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All Journal Sport and Fitness Journal METAMORFOSA Journal of Biological Sciences INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana JURNAL BIOMEDIK Public Health of Indonesia ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico IJAAM (Indonesian Journal of Anti-Aging Medicine) Jurnal Ilmiah Sangkareang Mataram Public Health and Preventive Medicine Archive Journal of Global Pharma Technology
Gde Ngurah Idraguna Pinatih
Bagian Ilmu Kedokteran Komunitas/Ilmu Kedokteran Pencegahan Fakultas Kedokteran Universitas Udayana
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Pomegranate extract (Punica granatum) not as effective as simvastatin in improving profile lipid in dyslipidemic male wistar rats (Rattus norvegicus) Ken Andrina Anindita; I Gusti Made Aman; Gde Ngurah Indraguna Pinatih
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.89

Abstract

Introduction: Dyslipidemia is one of the factors of the occurrence of heart disease and atherosclerosis. Simvastatin and Pomegranate (Punica granatum) work by improving the lipid profile. The aim of this study was to prove that red pomegranate extract (Punica granatum) improve lipid profile of male white rats that are dyslipidemic. Method: This research is a experimental study with randomized pre test and post test control group design, using 20 adult male white rats as sample. After 30 days, rats were divided into 2 study groups with 10 rats per group. The group was classified into two (P1 and P2). Prior to the treatment, the rats were examined the first diluted T-cholesterol, triglyceride, LDL and HDL levels as pretest data. Treatment was performed for 15 days. Results: The mean pretest HDL level in the simvastatin group was 23.84 ± 2.54 mg / dL and the red pomegranate extract group was 25.41 ± 2.34 mg / dL and p = 0.167. After treatment for 15 days, the mean posttest the red pomegranate extract group was 126.55 ± 3.09 mg / dL and p = 0,001. The mean posttest HDL level in the simvastatin group was 58.72 ± 5.21 mg / dL and the red pomegranate extract group was 40.56 ± 2.87 mg / dL and p = 0,001. Conclusion: The administration of red Punica granatum is not as effective as simvastatin in improving lipid profile in dyslipidemic rats. Although not as effective as simvastatin, red pomegranate extract can significantly improve lipid profile.
PENGARUH PENGGUNAAN TATO PERMANEN DAN ALAT CUKUR SECARA BERGANTIAN TERHADAP INFEKSI VIRUS HEPATITIS B DI KOTA DILI TIMOR–LESTE H Da Silva; I. D. N Wibawa; Pinatih Indraguna; Mulyanto
JURNAL SANGKAREANG MATARAM Vol. 3 No. 1 (2017): Maret 2017
Publisher : SANGKAREANG

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Abstract

Penggunaan tato permanen dan silet cukur bergantian masih kerap sekali dijumpai pada penduduk Kota Dili, Timor-Leste. Hal ini berdampak pada terjangkitnya virus menular Hepatitis B. Tujuan penelitian ini adalah untuk mengetahui apakah ada pengaruhpenggunaan tattoo permanen danalat cukur (silet atau pisau cukur) dengan kejadian infeksi virus hepatitis B. Penelitian ini dilakukan dengan metode diskriptif korelatif.Analisis statistik menggunakan regresi binary logisticpada taraf signifikansi 5%. Sampel penelitian ditentukan dengan caramultistage random samplingsehingga diperoleh jumlah sampel sebanyak 110. Hasil penelitian menunjukkan bahwa terdapat pengaruh yangsignifikan (p<0,05) antara penggunaan tattoo permanendan alat cukur secara bergantian secara simultan terhadap infeksi Virus Hepatitis B. variabel prediktor penggunaan tatto permanen terhadap infeksi virus hepatitis B diperoleh hubungan positif yang signifikan, sedangkan prediktor penggunaan alat cukur bergantian terhadap infeksi virus hepatitis B diperoleh hubungan positif yang tidak signifikan. Secara simultan penggunaan tatto permanen dan alat cukur secara bergantian mempengaruhi kejadian infeksi virus hepatitis B sebesar 16,6%. Sehingga dapat disimpulkan bahwa terdapat pengaruh antara penggunaan tattoo permanen dan alat cukur bergantian terhadap kejadian infeksi virus hepatitis B di Kota Dili, Timor-Leste.
Morel berry leaf extract reduce levels of reactive oxygen species and increase levels of endothelial nitric oxide synthase of male Wistar rat exposed to cigarette smoke Felicia Hartono; Gde Ngurah Indraguna Pinatih; Anak Agung Ayu Ngurah Susraini
Neurologico Spinale Medico Chirurgico Vol 4 No 1 (2021)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v4i1.148

Abstract

Background: Exposure to cigarette smoke increased the level of reactive oxygen species (ROS) and caused oxidative stress which could lead to early aging includes vascular aging. Morel berry leaf contained flavonoid works as antioxidant that neutralized ROS. This study aimed to investigate effectivenes of Morel berry (Physalis angulata L.) leaf extract to decrease levels of ROS and increase levels of endothelial nitric oxide synthase (eNOS) in male Wistar rats exposed to cigarette smoke. Method: This research was an experimental study with pre test-post test control group design. 16 healthy male rats (Rattus norvegicus), Wistar strain, 3-4 months, weight 180-200gr were used, divided randomly into two groups. The control group was given aquadest and the treatment group was given Morel berry leaf extract 500 mg/kgBW/day. Continued to 30 minutes exposed to cigarette smoke. ROS and eNOS levels were measured before and after 28 days treatment, using rat ROS ELISA Kit and rat ENOS ELISA Kit respectively. Results: The results showed that the mean ROS levels in the treatment group decreased significantly and was significantly lower than in control group (75.789 + 3.298 vs 91.646 + 1.970; p < 0.001). The mean eNOS levels in the treatment group increased significantly and was significantly higher than control group (8.597 + 0.375 vs 5.957 + 0.329; p < 0.001). Conclusion: The results of this study indicated that administration of Morel berry leaf extract reduced levels of ROS and increased serum levels of eNOS in male Wistar rats exposed to cigarette smoke.
Bidara leaf extract (Ziziphus mauritiana) inhibits MMP-1 increase and collagen decrease in female Wistar rat skin exposed to UVB and cigarette smoke Citra Anggraeny; Anak Agung Gde Putra Wiraguna; Gde Ngurah Indraguna Pinatih
Neurologico Spinale Medico Chirurgico Vol 4 No 3 (2021)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v4i3.178

Abstract

Background: Exposure to cigarette smoke and UV-B, can activate enzymes that degrade collagen and inhibit its production through increased levels of MMP-1. Bidara leaves with high content of flavonoids and tannins may prevent damage caused by free radicals. This study aimed to prove the effect of bidara leaf extract in inhibiting the increase in MMP-1 levels and collagen reduction in female Wistar rats skin exposed to UV-B and cigarette smoke. Methods: A randomized posttest-only control group design study was conducted on 30 female Wistar rats, aged 8-10 weeks, weighing 130-150 grams. The rats were divided into three groups: the group without treatment, the base cream, and the 7.5% bidara leaves extract groups. The last two groups were exposed to UV-B light and cigarette smoke. After four weeks of intervention, the back skin tissue was taken to assess collagen amount and MMP-1 levels. Comparative analysis was performed to see the difference between groups. Results: The results showed that the mean levels of MMP-1 in the untreated group were lowest, followed by the bidara leaf extract cream and the base cream group. The mean of collagen amount of bidara leaf extract group was the highest, followed by the base cream and the untreated group. The analysis showed a significant difference in the mean levels of MMP-1 and collagen amount between groups (p<0.05). Conclusion: The 7.5% bidara leaf extract cream inhibited the increase in MMP-1 levels and the decrease in collagen in female Wistar rats exposed to UV-B light and cigarette smoke.
Gambaran status gizi balita pada penggunaan garam beryodium di Desa Sangkan Gunung Kecamatan Sidemen, Kabupaten Karangasem Thivyadharshini Uvaraju; G.N. Indraguna Pinatih
Intisari Sains Medis Vol. 8 No. 1 (2017): (Available online: 1 April 2017)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (723.904 KB) | DOI: 10.15562/ism.v8i1.116

Abstract

Nutritional status is one indicator of growth, nutritional status is a result of any use, absorption, and utilization of food. Iodine is needed in the body growth during gestation and early life, because iodine is an essential component in the formation of thyroid hormones. Thyroid hormone deficiency can reduce the activity of growth hormone such as (insulin growth hormone), which resulted in a number of developmental abnormalities and other functional. Toddlers (under five years) are one of age group in society most likely to suffer from nutritional disorders (susceptible nutrition) Methods: This study was a quantitative descriptive to describe the nutritional status of children in the use of iodized salt Sangkan Mountain Village district of Sidemen Karangasem regency. The target population was all Toddler Village Sangkan Mountains with a population of affordable homes that were accessible to researchers and have a toddler. This study used a total of 57 samples. Sample collection technique used is non-random consecutive sampling. Results: Nutritional Status based on Upper Arm Circumference (UAC), 5.3% Toddlers in the village Sangkan Gunung experiencing Malnutrition, and no toddlers (under 5 years old) were suffering Malnutrition. At 6 households using iodized salt, 5 infants (83%) with good nutrition and 1 infants (16.7%) with malnutrition. Meanwhile, from 51 families to use non-iodized salt, 49 infants (96.1%) with normal nutrition and 2 infants (3.9%) with malnutrition. Conclusion: The family of children who used iodized salt has the higher proportion of stunting than the family of children who did not use iodized salt. 
Gambaran tingkat pengetahuan terhadap hipertensi dan kepatuhan minum obat pada penderita hipertensi di wilayah kerja Puskesmas kintamani I Jaeynisha Mathavan; Gde Ngurah Indraguna Pinatih
Intisari Sains Medis Vol. 8 No. 3 (2017): (Available online: 1 December 2017)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (203.964 KB) | DOI: 10.15562/ism.v8i3.121

Abstract

Hipertensi seringkali disebut silent killer karena tidak adanya gejala dan tanpa disadari penderita mengalami komplikasi pada organ-organ vital. Seseorang dikatakan menderita hipertensi apabila tekanan darah sistolik >140 mmHg dan tekanan diastolik >90 mmHg. Dari data di Puskesmas Kintamani I masih banyak terdapat warga yang menderita hipertensi, kebanyakan dari mereka adalah pasien yang sering berkunjung untuk melakukan kontrol. Kepatuhan dalam pengobatan hipertensi sangat penting untuk mengontrol gejala hipertensi dan komplikasi yang dapat ditimbulkannya. Pengetahuan pasien mengenai penyakitnya sangatlah berpengaruh terhadap keputusannya dalam menjalani pengobatan. Kepatuhan pasien dalam menjalani pengobatan juga dipengaruhi oleh faktor internal dan faktor eksternal pasien.  Tujuan penelitian ini dilaksanakan agar dapat melihat gambaran tingkat pengetahuan terhadap hipertensi dan kepatuhan minum obat pada penderita hipertensi di wilayah Kintamani I. Penelitian ini merupakan studi deskriptif cross-sectional. Jumlah sample pada penelitian ini sebanyak 50 orang responden yang merupakan penduduk penderita hipertensi di wilayah kerja Puskesmas Kintamani I. Teknik pengambilan sample yang digunakan merupakan teknik simple random sampling. Pengambilan data dilakukan pada tanggal 22 - 29 Mei 2015 menggunakan kuesioner kepatuhan minum obat Morisky Medicaton Adherence Scale (MMAS-8). Penelitian ini mendapatkan hasil, Responden dengan tingkat pengetahuan tinggi sebesar 48,0%, sedangkan tingkat pengetahuan rendah sebesar 52,0%. Sebanyak 70% pasien mempunyai kepatuhan rendah terhadap minum obat hipertensi, sedangkan 30% pasien mempunyai kepatuhan tinggi.  Untuk mendukung angka keberhasilan pengobatan hipertensi perlu dilakukan penyuluhan terkait penyakit hipertensi sehingga kepatuhan minum obat penderita hipertensi dapat meningkat.
Gambaran karakteristik penderita hipertensi dan tingkat kepatuhan minum obat di wilayah kerja puskesmas Kintamani I Azri Hazwan; Gde Ngurah Indraguna Pinatih
Intisari Sains Medis Vol. 8 No. 2 (2017): (Available online: 1 August 2017)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.965 KB) | DOI: 10.15562/ism.v8i2.127

Abstract

Hipertensi merupakan penyakit yang sering ditemukan di Indonesia. Seseorang itu dikatakan menderita hipertensi apabila tekanan darah sistolik >140 mmHg dan tekanan diastolik >90 mmHg. Pada penderita hipertensi harus menjalani terapi dengan minum obat untuk mengontrol tekanan darah agar tidak tercetus komplikasi dari penyakit hipertensi. Dari data yang terdapat di Puskesmas Kintamani I masih terdapat banyak warga di wilayah Kintamani yang menderita hipertensi. Kepatuhan dalam menjalani pengobatan hipertensi sangat penting agar gejala hipertensi dapat dikontrol. Adapun beberapa faktor yang dapat mempengaruhi kepatuhan pasien minum obat seperti tingkat pengetahuan, pendidikan, dan demografi. Tujuan penelitian ini dilaksanakan agar dapat melihat gambaran kepatuhan minum obat hipertensi pada penderita hipertensi di wilayah Kintamani I.Penelitian ini adalah deskriptif cross-sectional. Responden yang menjadi subjek penelitian ini merupakan penduduk yang menderita hipertensi di wilayah kerja Puskesmas Kintamani I. Pengambilan data dilakukan pada tanggal 22 - 29 Mei 2015. Teknik sampling yang digunakan merupakan teknik simple random sampling dengan jumlah sample sebanyak 50 orang.Hasil penelitian ini secara umum menunjukkan sebanyak 30% pasien mempunyai kepatuhan tinggi terhadap minum obat hipertensi sedangkan sisanya sebesar 70% pasien mempunyai kepatuhan rendah. Untuk mendukung angka keberhasilan pengobatan hipertensi dapat dilakukan dengan adanya penyuluhan penyakit hipertensi sehingga kepatuhan minum obat penderita hipertensi dapat meningkat.
Gambaran perilaku masyarakat dalam pemberantasan sarang nyamuk demam berdarah dengue (PSN DBD) dan kemampuan mengamati jentik di wilayah kerja Puskesmas Banjarangkan II Rubagan Chelvam; I Gede Ngurah Indraguna Pinatih
Intisari Sains Medis Vol. 8 No. 3 (2017): (Available online: 1 December 2017)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (225.756 KB) | DOI: 10.15562/ism.v8i3.136

Abstract

Dengue Hemorrhagic Fever (DHF) is a disease caused by dengue virus infection which transmitted through Aedes aegypti mosquito bite and still a public health problem in tropical or subtropical areas worldwide.  One of the efforts which are considered appropriate in the prevention and eradication of DHF through cut the chain of transmission and controlling the vectors by eradication of mosquito nest caused Dengue Hemorrhagic Fever (PSN DBD). This study used cross sectional design in Puskesmas Banjarangkan II to describe the people’s behavior in eradicating mosquito nest caused DHF. Minimum sample size is 35 people which cover 6 villages and 26 hamlets (banjar)/environments in it. The results showed respondents who have poor PSN DBD behavior aound 57.1% and good around 42.9%. Based on the ability to monitor larvaes, respondents who have poor capabilities to observing it around 62.9% whereas who having good capabilitiesapproximately 31.1%. Accordingly, it can be concluded most of the people who included within the scope of Puskesmas banjarangkan II have poor PSN DBD capabilities as well as observing larvae so that it is necessary to do some attempts to overcome it. 
Entitas histopatologi penderita perdarahan uterus terkait gangguan hormonal di Laboratorium Patologi Anatomi Rsup Sanglah tahun 2014 -2018 Ida Ayu Eugenia Natasha Blanco Oka; IGA Sri Mahendra Dewi; Herman Saputra; Indraguna Pinatih; Indraguna Pinatih
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.071 KB) | DOI: 10.15562/ism.v10i2.383

Abstract

Introduction: Dysfunctional uterine bleeding (DUB) is a major cause of a significant burden of health care for women, their families, and the community as a whole, leading to high morbidity for women who experience it. The purpose of this study is to determine the prevalence, characteristics of patients, and histopathological description in patients with DUB. Method: This study uses a secondary data analysis method in the medical record data of patients with DUB who has been histopathologically examined at the Anatomy Pathology Laboratory, Sanglah General Hospital Denpasar in the period 2014 to 2018.Result: From the period 2014 to 2018, 24 cases of DUB were found, the highest number was found in the pre menopause age (41-50 years) in 15 cases (62.5%), based on the type of estrogen related bleeding hormonal disorders in 17 cases (70.8%), and 7 cases of progesterone related bleeding (29.2%). The most histopathological type in the estrogen related bleeding group was 13 disordered proliferative phases (54.2%). In the group with progesterone related bleeding, the highest histopathological picture was irregular shedding in 5 cases (20.8%).Conclusion: Estrogen related bleeding pattern still dominating the histopatological pattern in the dysfunctional uterine bleeding at Pathology Anatomy Laboratory, Sanglah General Hospital period 2014-2018.
Entitas histopatologi penderita perdarahan uterus terkait gangguan hormonal di Laboratorium Patologi Anatomi Rsup Sanglah tahun 2014 -2018 Ida Ayu Eugenia Natasha Blanco Oka; IGA Sri Mahendra Dewi; Herman Saputra; Indraguna Pinatih; Indraguna Pinatih
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.071 KB) | DOI: 10.15562/ism.v10i2.383

Abstract

Introduction: Dysfunctional uterine bleeding (DUB) is a major cause of a significant burden of health care for women, their families, and the community as a whole, leading to high morbidity for women who experience it. The purpose of this study is to determine the prevalence, characteristics of patients, and histopathological description in patients with DUB. Method: This study uses a secondary data analysis method in the medical record data of patients with DUB who has been histopathologically examined at the Anatomy Pathology Laboratory, Sanglah General Hospital Denpasar in the period 2014 to 2018.Result: From the period 2014 to 2018, 24 cases of DUB were found, the highest number was found in the pre menopause age (41-50 years) in 15 cases (62.5%), based on the type of estrogen related bleeding hormonal disorders in 17 cases (70.8%), and 7 cases of progesterone related bleeding (29.2%). The most histopathological type in the estrogen related bleeding group was 13 disordered proliferative phases (54.2%). In the group with progesterone related bleeding, the highest histopathological picture was irregular shedding in 5 cases (20.8%).Conclusion: Estrogen related bleeding pattern still dominating the histopatological pattern in the dysfunctional uterine bleeding at Pathology Anatomy Laboratory, Sanglah General Hospital period 2014-2018.
Co-Authors A. A. G. P. Wiraguna A. Santosa Adiputra, I Made Sudarma Anak Agung Ayu Ngurah Susraini Anak Agung Gde Putra Wiraguna Anak Agung Gde Putra Wiraguna Anak Agung Mas Putrawati Triningrat Ariastuti, Luh P. Ariesanti Tri Handayani, Ariesanti Tri Azri Hazwan Bunge Dianmentari Citra Anggraeny Devita Horax Dhumaranang, Hyangayu Dedari Dyah Pradnyaparmita Duarsa Fanny Rustandi Felicia Hartono Felix Kusmana Gede Putra IGN Gian Lisuari Adityasiwi Gina Septivani H Da Silva Hayatul Firi Herman Saputra I Dewa Nyoman Wibawa I Gede Widyatmika Pratama I Gusti Agung Triana Suharidewi I Gusti Ayu Sri Mahendra Dewi I Gusti Made Aman I Made Krisna Dinata I MADE MULIARTA . I Made Suganda Yatra I MADE SUTARGA I Putu Adiartha Griadhi I Putu Gede Adiatmika I Wayan Gede Artawan Eka Putra I Wayan Gede Jayanegara I Wayan Weta Ida Ayu Eugenia Natasha Blanco Oka Ida Bagus Ngurah IKG Muliartha Imtihanatun Najahah Jaeynisha Mathavan Kadek Tresna Adhi Ken Andrina Anindita Ketut Pramana Adiputra Ketut Tirtayasa Luh Made Indah Sri Handari Adiputra Luh Seri Ani Made Agus Kusumadjaja Makbullah - Marthin Alexander Rocky Muh. Irfan Muhammad Syairozi Hidayat Mulyanto Munawwarah, Muthiah Ni Made Ari Sukmandari Ni Made Septiari Maryani Ardi Ni Wayan Septarini Ni Wayan Trisnadewi, Ni Wayan NT Suryadhi Ompusunggu, Hillary Sekarningrum P., Gede Odi Bayu D. Pande Made Respa Dharma Syantih Pande Putu Januraga Pradnyaparamita, Dyah Putu Adhi Surya Pradana Rubagan Chelvam Samantha Celena Triadi Sawitri, Anak Agung Sagung Sriwiyanti Sriwiyanti Susy Purnawati Thivyadharshini Uvaraju Triyanto Nugroho Wahyuddin, Wahyuddin Widhayanthi, Trisna A. Wimpie I Pangkahila