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All Journal MEDIA MEDIKA INDONESIANA Jurnal Kedokteran Brawijaya Folia Medica Indonesiana Sari Pediatri Universa Medicina Paediatrica Indonesiana Biomolecular and Health Science Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Cermin Dunia Kedokteran MEDICINUS
Darto Saharso
Divisi Syaraf Anak, Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Airlangga - RSUD Dr. Soetomo, Jl. Mayjen Prof. Dr. Moestopo 6-8, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Dysentry from gastroenteritis in infancy Pitono Soeparto; Liek Djupri; Haroen Noerasid; Darto Saharso
Paediatrica Indonesiana Vol 21 No 7-8 (1981): July - August 1981
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (544.23 KB) | DOI: 10.14238/pi21.7-8.1981.161-7

Abstract

Sixty three infants aged below 3 years suffering from dysentery form gastroenteritis were investigated. The investigation included clinical symptoms, course of the disease, stool ova and parasites and stool cultures for enterobacterial pathogens.Stool examinaJions revealed: 25.4% Entamoeba histolytica, 22.2% E.E. coli, 15.9% Salmonellae, 1.6% E.E. coli and Salmonella, 1.6% E.E. coli and E. histolytica and 1.6% Staph. aureus.The etiologic agent in the remaining 31.8% oj the patients remained unknown.The clinical features, the possible pathogenesis and treatment of the discovered pathogens are briefly discussed.
Giant brain aneurysm in a two–year–old girl Prastiya Indra G; Hapsari Kusumawardani; Darto Saharso
Paediatrica Indonesiana Vol 50 No 4 (2010): July 2010
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1128.316 KB) | DOI: 10.14238/pi50.4.2010.252-8

Abstract

Brain aneurysm is an abnormal outward bulging of one of the brain arteries. Brain aneurysms are often discovered when they rupture, causing bleeding into the brain or the space surrounding the brain called the subarachnoid space. This subarachnoid hemorrhage can lead to hemorrhagic stroke, brain damage and death.1The aneurysm can present in all ages, but mainly after 50 year of age (ages 35 – 60), and exists a greater predisposition in females, with a ratio 3:2.2 Intracranial aneurysms in children are rare. About 0.5-4.6% of all aneurysms in children distinctly differ from adult, especially in male (2:1 to 3:1).3,4,5,6These injuries are located mainly in any cerebral artery specifically in those related to the well-known Circles of Willis such as internal carotid, middle cerebral and anterior cerebral artery as well as anterior communicating artery that corresponds to anterior circulatory circuit. In the posterior region they can be observed above the posterior cerebral artery, vertebral and basilar arteries, mainly. Aneurysm in children is mostly located at the bifurcation of ICA or vertebra-basilar artery posterior circulation, yet disproportionately with high incidence of posterior circulation aneurysm (40-50%) and of giant aneurysm (30-45%)
Correlation of Vitamin D and Calcium Levels in Children in New Diagnosed Epilepsy and Minimal 6 Months After Therapy Niluh Suwasanti; Aryati Aryati; Darto Saharso; Ferdy Royland Marpaung
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1348

Abstract

INTRODUCTION. Children with epilepsy should take long-term anti-epileptic drugs. Long-term use of anti-epileptic drugs can reduce vitamin D levels. Low vitamin D will lead to low blood calcium levels. This study aims to analyze the relationship between vitamin D and calcium levels in newly diagnosed epileptic children and ≥6 months after therapy. METHOD. These was an analytical observational study with cross sectional research design. The vitamin D examination instrument uses the ELFA method (enzyme linked fluorescent assay) with the Vidas instrument from bioMerieux. Samples were collected during June - August 2018 from Inpatient and Outpatient Clinics. The samples were divided into new diagnosis of epilepsy group and 6 months after therapy group. Each group was measured for vitamin D and serum calcium levels. The relationship between the two parameters were analyzed using T-Test independent. RESULTS. From the 19 new diagnosis of epilepsy, there were 57.9% low vitamin D and 10.5% low calcium levels. From the 20 subjects 6 months after therapy, 70% low vitamin D and 25% low calcium levels. There were a relationship between vitamin D and calcium levels in patients with newly diagnosed and ≥6 months after therapy. DISCUSSION. Low vitamin D and low calcium levels were found more in the anti-epileptic therapy group than the new diagnosis group of epilepsy. Low vitamin D levels can be caused by the use of long-term antiepileptic drugs that will affect serum calcium levels. CONCLUSION. This study showed a significant relationship between vitamin D and serum calcium levels in patients with newly diagnosed epilepsy and 6 months after therapy. Vitamin D and calsium serum examination should be done in every patient who gets long term therapy of antiepileptic drugs. KEY WORDS. Vitamin D, calcium, epilepsy, ELFA. 
A case of juvenile dermatomyositis responding to methotrexate and steroid Prastiya Indra Gunawan; Darto Saharso
Cermin Dunia Kedokteran Vol 44, No 6 (2017): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v44i6.793

Abstract

A 4-year-old patient presented with skin rash and weakness. She was diagnosed with juvenile dermatomyositis based on Bohan and Peter criteria and laboratory result. The treatment consist of steroid combined with methotrexate. The response is good.Pasien anak perempuan berusia 4 tahun dengan keluhan bercak kemerahan di kulit dengan kelumpuhan. Pasien didiagnosis juvenile dermatomyositis berdasarkan kriteria Bohar dan Peter dan hasil laboratorium. Pasien mendapat terapi steroid dikombinasi dengan methotrexate, menunjukkan hasil baik.
Correlation of Vitamin D and Calcium Levels in Children in New Diagnosed Epilepsy and Minimal 6 Months After Therapy Niluh Suwasanti; Aryati Aryati; Darto Saharso; Ferdy Royland Marpaung
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1348

Abstract

Children with epilepsy should take long-term anti-epileptic drugs. Long-term use of anti-epileptic drugs can reduce vitamin D levels. Low vitamin D will lead to low blood calcium levels. This study aims to analyze the relationship between vitamin D and calcium levels in newly diagnosed epileptic children and ≥6 months after therapy. These was an analytical observational study with cross sectional research design. The vitamin D examination instrument uses the ELFA method (enzyme linked fluorescent assay) with the Vidas instrument from bioMerieux. Samples were collected during June - August 2018 from Inpatient and Outpatient Clinics. The samples were divided into new diagnosis of epilepsy group and 6 months after therapy group. Each group was measured for vitamin D and serum calcium levels. The relationship between the two parameters were analyzed using T-Test independent. From the 19 new diagnosis of epilepsy, there were 57.9% low vitamin D and 10.5% low calcium levels. From the 20 subjects 6 months after therapy, 70% low vitamin D and 25% low calcium levels. There were a relationship between vitamin D and calcium levels in patients with newly diagnosed and ≥6 months after therapy. Low vitamin D and low calcium levels were found more in the anti-epileptic therapy group than the new diagnosis group of epilepsy. Low vitamin D levels can be caused by the use of long-term antiepileptic drugs that will affect serum calcium levels. This study showed a significant relationship between vitamin D and serum calcium levels in patients with newly diagnosed epilepsy and 6 months after therapy. Vitamin D and calsium serum examination should be done in every patient who gets long term therapy of antiepileptic drugs.    
Faktor Risiko Disabilitas Berat pada Anak dengan Guillain-Barré Syndrome di RSUD Dr. Soetomo Surabaya Ratih Dwi Andini; Darto Saharso; Prastiya Indra Gunawan
MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.648 KB) | DOI: 10.56951/medicinus.v34i1.48

Abstract

Latar Belakang: Guillain-Barré Syndrome (GBS) merupakan penyebab paralisis neuromuskular akut yang paling sering ditemukan. Prognosis anak-anak dengan GBS pada umumnya tergolong baik, namun terdapat kemungkinan prognosis buruk yang membutuhkan ventilasi mekanis dan mengakibatkan terjadinya defisit neurologis. Penelitian ini bertujuan untuk mengamati faktor risiko disabilitas yang berpengaruh pada anak dengan GBS di RSUD Dr. Soetomo Surabaya. Metode: Penelitian ini menggunakan desain cross-sectional yang dilakukan pada anak dengan GBS, menggunakan data yang diperoleh dari rekam medis. Outcome pasien selama perawatan pada penelitian ini adalah sembuh, disabilitas, dan meninggal. Analisis statistik menggunakan uji Chi-Square dengan nilai signifikansi p<0,05. Hasil: Sebanyak 61 anak dengan GBS memenuhi kriteria inklusi selama masa studi penelitian. Anak laki-laki didapatkan sebanyak 54,1% dan infeksi saluran pernafasan atas merupakan penyebab paling sering (73,8% kasus). Mean usia pada penelitian ini adalah 8,4(±3,79) tahun. Sebagian besar jenis GBS adalah acute inflammatory demyelinating polyradiculoneuropathy (AIDP) yakni sebanyak 89,1% kasus. Hasil analisis menunjukan bahwa pasien GBS yang mengalami gagal napas dengan penggunaan ventilasi mekanis, menunjukkan odds ratio terjadinya disabilitas berat sebesar 8,9(1/0,112) kali lebih besar dibandingkan pasien yang tidak menggunakan ventilasi mekanis. Kesimpulan: Penggunaan ventilasi mekanis merupakan faktor risiko terjadinya disabilitas berat pada anak dengan GBS.
Serum Level of 25-Hydroxyvitamin D in Children with Epilepsy Receiving Long-Term Antiepileptic Treatment Ismail, Chasan; Irawan, Roedi; Saharso, Darto
MEDICINUS Vol. 33 No. 2 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.621 KB) | DOI: 10.56951/medicinus.v33i2.59

Abstract

Background: Long-term treatment with antiepileptic drugs (AED) requires monitoring of potential side effects, one of them is the decreasing in serum vitamin D level. Low serum vitamin D level is also a global health problem in healthy children. There are conflicting results regarding the low serum vitamin D level in epileptic children due to treatment with AED. Purpose: This study aimed to compare serum vitamin D level between healthy children and children with epilepsy receiving long-term AED treatment in Soetomo General Hospital. Methods: This was a cross-sectional study conducted in the pediatric neurology clinic of Soetomo general academic hospital from August 2018 to July 2019. Subjects are children ages 2-18 years with epilepsy receiving AED treatment for over 6 months (n=22), with healthy children as control (n=22). Peripheral serum 25-hydroxyvitamin D level were measured using enzyme-linked fluorescence assay (ELFA) method. The differences of those groups were analyzed by comparing the mean of 25-hydroxyvitamin D level of both groups using Anova and T-test (95% CI). Results: Low serum vitamin D level were identified in 27% children with epilepsy and 13% healthy children. The mean of serum 25-hydroxyvitamin D level in children with epilepsy and healthy children was 21.5 ng/ml (SD 8.41) and 34.3 ng/ml (SD 10.09), respectively. There was a significant difference between groups (p<0.05). Conclusion: Children with epilepsy receiving long-term AED treatment have lower level of serum 25-hydroxyvitamin D than healthy children.
C-REACTIVE PROTEIN (CRP) AS A SUPPORTING MARKER OF ANTIBIOTIC EFFECTIVENESS ON CENTRAL NERVOUS SYSTEM (CNS) INFECTIONS Olevianingrum, Melawati; Yulistiani, Yulistiani; Saharso, Darto; Zairina, Nun
Folia Medica Indonesiana Vol. 51 No. 3 (2015): July - September 2015
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (87.093 KB) | DOI: 10.20473/fmi.v51i3.2821

Abstract

Infection of the central nervous system in pediatric patients have a high mortality as well as acute and chronic neurological sequelae. Signs of the disease are unclear, so cerebrospinal fluid (CSF) test is used as a gold standard for diagnosis, but the investigation has faced many obtacles. Empiric antibiotic therapy is the key factor in reducing morbidity and mortality. Microbiological culture result is obtained within 5-7 days. The effectiveness of empirical antibiotic use is questionable. Therefore, other investigations are conducted to determine the effectiveness of antibiotics by using one marker, the CRP. This study was to analyze CRP level in supporting antibiotic therapy effectiveness in pediatric patients with central nervous system (CNS) infections. A prospective cohort study was conducted to determine the relationship of CRP with other parameters, including clinical, microbiological and laboratory, in pediatric patients with central nervous system infections. Patients meeting blood samples criteria were taken before (H0), the third day (H3) and the fifth day (H5) after antibiotics administration. This study involved 10 patients with central nervous system infections (meningoencephalitis, encephalitis and encephalitis with cerebral edema). Six patients were male, with ages less than a year. Antibiotic treatment effectiveness was associated with improved condition of the patients' CRP level. It was 3.558 ±3.196 before (H0), 3.878±2.813 on the third day (H3) and 3.891±2.204 on the fifth day (H5) after antibiotic administration. Leukocyte levels were 13.680±1.660 before (H0), 17.832±7.213 on the third day (H5), and 10.546±3.671 on the fifth day (H5) after antibiotic administration. Pearson's correlation test analysis performed on CRP and WBC parameters showed H0 p=0.981, CRP and WBC H3 p=0.621, while CRP and WBC H5 obtained significance p=0.644. There was no significant correlation observed between CRP and WBC parameters before and after antibiotic administration. In conclusion, there was no correlation of CRP levels with clinical, laboratory and micobiological parameters in patients with central nervous system infections.
Co-Authors Ahmad Suryawan Aminuddin Harahap Aryati Aryati Atika Atika Dominicus Husada Emy, Emy Erny Erny Fatimah Indarso Ferdy Royland Marpaung Hapsari Kusumawardani Haroen Noerasid I Gusti Ngurah Twi Adnyana Ismail, Chasan Ismoedijanto Liek Djupri Melawati Olevianingrum, Melawati Moersintowarti BN Niluh Suwasanti Nun Zairina, Nun Nur Rochmah Pitono Soeparto Prastiya I. Gunawan Prastiya I. Gunawan, Prastiya I. Prastiya Indra G Prastiya Indra Gunawan Qorina Nadya Salfi Ratih Dwi Andini Retno Asih Setyoningrum Roedi Irawan Yulistiani Yulistiani, Yulistiani