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All Journal Jurnal Ilmu Kimia Universitas Brawijaya Journal of Innovation and Applied Technology Natural B The Journal of Pure and Applied Chemistry Research Makara Journal of Science
Mohammad Farid Rahman
Brawijaya University
Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology

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In vitro Clot Lysis Activity of Phenolic Compound Degrading Product From Lignin Sugarcane Baggase Using Ochrobactrum sp. Arie Srihardyastuti; Moh Farid Rahman; Tri Ardyati; Anna Roosdiana; Indah Prihartini
The Journal of Pure and Applied Chemistry Research Vol 9, No 3 (2020): Edition September-December 2020
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2020.009.03.489

Abstract

Sugarcane bagasse (Saccharum officinarum L) is a readily available waste product of cane sugar processing. The content of lignocelluloses in sugarcane bagasse is approximately 52.7% cellulose, 20% hemicelluloses, and 24.2% lignin. Lignin can be degraded enzymatically by using microorganisms, such as Ochrobactrum sp. Monomer derived from lignin degradation using these bacteria in the optimum condition of sugarcane fermentation (pH 6, temperature 40 °C, for 5 days of incubation, the concentrations of starter 29%) by GC-MS yielded phenolic compounds such as 4-methyl-2, 6-di-tert-butylphenol; 2,6-di-tert-butylquinone; phenol, and p-hydroxybenzaldehide. The thrombolytic activity of these lignin monomers can be tested in-vitro by measuring the ability of clot lysis. Lignin did not have in-vitro clot lysis activity, whereas the lignin monomers in filtrat of fermented sugarcane bagasse have an in-vitro clot lysis activity, although its capacity is not as high as streptokinase.
Nitration Time and Ultrasonic Waves Utilization Effects Against Mol Percentage of Nitrogen in Nitrocellulose Synthetic Based on Cotton Fiber Mohammad Farid Rahman; I Made Jiwa Astika; Yudhi Dwi Kurniawan; Suratmo Suratmo
Natural B, Journal of Health and Environmental Sciences Vol 1, No 2 (2011)
Publisher : Natural B, Journal of Health and Environmental Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (10.378 KB) | DOI: 10.21776/ub.natural-b.2011.001.02.10

Abstract

Nitrocellulose is an ester of nitric acid from cellulose which has important role in propellant manufacture, especially having minimal degree of substitution (DS) of 2.5. The aims of this research were to understand the influence of time of reaction in nitration of cotton fiber both synthesized with and without using ultrasonic wave irradiation to mole percentages of nitrogen in nitrocellulose products. The nitrations were conducted by using mixture of sulphuric acid and nitric acid with mass composition ratio of 3:1 (30 mLs of H2SO4 95-97% (w/w) solution; 20 mLs of HNO3 65% (w/w) solution) for 35, 40, 45, 50 and 55 minutes at temperature of 28-29oC, whereas in irradiation treatment by ultrasonic wave the initial temperature adjusted at the same. The mol percentages of nitrogen in nitrocellulose products were determined by using absorbance ratio method from IR spectra without external calibration prerequisite. The results showed that the mol percentages of nitrogen in nitrocelluloses both synthesized with and without using ultrasonic wave irradiation tended to increase up to about 45 minutes and tended to decrease after it. The highest mole percentage of nitrogen in nitrocellulose product synthesized without using ultrasonic wave irradiation was 33.05% with DS of 0.99; whereas that of using ultrasonic wave irradiation increased to 52.78% with DS of 1.58. The analysis of IR spectra and burning characteristic from nitrocellulose products showed the existence of the NO2 group in nitrocellulose products.
Photocatalytic Degradation of Methylene Blue Using TiO2-Natural Zeolite as A Photocatalyst Sri Wardhani; Moh. Farid Rahman; Danar Purwonugroho; Rachmat Triandi Tjahjanto; Christiana Adi Damayanti; Ika Oktavia Wulandari
The Journal of Pure and Applied Chemistry Research Vol 5, No 1 (2016)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (974.812 KB) | DOI: 10.21776/ub.jpacr.2016.005.01.232

Abstract

TiO2 - zeolite photocatalyst has been prepared by impregnation of TiO2 onto acid -activated natural zeolite. The XRD data confirmed that natural zeolite used in this work is predominated with mordenite and clinoplitolite types, whereas anatase type can be attributed to TiO2. The highest performance of TiO2 – zeolite, which is indicated by surface area of 13.304 m2/g and band gap energy of 3.15 eV, is obtained when 10 mmol of TiO2 is impregnated onto the zeolite. The ability of this photocatalyst is evaluated by examining degradation of methylene blue (MB) in the presence of UV source. The effects of MB concentration, pH and UV irradiation time on the degradation are studied in a batch reactor. It is interesting since the addition of H2O2 can improve the degradation effeciency of MB. The optimum result is achieved at pH 11, duration of UV irradiation of 50 min, showing degradation amount of 98.25 %. Surprisingly, the chemical oxygen demand (COD) in the degraded MB aqueous solution can be reduced about 77.9%, exhibiting the improvement of water quality. No loss of the activity of the degradation efficiency after reusability of this TiO2 - zeolite photocatalyst for at least 4 times.
Pelatihan Uji Fitokimia Senyawa Metabolit Sekunder Tanaman Secang (Caesalpinia sappan L.) Kepada Perkumpulan Pendidik Sains Kimia Indonesia (PPSKI) Siti Mariyah Ulfa; Elvina Dhiaul Iftitah; Moh. Farid Rahman
Journal of Innovation and Applied Technology Vol 8, No 1 (2022)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jiat.2022.008.01.8

Abstract

Kandungan senyawa aktif dalam tanaman dapat di analisis dengan metode uji fitokimia. Salah satu tanaman herbal yang banyak dikonsumsi adalah secang (Caesalpinia sappan). Secang biasa di simpan dalam bentuk sediaan teh herbal, diseduh dengan air panas dan diminum untuk mengurangi radang tenggorakan. Dalam rangka mengenalkan kegiatan riset sederhana di sekolah dilakukan pelatihan uji fitokimia metabolit sekunder tanaman lokal (dalam hal ini secang) kepada guru-guru kimia yang tergabung dalam Perkumpulan Pendidik Sains Kimia Indonesia (PPSKI). Metode yang dilakukan dengan pemberian materi secara daring menggunakan media zoom meeting, tutorial melalui video, diskusi, tanya jawab, dan pemberian tugas. Dalam pelatihan ini diberikan juga soal-soal pretes dan postes untuk mengukur kemampuan peserta sebelum dan sesudah pelatihan. Terdapat peningkatan pengetahuan peserta sebanyak 20% setelah pelatihan. Pelatihan uji fitokimia ini memberikan wawasn baru kepada para guru kimia untuk melakukan riset sederhana dengan bahan yang tersedia.
Biological Activity and Solubility of 5-Methoxy-1,4-Benzoquinone Having Bromoheptyl and Bromodecyl Substituents in the n-Octanol/Water System Ulfa, Siti Mariyah; Dwisari, Fath; Pangesti, Laras; Rahman, Mohammad Farid
Makara Journal of Science Vol. 25, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The biological activity and solubility of compounds are influenced by its chemical structure. These properties can be improved by substituting alkyl, alkoxy, and/or haloalkane in the parent skeleton. In this research, the synthesis of 3-(7-bromoheptyl)-2-methyl-5-methoxy-1,4-benzoquinone (3a) and 3-(10-bromodecyl)-2-methyl-5-methoxy-1,4-benzoquinone (3b) was achieved through the decarboxylation reaction. The solubility and biological activity of 3a and 3b were compared with that of thymoquinone (TQ), which acts as an anti-inflammatory agent. Compounds 3a and 3b were successfully synthesized and analyzed using Fourier Transform Infra-Red (FTIR) and Nuclear Magnetic Resonance (NMR). The FTIR spectrum showed the increasing intensity of C-H sp3 and the absorption of C-Br because of the presence of the bromoheptyl and bromodecyl substituents. 1H-NMR showed the prominent chemical shift of olefinic methylene at δ 1.29–3.40 ppm. The solubility test showed the differences in the partition coefficient (log P) of 3a and 3b in the n-octanol/water system. The log P values of 3a and 3b are higher than those of TQ, indicating that methoxy, bromoheptyl, and bromodecyl support the increase in solubility. Biological activity test using the in silico approach showed that 3a and 3b have a higher tendency to bind with the translocator protein (TSPO) macromolecule than the phosphatase and tensin homolog (PTEN) macromolecule. The binding interactions of TSPO-3a and TSPO-3b, similar to that of TSPO-TQ, showed that both synthesized compounds have comparable activity. The binding energy of TSPO-3a is lower than that of TSPO-3b, indicating that 3a has a higher activity for anti-inflammatory drug candidates than 3b.
Co-Authors Achmad Virdi Virosa Amini, Rekfa Wika Anna Roosdiana Arianto Y.P Wardoyo Arie Srihardyastuti Arinto Y.P. Wardoyo Chairulita Putri Kusumaningsih Christiana Adi Damayanti Danar Purwonugroho Edi Priyo Utomo Elvina Dhiaul Iftitah Esya, Firdausy Amalina Fatma, Aliya I Made Jiwa Astika Ika Oktavia Wulandari Indah Prihartini Khoirun Nisyak Masruri Masruri Nisa', Khibrun Pangesti, Laras Rachmat Triandi Tjahjanto Rendra Yudantara Meiliyanto Rurini Retnowati Shadiq, Jakfar Siti Mariyah Ulfa Sri Wardhani Suratmo Suratmo Sutrisno Sutrisno Tri Ardyati Yudhi Dwi Kurniawan