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All Journal Jurnal Farmasi Indonesia Media Farmasi Indonesia Journal of Educational Innovation and Public Health International Journal of Contemporary Sciences (IJCS)
arikha ayu susilowati
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Efek Ekstrak Etanol Daun Kelor (Moringa oleifera, Lamk.) Pada Mencit Model Demensia: Kajian Memori Spasial, Kadar Malondialdehid Dan Jumlah Sel Piramidal Hipokampus Area CA1 Dan CA2-CA3 arikha ayu susilowati; Gunawan Pamudji Widodo; Jason Merari
Jurnal Farmasi Indonesia Vol 16 No 2 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (868.86 KB) | DOI: 10.31001/jfi.v16i2.612

Abstract

ABSTRACT Dementia is a disease of nerve cells in the brain, due to the hippocampus damaged by free radicals. EEDK (Ethanol extract of kelor leaves)(Moringa oleifera, Lamk.) contains phytochemicals, carotene, vitamins, minerals, amino acids, flavonoids and phenolics, proven to reduce oxidative damage and memory deficits. This study aims to determine the effect of EEDK on spatial memory, MDA levels, the number of hippocampal pyramidal cells damaged in the CA1, CA2-CA3 area and histopathological features of mice. The design of this study was pre-test and post-test control group design for spatial memory test and post test control group design for MDA levels, hippocampal pyramidal cell counts and histopathological features. This Reseach using 30 mice divided into of 6 groups, each group consist of 5 mice, namely the normal control group, positive control, negative control, EEDK group 100, 200, and 400 mg/kg body weight, all groups induced by Pb acetate 50 mg / KgBB except the normal group. Positive control was treated with quercetin 50 mg/kgBB, while negative controls were not treated. Memory test data obtained from the Morris water maze pre and post-test, antioxidant status data obtained from MDA levels and histopathological data obtained from the calculation of pyramidal cell counts. Data analysis used repeated measures ANOVA and ANOVA with Post Hoc LSD. The results showed that latency time, MDA level test and brain histopathology examination had significant differences between the negative control group and the EEDK group. EEDK 400 mg/kgBB was most effective in improving spatial memory, decreasing MDA levels, and preventing damage to the hippocampal pyramidal cell CA1, CA2-CA3 area.
Sabun Cuci Tangan Berbahan Aktif Larutan Fermentasi Kombucha Bunga Telang (Clitoria ternatea L) Sebagai Produk Bioteknologi Farmasi Dalam Menghambat Pertumbuhan Bakteri Staphylococcus capitis, Bacillus cereus, dan Pantoea dispersa Arikha Ayu Susilowati; Rina Nurmaulawti; Firman Rezaldi
Journal of Educational Innovation and Public Health Vol. 1 No. 1 (2023): Januari : Journal of Educational Innovation and Public Health
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (238.51 KB) | DOI: 10.55606/innovation.v1i1.685

Abstract

Pharmaceutical biotechnology products in the form of hand washing soap with an active ingredient of telang flower kombucha fermented solution have the potential to inhibit the growth of Staphylococcus capitis, Bacillus cereus, and Pantoea dispersa bacteria. The aim of this study was to formulate and prepare hand washing soap with an active ingredient in a solution of seagrass kombucha fermentation to inhibit the growth of Staphylococcus capitis, Bacillus cereus, and Pantoea dispersa. This research is an experimental laboratory by making 4 hand washing soap preparations, which consist of a hand washing soap base without an active substance. Hand washing soap base added to a solution of fermented butterfly pea flower kombucha at a sugar concentration of 20%, 30%, and 40%. Disc diffusion is a method used to calculate the average diameter of the inhibition zone for the three tested bacterial growth. The research data obtained were analyzed through one way ANOVA and post hoc analysis. The results of the ANOVA test proved that the obtained p value <0.05, which means that there were significant differences in the three treatment groups in inhibiting the growth of the three test bacteria. The post hoc analysis results also proved that 40% concentration was the best concentration in inhibiting the growth of the three tested bacteria, namely 18.34 mm (S. capitis/strong), 16.39 mm (B. cereus/strong), and 13.33 mm (P. disperse/strong).
Antibacterial Activity Test of Kersen Fruit Kombucha ( Muntinga Calabura L. ) To Bacteria Staphylococcus Aureus and Escherichia Coli By In Vitro arikha ayu susilowati
Media Farmasi Indonesia Vol. 19 No. 1 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i1.244

Abstract

Bacterial infections of Staphylococcus aureus and Escherichia coli cause diarrhea. Kersen fruit can be used as the basis of kombucha, which has antibacterial benefits. This experimental activity aims to determine the antibacterial activity against Escherichia coli and Staphylococcus aureus. This study used a laboratory experimental method to test the antibacterial activity of Kersen Fruit Kombucha (KFK) at concentrations of 15%, 25%, and 35%, as well as positive control of cotrimoxazole and normal control of aqua pro injection. Antibacterial activity was measured in vitro using the disc diffusion method to compare affected and unaffected areas. The results of the study on Escherichia coli and Staphylococcus aureus bacteria showed that the diameter of the inhibition zone in 15% KFK was 7.07-8.63 mm, 25% KFK showed an inhibition zone diameter of 8.11-9.57 mm; and 35% KFK inhibition zone diameter was 12.07-13.07 mm; for the positive control inhibition zone diameter was 13.07-14.72 mm. 35% KFK has a larger inhibition zone diameter than 15% and 25% KFK. Based on the Kruskal-Wallis statistical test, there was a significant difference. This study aims to determine the antibacterial activity of Kersen fruit kombucha against Staphylococcus aureus and Escherichia coli by measuring the diameter of the inhibition zone
Hypnotic-Sedative Effectiveness Of Ethanol Extract Keji Beling (Strobilanthes Crispus) In Mice With Rotarod Test As An Indicator Of Motor Impairment arikha ayu susilowati; Yanuar As’hari Cahyaningrum; Nurul Hidayati Mar’ah
Media Farmasi Indonesia Vol. 20 No. 2 (2025): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v20i2.334

Abstract

Insomnia is a sleep disorder that adversely affects the quality of life, mental and physical health. Treatment of insomnia often utilizes pharmacological therapies that have side effects. Keji beling (Strobilanthes crispus) contains secondary metabolites of flavonoids, tannins, alkaloids, saponins, and triterpenoids that have potential as natural sedatives and hypnotics. This study uses the rotarod test to detect motor impairment and evaluate the effectiveness of the ethanol extract of keji beling leaves (EEKB) as a hypnotic-sedative agent in mice. Extraction of keji beling by maceration using 96% ethanol, the extract was tested on mice in four groups: diazepam 5 mg, CMC Na 1%, and EEKB 600 and 1200 mg/kgBB. The parameter measured was the number of falls on the rotarod for 30 minutes after administration. EEKB showed decreased motor balance. The 1200 mg/kgBB dose produced the highest mean number of falls (25 times), followed by the 600 mg/kgBB dose (11.25 times), similar to the diazepam 5mg (16.75 times). Statistical analysis indicated that EEKB exerted a significant hypnotic-sedative effect by modulating GABA receptors. EEKB in doses of 600 and 1200 mg/kgBB has an effectiveness comparable to diazepam as a hypnotic tranquilizer, so it has the potential to be developed as a natural-based insomnia therapy agent.
Exploring the Macroscopic and Microscopic Characteristics of Acalypha indica L. Simplisia Powder in the Context of Pharmabotanical Studies Saristiana, Yuneka; Anita Dwi Setyarini; Yunita Dian Permatasari; Hasriyani; Arikha Ayu Susilowati; Fendy Prasetyawan
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 3 (2024): January 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v2i1.8347

Abstract

Botanical studies form a cornerstone in pharmacy, providing insights into the therapeutic potential of medicinal plants. Acalypha indica L., commonly known as "Anting-anting," holds a significant place in traditional medicine. This research focuses on the macroscopic and microscopic analysis of Acalypha indica L. simplisia, aiming to contribute to its pharmacognostic profile and enhance the standardization of herbal formulations. The exploration encompasses its historical context, traditional uses, chemical constituents, and in vitro anti-arthritis activity. The study employs advanced tools, including optical and electron microscopes, for a comprehensive examination. The macroscopic analysis involves meticulous observation of external features, while the microscopic examination delves into cellular and tissue structures. This research aligns with contemporary pharmacognosy, bridging traditional knowledge with scientific approaches, fostering a deeper understanding of medicinal plant potential
Co-Authors Anita Dwi Setyarini Fendy Prasetyawan Firman Rezaldi Gunawan Pamudji Widodo Hasriyani Jason Merari Peranginangin Nurul Hidayati Mar’ah Rina Nurmaulawti Yanuar As’hari Cahyaningrum Yuneka Saristiana Yunita Dian Permatasari