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All Journal Jurnal Keperawatan Indonesia Indonesian Journal of Pharmaceutical Science and Technology JCES (Journal of Character Education Society) MEDIA INFORMASI JURNAL ILMIAH KESEHATAN SANDI HUSADA Pharmacoscript Media Informasi Edukasi Masyarakat Sehat Sejahtera (EMaSS) Journal of Pubnursing Sciences Jurnal Ilmiah Kesehatan Sandi Husada
Asep Kuswandi
Politeknik Kesehatan Kemenkes Tasikmalaya
Chemistry Computer Science & IT Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Biomolecular Mechanism of Herbal Medicine on Muscle Atrophy in Type 2 Diabetes Mellitus Rats: Systematic Review Kuswandi, Asep; Ikram, NKK; Muchtaridi, Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.50895

Abstract

Musculoskeletal atrophy causes an increase in advanced glycation end products, a proinflammatory phenotype, and oxidative stress, which can lead to micro- and macrovascular complications.This can cause loss of skeletal muscle mass, strength, and function, potentially leading to sarcopenia. Herbal medicines have been proven to be able to treat various diseases in humans, herbal medicines have the potential to increase skeletal muscle mass. There are various genes that have been induced by herbal medicines to prevent muscle atrophy in chronic diseases. It is necessary to explain the molecular mechanisms of the role of herbal medicines in preventing muscle atrophy due to chronic diseases. This study explores the biomolecular mechanisms of each herbal medicine based on the pathways of inflammation, protein synthesis, apoptosis, autophagy, and glucose uptake in T2DM mice. The research results show that herbal medicine can potentially activate 81 gene expressions that can prevent muscle atrophy in T2DM mouse models. Keywords: biomolecular, herbal medicine, musculoskeletal atrophy, type 2 diabetes 
Co-Authors Adi Wibowo Aryanti, Dewi Asep Abdul Rahman Asep Abdul Rahman Cahyati, Yanti Dewi Gayatri Holikin Holikin Ikram, NKK Imat Rochimat Kusmiyati Kusmiyati Lingga Ikaditya Mardheni Wulandari Mardiyah, Raiza Naimatul Mariani, Dini Meti Megawati METI MEGAWATI, METI Muchtaridi Muchtaridi Musfiratu 'Azma Muslim Kasim Nisa Habibah Kuswandi Nunung Yulia Ratna Sitorus Sutiswa, Shandra Isasi Tan’im Tan’im Unang Arifin Hidayat Yulia, Nunung