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All Journal Medicina Bulletin of Scientific Contribution : Geology EMPATI : JURNAL ILMU KESEJAHTERAAN SOSIAL Paediatrica Indonesiana Jurnal Geosains dan Teknologi OPHIOLITE : Jurnal Geologi Terapan

Hendra Santoso

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Author-ID : 370926

Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Energy Engineering Environmental Science Health Professions Medicine & Pharmacology Social Sciences

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JUVENILE RHEUMATOID ARTHRITIS Sartika, I N; Santoso, Hendra; Kumara Wati, Dewi
Medicina Vol 39 No 1 (2008): Januari 2008
Publisher : Medicina

Show Abstract | Download Original | Original Source | Check in Google Scholar

Juvenile rheumatoid arthritis (JRA) is the most common rheumatic condition in children. JRA is defined as persistent arthritis in 1 or more joints for at least 6 weeks, with the onset before age 16 years. The etiology of JRA is unknown. Antigen activated CD4+ T cell stimulate monocytes, macrophages, and synovial fibroblasts to produce the cytokines Interleukin-1 (IL-1), IL-6, and tumor necrosis factor ? (TNF-?) and to secrete matrix metalloproteinases, which lead to chronic inflammation due to infiltration of inflammatory cell, angiogenesis, destruction of cartilage and bone with pannus formation. The 3 major subtypes of JRA are based on the symptoms at disease onset and are designated systemic onset, pauciarticular onset, and polyarticular onset. For all patients, the goals of therapy are to decrease chronic joint pain and suppress the inflammatory process. Poor prognostic have been observed in patients with polyarticular onset, rheumatoid factor, persistent morning stiffness, tenosynovitis, involvement of the small joints, rapid appearance of erosions, active late onset childhood, subcutaneous nodules, or antinuclear antibody.

Efficacy of dexamethasone for lung maturity in preterm delivery in association with lamellar bodies count Ni Made Sumiartini; Hendra Santoso; Wayan Retayasa; Made Kardana
Paediatrica Indonesiana Vol 47 No 3 (2007): May 2007
Publisher : Indonesian Pediatric Society

Background Organ immaturities in preterm infants may result inperinatal death. One of the diseases is respiratory distress syndrome(RDS) which is caused by lung immaturity. Dexamethasone is oftenused to accelerate maturity of infant lungs.Objective To determine the efficacy of dexamethasone on lungmaturity measured by lamellar bodies count.Methods A quasi experimental study was done at PerinatologyDivision, Department of Child Health, Medical School, UdayanaUniversity, Sanglah Hospital, Denpasar. We recruited 72 subjects;36 subjects were given four times intramuscular dexamethasone5 mg every twelve hours before delivery. Thirty six subjects whodid not receive dexamethasone belonged to control group. Infantsâ€™lungs maturity assessment was performed using lamellar bodiescount taken from amniontic fluid.Results The gestational age ranged between 28 to 36 weeks, withthe mean gestational age in dexamethasone group was 32.2 (SD1.76) weeks and that in control group was 31.7 (SD 2.65) weeks.The efficacy of dexamethasone therapy on lung maturity wassignificant with Fisherâ€™s exact test P<0.0001, 95%CI 2.546;11.173. Using multivariate logistic regression analysis, there wassignificant correlation between dexamethasone and lung maturitymeasured by lamellar bodies count [OR=239.39; P<0.0001,95%CI 22.12;526.53].Conclusion Administration of dexamethasone in pregnantwomen during preterm delivery significantly improves lungmaturity measured by lamellar bodies count.

Prevalence and associated factors of airway hyper- responsiveness in children with recurrent chronic cough I Gusti Agung Ngurah Sugitha Adnyana; Putu Suwendra; Hendra Santoso
Paediatrica Indonesiana Vol 44 No 5 (2004): September 2004
Publisher : Indonesian Pediatric Society

Background Airway hyper-responsiveness (AH) is a common char-acteristic of asthma. Patient who has recurrent chronic cough withAH is commonly referred as â€œcough variant asthmaâ€. Histamineprovocation test should be performed to determine whether a pa-tient has â€œcough variant asthmaâ€ or recurrent viral bronchitis.Objective To determine AH prevalence in children with recurrentchronic cough and factors associated with it.Methods A cross sectional study was conducted on 6-12 year-oldchildren with recurrent chronic cough at the Pediatrics OutpatientClinic, Sanglah Hospital Denpasar from September 2002 until June2003Results Twenty one out of 64 (33%) subjects suffering from recur-rent chronic cough without wheezing had AH. Associated factorssignificantly associated with AH were age, allergic rhinitis, pater-nal and maternal history of atopy, passive smoking, use of mos-quito-coil, positive skin prick test, and eosinophilia. Spearman cor-relation analysis between associated factors and AH showed thatpositive skin prick test and passive smoking were moderately cor-related with AH (r=0.56, p<0.0001; r=0.57, p<0.0001, respectively),whereas multivariate regression logistic analysis on associatedfactors found true associated factors, such as positive skin pricktest (p=0.01; OR=14.82), history of atopy in father (p=0.02;OR=22.75), and passive smoking (p=0.03; OR=11.97).Conclusions The prevalence of airway hyper-responsiveness inchildren with recurrent chronic cough without history of wheezingwas 33%. Independent associated factors of AH in recurrent chroniccough children are positive skin prick test, history of atopy in fa-ther, and passive smoking

Factors associated with oral Candida colonization in neonates at intensive care unit I Putu Wijana; Hendra Santoso; I Made Swastika
Paediatrica Indonesiana Vol 44 No 5 (2004): September 2004
Publisher : Indonesian Pediatric Society

Background Oral candidiasis still has high prevalence andfrequently causes problems in the neonatal period.Objective To evaluate some factors associated with the occurrenceof oral Candida colonization in neonates.Methods A cross sectional study was performed at the IntensiveCare Unit, Neonatology Division, Department of Child Health,Medical School, Udayana University/Sanglah Hospital Denpasar,from November 2002 to April 2003. Eighty neonates were enrolled.Oral mucous swabs were obtained and examined for Candidacolonization using potassium hydroxide (KOH). Data were analyzedby prevalence ratio and logistic regression; a p value of <0.05 wasconsidered significant.Results The prevalence of oral Candida colonization was 55%(44/80). The colonization was significantly associated with age of>1 week, male sex, gestational age of <37 weeks, Apgar score of<7, birth weight of <1500 grams, oral mucous pH of <7, systemicantibiotic use, and steroid use by mother. Breastfeeding was aprotective factor. Correlation between variables using Spearmantest revealed correlation coefficient of <0.5. By logistic regres-sion, birth weight of <1500 grams (p=0.04) and systemic antibi-otic use (p=0.01) were significant associated factors of oralCandida colonization, while breastfeeding was a significant pro-tective factor (p=0.03).Conclusion Birth weight of <1500 grams and systemic antibioticuse were significant associated factors of oral Candida colonizationand breastfeeding was a significant protective factor of oral Candidacolonization in neonates

Juvenile rheumatoid arthritis associated with uveitis in a 4-year-old girl Made Sukmawati; Hendra Santoso; Niti Susila
Paediatrica Indonesiana Vol 46 No 2 (2006): March 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.2.2006.87-92

The variability of the disease may explain mis-conceptions that JRA is usually a benign disease. Acohort study in which 506 subjects during the periodof 1970-1999 found that approximately one-third ofJRA patients achieve disease remission. The visualcomplications are also important in determining theoutcome. Functional disability is common and can belong-lasting. Recognizing JRA symptoms earlier areimportant to prevent mortality, disability, and long-term complications. Although JRA is the most com-mon rheumatic disease in children, many doctors arenot familiar with this disease. The purpose of thispaper is to report a case of juvenile rheumatoid ar-thritis associated with uveitis in a 4-year, 8-month-old girl.

The value of IgG to IgM ratio in predicting secondary dengue infection I Putu Gede Karyana; Hendra Santoso; Bagus Ngurah Putu Arhana
Paediatrica Indonesiana Vol 46 No 3 (2006): May 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.3.2006.113-7

Background The determination of primary or secondary dengueinfection using hemagglutination inhibition (HI) test is time-con-suming. The IgG to IgM ratio which can be obtained earlier wasused by several studies to differentiate secondary from primaryinfection, but they still reported various cut-off points.Objective To find the diagnostic value and best cut off point ofIgG to IgM ratio for predicting secondary dengue infection.Methods This was a prospective study carried out between July2003 and June 2004. Children with suspected dengue hemor-rhagic fever (DHF) were tested for HI during acute and convales-cent phase. The IgG and IgM titer were examined during the acutephase using ELISA method.Results Sixty-two children were recruited, 48 with secondary in-fection and 14 with primary infection. The prevalence of second-ary infection was 77%. The best cut off point of the IgG to IgM ratioto predict secondary infection was >1.1 with sensitivity of 87.5%,specificity 92.9%, likelihood ratio 12.3, and post test probability97.7%.Conclusion The IgG to IgM ratio of >1.1 is a good predictor forsecondary infection

Food hypersensitivity as a cause of atopic dermatitis Hendra Santoso
Paediatrica Indonesiana Vol 37 No 9-10 (1997): September - October 1997
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi37.9-10.1997.208-15

Food hypersensitivity as a cause of atopic dermatitis.

Highly active antiretroviral therapy and left ventricular diastolic function in children with human immunodeficiency virus infection Ni Made Ayu Agustini; Eka Gunawijaya; Ni Putu Venny Kartika Yantie; Ketut Dewi Kumara Wati; Komang Ayu Witarini; Hendra Santoso
Paediatrica Indonesiana Vol 59 No 3 (2019): May 2019
Publisher : Indonesian Pediatric Society

Background In the past, cardiovascular involvement did not seem to be a common complication of HIV, but in recent years it has been described more frequently. With the advent of highly active antiretroviral therapy (HAART), the symptoms of cardiac disease has changed, as the number of HIV-infected patients with abnormal diastolic parameters has increased significantly, often presenting as symptomatic rather than asymptomatic. Objective To analyze for a possible correlation between HAART duration and left ventricular diastolic function in HIV-infected children. Methods This cross-sectional study was conducted from December 2016 to December 2017 at the Cardiology and Allergy-Immunology Division/Department of Child Health, Universitas Udayana Medical School/Sanglah Hospital, Denpasar, Bali. Subjects with HAART were collected using a consecutive sampling method. The following data were recorded for each subject: age, sex, current stage of HIV, CD4+ level, as well as HAART regimen and duration of use. Transthoracic echocardiography was performed for tissue doppler imaging (TDI) of diastolic function. Spearmanâ€™s test was used to analyze the strength of correlation based on normality test results. Results This study involved 53 subjects, 21 of whom had impaired diastolic function. There was no correlation between HAART duration and diastolic function in children with HIV infection (r= -0.03; P=0.82). Conclusion Diastolic dysfunction is found in children under HAART treatment, but there is no correlation between HAART treatment duration and diastolic dysfunction.

Efficacy of high-dose methylprednisolone and cyclophosphamide in childhood-onset systemic lupus erythematosus Putu Ayunda Trisnia; Ketut Dewi KUmara Wati; Komang Ayu Witarini; Ida Bagus Ramajaya Sutawan; Hendra Santoso
Paediatrica Indonesiana Vol 60 No 3 (2020): May 2020
Publisher : Indonesian Pediatric Society

Background Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease. Untreated SLE often become progressive and lead to increased risk of mortality. Corticosteroid and cyclophosphamide remain the treatment of choice for severe SLE. Disease activity assessed with SLE Daily Activity Index (SLEDAI). Objective To compare the disease activity of childhood-onset severe SLE at the time of diagnosis, after completion of high dose methylprednisolone, and after three month of cyclophosphamide by using SLEDAI. Methods This study was conducted in the Division of Pediatric Allergy and Immunology, Department of Child Health, Udayana University/Sanglah Hospital, Denpasar, Bali. Subjects were SLE patient aged 0-18 years who had severe clinical manifestations. Subject received therapy combination of high dose methylprednisolone and cyclophosphamide every 2 weeks for six doses. SLEDAI score was assessed at the time of diagnosis, after completion of high dose methylprednisolone, and after three month of cyclophosphamide. Results During the study period, 51 children were diagnosed as SLE. Twenty-one subjects were included for analysis. Median SLEDAI score at the time of diagnosis was 23 (range 13-39). SLEDAI score after three months of cyclophosphamide was decreased to 2 (range 0-14). Post hoc analysis with Wilcoxon signed-rank test showed the improvement of SLEDAI score at the time of diagnosis and after three months of cyclophosphamide was statistically significant (Z=-4.016, P<0.0001). Conclusion SLEDAI score reduced after completion of high-dose methylprednisolone and three month of cyclophosphamide therapy.

PENYELIDIKAN STABILITAS RENCANA PIT TAMBANG DENGAN ANALISIS KEMANTAPAN LERENG MAJEMUK DI DESA MEKAR JAYA, KECAMATAN SEBULU Santoso, Hendra; Situmorang, Roni Marudut
Bulletin of Scientific Contribution Vol 22, No 1 (2024): Bulletin of Scientific Contribution : GEOLOGY
Publisher : Fakultas Teknik Geologi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/bsc.v22i1.53231

Salah satu daerah yang telah menjadi fokus aktivitas pertambangan yaitu Desa Mekar Jaya, Kecamatan Sebulu, Kabupaten Kutai Kartanegara, Kalimantan Timur. Desa Mekar Jaya memiliki litologi berklasifikasi batuan lemah, yang meningkatkan potensi terjadinya kelongsoran lereng. Oleh karena itu, analisis yang cermat terhadap kemantapan lereng menjadi sangat penting untuk merancang desain lereng PIT tambang yang optimal daerah penelitian tersebut. Faktor keamanan kelongsoran untuk Perencanaan pembukaan PIT Tambang memerlukan perhitungan desain rencana tambang optimal untuk menjamin kestabilan lereng wilayah pertambangan. Penelitian ini bertujuan untuk memastikan kestabilan lereng wilayah PIT tambang dengan menggunakan pendekatan deterministic (statis) dan probabilistik (dinamis). Data-data yang diperlukan, seperti kondisi topografi, struktur geologi, serta sifat fisik dan mekanik material pembentuk lereng, akan diperoleh melalui kegiatan pemboran geoteknik. Penelitian ini akan merujuk pada standar peraturan Kepmen ESDM No.1827 tahun 2018 tentang Pedoman Pelaksanaan Kaidah Teknik Pertambangan yang Baik. Hasil analisis menunjukkan rekomendasi untuk desain lereng tambang, yaitu: (1) GT03: dikategorikan stabil dengan litologi batukalkarenit, batuserpih, batulempung dan batubara dengan tinggi 47-61 m, titik nilai FK statis 3.26-3.73, FK dinamis 2.2-2.54, dan PK 0% (2) GT 04 berdasar desain lereng tinggi dengan litologi batulempung, batulanau, dan batuserpih maksimal 50.7 meter dengan FK statis maksimal 1,3, dan berdasar FK dinamis stabil pada ketinggian maksimal 50,8 meter dan sudut lereng keseluruhan 41-48o dan FK dinamis 1,19-1,25, dan PK 0%. Analisis deterministik dan probabilistik memberikan rekomendasi yang hamper sama dalam menentukan rencana pembuatan ketinggian dan sudut kemiringan desain rencana lereng PIT yang optimal.

Co-Authors Bagus Ngurah Putu Arhana Eka Gunawijaya I Gusti Agung Ngurah Sugitha Adnyana I Komang Kari I Made Kardana I Made Swastika I N Sartika I Putu Gede Karyana I Putu Wijana Ida Bagus Krisna Jaya Sutawan Ketut Dewi Kumara Wati Komang Ayu Witarini Made Sukmawati N. K. Niti Susila, N. K. Ni Made Ayu Agustini Ni Made Sumiartini NP Veny Kartika Yantie Putu Ayunda Trisnia Putu Suwendra Situmorang, Roni Marudut Suwendra, I Putu Wayan Retayasa

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