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All Journal Jurnal Farmasi SYIFA Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Journal of Innovative and Creativity Jurnal Siti Rufaidah
Dumartina Hutauruk
Universitas Sari Mutiara Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Pengujian Aktivitas Antihiperglikemia Infusa Batang Muda Rotan (Calamus Caesius Blume) Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar Yang Diinduksi Aloksan Suharyanisa Suharyanisa; Jon Kenedy Marpaung; Dumartina Hutauruk; Juli Susanti
Jurnal Siti Rufaidah Vol. 1 No. 4 (2023): November : Jurnal Siti Rufaidah
Publisher : PPNI UNIMMAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jasira.v1i4.35

Abstract

Medicinal plants have been known and used worldwide for thousands of years. One type of medicinal plant that is often used is gaharu. The efficacy of gaharu leaves provides properties as a fever reducer, increases appetite, launches menstruation, and relieves pain. This study aims to determine whether there is an analgesic effect from the methanol extract of gaharu leaves in male Wistar rats using the heat stimulation method. This study was an experimental study using twenty-five male Wistar rats divided into five groups. Group I (negative control), rats were treated with 1% CMC-Na. Group II (positive control), rats treated with mefenamic acid 45 mg/kg BW. Group III, IV, and V rats were treated with gaharu leaf methanol extract suspension (100; 200, and 400) mg/kg BW. Pain stimulation was carried out by dipping the rat tail into a 40°C water bath. Data on response time to pain, stimuli were analyzed using the One-Way Analysis of Variance (ANNOVA) method with a 95% confidence level followed by a post-hoc Tukey test to determine which group had the same or significantly different effect. The results showed that the normal response time data for mice to painful stimuli ranged from 2.79 to 3.57 seconds. 1% CMC-Na treatment in mice was unable to increase the response time to a significant pain stimulus (p>0.05). Mefenamic acid treatment 45 mg/Kg BW significantly increased the response time to painful stimuli (p<0.05) with the longest average response time to painful stimuli, namely 8.87 seconds. Based on the method used in this research, methanol extract of agarwood leaves 400 mg/kgBW has almost the same analgesic effect as mefenamic acid 45 mg/KgBW.
Effectiveness Test Of Green Betel Leaf Ethanol Extract Gel Preparation (Piper Betle L.) Against Pseudomonas Aeruginosa Bacteria Dumartina Hutauruk; Jon Kenedy Marpaung; Nuranti Nurmela; Jansen Asriel Ginting
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.2056

Abstract

Pseudomonas aeruginosa is an opportunistic pathogenic bacterium commonly associated with nosocomial infections, particularly in immunocompromised patients. Inappropriate use of antibiotics can lead to resistance, highlighting the need for safer and more effective alternative treatments. Green betel leaf (Piper betle L.) contains active compounds such as flavonoids, tannins, and saponins that exhibit antibacterial properties. This study aims to evaluate the effectiveness of an ethanol extract gel formulation of green betel leaves against the growth of Pseudomonas aeruginosa. The methods included ethanol extraction of betel leaves through maceration, formulation of gels with varying extract concentrations, and antibacterial activity testing using the disk diffusion method. The results showed that the ethanol extract gel was able to inhibit the growth of P. aeruginosa, with inhibition zones increasing along with higher extract concentrations. In conclusion, the ethanol extract gel of green betel leaves has potential as a natural antibacterial agent against Pseudomonas aeruginosa.
Formulasi Dan Evaluasi Sediaan Shampo Ekstrak Etanol Daun Cengkeh (Syzygium Aromaticum L) Sebagai Penumbuh Rambut Pada Tikus Putih Jantan Manuppak Irianto Tampubolon; Dhea Nur Fadhilah; Dumartina Hutauruk
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 3 (2024): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i3.332

Abstract

Clove leaves have the property of overcoming hair growth problems, where the eugenol compound contained in clove leaves is efficacious as a hair growth agent. This research was conducted to formulate a clove leaf extract shampoo preparation. The research method used was the experimental method. Tests were carried out on experimental animals, namely male white mice in various groups. The first group (without treatment), the second group (negative control), the third group (5% clove leaf extract shampoo), the fourth group (10% clove leaf ethanol extract shampoo), the fifth group (15% clove leaf ethanol extract shampoo) and groups sixth (positive control). The shampoo preparations were tested and evaluated, the results of the preparation evaluation test showed that the four shampoo preparations were homogeneous and had a pH ranging from 5.1-5.7, with a viscosity of 1700-3000 cps and a foam height of 9-11 cm. This shampoo preparation also does not irritate the skin. The results of the data analysis obtained showed that all data were normally distributed (p> 0.005) and homogeneous (p> 0.005). The results of the one way ANOVA test show that F1 (5% formula), F2 (10% formula) and F3 (15% formula) have significant differences. This research shows that clove leaf ethanol extract shampoo with a concentration of 15% is the most effective formulation in hair growth in male white rats. However, the ethanol extract of clove leaves shampoo is less effective than minoxidil 5% for hair growth.
Formulasi Sediaan Body Scrub Ekstrak Etanol Daun Salam (Syzygium Polyanthum (Wight.) Walp) dan Serbuk Beras Putih (Oryza sativa L.) Sebagai Pelembab Kulit Monica Suryani; Julia Susanti; Dumartina Hutauruk
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 4 (2024): Oktober: Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v1i4.558

Abstract

Body scrub is a pharmaceutical preparation in the form of a beauty product that functions to smooth the skin of the body and remove damaged skin cells with the help of scrubs. Bay leaf (Syzygium polyanthum (Wight.)Walp) and white rice powder (Oryza sativa L.) are plants that are widely used to maintain health, as a traditional medicine and also as an antioxidant. The research method carried out is experimental. The purpose of this study was to formulate ethanol extracts of bay leaf (Syzygium polyanthum (Wight.)Walp) and white rice powder (Oryza sativa L.) in the form of Body Scrub preparations with concentrations 2, 4, and 6 that can be used as a skin moisturizer. The extract sample uses ethanol solvent, which will be formulated into the form of a Body Scrub preparation, then an examination of the physical quality test of the preparation, irritation test, hedonic test, moisturiser effectiveness test using a skin moisture analyzer is carried out. The results of this study show that the ethanol extract of bay leaf (Syzygium polyanthum) and white rice powder (Oryza sativa L.) can be formulated as a Body Scrub preparation that has met the physical quality requirements of the preparation which has a semi-solid shape, a more concentrated preparation color and a distinctive aroma of bay leaf extract. The preparation shows a homogeneous composition, M/A cream type, spread power range 5.7-6.2 cm, viscosity range 3,800- 4000 cPs, pH 6.4-6.7, non-irritating to the skin and stable in storage for 4 weeks of storage, hedonic value that is very preferred by researchers on the Body scrub F3 preparation. The effectiveness test showed an increase in humidity of 31.59%, which was the best in the preparation of F3 concentration. It can be concluded that the ethanol extract of bay leaf (Syzygium polyanthum (Wight.)Walp) and white rice powder (Oryza sativa L.) can be formulated in Body Scrub preparations that have met the physical quality requirements of the preparation as a skin moisturizer at a concentration of 6%.
Analisis Perbandingan Efektivitas Dan Mekanisme Biologis Pada Jamu, Obat Herbal Terstandar, Dan Fitofarmaka Dalam Pengobatan Diare Christika Ilsanaa Surbakti; Dumartina Hutauruk; Peri
Jurnal Farmasi SYIFA Vol 4 No 1 (2026): Jurnal Farmasi SYIFA
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/jfs.v4i1.1006

Abstract

Obat herbal Indonesia adalah kombinasi dari jamu, obat herbal terstandar, dan fitofarmaka yang memiliki perbedaan dalam tingkat pembuktian ilmiah serta efektivitas terapi. Evaluasi diperlukan untuk memahami nilai terapeutik dan mekanisme biologis masing-masing. Membandingkan efektivitas dan mekanisme biologis jamu, obat herbal terstandar, dan fitofarmaka dalam pengobatan diare berdasarkan bukti ilmiah terbaru. Studi ini menggunakan pencarian artikel-artikel yang diterbitkan dalam lima tahun terakhir sebagai metodologi penelitian: tinjauan pustaka naratif pada artikel yang diterbitkan tidak lebih awal dari tahun 2020 di Google Scholar, PubMed, dan jurnal terindeks SINTA. Analisis dilakukan dengan membandingkan tingkat bukti, farmakologi, dan mekanisme kerja. Jamu memiliki potensi antidiare berdasarkan pengalaman empiris dan kandungan fitokimia, tetapi efektivitas dan mekanisme biologisnya belum dibuktikan secara langsung. OHT menunjukkan efektivitas yang lebih konsisten karena telah diuji secara in vivo dengan mekanisme utama astringen, antimotilitas, dan antisekretori. Fitofarmaka memiliki bukti terkuat karena diuji secara klinis pada manusia, dengan mekanisme biologis yang paling lengkap dan relevan secara klinis. Semakin tinggi tingkat standardisasi obat tradisional, mulai dari jamu, kemudian obat herbal terstandar, hingga fitofarmaka, semakin kuat bukti efektivitasnya dan semakin jelas mekanisme biologisnya dalam pengobatan diare.
Co-Authors Christika Ilsanaa Surbakti Dhea Nur Fadhilah Jansen Asriel Ginting Jon Kenedy Marpaung Juli Susanti Julia Susanti Manuppak Irianto Tampubolon Monica Suryani Nuranti Nurmela Peri Suharyanisa Suharyanisa