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All Journal Stigma : Jurnal Matematika dan Ilmu Pengetahuan Alam Unipa Jurnal Pengabdian Pada Masyarakat METHABDI
Rizki Nur Wijayanti
Unknown Affiliation
Religion Agriculture, Biological Sciences & Forestry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Physics Public Health

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PREDIKSI INTERAKSI SENYAWA AKTIF BIDARA (Ziziphus mauritiana) SEBAGAI ANTIKANKER TERHADAP PROTEIN HER2 Nur Haniyyah Muslimah; Rizki Nur Wijayanti; Dewi Putriarti; Hidayatul Lailiyyah; Erlix Rakhmad Purnama
STIGMA: Jurnal Matematika dan Ilmu Pengetahuan Alam Unipa Vol 15 No 01 (2022)
Publisher : FMIPA : Universitas PGRI Adi Buana

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Abstract

Cervical cancer is a type of cancer that occurs in the cervix which is characterized by the presence of massive tissue cells that grow continuously and are not limited to the cervix and more than 90% are caused by HPV infection. Cervical cancer is in second place at 10.69% after breast cancer at 19.18%. Various efforts have been made to minimize cervical cancer but are inversely proportional to the effects on the body. On the other hand, Indonesia is rich in flora diversity, one of which is the bidara plant (Ziziphus mauritiana) which can produce fruit and has the potential as an anticancer. The purpose of this study was to determine the interaction of the active compound Ziziphus mauritiana on HER2 as an anticancer computationally. The research was conducted using online web databases including the PubChem web, PDB, and software including PyRx, AutoDock, PyMOL, and Discovery Studio 2021. The results of the study were the interaction of the active compound Ziziphus mauritiana against HER2 with PDB code: 6TFZ as a computational anticancer, namely clindamycin with the value of biding affinity is -7.6 kcal/mol; levetiracetam and nonanoic acid with a binding affinity value of -4.8 kcal/mol were rated lower as cervical anticancer compared to trastuzumab with a binding affinity value of -8.8 kcal/mol. Keywords: Cervical cancer, computing, Ziziphus mauritiana
Pemberdayaan Masyarakat Desa Kedungwungu melalui Sosialisasi dan Pelatihan Kerajinan Tangan dari Limbah Jerami Amalia, Eka Nurul; Farcha, Iddiya; Anggraini, Devy Dwi; Fatmawati, Fatmawati; Akrom, Luqi Zidan Shofi; Ibadillah, M. Nashuikhul; Sari, Putri Nabela Sintiya; Putri, Resti Astuti Misatun; Rizka Ulima Qotrunnida; Rizki Nur Wijayanti; Vicky Mailani Widya Astuty; Zunita Zahrotur Rohmah; Ahmad Febrizan; Andni, Riyan; Kirom, Cihwanul; Noor, Sufiana
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 4 No 2 (2024): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol4No2.pp240-246

Abstract

Kedungwungu Village is one of the villages with prime commodities in the form of rice agricultural products. The existence of rice farming products has a positive impact on economic growth in Kedungwungu Village. However, the boom in rice farming also hurts society. Straw waste which is the result of rice farming is not utilized by the people of Kedungwungu Village. The people of Kedungwungu Village prefer to burn or leave straw waste next to the rice fields. Accumulating straw waste can pollute the environment and even cause various diseases. Meanwhile, burning straw waste can hurt human health and pollute the air. Based on these problems, outreach, and training on straw crafts were carried out to minimize the non-utilization of straw waste by the people of Kedungwungu Village. There are two sessions, namely a socialization session and a training session. The outreach session aims to provide public understanding of the dangers of not utilizing straw waste from various aspects of life. Meanwhile, the training session provided the public with an understanding of the use of straw waste in more useful items, namely straw crafts. This activity involved members of the Kedungwungu Village PKK as participants. From this activity, it was found that the participants were happy with the activities carried out because they could provide insight into the negative impacts of not utilizing straw waste and how to use it. Participants also explained that with this activity they also gained knowledge about making crafts from straw waste which adds functional value and economic value.
Co-Authors Ahmad Febrizan Akrom, Luqi Zidan Shofi Amalia, Eka Nurul Andni, Riyan Anggraini, Devy Dwi Dewi Putriarti Erlix Rakhmad Purnama Farcha, Iddiya Fatmawati Fatmawati Hidayatul Lailiyyah Ibadillah, M. Nashuikhul Kirom, Cihwanul Nur Haniyyah Muslimah Putri, Resti Astuti Misatun Rizka Ulima Qotrunnida Sari, Putri Nabela Sintiya Sufiana Noor Vicky Mailani Widya Astuty Zunita Zahrotur Rohmah