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All Journal HAYATI Journal of Biosciences Majalah Obat Tradisional Communications in Science and Technology Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia SULUH: Jurnal Abdimas Community Empowerment Gemakes: Jurnal Pengabdian Kepada Masyarakat Magistrorum et Scholarium: Jurnal Pengabdian Masyarakat Journal of Natural Product for Degenerative Diseases Indonesian Journal of Jamu

Diah Kartika Pratami

Universitas Pancasila

Author-ID : 3685469

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Engineering Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Formulasi Nanoemulsi Ekstrak Etanol Buah Okra (Abelmoschus esculentus (L.) Moench.) dan Uji Aktifitas Antikolesterol secara In-vitro Ratna Djamil; Sarah Zaidan; Vera Butar Butar; Diah Kartika Pratami
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Okra fruit has a flavonoid, phytosterol and pectin content, which is potential as an anticholesterol agent. The pharmacological activity of ethanol extract 70 % of okra fruit (EEOF) can be improved by forming nanoemulsion. This study aimed to prepare an ethanol extract 70 % and nanoemulsion of okra fruit and to prove the cholesterol inhibition in vitro EEOF is smaller than the nanoemulsion of EEOF. The okra fruit was extracted by kinetic maceration, the EEOF was analyzed by a phytochemical screening test and cholesterol inhibition assay in vitro using Liebermann-Burchard reagent. The anticholesterol activity was expressed as IC50 values. Nanoemulsion of EEOF prepared by spontaneous emulsification method using capmul, propylenglycol, glycerin (1 : 2.5 : 2 mL). The result of phytochemical screening of okra fruit simplicia and EEOF were contained flavonoid, steroid, triterpenoid, saponin, and coumarin. The resulting nanoemulsion has a 134.7 nm in diameter with a potential zeta value of -26.72 mV. EEOF has IC50 of 764.11 µg/mL and nanoemulsion of EEOF have IC50 of 712.50 µg/mL. Nanoemulsion can improve anticholesterol IC50 value because it was penetrated the gap between cells so that the delivery and bioavailability were higher.

Standardisasi dan Uji Aktivitas Antioksidan Ekstrak Bahan Alam Propolis untuk Terapi Infeksi SARS-CoV2 Diah Kartika Pratami; Yesi Desmiaty; Evita Maria Simorangkir; Deby Faradhila
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1062

Natural ingredients with immunomodulatory, anti-inflammatory, and antioxidant activities can be used as supportive therapy for SARS-CoV2 infection. The aims were standardized the quality and safety of propolis and determined the antioxidant activity of propolis. There are two types of propolis powder samples: microencapsulated propolis powder containing wax (SMPW) and non-waxed (SMP). Standardization includes specific and non-specific parameters. Antioxidant activity test using FRAP and ABTS methods. The total flavonoids of SMPW and SMP were 0.31% and 1.59%. The total phenolic of SMPW and SMP were 83.9082 and 98.0821 mg GAE/g. The losses on drying of SMPW and SMP were 3.65% and 3.88%. The water content of SMPW and SMP were 5.12% and 5.11%. The total ash content of SMPW and SMP were 0.80% and 0.65%. Heavy metal propolis powder negative. ALT and AKK values < 10 CFU/g, microbiology contamination was negative. Antioxidant activity of SMPW with IC50 ABTS 2.4177 ppm and EC50 FRAP 26.41 g/mL. Meanwhile, the antioxidant activity of SMP with IC50 ABTS 2.213 ppm and EC50 FRAP 32.10 g/mL. It was concluded that the extract of propolis met the requirements of the standard for extracts of natural ingredients and had strong antioxidant activity. Propolis powder can be developed for supportive therapy for SARS-CoV2 infection.

Pemeriksaan Parameter Mutu dan Uji Aktivitas Penghambatan Enzim α-Glukosidase dari Ekstrak Etanol 70% Daun Keji Beling (Sericocalyx Crispus (L.) Bremek) Ratna Djamil; Diah Kartika Pratami; Lola Vidia Riyantika
Jurnal Jamu Indonesia Vol. 5 No. 1 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Daun keji beling (Sericocalyx crispus (L.) Bremek) [Sinonim Strobilanthes crispa (L.)] merupakan salah satu tanaman yang secara empiris digunakan oleh masyarakat untuk membantu pengobatan. Menurut penelitian daun keji beling diketahui mempunyai khasiat sebagai antidiabetes. Penelitian ini bertujuan untuk mengidentifikasi golongan senyawa yang terkandung dalam ekstrak, mutu ekstrak dan aktivitas penghambatan enzim α-Glukosidase secara in vitro. Serbuk simplisia diekstraksi dengan pelarut etanol 70% secara maserasi kinetik, kemudian dilakukan penapisan fitokimia, penetapan mutu ekstrak dan uji aktivitas penghambatan enzim α-Glukosidase. Hasil penapisan menunjukkan ekstrak mengandung senyawa flavonoid, saponin, steroid dan triterpenoid. Hasil penetapan mutu ekstrak menunjukkan bentuk ekstrak kental berwarna hijau kehitaman; rasa pahit; kadar sari larut air 60,46%; kadar sari larut etanol 73,45%; kadar abu total 15,06%; kadar abu tidak larut asam 3,10%; kadar abu larut air 11,29%; kadar air 7,68%; susut pengeringan 9,25%; sisa pelarut 0,38%; kadar Pb 0,4941 bpj; kadar Cd 0,0222 bpj; Angka Lempeng Total (ALT) 4,52x102 koloni/g; Angka Kapang Kamir (AKK) terlalu sedikit untuk dihitung (TSUD); dan kadar flavonoid total 2,39%. Hasil uji aktivitas penghambatan enzim α-Glukosidase pada akarbose dan ekstrak kental keji beling menunjukkan IC50 masing-masing sebesar 50 bpj dan 86,2 bpj. Dapat disimpulkan ekstrak kental daun keji beling memenuhi persyaratan mutu ekstrak dan memiliki aktivitas sebagai penghambat enzim α-Glukosidase. Keji beling memiliki potensi untuk dikembangkan lebih lanjut sebagai obat herbal antidiabetes.

The Potency of Alpinia galanga as Natural Antioxidant Dian Ratih Laksmitawati; Diah Kartika Pratami; Wahyu Widowati; Hanna Sari Widya Kusuma; Cahyaning Riski Wijayanti; Rizal Rizal
Majalah Obat Tradisional Vol 27, No 3 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.72450

An antioxidant is a chemical compound that can bind free radicals in the body. Reactive oxidative species (ROS) is a reaction that involves oxygen. ROS consists of free radicals and non-radical ones. The imbalance between ROS and antioxidants can cause oxidative stress, one of the factors contributing to the development of numerous diseases. This study aims to evaluate the possible antioxidant activity of lengkuas extract (LE), which may be employed as a medicine component to reduce ROS. The method that used in this research were total phenolic content, total flavonoid content, 2,2 diphenyl 1 picrylhydrazyl (DPPH) scavenging, hydrogen peroxide (H2O2), NO scavenging, 2,2′-Azinobis(3-Ethylbenzthiazoline-6-Sulfonate) (ABTS), and ferric reducing antioxidant power (FRAP). The result shows that the TPC of LE was 6.80 ± 0.34 (GAE) µg/mg with gallic acid standard and the TFC was 3.39 ± 0.06 µg/mg by quercetin standard. The IC50 value of LE were 121.20; 87.65; 139.94; 181.09 µg/ml by ABTS, DPPH, NO, and H2O2 assay respectively. The scavenging activity of LE was increased with a higher concentration in every method. In conclusion, Alpinia galanga has the potential as an antioxidant. Thus, it can be widely consumed or used as a mixture in medicine to reduce ROS.

PELATIHAN VISUALISASI MOLEKUL KIMIA DENGAN SOFTWARE CHEMSKETCH UNTUK SISWA TINGKAT SEKOLAH MENENGAH ATAS Esti Mulatsari; Esti Mumpuni; Liliek Nurhidayati; Agus Purwanggana; Diah Kartika Pratami
Magistrorum et Scholarium: Jurnal Pengabdian Masyarakat Vol 2 No 1 (2021)
Publisher : Universitas Kristen Satya Wacana Salatiga

Senior High School (SMA) has a very broad scientific scope, one of which is chemistry. In chemistry, it presents the processes, chemical notations, types, and arrangements of matter. Chemical processes can be written in a concise form, such as a reaction equation, without eliminating the microscopic and macroscopic aspects that occur in the chemical process. This equation for the reaction is a symbolic aspect of chemistry. All the substances involved in the equation of the reaction are also symbolic aspects of chemistry. In other words, chemical formulas, such as atomic symbols, element symbols, compound symbols or formulas, all of these are symbolic aspects of chemistry. This symbolic aspect is of great importance in chemistry. Training on the use of ChemSketch software is very important for high school students, especially science majors, as an enrichment for chemistry subjects and improves skills in presenting chemical data in order to improve the quality of graduates. ChemSketch software provides process symbols, chemical notations, types, arrangement of materials, and several image representations of various laboratory tools, which are quite easy to use. Training on the use of ChemSketch for SMA N 13 Depok students has been enthusiastically carried out online, the material is relevant to chemistry subject matter, easy to accept and the delivery of the material is quite interesting.

Comparison of Total Phenolic Content and Antioxidant Activity of Indonesian Propolis Extracted with Various Solvents. Diah Kartika Pratami; Nur Elistiani Eksadita; Muhamad Sahlan; Abdul Mun’im; Asep Bayu; Kaysa Faradis Mahira
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1400

Propolis is a widely used medicine that may be found in both its pure form and when combined with othernatural ingredients in over-the-counter preparations, cosmetics, and health foods. Some customers develop alcohol sensitivity after using ethanol, which is a common solvent to extract propolis. As propolis solvents, various Natural Deep Eutectic Solvents (NaDES) were examined in this study. Choline chloride, propylene glycol, glycerol, citric acid, and 1,2-propanediol were combined in molar ratios to create some of the NaDES that were employed. Propolis and solvents were used in a kinetic maceration ratio for the extraction process. The Folin-Ciocalteu method was used to measure the total phenolic content (TPC), and the DPPH assay was used to measure antioxidant activity. In ethanol and NaDES solvents, the TPC of propolis extract ranged from 136.52 ± 27.9 to 365.8 ± 20.54 mgGAE/g. The values for antioxidant activity were 45.94 to 183.76 ppm. The propolis extract with the lowest IC50 and the highest TPC content was choline chloride-glycerol (CCG). It was discovered that the optimum NaDES solvent for extracting propolis was CCG-based. NaDES may be a potential solvent for use in Indonesian propolis, both as an extraction medium and as a formulation element.

Formulation of Anti-Oral Mouthwash Nanoemulsion Biofilm Based on Propolis Extract Heterotrigona itama, Tetragonula sapiens, and Tetragonula clypearis Muhamad Sahlan; Alya Fadhila Ismail; Diah Kartika Pratami; Apriliana Cahya Khayrani
HAYATI Journal of Biosciences Vol. 30 No. 6 (2023): November 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.6.1175-1186

The use of mouthwash is one of the actions against biofilms that are often used. However, commercial mouthwashes have a fairly high alcohol content, which is around 26.9% of the total volume, which is considered to have a prolonged impact where high alcohol content in direct contact with the oral mucosa can cause lesions or abnormalities, resulting in a shift in the medical paradigm towards eco-friendly widely considered as a solution. Propolis with antibacterial ability was formulated using the nanoemulsion steps, which were initiated by separating pure propolis through drying, and then there were variations in the formulation of 3 types of bee propolis: Heterotrigona itama, Tetragonula sapiens, and Tetragonula clypearis along with the addition of Tween 80, propylene glycol, glycerin and then the effect on microbial growth of S. mutans was compared with antimicrobial agents in Brazilian propolis with the identification and comparison of the antibacterial activity stability of the organoleptic formula. Where the active ingredient content of propolis is the highest in H. itama propolis with a total flavonoid content of 38.94 mgQE/L sample and T. clypearis propolis has the lowest total flavonoid content of 14.23 mgQE/L sample with its function as an anti-oral biofilm agent by inhibiting the glucosyltransferase was proven with a minimum percentage of 49% inhibition of S. mutans and degradation of 18% with the use of a combined surfactant proved to be able to increase the stability of the preparation shown at 2:1 (v/v).

Education on detection of dangerous additives in foods for elementary school students in Bogor Esti Mulatsari; Diah Kartika Pratami; Intan Permata Sari; Esti Mumpuni; Anisah Kholilah; Alifah Wardah Zahiroh; Roro Dyah Ayu; Safi La'rosa Linson Queeny; Rizqya Cahya Handayani; Widiya Chourinisa; Iqbal Ananda Taqwa; Nadira Zahra Salsabila
Community Empowerment Vol 9 No 3 (2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.11093

Elementary school children generally start to be able to choose the foods they want. However, when selecting foods, they tend to choose visually appealing, inexpensive, and easily accessible foods without considering their nutritional content. This makes elementary school children vulnerable to health problems due to unhealthy snacks. The aim of this community service activity is to increase students' knowledge about dangerous snacks and how to detect them, provide examples of healthy alternatives from medicinal plants, and practice making food and drinks from medicinal plants. This educational activity is conducted at Athalla Cendekia Elementary School in Bogor. The method used in this community service activity is delivering materials and practicing the detection of additives such as rhodamine-b, formalin, and borax in several snack food samples around the school. Some of the snack foods tested include sausages, meatballs, sauces, fried tofu, fried meatballs, jelly, and sweetened condensed milk. Testing is carried out using reagent kits, and all 6th-grade students (25 students) are actively involved in the implementation process. Food and drink processing are conducted through direct practice in the manufacturing process and direct practice in the planting process of medicinal plants. The results of the activity show that the training proceeds attractively, with each child recording the test results in a testing booklet and being able to present the test results. Some foods tested positive for containing formalin, while some tested negative. With this education and training on detecting additives, students' knowledge increases as they can identify the types of foods containing harmful additives in the tested samples.

PKM Pengembangan Usaha Desinfektan dan Antiseptik Berbahan Daun Bidara Pada Aspek Produksi dan E-Marketing Pratami, Diah Kartika; Saputra, Agung; Budiati, Anarisa; Nadya Aulena, Desi; Nafisa, Safira; Moordiani
SULUH: Jurnal Abdimas Vol 4 No 1 (2022): SULUH: Jurnal Abdimas Agustus
Publisher : FEB-UP Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/suluh.v4i1.3512

Tujuan kegiatan PKM membantu UKM yang memproduksi antiseptik dan desinfektan yang mengandung daun bidara dan serai wangi dalam permasalahan standardisasi produk, pemenuhan SNI, dan membuat sistem penjualan distributor/kegenan/reseller dengan memanfaatkan sistem teknologi informasi. Metode yang digunakan pemenuhan standard produk dengan pengujian potensi antimikroba produk di laboratorium FFUP. Kedua, membangun sistem teknologi informasi dengan membuatkan sistem informasi untuk kegiatan manajerial, distribusi dan pemasaran dengan metode less contact economy. Ketiga, melakukan pendampingan pembuatan konten produk untuk mengoptimalkan pemasaran online dan digital branding sebagai sarana komunikasi dengan target konsumennya. Hasil yang diperoleh UKM memperoleh sertifikat analisis produksi yang memenuhi standard mutu dan keamanan; dapat tercapai transfer knowledge metode produksi, pemastian mutu dan kualiti kontrol agar produk yang dihasilkan sesuai standard; terbentuknya sistem teknologi informasi dalam kegiatan manajerial, distribusi dan pemasaran produk yang bersifat less contact economy; serta tercapainya media online yang berisi konten edukasi kepada masyarakat. Luaran yang dihasilkan berupa prototipe produk yang telah memenuhi standard mutu dan keamanan sesuai regulasi Kemenkes, video kegiatan PKM di Youtube, pemberitaan di media massa, materi narasumber untuk digital branding, dan satu publikasi artikel ilmiah.

Antifungal activity of microcapsule propolis from Tetragonula spp. to Candida albicans Pratami, Diah Kartika; Indrawati, Teti; Istikomah, Iis; Farida, Siti; Pujianto, Paksi; Sahlan, Muhamad
Communications in Science and Technology Vol 5 No 1 (2020)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Propolis is a mixture of resin and saliva of Tetragonula spp. that have antifungal activity. The purpose of this study was to develop spray-dried microcapsule propolis (SDMP) and to analyze its antifungal activity to Candida albicans. The SDMP was obtained using a spray drying method by maltodextrin and gum arabic coating. The antifungal activity of SDMP of rough propolis (taken from the outside beehive) and smooth propolis (taken from the inside beehive) was analyzed. The macroscopic characterization showed that SDMP has a powder form with brownish-yellow color. The microscopic characterization showed SDMP has a spherical uniform particle shape with particle size 9.32 - 14.61 µm. The encapsulation efficiency of smooth and rough SDMP was 81.22% and 83.04%; moisture content 5.58% and 5.84%; water solubility 98.19% and 98.31%, respectively. The microbial inhibitory concentration to C. albicans was the diameter of 6.33±1.5 to 10±2.5 mm. SDMP displayed remarkable activity in the assays against C. albicans.

Co-Authors Abdul Mun’im Agung Saputra Alifah Wardah Zahiroh Alya Fadhila Ismail Anisah Kholilah Asep Bayu Budiati, Anarisa Cahyaning Riski Wijayanti Deby Faradhila Dellia Nursyifa Rosdiana Dian Ratih Laksmitawati Djamil, Ratna Esti Mumpuni Esti Mumpuni Evita Maria Simorangkir Hanna Sari Widya Kusuma Intan Permata Sari intan permata sari Iqbal Ananda Taqwa Iskandar, Maria Clarissa Istikomah, Iis Kaysa Faradis Mahira Khayrani, Apriliana Cahya Liliek Nurhidayati Lola Vidia Riyantika Moordiani Moordiani Mulatsari, Esti Nadira Zahra Salsabila Nadya Aulena, Desi Nur Elistiani Eksadita Pujianto, Paksi Ratna Djamil Rizal Rizal Rizqya Cahya Handayani Roro Dyah Ayu Safi La'rosa Linson Queeny Safira Nafisa SAHLAN, MUHAMAD Sarah Zaidan Shelly Taurhesia Siti Farida Teti Indrawati Vera Butar Butar Vidia Riyantika, Lola Wahyu Widowati Widiya Chourinisa Yesi Desmiaty, Yesi

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