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Sarah Zaidan
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Formulasi Nanoemulsi Ekstrak Etanol Buah Okra (Abelmoschus esculentus (L.) Moench.) dan Uji Aktifitas Antikolesterol secara In-vitro Ratna Djamil; Sarah Zaidan; Vera Butar Butar; Diah Kartika Pratami
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (465.075 KB) | DOI: 10.35814/jifi.v18i1.820

Abstract

Okra fruit has a flavonoid, phytosterol and pectin content, which is potential as an anticholesterol agent. The pharmacological activity of ethanol extract 70 % of okra fruit (EEOF) can be improved by forming nanoemulsion. This study aimed to prepare an ethanol extract 70 % and nanoemulsion of okra fruit and to prove the cholesterol inhibition in vitro EEOF is smaller than the nanoemulsion of EEOF. The okra fruit was extracted by kinetic maceration, the EEOF was analyzed by a phytochemical screening test and cholesterol inhibition assay in vitro using Liebermann-Burchard reagent. The anticholesterol activity was expressed as IC50 values. Nanoemulsion of EEOF prepared by spontaneous emulsification method using capmul, propylenglycol, glycerin (1 : 2.5 : 2 mL). The result of phytochemical screening of okra fruit simplicia and EEOF were contained flavonoid, steroid, triterpenoid, saponin, and coumarin. The resulting nanoemulsion has a 134.7 nm in diameter with a potential zeta value of -26.72 mV. EEOF has IC50 of 764.11 µg/mL and nanoemulsion of EEOF have IC50 of 712.50 µg/mL. Nanoemulsion can improve anticholesterol IC50 value because it was penetrated the gap between cells so that the delivery and bioavailability were higher.
Aktivitas Senyawa Sargassum sp. sebagai Anti-aterosklerosis dengan Pembandingan Ligan-Reseptor HMG-CoA Reduktase- Simvastatin (1HW9) dan Uji Toksisitas secara In-Silico Sarah Zaidan; Syamsudin Abdillah; Deni Rahmat; Ratna Djamil; Esti Mumpuni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (539.479 KB) | DOI: 10.35814/jifi.v17i1.557

Abstract

Introduction:Sargassum.sp is one of the marine biota published as antiaterosclerosis, but compound toxicity data need to be explored for safety. Method: Virtual screening has been done with MVD software from active compounds contained in sargassum where has activity as antiaterosclerosis with the mechanism of hypolipidemic effects. Test compounds in sargassum include: fucoidan, rhamnose, fucose, galactose, fucoxantin, alginate, phlorofucofuroeckol A, phloroglucinol, phlorotannin, with HMG-COA Reductase-Simvastatin adenosine receptors with a 1HW9 /PDB code. Its toxicity is predicted using pkCSM (online). Results: The value RS, RMSD value as a result of the docking simulation carried out on said compounds, the following results are obtained: fucoidan (-110,420; 1,478), rhamnose (-72,081; 1,629), fucose (-98,408; 1,546), galactose (-95,757; 5,187), fucoxantin (-106,297; 2,161), alginate (-84,674; 2,897), phlorofucofuroeckol A (-106.701; 2,809), phloroglucinol (-103,140; 2,142), phlorotannin (-48,826; 7,750). The prediction results of toxicity showed fucoidan, rhamnose, fucose, galactose, fucoxantin, alginate, phlorofucofuroeckol A, phloroglucinol and phlorotannin not toxic with LD50 0.95-2.482g / kg. Conclusion:Based on RS values, fucoidan, fucoxantin and phlorofucofuroeckol A compounds contained in brown seaweed were predicted to have activity as antiaterosclerosis. Compounds in brown seaweed can also be predicted to be relatively non-toxic with a value of LD50 0.95-2.482g / kg.
Co-Authors Deni Rahmat Diah Kartika Pratami Esti Mumpuni Ratna Djamil Syamsudin Abdillah Vera Butar Butar