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All Journal Journal of Innovative and Creativity Jurnal Siti Rufaidah
Dumartina Hutauruk
Universitas Sari Mutiara Indonesia
Education Health Professions Languange, Linguistic, Communication & Media Mathematics Nursing Public Health Social Sciences Other

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Pengujian Aktivitas Antihiperglikemia Infusa Batang Muda Rotan (Calamus Caesius Blume) Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar Yang Diinduksi Aloksan Suharyanisa Suharyanisa; Jon Kenedy Marpaung; Dumartina Hutauruk; Juli Susanti
Jurnal Siti Rufaidah Vol. 1 No. 4 (2023): November : Jurnal Siti Rufaidah
Publisher : PPNI UNIMMAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jasira.v1i4.35

Abstract

Medicinal plants have been known and used worldwide for thousands of years. One type of medicinal plant that is often used is gaharu. The efficacy of gaharu leaves provides properties as a fever reducer, increases appetite, launches menstruation, and relieves pain. This study aims to determine whether there is an analgesic effect from the methanol extract of gaharu leaves in male Wistar rats using the heat stimulation method. This study was an experimental study using twenty-five male Wistar rats divided into five groups. Group I (negative control), rats were treated with 1% CMC-Na. Group II (positive control), rats treated with mefenamic acid 45 mg/kg BW. Group III, IV, and V rats were treated with gaharu leaf methanol extract suspension (100; 200, and 400) mg/kg BW. Pain stimulation was carried out by dipping the rat tail into a 40°C water bath. Data on response time to pain, stimuli were analyzed using the One-Way Analysis of Variance (ANNOVA) method with a 95% confidence level followed by a post-hoc Tukey test to determine which group had the same or significantly different effect. The results showed that the normal response time data for mice to painful stimuli ranged from 2.79 to 3.57 seconds. 1% CMC-Na treatment in mice was unable to increase the response time to a significant pain stimulus (p>0.05). Mefenamic acid treatment 45 mg/Kg BW significantly increased the response time to painful stimuli (p<0.05) with the longest average response time to painful stimuli, namely 8.87 seconds. Based on the method used in this research, methanol extract of agarwood leaves 400 mg/kgBW has almost the same analgesic effect as mefenamic acid 45 mg/KgBW.
Effectiveness Test Of Green Betel Leaf Ethanol Extract Gel Preparation (Piper Betle L.) Against Pseudomonas Aeruginosa Bacteria Dumartina Hutauruk; Jon Kenedy Marpaung; Nuranti Nurmela; Jansen Asriel Ginting
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.2056

Abstract

Pseudomonas aeruginosa is an opportunistic pathogenic bacterium commonly associated with nosocomial infections, particularly in immunocompromised patients. Inappropriate use of antibiotics can lead to resistance, highlighting the need for safer and more effective alternative treatments. Green betel leaf (Piper betle L.) contains active compounds such as flavonoids, tannins, and saponins that exhibit antibacterial properties. This study aims to evaluate the effectiveness of an ethanol extract gel formulation of green betel leaves against the growth of Pseudomonas aeruginosa. The methods included ethanol extraction of betel leaves through maceration, formulation of gels with varying extract concentrations, and antibacterial activity testing using the disk diffusion method. The results showed that the ethanol extract gel was able to inhibit the growth of P. aeruginosa, with inhibition zones increasing along with higher extract concentrations. In conclusion, the ethanol extract gel of green betel leaves has potential as a natural antibacterial agent against Pseudomonas aeruginosa.
Co-Authors Jansen Asriel Ginting Jon Kenedy Marpaung Juli Susanti Nuranti Nurmela Suharyanisa Suharyanisa