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Siti Sofiah
Universitas Pancasila
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Formulasi Tablet Matriks Mukoadhesif Diltiazem Hidroklorida Menggunakan Hidroksi Propil Metil Selulosa dan Carbopol 940 Siti Sofiah; Faizatun Faizatun; Yulia Riyana
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 2 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Diltiazem hydrochloride has a half life of 3-4 hours and a bioavailability of 40%. The influence of a mixture of carbopol 940 and hydroxypropyl methyl cellulose as a mucoadhesive matrix on tablets made by the wet granulation method, had been determined by the dissolution and “wash off method. The result showed that increasing the concentration of carbopol 940 decreased the dissolution rate. The concentration of carbopol 940 and hydroxypropyl methyl cellulose in formula I (0%; 40%), II (5%; 35%), III (10%; 30%), IV (15%; 25%), and V (20%; 20%) released respectively 75,99%; 74,08%; 73,07%; 72,04%; and 71,29% diltiazem hydrochloride. The higher the concentration of carbopol 940 in acid solution, the shorter is the mucoadhesive action: 2 hours in formula I and II, and 1 hour in formula III, IV, and V. All of the formulas (pH 7,2) did not show a difference in mucoadhesive duration; after 8 hours, still attached to the mucosa of the small intestines.
Efek Antioksidan Larutan Kosolven Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) pada Tikus dengan Parameter MDA dan SOD ROS SUMARNY; LILIEK NURHIDAYATI; SITI SOFIAH; YATI SUMIYATI; FRANSISKA DIANA SANTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Mangosteen (Garcinia mangostana L.) rinds extract in capsule form has been marketed. a-mangostin, the active compound of G. mangostana had been known has low solubility in water. This study was aimed to measure and compare antioxidant effect of a-mangostin as cosolvent solution to extracts suspentions. 25 rats were divided into 5 groups: negative (I) and positive (II) control, cosolvent solution (III), extract (IV) and extract® (V). Treatment were given for 14 days, free radicals were induced by CCl . MDA were analyzed using thiobarbituric acid method while SOD by using adenochrome assay. Results showed MDA level were: 1.0±0.19; 0.3±0.05; 0.4±0.04; 0.6±0.04 and 0.5±0.00 nmol/mL, whereas SOD activity were: 17±0.0; 123±25.3; 107±19.0; 73±18.9 and 97±27.0 U/mL for group I, II, III, IV and V, respectively. Kruskal Wallis test showed a significant difference in MDA between group III with IV and V (p>0.05), showing cosolvent has higher ability to decrease MDA than the extracts suspension. There were significant differences of SOD between group III and IV (p>0.05), meaning cosolvent has higher ability to increase SOD activity compare to the extracts. Research showed cosolvent has a higher antioxidant effect with potential to inhibit MDA formation by 70% and increase SOD activity by 623%.
Co-Authors Faizatun FRANSISKA DIANA SANTI Liliek Nurhidayati ROS SUMARNY YATI SUMIYATI Yulia Riyana