Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

0.778

P-Index

This Author published in this journals

All Journal Jurnal Ilmu Kefarmasian Indonesia Archives of The Medicine and Case Reports Jurnal Sains dan Kesehatan Journal of Natural Product for Degenerative Diseases

Syamsudin Abdillah

Unknown Affiliation

Author-ID : 3528436

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Published : 7 Documents Claim Missing Document

Claim Missing Document

Articles

Pengaruh Crude Fukoidan dari Ekstrak Sargassum crassifolium terhadap Kadar ICAM-1 dan VCAM-1 pada Sel Raw 264.7 yang Diinduksi Lipopolisakarida Ayu Werawati; Esti Mumpuni; Kusmardi Kusmardi; Dian Ratih Laksmitawati; Syamsudin Abdillah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Inflammation is the response of vascular tissue to infection and damaged tissue to remove agents that cause inflammation. Macrophages are the dominant cells in the inflammatory reaction. Adhesion of leukocytes to vascular endothelium is a main feature of the inflammatory process. The presence of adhesion molecules, such as ICAM-1 and VCAM-1, can lead to adhesion of monocytes and lymphocytes to endothelial cells via bonding adhesion molecules to endothelial cells. Crude fukoidan derived from Sargassum crassifolium taken from Garut waters and extracted with dilute HCl, tested for anti-inflammatory activity through inhibition of ICAM-1 and VCAM-1 using lipopolysaccharide-induced RAW 264.7 cell models. The viability test was carried out in the concentration range of 0.49-1000 µg / mL. The pattern of inhibition of cell proliferation is influenced by concentration. The highest concentration that caused cell viability of 80% was the concentration of 86.46μg / ml. Crude fukoidan reduced ICAM-1 and VCAM-1 levels at concentrations of 50 and 25 μg / ml.. Percent inhibition of ICAM-1 at 50 µg / mL concentration was 61.04% compared to control and 74.26% at 25 µg / mL concentration. While the percent inhibition of VCAM-1 a

Identifikasi Senyawa Penghambat Enzim α-Glukosidase dari Ekstrak Etanol 96% Daun Yakon (Smallanthus sonchifolius [Poepp.& Endl.]H. Robinson) Zuhelmi Aziz; Farhana Hanida Al Qisthi; Ratna Djamil; Nancy Dewi Yuliana; Partomuan Simanjuntak; Syamsudin Abdillah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

The leaves of yacon (Smallanthussonchi folius [Poepp. &Endl.] H. Robinson) or in Indonesia known as “Daun insulin” (Insulin leaf), scientifically has various medicinal properties and one of them as antidiabetic. The aim of this research is to know α-glucosidase enzyme inhibitor compound in the ethanol 96% extract of yacon leaves. Fractionation of ethanol extract subjected to column chromatography (SiO2; dichloromethane-methanol-water = 5 : 5 : 1) gave 5 fractions (Fr -1 ~Fr – 5). The results of the -glucosidase enzyme inhibition activity test in vitro against the five fractions obtained the 3rd fraction as the most active of 87.84 %. Purification of the 3rd fraction with preparative thin layer chromatography (SiO2; n-BuOH-ethanol-water = 4 : 1 : 2.2) gave pure isolate as Fr 3-1. Identification of pure isolates Fr 3-1 was carried out by interpreted spectra of Ultraviolet, Fourier Transform-Infra Red, Mass Spectra (from LC-MS) and compared data on the chemical shift of the Nuclear Magnetic Resonance (proton and carbon) and determined as Nystose (GF3) compound. The results of the -glucosidase enzyme inhibition activity showed that Fr 3-1 has IC50 of 21.36 ppm

Perbandingan Profil Lipid pada Tikus Putih yang diberi Crude Fucoidan dari Rumput Laut Coklat (Sargassum polycystum) yang Diinduksi Diet Tinggi Lemak Juliana Irem Adriana Purukan; Kusmardi Kusmardi; Dian Ratih Laksmitawati; Syamsudin Abdillah; Bambang Ponco Priosoeryanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

: Brown seaweed (Sargassum polycystum) is one of the plants that produces pharmacological activity which is as anti-atherosclerotic with the potential chemical content is fucoidan. The aim of this research is to know the effectiveness of crude fucoidan in decreasing total cholesterol, LDL, TG, increasing HDL levels and atherogenic index. In the optimization phase, 5 rat test animals were used to see the effect of the composition of a high-fat diet given on lipid profiles. While in the testing phase 30 test animals were divided into 6 groups to see the effect of a high-fat and crude fucoidan diet given to lipid profiles. Examination of lipid profiles was carried out three times, namely on the 0th, 14th and 36th days, after that the atherogenic index is calculated. On the 36th day the test, rats were anesthetized and necropsy for subsequent blood collection through the heart organ.The results showed that 200 mg crude fucoidan dose could significantly decreasing total cholesterol, LDL, TG, increased HDL levels and significantly decreased the atherogenic index of rat serum compared to the dosages of 100 mg and 50 mg, but did not differ significantly from the positive control at 10 mg atorvastatin.

Aktivitas Senyawa Sargassum sp. sebagai Anti-aterosklerosis dengan Pembandingan Ligan-Reseptor HMG-CoA Reduktase- Simvastatin (1HW9) dan Uji Toksisitas secara In-Silico Sarah Zaidan; Syamsudin Abdillah; Deni Rahmat; Ratna Djamil; Esti Mumpuni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Introduction:Sargassum.sp is one of the marine biota published as antiaterosclerosis, but compound toxicity data need to be explored for safety. Method: Virtual screening has been done with MVD software from active compounds contained in sargassum where has activity as antiaterosclerosis with the mechanism of hypolipidemic effects. Test compounds in sargassum include: fucoidan, rhamnose, fucose, galactose, fucoxantin, alginate, phlorofucofuroeckol A, phloroglucinol, phlorotannin, with HMG-COA Reductase-Simvastatin adenosine receptors with a 1HW9 /PDB code. Its toxicity is predicted using pkCSM (online). Results: The value RS, RMSD value as a result of the docking simulation carried out on said compounds, the following results are obtained: fucoidan (-110,420; 1,478), rhamnose (-72,081; 1,629), fucose (-98,408; 1,546), galactose (-95,757; 5,187), fucoxantin (-106,297; 2,161), alginate (-84,674; 2,897), phlorofucofuroeckol A (-106.701; 2,809), phloroglucinol (-103,140; 2,142), phlorotannin (-48,826; 7,750). The prediction results of toxicity showed fucoidan, rhamnose, fucose, galactose, fucoxantin, alginate, phlorofucofuroeckol A, phloroglucinol and phlorotannin not toxic with LD50 0.95-2.482g / kg. Conclusion:Based on RS values, fucoidan, fucoxantin and phlorofucofuroeckol A compounds contained in brown seaweed were predicted to have activity as antiaterosclerosis. Compounds in brown seaweed can also be predicted to be relatively non-toxic with a value of LD50 0.95-2.482g / kg.

Effects of Momordica charantia (MC) Extract on Clinical Symptoms, Parasite Account, Thrombocytes, Total Bilirubin and Direct Bilirubin in Patients with Uncomplicated Plasmodium falciparum Malaria: A Case Report Yudianto, Dian; Syamsudin Abdillah; Hesty Utami Ramadaniaty; Erni Juwita Nelwan
Archives of The Medicine and Case Reports Vol. 5 No. 1 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i1.417

Clinical symptoms during the treatment of uncomplicated P. falciparum malaria have been reported in several studies. Parasite density in the blood is associated with clinical symptoms, platelet, and bilirubin count. A 52-year-old male, weighing 52 kg, was given one capsule containing 325 mg bitter melon (Momordica charantia) extract for 3 days of treatment. Patients were followed up for 28 days, days 1,2,3,4,7,14,21,28, and peripheral blood microscopic examination and clinical symptoms were carried out. Measurement of platelets, total bilirubin, direct bilirubin D0, D14 and D28. Naranjo Scale, adverse events measurements were taken on D7, no signs of severe malaria, no comorbidities, no history of malaria, blood pressure 110/80 mmHg, peripheral blood parasite examination on D0 found P. falciparum parasites of 31,714/µL, D0 platelet value of 94x10 /mm3, D0 total bilirubin value of 1.3 mg% and D0 direct bilirubin value of 0.6 mµ/mL. On D1 parasite count was 2,400/µL, D2 was 372/µL, D3, D4, D7, D14, D21, D28 no asexual parasites were found again. Clinical symptoms that arose on D0 were nausea, no appetite, sweating, chills, sleep disturbance, dizziness, headache, and weakness with a body temperature of 37°C. After D3 of bitter melon extract treatment, no clinical symptoms were found again. Naranjo scale score based on nurse and pharmacist agreement was 6 (probable) at D7 for the adverse events of nausea and vomiting. There were no reported adverse events such as nausea, vomiting, diarrhea, abdominal pain, cough, sleep disturbance, dizziness, headache and weakness on D2 treatment. Bitter melon extract is effective for uncomplicated malaria P. falciparum, reduces clinical symptoms, and is safe.

Efikasi dan Keamanan Kombinasi Kapsul Pare-Primakuin sebagai Antimalaria pada Pasien Malaria Falsiparum Tanpa Komplikasi Di RSUD Manokwari: Efficacy and Safety Antimalarial Combination Pare Capsule-Primaquine In Malaria Falciparum without Complications In Manokwari Hospital Mitra Wynne Timburas; Delina Hasan; Syamsudin Abdillah
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i4.148

Salah satu tantangan terbesar dalam upaya penanggulangan kejadian malaria yaitu penurunan efikasi terhadap obat-obatan malaria yang telah mengalami resistensi akibat penggunaan yang tidak terkontrol, adanya mutasi genertik yang secara alami terjadi pada parasit malaria serta adanya efek samping yang terhadap penggunaan terapi kombinasi artemisin. Tanaman Pare merupakan salah satu tanaman yang telah lama digunakan secara tradisional untuk mengobati malaria. Penelitian ini bertujuan untuk mengetahui efikasi kombinasi kapsul pare dan primakuin pada pasien malaria falsiparum tanpa komplikasi di RSUD Manokwari. Rancangan penelitian ini dilakukan secara acak dengan ketersamaran ganda. Sebanyak 25 subjek malaria falsiparum yang berhasil direkrut dan dipantau hingga H-42. Terdapat dua kasus tidak dapat diikuti pada H-42 karena tidak kontrol secara teratur dan bepergian dalam waktu lama. Tidak ditemukan ada yang gagal pengobatan dini maupun gagal pengobatan kasep. Proporsi kesembuhan sebesar 92% dengan waktu bebas parasit pada H-7. Efek samping yang ditemukan bersifat ringan dan mirip dengan gejala khas malaria yaitu sakit perut, diare dan sakit kepala.

In Silico Studies: Stigmastan-3,6-dione in the Ethyl Acetate Fraction of Momordica charantia L Fruit has immunostimulant and anti-inflammatory activity Rachmi Ridho; Bambang Pontjo Priosoeryanto; Esti Mumpuni; Andri Prasetiyo; Syamsudin Abdillah
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.6865

Momordica charantia L fruit provides an immunomodulatory effect by stimulating certain components of the body's immune system. Bioactive phytochemicals from M. charantia L function as anti-inflammatory agents by reducing levels of pro-inflammatory cytokine secretion including IL-1, IL-6, IL-8, TNF-α, NF-kB. This research looks at the insilico mechanism of action of the active ingredient of the EtOAc fraction of M. charantia L fruit as an immunostimulant and anti-inflammatory. The materials and methods used were an Intel Core i7 10 Th Gen laptop, Chem Office Professional 17.1, Chem 2D, Chem 3D software, PDB code (6W9K) and ligand (TUA), Stigmastan-3,6 dione (C29H48O2) from the EtOAc fraction of fruit M. charantia L was docked using MVD software, RMSD and RMSF values were viewed using Yasara Software, pkCSM online tool to predict compound toxicity, toxicity prediction (LD50) was used by Protox online tool. The results of molecular docking of standard compounds, namely Methylprednisolone and Prednisolone and Stigmastan-3,6-dione, have Rerank Score values of -120.62, -121.47, -79.50, respectively. The lower the Rerank score value, the lower the binding energy between the protein and the ligand, causing the protein and ligand bonds to be more stable and it is predicted that the activity of the compound will be greater. The movement of RMSD values between 0.6-1.9 Å for the 3 (three) compounds, is still within stable limits and does not undergo conformation. The RMSF value of the 3 (three) compounds has the same amino acid residue pattern. The insilico toxicity prediction for the 3 (three) compounds is still within safe limits. The EtOAc fraction of M. charantia L fruit with the active compound Stigmastan-3,6-Dione in its mechanism of action in silico shows activity as an anti-inflammatory and immunostimulant that works on the NF-kB pathway.

Co-Authors Andri Prasetiyo Ayu Werawati Bambang Ponco Priosoeryanto Bambang Pontjo Priosoeryanto Delina Hasan Deni Rahmat Dian Ratih Laksmitawati Erni Juwita Nelwan, Erni Juwita Esti Mumpuni Farhana Hanida Al Qisthi Hendig Winarno Hesty Utami Ramadaniaty Juliana Irem Adriana Purukan Kusmardi Kusmardi Mitra Wynne Timburas Nancy Dewi Yuliana Pangartika Hikariastri Partomuan Simanjuntak Rachmi Ridho Ratna Djamil Ratna Djamil Sarah Zaidan Yudianto, Dian Zuhelmi Aziz

Title

Found 7 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 7 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 7 Documents
Search