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All Journal Jurnal Sain Veteriner Jurnal Akademika Biologi Pro-Life E-Dimas: Jurnal Pengabdian kepada Masyarakat Jurnal Biologi Tropika Indonesia Journal of Halal NICHE Journal of Tropical Biology Jurnal Surya Masyarakat Scripta Biologica To Maega: Jurnal Pengabdian Masyarakat Jurnal Surya Masyarakat Prosiding Konferensi Nasional PKM-CSR Jurnal Pengabdian Vokasi Jurnal Teknologi Pangan E-Amal: Jurnal Pengabdian Kepada Masyarakat
Siti Nur Jannah
Biotechnology Laboratory, Departement Of Biology, Faculty Of Science And Mathematics, Diponegoro University
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Nursing Public Health Social Sciences Veterinary Other

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Journal : Pro-Life

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STUDI HISTOLOGI PANKREAS TIKUS PUTIH (Rattus norvegicus L.) SETELAH PEMBERIAN CUKA DARI KULIT NANAS (Ananas comosus L. Merr) Christin Monica Hermawati; Agung Janika Sitasiwi; Siti Nur Jannah
Jurnal Pro-Life Vol. 7 No. 1 (2020): Maret
Publisher : Program Studi Pendidikan Biologi Fakultas Keguruan dan Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/jpvol6Iss2pp102

Abstract

Diabetes mellitus is a metabolic disease that occurs due to impaired insulin secretion caused by progressivedestruction of beta cells. Pineapple peel vinegar containing acetic acid and antioxidants has the potential to helpimprove the structure of beta cells in the Langerhans islet. This study aims to examine the effectiveness of pineapplepeel vinegar towards the histological improvement of Langerhans islet in diabetic rats. Twenty-four rats weredivided into 6 groups, normal control, positive control (diabetes + 0,4 ml apple vinegar), negative control(diabetes + water), test groups dose I, II, and III (0,2 ml; 0,4 ml; 0,8 ml pineapple vinegar). The treatment groupthat given 0.4 ml pineapple peel vinegar showed improvement in islet's structure as indicated by its size andnumber that close to normal. The results of the statistical analysis using Kruskal-Wallis followed by Mann-Whitneyshowed that the diameter of the Langerhans islet in group P2 (treated by 0,4 ml pineapple peel vinegar) was closeto normal. The improved structure of the Langerhans islet resulted in a decrease in blood sugar levels by 41,63%.This percentage is still lower than the K+ group (treated by 0,4 ml apple vinegar) by 52,89%. The antioxidantactivity in vinegar improves the structure of the Langerhans islet by binding to free radicals that cause damage.The acetic acid in vinegar inhibits disaccharidase activity so that it can control blood sugar levels.Keywords: Diabetes mellitus, alloxan, pineapple peel vinegar, antioxidants, acetic acid
UJI AKTIVITAS ANTIDIABETES CUKA KULIT NANAS (Ananas comosus L. Merr.) PADA TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN Mohammad Affan Dwica Putra; Siti Nur Jannah; Agung Janika Sitasiwi
Jurnal Pro-Life Vol. 7 No. 2 (2020): Juli
Publisher : Program Studi Pendidikan Biologi Fakultas Keguruan dan Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/jpvol6Iss2pp102

Abstract

Diabetes mellitus is a metabolic disorder characterized by increased levels of glucose in the blood (hyperglycemia). The increasing number of diabetics in the world encourages the discovery of certain drugs that are effective and relatively safe for managing diabetes. One alternative medicine that can be used is vinegar. Pineapple skin can be an alternative raw material for making vinegar because it contains a large amount of sugar and contains acetic acid and various secondary metabolites that can reduce blood glucose levels. The purpose of this study was to determine whether pineapple skin vinegar has antidiabetic activity. The test was carried out by dividing each of the 4 rats into six groups namely normal control, positive control, negative control, and three test groups that were given pineapple skin vinegar as much as 0.2, 0.4, and 0.8 cc. The treatment was carried out for 28 days, starting 4 days after induction of an alloxan dose of 150 mg / kg body weight. Measurement of blood glucose and body weight of rats were carried out before induction, after induction, and on the 7th, 14th, 21st, and 28th day, while the measurement of feed consumption was carried out every day starting from the day of pineapple skin vinegar administration. The results of the analysis showed that the administration of pineapple skin vinegar by 0.4 cc with acetic acid levels of 1.43% can reduce blood glucose levels most significantly that is 41.63%.Keywords: vinegar, pineapple skin, acetic acid, antidiabetic
Co-Authors Agung Janika Sitasiwi Alina Akhdiya Ana Bila Nadia Anindya Ardiansari Annisa Dhea Lathifa Annisa Yulina Susilowati Bodhicitta Wardaja Budi Raharjo Budi Setiyana Christin Monica Hermawati Dwi Handayani Hendrawati Retno Wulandari Hermawan Dwi Ariyanto Hermin Pancasakti Kusumaningrum Hermin Pancasakti Kusumaningrum Ilyas Teguh Pangestu Indriana Putri Khoirin Nisa MG Isworo Rukmi Mohamad Endy Y Yulianto Mohammad Affan Dwica Putra Peni Koriasih Rejeki Siti Ferniah Rizky Wahyu Saputro Salindri Prawitasari SRI ISDADIYANTO Sri Pujiyanto Sri Pujiyanto Sri Rustini Sulistiani Sulistiani Sulistiani Susiana Purwantisari Tazkia Annisa Widayu Mutiya Ramadhani Yunior William Susanto