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All Journal Medfarm: Jurnal Farmasi dan Kesehatan FORTE JOURNAL Journal of Innovative and Creativity Jurnal Siti Rufaidah
Jon Kenedy Marpaung
Universitas Sari Mutiara Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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KARAKTERISASI DAN SKRINING FITOKIMIA DARI TEPUNG BUAH BIT (Beta vulgaris L.) Siti Maimunah; Amila Amila; Jon Kenedy Marpaung; Vierto Irennius Girsang; Henny Syapitri
FORTE JOURNAL Vol 1 No 2 (2021): Edisi Juli 2021
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (159.702 KB) | DOI: 10.51771/fj.v1i2.141

Abstract

Buah bit (Beta vulgaris L.) merupakan tanaman yang banyak mengandung senyawa betalain. sumber utama pewarna merah alami. Salah satu inovasi pemanfaatan buah bit yaitu pembuatan tepung bit. Tujuan penelitian ini adalah mengetahui karakterisasi dan skrining fitokimia umbi bit, serta mengetahui tingkat penerimaan umbi bit yang dijadikan tepung bit bagi para panelis. Penelitian ini merupakan eksperimental dengan menguji kandungan senyawa kimia melalui uji karakterisasi dan skrining fitokimia. Hasil uji skrining fitokimia menunjukkan bahwa tepung bit (Beta vulgaris L.) memiliki senyawa alkaloid, tanin, saponin, flavanoid, steroid, glikosida gula, dan polifenol. Karakterisasi tepung bit dengan kadar air 9,28%, kadar abu total 0,99%, kadar abu tidak larut asam 0,82% dan kadar sari larut dalam air 0,82% dapat disimpulkan karakterisasi tepung buah bit memenuhi persyaratan Materia Media Indonesia (MMI). Uji Organoleptik dilakukan oleh 20 panelis, dengan kriteria penilaian sebanyak 9 panelis menyukai rasa, 6 panelis menyukai aroma, 12 panelis menyukai warna merah maroon, 12 panelis menyukai tekstrur, dan 11 panelis memiliki daya terima untuk tepung bit.
PENGUJIAN EFEK DIURETIK INFUSA DAUN KOPI (Coffea arabica L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR Suharyanisa Suharyanisa; Jon Kenedy Marpaung; Ivan Elisabeth Purba; Bengi Simahara
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 11 No 2 (2022): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v11i2.139

Abstract

Diuretik bekerja pada ginjal dengan cara meningkatkan eksresi air dan natrium klorida. Kecenderungan masyarakat mengonsumsi diuretik berbahan kimia menyebabkan banyaknya efek negatif yang ditimbulkan. Penggunaan bahan alam sudah banyak diteliti untuk menggantikan obat-obatan kimia. Salah satu bahan alam yang memiliki khasiat yaitu tanaman kopi. Tanaman kopi yang digunakan bagian daunnya mengandung senyawa-senyawa antioksidan (flavonoid, alkaloid, saponin, kafein dan polifenol) yang bermanfaat sebagai anti inflamasi (anti peradangan), anti kanker, diuretik, antimikroba dan aktivitas antioksidan. Infusa Daun Kopi (IDK) diperoleh menggunakan teknik infusa dengan pelarut akuades kemudian digunakan pada 25 ekor tikus yang dibagi menjadi 5 kelompok. Kelompok I (negatif) Na-CMC 0,5 %, kelompok II (positif) Furosemid 3,6 mg/kgBB, kelompok III, IV, V IDK dosis 10, 20, 40% diberikan secara oral. Tikus diberi akuades secara oral dengan dosis 15 ml/kgBB. Tikus di letakkan di dalam kandang metabolik, kemudian pemeriksaan fisik urin dilakukan setiap 1 jam sekali selama 6 jam. Hasil penelitian menunjukkan bahwa IDK dengan dosis terbaik adalah 40% yang memberikan peningkatan volume urin, memberi pengaruh terhadap pH urin, memberi pengaruh terhadap berat jenis urin, memberi pengaruh terhadap warna urin dan memberi pengaruh terhadap kejernihan urin.
Pengujian Aktivitas Antihiperglikemia Infusa Batang Muda Rotan (Calamus Caesius Blume) Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar Yang Diinduksi Aloksan Suharyanisa Suharyanisa; Jon Kenedy Marpaung; Dumartina Hutauruk; Juli Susanti
Jurnal Siti Rufaidah Vol. 1 No. 4 (2023): November : Jurnal Siti Rufaidah
Publisher : PPNI UNIMMAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jasira.v1i4.35

Abstract

Medicinal plants have been known and used worldwide for thousands of years. One type of medicinal plant that is often used is gaharu. The efficacy of gaharu leaves provides properties as a fever reducer, increases appetite, launches menstruation, and relieves pain. This study aims to determine whether there is an analgesic effect from the methanol extract of gaharu leaves in male Wistar rats using the heat stimulation method. This study was an experimental study using twenty-five male Wistar rats divided into five groups. Group I (negative control), rats were treated with 1% CMC-Na. Group II (positive control), rats treated with mefenamic acid 45 mg/kg BW. Group III, IV, and V rats were treated with gaharu leaf methanol extract suspension (100; 200, and 400) mg/kg BW. Pain stimulation was carried out by dipping the rat tail into a 40°C water bath. Data on response time to pain, stimuli were analyzed using the One-Way Analysis of Variance (ANNOVA) method with a 95% confidence level followed by a post-hoc Tukey test to determine which group had the same or significantly different effect. The results showed that the normal response time data for mice to painful stimuli ranged from 2.79 to 3.57 seconds. 1% CMC-Na treatment in mice was unable to increase the response time to a significant pain stimulus (p>0.05). Mefenamic acid treatment 45 mg/Kg BW significantly increased the response time to painful stimuli (p<0.05) with the longest average response time to painful stimuli, namely 8.87 seconds. Based on the method used in this research, methanol extract of agarwood leaves 400 mg/kgBW has almost the same analgesic effect as mefenamic acid 45 mg/KgBW.
Effectiveness Test Of Green Betel Leaf Ethanol Extract Gel Preparation (Piper Betle L.) Against Pseudomonas Aeruginosa Bacteria Dumartina Hutauruk; Jon Kenedy Marpaung; Nuranti Nurmela; Jansen Asriel Ginting
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.2056

Abstract

Pseudomonas aeruginosa is an opportunistic pathogenic bacterium commonly associated with nosocomial infections, particularly in immunocompromised patients. Inappropriate use of antibiotics can lead to resistance, highlighting the need for safer and more effective alternative treatments. Green betel leaf (Piper betle L.) contains active compounds such as flavonoids, tannins, and saponins that exhibit antibacterial properties. This study aims to evaluate the effectiveness of an ethanol extract gel formulation of green betel leaves against the growth of Pseudomonas aeruginosa. The methods included ethanol extraction of betel leaves through maceration, formulation of gels with varying extract concentrations, and antibacterial activity testing using the disk diffusion method. The results showed that the ethanol extract gel was able to inhibit the growth of P. aeruginosa, with inhibition zones increasing along with higher extract concentrations. In conclusion, the ethanol extract gel of green betel leaves has potential as a natural antibacterial agent against Pseudomonas aeruginosa.
Antibacterial Activity Test Of Ethanolic Extract Patch Preparations From Noni Leaves (Morinda Citrifolia L.) Using The Zone Of Inhibition Against Staphylococcus Aureus And Staphylococcus Epidermidis Bacteria Yanti Musyaawarah; Suharyanisa Suharyanisa; Jon Kenedy Marpaung; Aditiya Baginda Marpaung
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.2060

Abstract

Wounds occur when there is damage or loss of body tissue due to factors that interfere with the body's protective system and cause infection caused by Staphylococcus aureus and Staphylococcus epidermidis.Noni leaf (Morinda citrifolia L.) has strong potential as an antibacterial, so researchers are interested in formulating ethanol extract of noni leaf (EEDM) into a patch preparation. Objective: Knowing that EEDM can be formulated as a patch preparation, as well as knowing its antibacterial activity. Methods: Four formulas were made with variations in extract concentration, namely F0 (blank); FI : 5%; FII: 10%; and FIII: 15%. Antibacterial testing using disc paper diffusion method. Results: A clear patch preparation was produced in F0, while in FI, FII and FIII the gel was blackish green with a distinctive smell of EEDM. The results of the antibacterial activity test against Staphylococcus aureus in each formula are FI: 2.58 mm; FII: 2.35 mm; FIII: 2.41 mm, while against Staphylococcus epidermidis, FI: 1.46; FII: 2.28; FIII: 3.33. Conclusion: EEDM can be formulated into patch preparations. The antibacterial potential of the three formulas is in the weak category.
Co-Authors Aditiya Baginda Marpaung Bengi Simahara Dumartina Hutauruk Ivan Elisabeth Purba Jansen Asriel Ginting Juli Susanti Nuranti Nurmela Siti Maimunah Suharyanisa Suharyanisa Syapitri, Henny Vierto Yanti Musyaawarah