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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Indonesia
RAMADON, DELLY
Laboratorium Farmasetika Dan Teknologi Farmasi, Fakultas Farmasi Universitas Indonesia, Kampus UI Depok, 16424, Jawa Barat
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health

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Pemanfaatan Nanoteknologi dalam Sistem Penghantaran Obat Baru untuk Produk Bahan Alam DELLY RAMADON; ABDUL MUN’IM
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2157.535 KB)

Abstract

Sejak dahulu banyak ekstrak dari bahan alam yang secara empiris dimanfaatkan untuk pengobatan. Ekstrak-ekstrak tersebut digunakan karena mengandung senyawa bioaktif yang dapat memberikan efek farmakologis. Isolat dari ekstrak tersebut diuji baik secara in vitro maupun in vivo untuk mengetahui efek dan bioavailabilitas dalam tubuh secara ilmiah. Namun demikian diperkirakan lebih dari 40% senyawa bahan alam memiliki kelarutan yang rendah di dalam air atau bahkan memberikan toksisitas yang tinggi. Kelarutan yang rendah di dalam air serta kurangnya kemampuan permeabilitas menembus barrier absorpsi dapat mempengaruhi bioavailabilitas senyawa bahan alam di dalam tubuh. Tidak hanya itu, bioavailabilitas suatu senyawa juga sangat dipengaruhi oleh stabilitas terhadap pH lambung dan kolon, metabolisme oleh mikroflora normal dalam saluran pencernaan, absorpsi melalui dinding usus, mekanisme aktif pompa efflux dan metabolisme lintas pertama. Solusi dari permasalahan tersebut adalah dengan mengembangkan sistem penghantaran obat yang dikenal dengan sistem penghataran obat baru (novel drug delivery system). Sistem penghantaran obat baru merupakan suatu sistem penghantaran obat yang lebih modern dengan cara mengontrol pelepasan obat sehingga aktivitas farmakologis menjadi lebih baik. Pembuatan sediaan berbasis teknologi baru ini dapat menjadi alternatif dalam pembuatan produk herbal dan diharapkan bioavailabilitas produk herbal dalam tubuh menjadi lebih baik sehingga dapat memberikan efek terapi yang lebih baik
Untargeted LC-QTOF-MS/MS Based Metabolomic Profile Approach of Bacterial Ferment Lysates and Skin Commensal Bacterial Cocktail Ferment Lysates Ahmad Baikuni; Fathan Luthfi Hawari; Sutriyo; Delly Ramadon; Amarila Malik
HAYATI Journal of Biosciences Vol. 30 No. 3 (2023): May 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.3.576-587

Abstract

Microbial therapy has been increasingly developed in the medical and health fields and has triggered advances in the process of formulating skincare products. The skin microbiota becomes the target in the development of active ingredients to produce an optimal effect in the balance of its composition which leads to its usefulness in maintaining skin health and providing protection. Postbiotic bacteria can maintain homeostasis of the skin microbiome so that it has the potential to be used as an active ingredient in Active Pharmaceutical Ingredient (API) in skincare products and have broad benefits due to its various active substances. The aim of this study was to examine the metabolites profile contained in the bacterial fermented lysate fraction, which is also served as a marker in identifying the metabolite variations of the lysate fractions and their API dosage forms. Ferment lysate API preparations were prepared in the form of freeze dried and spray dried. The metabolite profile analysis was carried out using the untargeted LC-QTOF-MS/MS metabolomic approach and multivariate analysis. Result revealed 30 differential features of the putative metabolites, and by performing metabolites annotationfor their bioactivities through intensive literature research, such as antimicrobial, antioxidant, and anti-inflammatory, we elucidated these compounds are discovered in dry form of lysates.
Transdermal Delivery of Ketoprofen for Osteoarthritis Treatment and Management: A Literature Review on Current Progression Ramadhani, Dwi Asih; Harahap, Yahdiana; Sagita, Erny; Permata Sari, Kartika Citra Dewi; Andranilla, Rr. Kirana; Trisina, Jessica; Punu, Gabriella Frederika; Ramadon, Delly
Pharmaceutical Sciences and Research Vol. 11, No. 1
Publisher : UI Scholars Hub

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Abstract

Arthritis, a diverse spectrum of joint disorders, is characterized by chronic pain and inflammation. Osteoarthritis (OA), the most prevalent form, leads to disabling pain, functional limitations, and reduced mobility. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for managing OA pain, with ketoprofen recognized as one of the effective options. However, oral administration of ketoprofen may cause gastrointestinal irritation. Addressing this issue, Transdermal Drug Delivery Systems (TDDS) emerge as a promising alternative route of administration. TDDS facilitates delivery of various drugs through the skin without undergoing first-pass metabolism. Recent studies have centered on enhancing ketoprofen’s transdermal delivery, particularly focusing on different methods (such as patches, gels, electroporation technology, and stratum corneum bypass methods), with microneedles emerging as a promising approach for delivering anti-inflammatory drugs through transdermal routes. This review aims to explore recent advancements in transdermal drug delivery systems for managing OA. The utilization of transdermal ketoprofen presents innovative opportunities for future research and development in novel drug delivery systems.
Solid Lipid Nanoparticles (SLN): Formulation and Fabrication Punu, Gabriella F.; Harahap, Yahdiana; Anjani, Qonita Kurnia; Hartrianti, Pietradewi; Donnelly, Ryan F.; Ramadon, Delly
Pharmaceutical Sciences and Research Vol. 10, No. 2
Publisher : UI Scholars Hub

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Abstract

Solid lipid nanoparticles (SLN) have emerged as a novel drug delivery system and have been utilized for delivering various kinds of drugs since the 1990s. These particles may consist of multiple solid lipids, including glycerides, waxes, and fatty acids, and can be stabilized by a wide range of surfactants. SLN have garnered significant attention from researchers due to its innovative and versatile nature. Moreover, such delivery system has numerous advantages over traditional colloidal carriers, such as liposomes, polymeric nanoparticles, and emulsions. Several research groups have been developing SLN formulations and fabrication techniques based on their intended purpose, and this research number is still increasing globally. Given the vast potential for the development of SLN in the future, coupled with the wide variety of materials and techniques to be considered during the manufacturing process, this paper provides an extensive overview of the general introduction of SLN, their benefits and drawbacks, and the numerous excipients which can be associated with the SLN formulation. Various aspects related to the models of drug incorporation and fabrication methods are also systematically discussed in this review. In addition, an analysis of the factors that impact the stability of the SLN will also be documented to provide further insight for future advancements in SLN research.
Pengaruh Antioksidan dan Kombinasi Pengawet terhadap Stabilitas Ekstrak Cair NADES Biji Kopi Hijau Ramadon, Delly; Septiani, Rosalina Mesusi; Putri, Salsabila Nursyifa; Mun'im, Abdul
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (715.158 KB) | DOI: 10.35617/jfionline.v13i2.64

Abstract

Green coffee beans (Coffea canephora Pierre ex A. Froehner) contain caffeine and chlorogenic acid which are beneficial for health. These two main ingredients can be extracted using Natural Deep Eutectic Solvents (NADES) in combination with the Ultrasound-Assisted Extraction (UAE) method which is environmentally friendly. NADES can be used for extracting green coffee beans, but the solvent cannot be evaporated, thus the result is a liquid extract. During storage, liquid extracts are susceptible to oxidation and bacterial growth so that they can disrupt physical, chemical, and microbiological stabilities. In this study, butylated hydroxytoluene (BHT) was added as a synthetic antioxidant and a combination of methylparaben-propylparaben as preservative to determine its effect on the physical, chemical, and microbiological stability of the NADES liquid extract of green coffee beans, as well as to determine the best storage temperature. The concentrations of BHT added in this study were 10, 20, and 30 ppm. The concentration of the methyl paraben:propyl paraben combination added was 110:55 ppm, 100:50 ppm, and 90:45 ppm. Each extract was stored at storage temperatures of -20°C ± 5°C, 5°C ± 3°C, and 30°C ± 2°C for 54 days. The results showed that the liquid extract added with 30 ppm BHT concentration and a combination of preservatives with a concentration of 110:55 ppm and stored at a storage with the temperature of -20°C ± 5°C which had the best physical, chemical, and microbiological stability. This shows that the addition of BHT and a combination of preservatives can increase the stability of the green coffee bean NADES extract.
Co-Authors ABDUL MUN’IM Ahmad Baikuni Amarila Malik Andranilla, Rr. Kirana Anjani, Qonita Kurnia Donnelly, Ryan F. Erny Sagita, Erny Fathan Luthfi Hawari Hartrianti, Pietradewi Mun'im, Abdul Permata Sari, Kartika Citra Dewi Punu, Gabriella F. Punu, Gabriella Frederika Putri, Salsabila Nursyifa Ramadhani, Dwi Asih Septiani, Rosalina Mesusi Sutriyo Trisina, Jessica Yahdiana Harahap