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All Journal Medfarm: Jurnal Farmasi dan Kesehatan Journal of Innovative and Creativity Jurnal Siti Rufaidah
Suharyanisa Suharyanisa
Universitas Sari Mutiara Indonesia
Chemistry Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENGUJIAN EFEK DIURETIK INFUSA DAUN KOPI (Coffea arabica L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR Suharyanisa Suharyanisa; Jon Kenedy Marpaung; Ivan Elisabeth Purba; Bengi Simahara
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 11 No 2 (2022): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v11i2.139

Abstract

Diuretik bekerja pada ginjal dengan cara meningkatkan eksresi air dan natrium klorida. Kecenderungan masyarakat mengonsumsi diuretik berbahan kimia menyebabkan banyaknya efek negatif yang ditimbulkan. Penggunaan bahan alam sudah banyak diteliti untuk menggantikan obat-obatan kimia. Salah satu bahan alam yang memiliki khasiat yaitu tanaman kopi. Tanaman kopi yang digunakan bagian daunnya mengandung senyawa-senyawa antioksidan (flavonoid, alkaloid, saponin, kafein dan polifenol) yang bermanfaat sebagai anti inflamasi (anti peradangan), anti kanker, diuretik, antimikroba dan aktivitas antioksidan. Infusa Daun Kopi (IDK) diperoleh menggunakan teknik infusa dengan pelarut akuades kemudian digunakan pada 25 ekor tikus yang dibagi menjadi 5 kelompok. Kelompok I (negatif) Na-CMC 0,5 %, kelompok II (positif) Furosemid 3,6 mg/kgBB, kelompok III, IV, V IDK dosis 10, 20, 40% diberikan secara oral. Tikus diberi akuades secara oral dengan dosis 15 ml/kgBB. Tikus di letakkan di dalam kandang metabolik, kemudian pemeriksaan fisik urin dilakukan setiap 1 jam sekali selama 6 jam. Hasil penelitian menunjukkan bahwa IDK dengan dosis terbaik adalah 40% yang memberikan peningkatan volume urin, memberi pengaruh terhadap pH urin, memberi pengaruh terhadap berat jenis urin, memberi pengaruh terhadap warna urin dan memberi pengaruh terhadap kejernihan urin.
Pengujian Aktivitas Antihiperglikemia Infusa Batang Muda Rotan (Calamus Caesius Blume) Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar Yang Diinduksi Aloksan Suharyanisa Suharyanisa; Jon Kenedy Marpaung; Dumartina Hutauruk; Juli Susanti
Jurnal Siti Rufaidah Vol. 1 No. 4 (2023): November : Jurnal Siti Rufaidah
Publisher : PPNI UNIMMAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jasira.v1i4.35

Abstract

Medicinal plants have been known and used worldwide for thousands of years. One type of medicinal plant that is often used is gaharu. The efficacy of gaharu leaves provides properties as a fever reducer, increases appetite, launches menstruation, and relieves pain. This study aims to determine whether there is an analgesic effect from the methanol extract of gaharu leaves in male Wistar rats using the heat stimulation method. This study was an experimental study using twenty-five male Wistar rats divided into five groups. Group I (negative control), rats were treated with 1% CMC-Na. Group II (positive control), rats treated with mefenamic acid 45 mg/kg BW. Group III, IV, and V rats were treated with gaharu leaf methanol extract suspension (100; 200, and 400) mg/kg BW. Pain stimulation was carried out by dipping the rat tail into a 40°C water bath. Data on response time to pain, stimuli were analyzed using the One-Way Analysis of Variance (ANNOVA) method with a 95% confidence level followed by a post-hoc Tukey test to determine which group had the same or significantly different effect. The results showed that the normal response time data for mice to painful stimuli ranged from 2.79 to 3.57 seconds. 1% CMC-Na treatment in mice was unable to increase the response time to a significant pain stimulus (p>0.05). Mefenamic acid treatment 45 mg/Kg BW significantly increased the response time to painful stimuli (p<0.05) with the longest average response time to painful stimuli, namely 8.87 seconds. Based on the method used in this research, methanol extract of agarwood leaves 400 mg/kgBW has almost the same analgesic effect as mefenamic acid 45 mg/KgBW.
LC₅₀ Toxicity Activity Test Of Ethanol Extract Of Cardamom Leaves (Amomum cardamomum L.) On Shrimp Larvae (Artemia salina L) Using Brine Shrimp Lethality Test (BSLT) Method Suharyanisa Suharyanisa; Betharina Br Tarigan; Yanti Musyawarah; Jhon Manrius Laia
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.1864

Abstract

There are many negative effects on the use of chemical-based medicine, therefore many researchers are interested in finding natural ingredients that have the potential to replace chemical treatment. One of the plants from the Zingiberaceae family that is used as a medicinal ingredient is cardamom plant (Amomum cardamomun L), Many people often use cardamom for treatment such as aromatic ingredients, carminative (reducing gas in the stomach), cough medicine, halitosis and so on. Cardamom contains phytochemical compounds such as alkaloids, flavonoids, tannins, and saponins. The purpose of this study was to analyze the level of bioactivity of cardamom leaf ethanol extract to Artemia salina L shrimp larvae by BSLT method and determine the LC₅₀ value. This study used quantitative methods that were experimental and used 6 treatment concentrations, namely 25 ppm, 50 ppm, 100 ppm, 200 ppm, 500 ppm, 1000 ppm and 1 negative control with each concentration replicated 5 times. Artemia salina L larvae were used as many as 350 heads with 10 heads each for each concentration. The death of larvae is calculated after 24 hours of treatment. The calculation result of LC₅₀ from cardamom leaf ethanol extract (Amomum cardamomum L) with data analysis using SPSS version 25 is 151,671 ppm. This shows that cardamom leaf ethanol extract (Amomum cardamomum L) is toxic due to LC₅₀
Antibacterial Activity Test Of Ethanolic Extract Patch Preparations From Noni Leaves (Morinda Citrifolia L.) Using The Zone Of Inhibition Against Staphylococcus Aureus And Staphylococcus Epidermidis Bacteria Yanti Musyaawarah; Suharyanisa Suharyanisa; Jon Kenedy Marpaung; Aditiya Baginda Marpaung
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.2060

Abstract

Wounds occur when there is damage or loss of body tissue due to factors that interfere with the body's protective system and cause infection caused by Staphylococcus aureus and Staphylococcus epidermidis.Noni leaf (Morinda citrifolia L.) has strong potential as an antibacterial, so researchers are interested in formulating ethanol extract of noni leaf (EEDM) into a patch preparation. Objective: Knowing that EEDM can be formulated as a patch preparation, as well as knowing its antibacterial activity. Methods: Four formulas were made with variations in extract concentration, namely F0 (blank); FI : 5%; FII: 10%; and FIII: 15%. Antibacterial testing using disc paper diffusion method. Results: A clear patch preparation was produced in F0, while in FI, FII and FIII the gel was blackish green with a distinctive smell of EEDM. The results of the antibacterial activity test against Staphylococcus aureus in each formula are FI: 2.58 mm; FII: 2.35 mm; FIII: 2.41 mm, while against Staphylococcus epidermidis, FI: 1.46; FII: 2.28; FIII: 3.33. Conclusion: EEDM can be formulated into patch preparations. The antibacterial potential of the three formulas is in the weak category.
Co-Authors Aditiya Baginda Marpaung Bengi Simahara Betharina Br Tarigan Dumartina Hutauruk Ivan Elisabeth Purba Jhon Manrius Laia Jon Kenedy Marpaung Juli Susanti Yanti Musyaawarah Yanti Musyawarah