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All Journal Paediatrica Indonesiana Oto Rhino Laryngologica Indonesiana eJournal Kedokteran Indonesia Prosiding University Research Colloquium
Safitri, Eka Dian
Clinical Epidemiology And Evidence Based Medicine Unit, Faculty Of Medicine, University Of Indonesia / Cipto Mangunkusumo Hospital, Jakarta
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health

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Round window sealing with steroid-soaked sponge in sudden sensorineural hearing loss Putranto, Fikri Mirza; Safitri, Eka Dian; Shafira, Ardys
Oto Rhino Laryngologica Indonesiana Vol. 54 No. 1 (2024): VOLUME 54, NO. 1 JANUARY - JUNE 2024
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v54i1.654

Abstract

Background: A rescue treatment is needed in cases of Sudden Sensorineural Hearing Loss (SSNHL)which fail to obtain complete hearing restoration after conservative steroid therapy. In order to acquirebetter access of steroid to the cochlea, sealing the round window with a sponge soaked in steroid couldbe considered as an alternative delivery strategy. Purpose: To review the evidence about the impact ofround window sealing in SSNHL patients whose hearing failed to recover completely after treated withsystemic and/or intratympanic steroid. Cases: Seven patients with SSNHL, who had experienced either noor slight response to previous systemic and/or intratympanic steroid administration, underwent transcanalround window sealing with steroid-soaked sponge. Pure Tone Audiometry (PTA) results and symptoms(hearing loss, tinnitus, vertigo) were compared pre- and post-operatively. Five patients reported betterhearing and tinnitus symptom. Method: A scoping review was made by conducting literature searchingat Cochrane, Pubmed, and Google Scholar using keywords “sudden sensorineural hearing loss”, AND“round window sealing”, and their relevant synonymous terms, employing Boolean operators. Result: Atotal of 8 observational studies with 430 subjects met the inclusion criteria. Time measurement of hearingimprovement range from 6 days until 1 year. Most of the studies agreed that the procedure of sealingthe round window had a positive impact on hearing improvement. Conclusion: This study revealed thatround window sealing with steroid-soaked sponged could be considered as an alternative approach forpatients with SSNHL who failed in conservative therapy.   Keywords: “round window sealing; sudden sensorineural hearing loss; transtympanic steroid”    
Peran radioterapi lokoregional pada kasus karsinoma nasofaring dengan metastasis jauh: laporan serial kasus berbasis bukti Ika Dewi Mayangsari; Muhammad Ade Rahman; Marlinda Adham; Gregorius Ben Prajogi; Rahmat Cahyanur; Eka Dian Safitri
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 2 (2023): VOLUME 53, NO. 2 JULY - DECEMBER 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i2.638

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a highly metastatic head and neck cancer primarilytreated with platinum-based chemotherapy. The oligometastasis hypothesis proposed by Hellman andWeichselbaum suggested that controlling the primary tumor through locoregional radiotherapy couldsignificantly improve prolonged disease-free survival. Purpose: To evaluate the effectiveness of combining locoregional radiotherapy with chemotherapy for metastatic NPC. Case series report: The first case involved a 57-year-old male with NPC at T4N3M1 (lungs) with partial response to chemotherapy, who then underwent concurrent chemoradiotherapy. However, his condition deteriorated after completing chemoradiation. The second case featured a 56-year-old male with NPC at T4N3M1 (liver), exhibiting partial response to chemotherapy and remaining at a stable condition after concurrent chemoradiotherapy. Method: Using specific keywords based on clinical questions in the PubMed, Cochrane, EBSCOhost, and Proquest databases. Inclusion criteria, exclusion criteria, and critical appraisal were carried out to find relevant studies. Result: Eleven articles were appraised critically based on the Oxford Centre for Evidence-based Medicine (CEBM) worksheet and include the validity, importance, and applicability in clinical scenarios. Conclusion: Metastatic NPC patients had better overall survival outcomes when treated with locoregional radiotherapy and systemic chemotherapy. Predictive factors influencing survival included oligometastasis, locoregional radiotherapy, chemotherapy response, lactate dehydrogenase, C-reactive protein, EBV DNA, total chemotherapy administration, Karnofsky performance score, number of metastatic lesions, and liver metastases. Platinum-based chemotherapy combined with locoregional radiotherapy could be considered as a management approach for cases of oligometastatic NPC.Keywords: nasopharyngeal carcinoma, chemotherapy, metastasis, overall survival, radiotherapy
Co-Authors Aldri Frinaldi Amanda R. McCullough Ayu Astria Sriyana Christopher B. Del Mar Dwiyani, Kartika Elaine M. Beller Gregorius Ben Prajogi Ika Dewi Mayangsari Irfan Irfan Kartika Dwiyani Lazarus, Gilbert Manalu, Josua Marlinda Adham Marpaung, Dora A Mayangsari, Ika Dewi Muhammad Ade Rahman Prajogi, Gregorius Ben Priyono, Harim Putranto, Fikri Mirza Rahman, Muhammad Ade Rahmat Cahyanur Ranakusuma, Respati Wulansari Rangga Rayendra Saleh Ratna Dwi Restuti Reksodiputro, Mirta Hediyati Respati Wulansari Ranakusuma Restuti, Ratna Dwi S Slamet, S Saleh, Rangga Rayendra Shafira, Ardys Sriyana, Ayu Astria Widodo, Dini Widiarni Widyaningsih Widyaningsih Yulian Wahyu Permadi Yupitri Pitoyo Yupitri Pitoyo