Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Jurnal Surya Medika PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia
IKA PUSPITA SARI
UNIVERSITAS GADJAH MADA
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Kurkumin Analog, PGV-0 dan GVT-0 Menghambat Absorpsi Kolesterol dengan Penghambatan Aktivitas Enzim Li IKA PUSPITA SARI; ARIEF NURROCHMAD; IRFAN MURIS SETIAWAN; SARDJIMAN SARDJIMAN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.073 KB)

Abstract

Curcumin has been known to reduce cholesterol levels in hyperlipidemic state. Faculty of Pharmacy Universitas Gadjah Mada (UGM) synthesized curcumin analogues namely PGV-0 and GVT-0. Like curcumin, both PGV-0 and GVT-0 exhibit anti-inflammatory activities. The aims of this study were to determine the effect and the mechanism of curcumin analogues PGV-0 and GVT-0 on regulation of cholesterol levels in serum. This study was aimed to examine whether PGV-0 and GVT-0 affected cholesterol levels through cholesterol absorption which is regulated by lipase enzyme. To determine the reduction in cholesterol levels, rats were feed with high fat diet (HFD) for 45 days. PGV-0 and GVT-0 were given on day 31-45 at doses of 40 mg/kg bw and 60 mg/kg bw consecutively. Total cholesterol and lipase activity in serum were measured and then statistically analyzed using ANOVA and t-test. The increase of cholesterol levels was markedly reduced by the treatment with both curcumin analogues. Furthermore, lipase activity was clearly inhibited by the treatment with PGV-0 and GVT-0, suggesting that these compounds inhibit cholesterol levels through the reduction of lipase enzyme activity
Effective Empiric Antimicrobial Therapy of Bacterial Meningitis and Encephalitis Diyan Ajeng Rossetyowati; Ika Puspita Sari; Tri Murti Andayani; Titik Nuryastuti
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 02 Desember 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i2.13257

Abstract

Bacterial meningitis-encephalitis (ME) management therapy is critical to appropriately manage clinical outcomes. This study aims to provide recommendations on appropriate empiric antimicrobial to support the healing period and reduce the risk of disease severity. A cross-sectional study, including inpatients without comorbid diagnosed with bacterial ME, was conducted, and records of antimicrobial prescriptions were obtained. Sociodemographic, clinical (diagnostic), and pharmacological (antimicrobial) variables were assessed. Through multivariate analysis, variables associated with the use of antimicrobials for bacterial infections were identified. A total of 45 patients with ME. The patients, who were from surrounding Center Java and Yogyakarta, had a mean age of 11.27 ± 16.93 years and a male predominance of 56.9% (n = 23). The most frequent bacterial infections were caused by: S. haemolyticus and S. epidermidis (25.93%). A total of 100% the patients (n = 45) received a prescription for empiric antibiotics, predominantly 3rd generation cephalosporin e.c ceftriaxone (35.56%) and cefotaxime (13.33%). Empiric antimicrobials are frequently prescribed for the first management of bacterial ME, are considered an inappropriate practice due to a lack of clinical benefits, increased generation of antimicrobial resistance, and risk of adverse reactions due to the use of medications that patients do not require. Drug utilization studies are a great tool for monitoring how antimicrobial is being used and planning interventions to improve their use.
The Practice of Prolonging Meropenem Infusion: A Narrative Review of Literatures Over the Last Decade: The Practice of Prolonging Meropenem Infusion: A Narrative Review of Literatures Over the Last Decade Rifani Fauzi; Widyati Widyati; Ika Puspita Sari
Jurnal Surya Medika (JSM) Vol. 10 No. 1 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i1.7162

Abstract

Background: The emergence of Antimicrobial Resistance (AMR) has forced clinicians and medical professionals to implement a strict Antimicrobial Stewardship policy. One of the pillar of Antimicrobial Stewardship is by optimizing the use of antibiotic agents. Beta-lactams demonstrate a time-dependent effect in combating bacteria. Since it is pharmacodynamically supported, a prolonged exposure via intravenous administration could be a feasible strategy to maximize the bactericidal effect. Meropenem, a beta-lactam antibiotic of carbapenems sub-class, also falls into the category above. However, there are questions to be answered regarding its stability, compatibility, safety, and clinical outcomes superiority compared to the standard intermittent infusion, before we can determine its effectiveness to be delivered as prolonged or extended infusion. Aims: This article would like to review literatures regarding the rationale behind the practice of prolonging meropenem infusion from the last decade. Method: For this narrative review we utilized articles extracted from Cochrane Library, ScienceDirect, and SageJournals databases from the last ten years. We also added complementary related articles from UpToDate®. Selected articles were limited to those published in english. Inclusion criteria specifically only including related articles to the practice of prolonging meropenem infusion on adult patients. A total of 18 articles were reviewed for the synthesis of this narrative review. Conclusion: Meropenem is eligible for prolonged infusion protocol since it is theoretically supported, adequate in stability, less concern for incompatibility, and potentially can provide better clinical outcomes compared to standard intermittent infusion.
Co-Authors ARIEF NURROCHMAD Diyan Ajeng Rossetyowati Irfan Muris Setiawan Rifani Fauzi Sardjiman Sardjiman Titik Nuryastuti Tri Murti Andayani Widyati Widyati