safety profile of this nicotine-free liquid vape by observing chemical characteristics using gas chromatography-mass spectrometry (GC-MS) and (2) its efficacy in reducing short-term anxiety in healthy volunteers who had previously used nicotine vape. The most complicated vape liquid formula (F4), containing propylene glycol, vegetable glycerin, with those three EOs, was injected into GC-MS, and the mass spectra were compared to the Wiley mass spectral library to identify the compound name. For the efficacy test, subjects who met inclusion criteria and fulfilled informed consent were randomly assigned to five groups (four groups received test liquids formula (F1-F4) while one group received placebo). Before and after using the vape liquid, subjects were asked to complete the State-Trait Anxiety Inventory (STAI) questionnaire to assess its anxiety-reduction effects. The result showed that nicotine-free vape liquids containing three EOs did not show any foreign substances that had never been encountered before, which means our product is safer than nicotine-containing vape liquids. This safety was also supported by all study subjects who did not report any adverse effects. The efficacy test showed that subjects who used vape liquids with essential oils (F1-F4) experienced a significant decrease in heart rate and systolic blood pressure. At the same time, 50% had a lower post-test STAI score, indicating a decrease in anxiety, although it was not statistically significant.
PENINGKATAN HIGIENITAS DAN KUALITAS PRODUK OLAHAN SUSU SAPI BAGI KELOMPOK MASYARAKAT DUSUN BRAU, KOTA BATU Wardana, Andika Pramudya; Suyatno; Taufikurohmah, Titik; Wikandari, Prima Retno; Ramadhania, Nurina Rizka; Prasetya, Rahmad Aji
Jurnal Pengabdian Masyarakat FKIP UTP Vol 7 No 1 (2026): PROFICIO : Jurnal Abdimas FKIP UTP
Publisher : FKIP UNIVERSITAS TUNAS PEMBANGUNAN SURAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36728/jpf.v7i1.5689

Abstract

Dusun Brau di Kota Batu, Jawa Timur, merupakan salah satu sentra produksi susu sapi yang menghadapi tantangan dalam pengolahan produk turunan seperti keju, terutama pada aspek higienitas dan kualitas produk. Permasalahan utama terletak pada keterbatasan pengetahuan masyarakat mengenai sanitasi pangan dan standar mutu berdasarkan Standar Nasional Indonesia (SNI 8896:2020). Untuk itu diberikan pelatihan partisipatif yang dirancang melalui pemaparan teori, praktik langsung pembuatan keju, pengemasan, pelabelan, serta penyusunan rencana bisnis. Evaluasi dilakukan dengan membandingkan nilai prates dan pascates 13 peserta menggunakan analisis statistik (Shapiro-Wilk dan Wilcoxon). Hasil menunjukkan adanya peningkatan skor rata-rata dari 70,77 (prates) menjadi 83,08 (pascates), meskipun secara statistik tidak signifikan (p=0,2656). Meskipun demikian, peserta menunjukkan peningkatan pemahaman dalam penerapan prinsip higienitas, sanitasi produksi, serta pemenuhan standar mutu produk olahan susu. Temuan ini menegaskan bahwa pelatihan aplikatif dan partisipatif mampu meningkatkan keterampilan teknis maupun kesadaran kualitas, sehingga mendukung peningkatan daya saing produk olahan susu sapi di tingkat lokal maupun nasional.
Co-Authors Aphrodita Cahya Buwana Bani Bacan Hacantya Yudanagara Deby Nanda Tri Widia Devyani D. Wulansari Djamilah Arifiyana Erlyn Dwi Cahyani Fitria Abbas Thalib Hilya Nur Imtihani Indi R. Tsani Izzatul Ma'rifah Prima Retno Wikandari Putu Vidyastitha Wiguna Ramadhania, Nurina Rizka Sulfa Putri SUYATNO Syulthoni, Zain Budi Tiara Sri Dewi Titik Taufikurohmah Wardana, Andika Pramudya