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All Journal Health Notions Jurnal Kreativitas PKM Ensiklopedia of Journal International Journal of Nursing and Health Services (IJNHS) Babali Nursing Research Community Empowerment Lentera Perawat JURNAL INSAN CENDEKIA
Eva Riantika Ratna Palupi
STIKES Rajekwesi Bojonegoro, Bojonegoro, Indonesia
Arts Humanities Computer Science & IT Dentistry Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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The Effect of Transdermal Application of Ananas comosus Peel Extract on Lowering Blood Pressure: A Randomized Controlled Trial Palupi, Eva Riantika Ratna; Sandi, Yudisa Diaz Lutfi; Rahmawati, Rahmi
Babali Nursing Research Vol. 7 No. 2 (2026): April
Publisher : Babali Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37363/bnr.2026.72548

Abstract

Aims: This study examined whether transdermal application of Ananas comosus peel extract could effectively reduce blood pressure in elderly hypertensive patients within a primary health care setting. Methods: A randomized controlled trial was conducted at Primary Health Centre involving 86 elderly with hypertension. After exclusion and dropout, 64 participants completed the study (32 in intervention group, 32 in control group). The intervention group received daily transdermal application of Ananas comosus peel extract, while the control group received no active treatment, over seven consecutive days. Blood pressure was measured each morning and evening. Between-group differences were tested with independent t-tests; within-group changes with paired t-tests. Results: Baseline demographic and clinical characteristics did not differ significantly between groups (p > 0.05). No significant differences in systolic blood pressure (SBP), diastolic blood pressure (DBP), or mean arterial pressure (MAP) were observed between groups during Days 1–3. By Day 4, the intervention group showed significantly greater reductions in SBP (p= 0.005), DBP (p= 0.034), and MAP (p= 0.014), with progressively larger differences through Day 7 (all p< 0.001). Within the intervention group, SBP, DBP, and MAP decreased significantly from baseline to Day 7 (p< 0.001), whereas the control group exhibited minimal, non-significant changes. Conclusion: Transdermal application of Ananas comosus peel extract produced a statistically significant and time-dependent reduction in blood pressure starting from Day 4, with continued improvement until one week. These findings support its potential as a non-pharmacological adjunct in managing essential hypertension among older adults
Co-Authors agustian, irwan Ah Yusuf Ah. Yusuf Aria Aulia Nastiti Aria Aulia, Aria Bunga, Dinda Nur Fajri Hidayati Dwi Diana Putri Esti Yunitasari Fatia Rizki Nuraini Firstania, Aurellia Fitri Handayani Hanafiah, Yusuf Helza Risdianti Indra Gilang Pamungkas Khoirot, Risyda Ma'rifatul Kusuma, M. Iqbal Angga M.Iqbal Angga Kusuma Munfarida, Aulia Isnaini Nina Difla Muflikhah Noorma, Nilam Nugroho, Kristianto Dwi Rahmawati, Rahmi Retno Puji Astuti Sabiha, Febinda Azra Sandi, Yudisa Diaz Lutfi Suprayogi Suprayogi Titik Nuryanti Wirawan, Nandar Wiwik Utami Zaharany, Tsania Ayu