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All Journal International Journal of Public Health Science (IJPHS) Majalah Farmaseutik PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia
IKA PUSPITA SARI
UNIVERSITAS GADJAH MADA
Biochemistry, Genetics & Molecular Biology Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Kurkumin Analog, PGV-0 dan GVT-0 Menghambat Absorpsi Kolesterol dengan Penghambatan Aktivitas Enzim Li IKA PUSPITA SARI; ARIEF NURROCHMAD; IRFAN MURIS SETIAWAN; SARDJIMAN SARDJIMAN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.073 KB)

Abstract

Curcumin has been known to reduce cholesterol levels in hyperlipidemic state. Faculty of Pharmacy Universitas Gadjah Mada (UGM) synthesized curcumin analogues namely PGV-0 and GVT-0. Like curcumin, both PGV-0 and GVT-0 exhibit anti-inflammatory activities. The aims of this study were to determine the effect and the mechanism of curcumin analogues PGV-0 and GVT-0 on regulation of cholesterol levels in serum. This study was aimed to examine whether PGV-0 and GVT-0 affected cholesterol levels through cholesterol absorption which is regulated by lipase enzyme. To determine the reduction in cholesterol levels, rats were feed with high fat diet (HFD) for 45 days. PGV-0 and GVT-0 were given on day 31-45 at doses of 40 mg/kg bw and 60 mg/kg bw consecutively. Total cholesterol and lipase activity in serum were measured and then statistically analyzed using ANOVA and t-test. The increase of cholesterol levels was markedly reduced by the treatment with both curcumin analogues. Furthermore, lipase activity was clearly inhibited by the treatment with PGV-0 and GVT-0, suggesting that these compounds inhibit cholesterol levels through the reduction of lipase enzyme activity
Effective Empiric Antimicrobial Therapy of Bacterial Meningitis and Encephalitis Diyan Ajeng Rossetyowati; Ika Puspita Sari; Tri Murti Andayani; Titik Nuryastuti
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 02 Desember 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i2.13257

Abstract

Bacterial meningitis-encephalitis (ME) management therapy is critical to appropriately manage clinical outcomes. This study aims to provide recommendations on appropriate empiric antimicrobial to support the healing period and reduce the risk of disease severity. A cross-sectional study, including inpatients without comorbid diagnosed with bacterial ME, was conducted, and records of antimicrobial prescriptions were obtained. Sociodemographic, clinical (diagnostic), and pharmacological (antimicrobial) variables were assessed. Through multivariate analysis, variables associated with the use of antimicrobials for bacterial infections were identified. A total of 45 patients with ME. The patients, who were from surrounding Center Java and Yogyakarta, had a mean age of 11.27 ± 16.93 years and a male predominance of 56.9% (n = 23). The most frequent bacterial infections were caused by: S. haemolyticus and S. epidermidis (25.93%). A total of 100% the patients (n = 45) received a prescription for empiric antibiotics, predominantly 3rd generation cephalosporin e.c ceftriaxone (35.56%) and cefotaxime (13.33%). Empiric antimicrobials are frequently prescribed for the first management of bacterial ME, are considered an inappropriate practice due to a lack of clinical benefits, increased generation of antimicrobial resistance, and risk of adverse reactions due to the use of medications that patients do not require. Drug utilization studies are a great tool for monitoring how antimicrobial is being used and planning interventions to improve their use.
Empirical Use of Cephalosporins in Pediatric Infections in Indonesia: A Systematic Review Melisa Rezki Puspitasari; Tifany Maulida Candra; Agung Endro Nugroho; Ika Puspita Sari
Majalah Farmaseutik Vol 22, No 2 (2026): in press
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i2.110356

Abstract

Cephalosporins, particularly third-generation agents like ceftriaxone, remain widely used in pediatric populations in Indonesia despite declining effectiveness due to high rates of ESBL-producing pathogens. This systematic review synthesized evidence on cephalosporin use, resistance patterns, and effectiveness in Indonesian children across various clinical settings, based on five studies published between 2019–2025. Data included study characteristics, patient profiles, indications, and outcomes. Ceftriaxone was the most common empirical choice for infections such as sepsis, pneumonia, and urinary tract infections. However, susceptibility of Escherichia coli and Klebsiella pneumoniae was often below 30%, whereas amikacin and meropenem maintained over 90% activity. Notably, one tertiary pediatric ward reduced ESBL prevalence after restricting ceftriaxone use, demonstrating the potential of targeted stewardship programs. The findings reveal a disconnect between prescribing practices and resistance data, emphasizing the need for real-time microbiological surveillance, updated pediatric empirical therapy guidelines, and improved prescriber education. Strengthening pediatric antimicrobial stewardship is crucial to preserving antibiotic effectiveness and optimizing clinical outcomes in children amid rising resistance.
User-centred socio-technical requirements for telehomecare in hospital-based homecare services in Indonesia: a qualitative study Iman Permana; Moch Zihad Islami; Winny Setyonugroho; Ika Puspita Sari; Janatarum Sri Handono; Sentagi Sesotya Utami
International Journal of Public Health Science (IJPHS) Vol 15, No 2: June 2026
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v15i2.26989

Abstract

The increasing number of homebound and bedridden patients in Indonesia illustrates the importance of effective hospital-based telehomecare. While telehomecare can improve access and continuity of care, its implementation depends on alignment with user needs. This study aimed to identify user-centered socio-technical requirements for telehomecare in hospital-based homecare services in Indonesia. A qualitative descriptive study was conducted using in-depth interviews and a focus group discussion with 12 purposively selected stakeholders. A telemonitoring device was used as a contextual probe. Data were analyzed using inductive thematic analysis with stakeholder triangulation. Three main areas of needs were identified: i) functional needs, which include constant monitoring, settings for specific diseases, early warning alerts, organized communication, and access to long-term data; ii) technical needs, like ease of use for older people, access through mobile devices, support for location tracking, easy-to-read dashboards, and compatibility with hospital information systems; and iii) data security, privacy, and making sure everyone can use the system, which involves dealing with. These findings help shape the design and growth of fair telehomecare systems in health settings with limited resources and provide real-world evidence from a low- and middle-income country.
Co-Authors Agung Endro Nugroho ARIEF NURROCHMAD Diyan Ajeng Rossetyowati Iman Permana Irfan Muris Setiawan Janatarum Sri Handono Melisa Rezki Puspitasari Moch Zihad Islami Sardjiman Sardjiman Setyonugroho, Winny Tifany Maulida Candra Titik Nuryastuti Tri Murti Andayani Utami, Sentagi Sesotya