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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Sains dan Teknologi Farmasi Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Andriana Sari
Fakultas Farmasi Universitas Ahmad Dahlan Jl Prof Dr Soepomo Yogyakarta, Telp. (0274) 379418
Chemistry Computer Science & IT Education Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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IDENTIFIKASI POTENSI INTERAKSI OBAT PADA PASIEN RAWAT INAP PENYAKIT DALAM DI RSUD Prof. Dr. MARGONO SOEKARJO PURWOKERTO DENGAN METODE OBSERVASIONAL RETROSPEKTIF PERIODE NOVEMBER 2009 - JANUARI 2010 Sari, Andriana; Wahyono, Djoko; Raharjo, Budi
PHARMACIANA Vol 2, No 2: November 2012
Publisher : PHARMACIANA

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Abstract

Potensi interaksi obat adalah potensi aksi suatu obat diubah atau dipengaruhi oleh obat lain yang diberikan bersamaan. Interaksi obat didefinisikan sebagai fenomena yang terjadi ketika efek farmakodinamik dan farmakokinetik dari suatu obat berubah karena adanya pemberian obat yang lain. Interaksi obat dapat menyebabkan advers drug reaction apabila potensi terjadinya interaksi tersebut tidak diketahui sebelumnya upaya optimalisasi tidak dapat dilakukan. Tujuan penelitian ini adalah mengidentifikasi potensi interaksi obat pada pasien rawat inap penyakit dalam RSUD Prof. Dr. Margono Soekarjo Purwokerto. Metode penelitian adalah observasional retrospektif (November 2009 - Januari 2010) dengan menggunakan metoda deskriptif untuk analisa data. Hasil penelitian menunjukkan potensi interaksi obat pada pasien rawat inap penyakit dalam RSUD Prof. Dr. Margono Soekarjo Purwokerto sebesar 56,76% (n = 259). Berdasarkan kategori signifikansi yang dikemukakan Tatro (2006), terdapat potensi interaksi obat kategori signifikansi 1 pada pasien rawat inap penyakit dalam RSUD Prof. Dr. Margono Soekarjo Purwokerto sebesar 16,60%. Penggunaan obat berpotensi interaksi yang masuk kategori signifikansi 1 sebaiknya disesuaikan dengan kebutuhan pasien akan obat, risk and benefit serta dilakukan upaya optimalisasi.
Kualitas Hidup Pasien Hipertensi Rawat Jalan di Rumah Sakit PKU Muhammadiyah Bantul Yogyakarta Dengan Terapi Kombinasi Angiotensin Reseptor Blocker dan Calcium Channel Blocker Sari, Andriana; Baroroh, Faridah
Jurnal Sains dan Teknologi Farmasi Vol 19 No Supl1 (2017): Vol 19 Supplement 1, December 2017
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Hypertension medication may utilize a single antihypertensive or combined antihypertensives in accordance with the patient’s condition. Hypertension medication is carried out in a lengthy period and thus can affect the patient’s quality of life. This study aims to assess the quality of life of hypertensive outpatients under combination therapy with an angiotensin receptor blocker and a calcium channel blocker at a private hospital in Yogyakarta. The research applied a prospective cohort design, where the outcome observations were made three months after medication, on patients meeting the inclusion criteria by gauging their quality of life through validated EQ5D questionnaires and a VAS method. Analysis of the quality of life used the conversion of EQ5D dimension scores into an EQ5D index score and the VAS data by calculating the mean and standard deviation. Analysis of differences in quality of life between 3 antihypertensive drug combinations employed an ANOVA test. Results show that of 58 patients, 24 received a candesartan-amlodipine combination, 9 had candesartan-diltiazem and 25 were given irbesartan-amlodipine; 74.13% were female, 34.48%  were aged 51-60, and the most frequent complication was diabetes mellitus (60.34%). The quality-of-life analysis yielded an EQ5D index score of 1 in 24.14%patients and 0.796 in 13.79 % patients. The mean value from the VAS method is 66.17 with a minimum of 45 and maximum 90. The ANOVA test on the EQ5D quality-of-life index scores of the 3 drug combinations produced a sig value of p = 0.168 while the VAS method’s sig value is p = 0.433. Therefore, there was no significant difference in the quality of life of hypertensive outpatients who received candesartan-amlodipine, candesartan-diltiazem and irbesartan-amlodipine combinations
STUDI PENGGUNAAN ANTIBIOTIKA PASIEN PNEUMONIA ANAK DI RS. PKU MUHAMMADIYAH YOGYAKARTA DENGAN METODE DEFINED DAILY DOSE (DDD) Sari, Andriana; Safitri, Indah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 1, No 2 (2016)
Publisher : Akademi Farmasi ISFI Banjarmasin

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Abstract

Pneumonia  adalah  salah  satu  penyakit  infeksi  saluran  napas  yang  paling  sering terjadi.  Pengobatan  pneumonia  pada  umumnya  dilakukan  dengan  terapi  empiris  yaitu menggunakan  antibiotika  spektrum luas.  Tingginya konsumsi antibiotika berkontribusi  pada resistensi. Penelitian  ini bertujuan  untuk  mengetahui  kuantitas  penggunaan  dan  jenis  penggolongan antibiotika dengan menggunakan metode Defined Daily Dose (DDD) pada pasien  pneumonia anak  rawat  inap  di  RS  PKU  Muhammadiyah  Yogyakarta  periode  Januari-Desember  2014.Jenis  penelitian  ini  merupakan  penelitian  observasional  dengan  pengumpulan  data secara retrospektif yang didasarkan pada lembar rekam medik pada tahun 2014. Penelitian ini dilakukan terhadap 87 pasien  pneumonia anak yang memenuhi kriteria inklusi dan ekslusi.Hasil  penelitian menunjukkan  terdapat  11  jenis  antibiotika  yang  digunakan.  Total nilai  penggunaan antibiotika  sebesar  24,51  DDD/100  patient-days.  Kuantitas  penggunaan antibiotika  tiga terbesar  yaitu  Cefotaxime  14,64  DDD/100  patient-days,  Ampicillin  4,06 DDD/100 patient-days, dan Ceftazidime 1,84 DDD/100 patient-days. Berdasarkan  perhitungan  kuantitas  penggunaan  antibiotika  yang  pemakaiannnya paling  besar  untuk  pasien  pneumonia  anak  rawat  inap  di  RS  PKU  Muhammadiyah Yogyakarta periode Januari-Desember 2014 adalah cefotaxime 14,64 DDD/100 patient-days. 
PENGUKURAN KUALITAS HIDUP PASIEN HIPERTENSI DI PUSKESMAS MERGANGSAN YOGYAKARTA MENGGUNAKAN EUROPEAN QUALITY OF LIFE 5 DIMENSIONS (EQ5D) QUESTIONNAIRE DAN VISUAL ANALOG SCALE (VAS) Sari, Andriana; Lolita, Lolita; Fauzia, Fauzia
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 2, No 1 (2017)
Publisher : Akademi Farmasi ISFI Banjarmasin

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Abstract

Hipertensi dapat mempengaruhi kualitas hidup pasien yang membutuhkan terapi yang lama dan komplikasi penyakit, sehingga menyebabkan penurunan kualitas hidup dalam aspek fisik, psikologis dan sosial. Tujuan penelitian ini adalah mengukuran kualitas hidup pasien hipertensi untuk mengetahui gambaran kualitas hidup supaya bisa dilakukan evaluasi dan pencegahan penurunan kualitas hidup.Design penelitian adalah observasional cross sectional. Data diambil secara purposive sampling pada pasien hipertensi dengan atau tanpa komplikasi yang menjalani pengobatan rawat jalan di Puskesmas Mergangsan Yogyakarta yang memenuhi kriteria inklusi dan eklusi. European Quality of Life 5 Dimension (EQ5D) kuisioner dan Visual Analog Scale (VAS) digunakan untuk pengumpulan data. Analisis data dilakukan dengan mengkonversi EQ5D dimensi menjadi EQ5D Indeks, mencari nilai mean/median dan simpang baku dari score VAS serta uji independent sample t test.Pengukuran kualitas hidup terhadap 107 subjek diperoleh 24 subjek (22,4%) yang tidak bermasalah pada kelima dimensi dengan skor EQ5D indeks tertinggi yaitu 1,000. Dimensi yang bermasalah adalah pada dimensi rasa sakit/tidak nyaman (55,1%), dimensi berjalan/bergerak (47,6%), dimensi rasa cemas/depresi (33,6%), dimensi kegiatan yang biasa dilakukan (22,4%) dan dimensi perawatan diri (7,5%). Kualitas hidup diukur dengan VAS memiliki nilai median 70. Hasil Uji mann whitney dan 2-independent sample t-test untuk mengetahui perbedaan kualitas hidup antara pasien hipertensi dengan komplikasi dan tanpa komplikasi diperoleh nilai p= 0,967 (EQ5D indeks ) dan p= 0,590 (VAS). Kesimpulan pengukuran kualitas hidup pasien hipertensi dengan EQ5D diperoleh 22,4% memiliki skor EQ5D indeks tertinggi dan nilai median VAS adalah 70. Kualitas hidup pasien hipertensi dengan komplikasi dan tanpa komplikasi menunjukkan tidak berbeda signifikan.
VALIDASI ST EUROPEAN QUALITY OF LIFE-5 DIMENSIONS (EQ-5D) VERSI INDONESIA PADA PASIEN HIPERTENSI DI PUSKESMAS KOTAGEDE II YOGYAKARTA Sari, Andriana; Yuni Lestari, Nidia; Aryani Perwitasari, Dyah
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.101 KB) | DOI: 10.12928/pharmaciana.v5i2.2483

Abstract

Hypertension is a major risk factor for the occurrence of deaths from non-communicable diseases in the world. In the World Health Statistics 2012, WHO reported that approximately 51% of deaths from stroke and 45% of coronary heart disease due to hypertension. Patients with obsesitas, hypertension, and diabetes can worsen patient’s quality of life both physically and mental status. This study aims to assess the quality of life by the European Quality of Life-5 Dimensions (EQ-5D) questionnaire. This study aims to determine the validity and reliability of the EQ-5D in Indonesian version as an instrument for measuring the quality of life of patients with hypertension in the Health Center Kotagede II Yogyakarta. The method of this study was descriptive observational. Data were collected using a questionnaire conducted at a particular time. The instrument used in this study is the EQ-5D which has been translated into Indonesian. Affordable population in this study were all patients with hypertension in Health Center Kotagede II Yogyakarta at May to June 2014. The sample in this study are in accordance with the criteria for inclusion and exclusion criteria. Analysis of the validity was constructs validity with Pearson method. Test reliability was Cronbachs alpha coefficient. From the data analysis for 51 patients Hypertension Pearson correlation coefficient obtained results are above 0.30, so it can be concluded instrument EQ-5D questionnaire Indonesian version is valid. Results Cornbachsα is 0718 so it can be concluded instrument EQ-5D questionnaire Indonesian version is reliable.
IDENTIFIKASI POTENSI INTERAKSI OBAT PADA PASIEN RAWAT INAP PENYAKIT DALAM DI RSUD Prof. Dr. MARGONO SOEKARJO PURWOKERTO DENGAN METODE OBSERVASIONAL RETROSPEKTIF PERIODE NOVEMBER 2009-JANUARI 2010 Sari, Andriana; Wahyono, Djoko; Raharjo, Budi
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (72.901 KB) | DOI: 10.12928/pharmaciana.v2i2.669

Abstract

The potensial drug interaction is potential action of a drug that changed orinfluced by other drugs concurrenly. Drug interactions are defined as a phenomenonthat occurs when the pharmacokinetic effect of a drug changes due to other drugdelivery. Drug interactions could cause advers drug reactions when the potential for apreviously unknown interaction. The purpose of this study is to identify potential druginteractions in patient hospitalized in the Prof. Dr. Margono Soekarjo PurwokertoHospital. The research method was an observasional retrospective study (November2009-January 2010) by using descriptive methods for the data analysis.The resultshowed that the potential drug interactions in the hospitalized patients in Prof. Dr.Margono Soekarjo Hospital is 56,76% (n= 259). Based on the significance categorieswhich proposed by Tatro (2006): a potential drug interaction with significancecategory 1 in ward patients in prof. Dr. Margono Soekarjo Hospital is 16,67%. Thedrug used thet known potential interaction, especially in the category of significance 1should be tailored to the patient’s need, risk and benefit, and have made efforts tooptimize it.
Proportion and Factors Predicted Self- Medication in Elderly Population in Yogyakarta Sari, Andriana; Supadmi, Woro; Perwitasari, Dyah Aryani
Media Farmasi: Jurnal Ilmu Farmasi Vol 12, No 1: Maret 2015
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (91.48 KB) | DOI: 10.12928/mf.v12i1.3025

Abstract

Pharmacists should give more attention in giving pharmaceutical care services to the elderly patients, because the decrease of physiological function could result more drug related problems. Currently, elderly patients are interesting to do self- medication before visiting the physician. Thus, our study was aimed to understand  the proportion of elderly patients who are interesting to do the self-medication and to explore the factors predicted self-medication behavior. This study was carried out by cross-sectional design. Data was collected by doing interview and giving questionnaire to the 544 elderly patients in the pharmacies of YogyakartaProvince which were chosen by proportional area sampling method. Data was analyzed descriptively and using the chi square test to understand factors which could be influenced self medication behavior. Most of the patients choose to do the self medication (63.6%) rather than directly went to the physician (36.4%).  There were 3 predictors of self medication behavior in our study, which were occupation, income and type of disease with the RR were; 0.823 (95% CI:0.7010.965), 1.433 (95% CI:1.173-1.751) and 1.027 (95% CI: 1.059-1.376), respectively.The occupation, income and chronic disease could predict of self medication behavior in elderly patients.Keywords: self medication, elderly, predictor
Comparison effectiveness of use antihypertensive in preeclampsia patient in RSUD Panembahan Senopati Bantul Andriana Sari; Wisi Unggul Pertiwi; Faridah Baroroh
Pharmaciana Vol 13, No 2 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i2.23603

Abstract

Preeclampsia is one of many unsolved obstetric problems. The purpose of this research is to compare effectiveness of antihypertensive in preeclampsia patient in RSUD Panembahan Senopati Bantul in the period January-July 2019. This study needs to analyze about antihypertensive drugs in preeclampsia because Preeclampsia is the 3rd rank of disease in pregnancy that causes maternal death after hemorrhagic and cardiovascular diseases. The study was conducted at Panembahan Senopati Hospital Bantul because hypertension in inpatient was ranked first in 10 distributions of non-communicable diseases. The research was observational analytic using a cross sectional study with retrospective data collection of patient medical record. Samples were selected on inclusion and exclusion criteria in 46 cases. Data analysis using Mann-Whitney to determine differences in drug effectiveness and Fisher's to determine the relationship. The results are found that no relationship between maternal age, obstetrical age, pregnancy status, method of birth, and length of stay, but there was a relationship between the severity of preeclampsia with the achievement of blood pressure targets. The results of comparative analysis of the effectiveness nifedipine monotherapy with combination of nifedipine + methyldopa there was a significant difference (p = 0.006), and there was a significant relationship between nifedipine monotherapy and combination of nifedipine + methyldopa (p = 0.015) OR results = 7.200. The conclusion of this study is more effective to use the combination of nifedipine + methyldopa for patients with preeclampsia.
Proportion and Factors Predicted Self- Medication in Elderly Population in Yogyakarta Sari, Andriana; Supadmi, Woro; Perwitasari, Dyah Aryani
Media Farmasi: Jurnal Ilmu Farmasi Vol. 12 No. 1: Maret 2015
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v12i1.3025

Abstract

Pharmacists should give more attention in giving pharmaceutical care services to the elderly patients, because the decrease of physiological function could result more drug related problems. Currently, elderly patients are interesting to do self- medication before visiting the physician. Thus, our study was aimed to understand  the proportion of elderly patients who are interesting to do the self-medication and to explore the factors predicted self-medication behavior. This study was carried out by cross-sectional design. Data was collected by doing interview and giving questionnaire to the 544 elderly patients in the pharmacies of YogyakartaProvince which were chosen by proportional area sampling method. Data was analyzed descriptively and using the chi square test to understand factors which could be influenced self medication behavior. Most of the patients choose to do the self medication (63.6%) rather than directly went to the physician (36.4%).  There were 3 predictors of self medication behavior in our study, which were occupation, income and type of disease with the RR were; 0.823 (95% CI:0.7010.965), 1.433 (95% CI:1.173-1.751) and 1.027 (95% CI: 1.059-1.376), respectively.The occupation, income and chronic disease could predict of self medication behavior in elderly patients.
KEPATUHAN TERHADAP PENGOBATAN PADA PASIEN HIPERTENSI DENGAN KOMPLIKASI DIABETES MELITUS DI PUSKESMAS YOGYAKARTA Rahmadani, Mufti Alifia; Sari, Andriana
Media Farmasi: Jurnal Ilmu Farmasi Vol. 15 No. 2: September 2018
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v15i2.12662

Abstract

Kepatuhan terhadap pengobatan mempengaruhi keberhasilan terapi pasien. Tujuandalam penelitian ini untuk mengetahui kepatuhan pengobatan pada pasien hipertensidengan komplikasi diabetes melitus di Puskesmas wilayah Kota Yogyakarta. Penelitianobservasional ini menggunakan pendekatan desain cross sectional. Pengambilan datadilakukan dengan menggunakan kuesioner Medication Adherence Report Scale(MARS). Responden dalam penelitian ini adalah semua pasien hipertensi dengankomplikasi diabetes melitus yang menjalani rawat jalan di 5 Puskesmas wilayah KotaYogyakarta pada periode bulan November 2017 – Januari 2018. Analisa distribusifrekuensi digunakan untuk mengetahui kepatuhan terhadap pengobatan pasien.Penelitian ini melibatkan 44 responden dari 5 Puskesmas wilayah Kota Yogyakarta.Puskesmas yang digunakan sebagai tempat pengambilan data yaitu PuskesmasNgampilan, Puskesmas Mergangsan, Puskesmas Kotagede I, Puskesmas Danurejan Idan Puskesmas Gondokusuman II. Data karakteristik responden tertinggi padaperempuan (63,6%), kelompok umur 60-79 tahun (75,0%), berpendidikan tamatSLTA/Sederajat (40,9%), dan pasien tidak bekerja (54,5%). Hasil analisa kepatuhanpasien diketahui 59,1% patuh dan 40,9% tidak patuh dalam pengobatannya.Kesimpulan dari penelitian ini adalah sebagian besar pasien hipertensi dengankomplikasi diabetes melitus di puskesmas wilayah Kota Yogyakarta patuh terhadappengobatannya.
Co-Authors Budi Raharjo Djoko Wahyono Dyah Aryani Perwitasari Faridah Baroroh Faridah Baroroh Fauzia Fauzia Kodriati, Nurul Lolita Lolita Meyleni, Reni Mufti Alifia Rahmadani Nidia Yuni Lestari, Nidia Novitasari, Putri Rachma Nurul Ichwan, Willy Purwanto, Barkah Djaka Raharjo, Budi Ratu Matahari Safitri, Indah Wahyono, Djoko Wisi Unggul Pertiwi Woro Supadmi