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All Journal The Indonesian Biomedical Journal Jurnal Ilmu Kefarmasian Indonesia Abdi Implementasi Pancasila: Jurnal Pengabdian kepada Masyarakat Jurnal Janata Borneo Journal of Pharmacy
YATI SUMIYATI
UNIVERSITAS PANCASILA
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Engineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Transportation

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Correlation between Inflammation and Fibrinolysis in Hypertensive Centrally Obese Subjects: A Study on C-Reactive Protein, Plasminogen Activator Inhibitor-1 and Thrombin Activatable Fibrinolysis Inhibitor Yati Sumiyati; Syakib Bakri; Mansyur Arif
The Indonesian Biomedical Journal Vol 4, No 3 (2012)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v4i3.175

Abstract

BACKGROUND: Hypertension and central obesity are risk factors of cardiovascular disease. Epidemiology studies have shown that these two conditions are closely linked and often occur simultaneously. Inflammation is an underlying pathomechanism in hypertension and obesity. Vascular inflammation is related to coagulation pathway, whereby high level of inflammation increases the risk of atherothrombosis event. The aim of this study was to investigate the correlation between inflammation and fibrinolysis in hypertensive centrally obese subjects compared with hypertensive non obese sbjects.METHODS: This was a cross sectional study conducted in October 2009-June 2010 involving 53 eligible subjects according to the following criteria: men or women aged 30-65 years, had neither diabetes (FPG <126 mg/dL and or OGTT <200 mg/dL) nor CKD (eGFR ≥60 mL/minutes). All subjects were not in an acute inflammation state, had no unspecific infection (hs-CRP ≤10 mg/L), or taking anti-inflammation or anti-hypertensive medication.RESULTS: In this study we found that the levels of hs-CRP (2.636 mg/L vs 1.024 mg/L, p=0.007), PAI-1 (43.58 ng/mL vs. 28.43 ng/mL, p=0.089) and TAFI (12.73 ng/mL vs. 12.19 ng/mL, p=0.479) were respectively higher in hypertensive subjects with central obesity than in hypertensive subjects with no central obesity. In hypertensive centrally obese subjects there was significant positive correlation between hs-CRP and PAI-1 (r=0.491, p=0.001) and TAFI (r=0.312, p=0.0390, meanwhile in hypertensive non-obese subjects significant correlation was found only between hs-CRP and TAFI (r=0.929, p=0.003).CONCLUSIONS: Obesity in hypertensive subjects has higher inflammation state that is correlated with fibrinolysis disruption.KEYWORDS: hypertensive, obesity, hs-CRP, PAI-1, TAFI
Efek Antioksidan Larutan Kosolven Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) pada Tikus dengan Parameter MDA dan SOD ROS SUMARNY; LILIEK NURHIDAYATI; SITI SOFIAH; YATI SUMIYATI; FRANSISKA DIANA SANTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (407.637 KB)

Abstract

Mangosteen (Garcinia mangostana L.) rinds extract in capsule form has been marketed. a-mangostin, the active compound of G. mangostana had been known has low solubility in water. This study was aimed to measure and compare antioxidant effect of a-mangostin as cosolvent solution to extracts suspentions. 25 rats were divided into 5 groups: negative (I) and positive (II) control, cosolvent solution (III), extract (IV) and extract® (V). Treatment were given for 14 days, free radicals were induced by CCl . MDA were analyzed using thiobarbituric acid method while SOD by using adenochrome assay. Results showed MDA level were: 1.0±0.19; 0.3±0.05; 0.4±0.04; 0.6±0.04 and 0.5±0.00 nmol/mL, whereas SOD activity were: 17±0.0; 123±25.3; 107±19.0; 73±18.9 and 97±27.0 U/mL for group I, II, III, IV and V, respectively. Kruskal Wallis test showed a significant difference in MDA between group III with IV and V (p>0.05), showing cosolvent has higher ability to decrease MDA than the extracts suspension. There were significant differences of SOD between group III and IV (p>0.05), meaning cosolvent has higher ability to increase SOD activity compare to the extracts. Research showed cosolvent has a higher antioxidant effect with potential to inhibit MDA formation by 70% and increase SOD activity by 623%.
EDUKASI DAN PENDAMPINGAN SERTIFIKASI HALAL SELF DECLARE PRODUK PANGAN SEHAT UMK RW 19 KELURAHAN CILANGKAP Yati Sumiyati; Esti Mulatsari; Nathalia Perdhanti Soemantri; Novi Yantih; Gumilar Adhi N Nugroho; Fauzia Noprima Okta; Trisna Permadi; Arfin Ahsanul Ihsan; Zahra Afifah; Anggiyasari Anggiyasari
Abdi Implementasi Pancasila:Jurnal Pengabdian kepada Masyarakat Vol 2 No 2 (2022): November
Publisher : Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (376.255 KB) | DOI: 10.35814/abdi.v2i2.4274

Abstract

Pembangunan nasional berkelanjutan terus dilakukan pemerintah untuk meningkatkan kesejahteraan masyarakat. Pemberdayaan Kesejahteraan Keluarga (PKK) merupakan organisasi kemasyarakatan yang memberdayakan wanita untuk turut berpartisipasi dalam pembangunan Indonesia. Organisasi ini dimotori oleh ibu-ibu rumah tangga yang peduli terhadap kesejahteraan lingkungannya, berusaha mencurahkan waktu ditengah kesibukan mengurus keluarganya. PKK RW19 berlokasi di Perumahan Griya Telaga Permai, Kelurahan Cilangkap, Kecamatan Tapos, Kota Depok. Dalam menjalankan program kerjanya, PKK ini dibagi menjadi 3 kelompok kegiatan (Poktan) yaitu Posyandu, posbindu dan Usaha Peningkatan Pendapatan Keluarga Sejahtera (UPPKS). Pandemik Covid-19 memberikan implikasi ekomomi khususnya terhadap kesejahteraan Warga RW19. Jika dipandang dari sudut positif, pandemik menginisiasi tumbuhnya Usaha Mikro Kecil (UMK) di sektor pangan. Banyak ibu-ibu rumah tangga yang mulai berdagang makanan dengan tujuan membantu perekonomian keluarganya. Pelaku usaha umumnya masih memproduksi makanan secara konvensional berdasarkan pengalaman dengan menggunakan bahan-bahan yang ‘terjangkau’ untuk menekan harga. Terhadap permasalahan ini Tim PKM berencana memperkuat Kembali fungsi PKK RW19 dengan membangun high performance teams dan elaborasi untuk membina UMK agar dapat optimal membangun bisnisnya. Sementara permasalahan pada UMK terkait produk adalah minimalnya pengetahuan mengenai pangan fungsional yang berimplikasi terhadap imunitas tubuh dan berbagai peraturan pemerintah yang berkaitan dengan keamanan pangan serta jaminan produk yang thayyib. Di lain pihak, regulator memiliki keterbatasan sumber daya manusia dalam pengawasan dan pengendalian produk pangan yang beredar. UMK juga memiliki ketebatasan pemahaman mengenai brand image dan pemasaran produk. Solusi yang diberikan adalah memberikan edukasi, pelatihan, dan pendampingan mulai dari pangan sehat/fungsional, brand image, hingga pendampingan perolehan sertifikat halal (self-declare). Kegiatan yang dilakukan ini akan meningkatkan citra produk dan penjualan UMK yang akan meningkatkan kesejahteraan pelaku usaha dan warga sekitar.
PERBAIKAN EKSTRAKSI PRODUK HERBAL Arif Tatak; Yati Sumiyati; Rovida Camalia Hartantrie; Yesi Desmiaty; Gumilar Adhi Nugroho
Jurnal JANATA Vol 2 No 2 (2022): Jurnal Janata
Publisher : Program Studi Teknik Sipil Fakultas Teknik Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/janata.v2i2.4364

Abstract

Produk herbal yang dimanfaatkan untuk menjaga stamina dan pengobatan saat ini sudah diolah sehingga bisa diperoleh dalam sediaan serbuk yang dikemas sebagai kapsul, tablet atau sirup. Serbuk tersebut adalah hasil ekstraksi dari bahan herbal. Salah satu tahapan dalam proses ekstraksi herbal adalah proses pemasakan bahan herbal. Proses pemasakan ini memegang peranan sangat penting karena menentukan kualitas ekstrak herbal yang dihasilkan. Penggunaan panas berlebih (over heat) akan mengakibatkan rusaknya kandungan nutrisi yang ada pada bahan herbal. Untuk meminimalisasi terjadinya panas berlebih pada proses pemasakan maka digunakan panas dari uap air yang dihasilkan oleh boiler. Hal ini diharapkan dapat memperbaiki kualitas produk ekstrak herbal yang sebelumnya dimasak menggunakan kompor gas.
Comparison of Pain Scale, Hemodynamics, and Side Effects of Percutaneous and Intravenous Fentanyl in Post Sectio Caesaria Patients at Bunda Hospital Annisa`'a Nurillah Moesthafa; Achmad Riviq Said; Ros Sumarny; Yati Sumiyati
Borneo Journal of Pharmacy Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i1.2876

Abstract

This is novel research about comparison pain scale, hemodynamics, and side effects of percutaneous and intravenous fentanyl in post sectio cesarean patients. Sectio cesarean is a method of delivering a fetus through an incision in the abdominal wall (laparotomy) and the uterus wall. This method induces pain in the incision, so patients feel complicated or afraid to mobilize. Fentanyl is one of the opioid analgesics, which is the main choice in section caesarian surgery because safe for breastfeeding, is more potent than morphine, and acts as balanced anesthesia—comparing the use of percutaneous fentanyl with intravenous fentanyl with pain scale parameters, hemodynamics, and side effects in sectio caesarian patients at Bunda Mother and Child Hospital Jakarta. Before conducting this research, an observational study first makes an ethical approval. Data were taken prospectively and collected simultaneously to compare percutaneous and intravenous fentanyl performed on post sectio cesarean patients with the physical status of the American Society of Anesthesiologists (ASA) I–II at Bunda Mother and Child Hospital Jakarta from September to November 2020. Comparative data observed were pain scale parameters, hemodynamics, and side effects after percutaneous fentanyl therapy or intravenous fentanyl therapy. Data were processed using SPSS 22 version and Microsoft Excell 2016. In conclusion, intravenous fentanyl is more effective in reducing pain scale and has more minor side effects than percutaneous fentanyl. There is no significant difference in hemodynamic parameters (p-value >0.05).
Co-Authors Achmad Riviq Said Anggiyasari Anggiyasari Annisa`'a Nurillah Moesthafa Arfin Ahsanul Ihsan Arif Tatak Camalia Hartantrie, Rovida Fauzia Noprima Okta FRANSISKA DIANA SANTI Gumilar Adhi Nugroho Liliek Nurhidayati Mansyur Arif Manuppak Irianto Tampubolon Mulatsari, Esti Nathalia Perdhani Soemantri Noviyantih, Noviyantih ROS SUMARNY Siti Sofiah Syakib Bakri Trisna Permadi Yesi Desmiaty, Yesi Zahra Afifah