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UJI EFEK ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN KACAPIRING (Gardenia augusta, Merr) PADA TIKUS PUTIH JANTAN GALUR WISTAR Baroroh, Faridah; Aznam, Nurfina; Susanti, Hari
PHARMACIANA Vol 1, No 1: Mei 2011
Publisher : PHARMACIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.03 KB)

Daun kacapiring (Gardenia augusta, Merr) sering digunakan secara tradisional untuk pengobatan diabetes mellitus. Penelitian ini dilakukan untuk mengetahui apakah ekstrak etanol daun kacapiring dapat menurunkan kadar glukosa darah pada tikus putih jantan galur Wistar dan seberapa besar efek antihiperglikemiknya jika dibandingkan dengan obat antidiabetes glibenklamid. Penelitian ini menggunakan metode uji toleransi glukosa oral dengan pembebanan glukosa dosis 4,5 g/kgBB. Hewan uji yang digunakan tikus putih jantan galur Wistar umur 2-3 bulan, berat badan 180-250 gram, sebanyak 24 ekor yang dibagi menjadi 4 kelompok masing-masing kelompok terdiri dari 6 ekor tikus. Kelompok I sebagai kelompok kontrol negatif diberi CMC-Na 1%, kelompok II sebagai kelompok kontrol positif diberi glibenklamid dosis 1,35 mg/kgBB, kelompok III dan kelompok IV diberi ekstrak etanol daun kacapiring masing-masing dosis 500 mg/kgBB dan 250 mg/kgBB. Glibenklamid dan ekstrak diberikan secara peroral 60 menit sebelum pemberian glukosa. Pengambilan darah melalui sinus orbitalis secara keseluruhan dilakukan pada menit ke-(-90), (-60), 0, 30, 60, 120, 180, 240, dan 300. Kadar glukosa darah diukur dengan metode enzimatik dengan pereaksi GOD PAP (Glucose Oxidase Phenol 4-Aminoantipirin) yang menghasilkan larutan merah dan absorbansi dibaca dengan spektrofotometer UV-Vis pada panjang gelombang 500 nm. Hasil penelitian menunjukkan bahwa ekstrak etanol daun kacapiring dosis 500 mg/kgBB dan 250 mg/kgBB dapat berefek menurunkan kadar glukosa darah. Ekstrak etanol daun kacapiring dosis 500 mg/kgBB dan 250 mg/kg dapat menurunkan kadar glukosa darah sebesar 58,97% dan 80,60% disbanding glibenklamid dosis 1,35 mg/kgBB yang dapat menurunkan kadar glukosa darah sebesar 73,93%.

EVALUASI IMPLEMENTASI PELAYANAN INFORMASI OBAT PASIEN RAWAT JALAN DI INSTALASI FARMASI RUMAH SAKIT YOGYAKARTA Baroroh, Faridah
PHARMACIANA Vol 1, No 2: November 2011
Publisher : PHARMACIANA

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Upaya untuk menunjang pelayanan kesehatan yang bermutu tinggi di rumah sakit, Instalasi Farmasi Rumah Sakit Yogyakarta perlu melakukan evaluasi implementasi pelayanan informasi obat pasien rawat jalan. Tujuan dari penelitian ini adalah untuk mengetahui realisasi implementasi pelayanan informasi obat pasien rawat jalan di instalasi farmasi Rumah Sakit Yogyakarta jika dibandingkan dengan target yang diinginkan. Penelitian ini merupakan penelitian deskriptif dengan melihat dokumentasi data sekunder tentang program kerja instalasi farmasi, wawancara dengan apoteker yang bertugas melayani pasien rawat jalan sebagai subyek penelitian, serta pengamatan langsung terhadap pelayanan informasi obat pasien rawat jalan. Untuk mengetahui perbandingan realisasi dengan target yang diinginkan digunakan analisis kesenjangan. Hasil penelitian evaluasi implementasi pelayanan informasi obat pasien rawat jalan terlaksana dengan realisasi terjadi kesenjangan negatif sebesar (-0,67%). Komponen informasi obat yang disampaikan meliputi khasiat, cara penggunaan, aturan pakai, lama penggunaan obat, efek samping obat, sedangkan komponen informasi obat yang tidak disampaikan di instalasi farmasi Rumah Sakit Yogyakarta yaitu informasi jadwal pengobatan, dan tanda-tanda toksisitas.

Kualitas Hidup Pasien Hipertensi Rawat Jalan di Rumah Sakit PKU Muhammadiyah Bantul Yogyakarta Dengan Terapi Kombinasi Angiotensin Reseptor Blocker dan Calcium Channel Blocker Sari, Andriana; Baroroh, Faridah
Jurnal Sains dan Teknologi Farmasi Vol 19 No Supl1 (2017): Vol 19 Supplement 1, December 2017
Publisher : Fakultas Farmasi Universitas Andalas

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Hypertension medication may utilize a single antihypertensive or combined antihypertensives in accordance with the patientâs condition. Hypertension medication is carried out in a lengthy period and thus can affect the patientâs quality of life. This study aims to assess the quality of life of hypertensive outpatients under combination therapy with an angiotensin receptor blocker and a calcium channel blocker at a private hospital in Yogyakarta. The research applied a prospective cohort design, where the outcome observations were made three months after medication, on patients meeting the inclusion criteria by gauging their quality of life through validated EQ5D questionnaires and a VAS method. Analysis of the quality of life used the conversion of EQ5D dimension scores into an EQ5D index score and the VAS data by calculating the mean and standard deviation. Analysis of differences in quality of life between 3 antihypertensive drug combinations employed an ANOVA test. Results show that of 58 patients, 24 received a candesartan-amlodipine combination, 9 had candesartan-diltiazem and 25 were given irbesartan-amlodipine; 74.13% were female, 34.48%  were aged 51-60, and the most frequent complication was diabetes mellitus (60.34%). The quality-of-life analysis yielded an EQ5D index score of 1 in 24.14%patients and 0.796 in 13.79 % patients. The mean value from the VAS method is 66.17 with a minimum of 45 and maximum 90. The ANOVA test on the EQ5D quality-of-life index scores of the 3 drug combinations produced a sig value of p = 0.168 while the VAS methodâs sig value is p = 0.433. Therefore, there was no significant difference in the quality of life of hypertensive outpatients who received candesartan-amlodipine, candesartan-diltiazem and irbesartan-amlodipine combinations

EVALUASI KEPUASAN KONSUMEN TERHADAP PELAYANAN KEFARMASIAN DI APOTEK KOTA YOGYAKARTA Baroroh, Faridah
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Customer satisfaction with pharmaceutical care in pharmacy can be measured bycomparing the expectations of consumers on the quality of pharmacy services desired by thefact that it received. This study was aimed to identify the dimensions of the expected quality ofpharmaceutical care, is considered important, and which has a good performance with a modelof quality pharmaceutical care to costumer at pharmacy in Yogyakarta. This study wasobservational descriptive method and the results are presented with quadrant diagram. Theresults showed that the costumer at pharmacy in Yogyakarta satisfied with pharmaceutical carein Tangible and Empathy dimension. The Tangible and Empathy dimensions are in quadrant IIof the diagram. Howefer, the Assurance, Responsiveness and Reliability dimension, costumersless satisfied because the assume of patients if the pharmacy performance is still lower than theexpectations of consumers. That showed the Assurance, Responsiveness and Reliabilitydimensions are in quadrant III of the diagram.

EVALUASI KEPUASAN KONSUMEN TERHADAP PELAYANAN KEFARMASIAN DI APOTEK KOTA YOGYAKARTA Faridah Baroroh
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Customer satisfaction with pharmaceutical care in pharmacy can be measured bycomparing the expectations of consumers on the quality of pharmacy services desired by thefact that it received. This study was aimed to identify the dimensions of the expected quality ofpharmaceutical care, is considered important, and which has a good performance with a modelof quality pharmaceutical care to costumer at pharmacy in Yogyakarta. This study wasobservational descriptive method and the results are presented with quadrant diagram. Theresults showed that the costumer at pharmacy in Yogyakarta satisfied with pharmaceutical carein Tangible and Empathy dimension. The Tangible and Empathy dimensions are in quadrant IIof the diagram. Howefer, the Assurance, Responsiveness and Reliability dimension, costumersless satisfied because the assume of patients if the pharmacy performance is still lower than theexpectations of consumers. That showed the Assurance, Responsiveness and Reliabilitydimensions are in quadrant III of the diagram.

SOSIOEKONOMI, PENGETAHUAN PENYAKIT DIARE DAN PENGETAHUAN SWAMEDIKASI DIARE PADA IBU BALITA DI YOGYAKARTA Faridah Baroroh; Ana Hidayati; Siti Nurbayanti; Intan Tin Sari; Atikah Zain; Redy Redy; Siwi Retnaning Dyahayu
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

In Indonesia, the prevalence of diarrhea is highest among children under five. Economic factors and maternal knowledge are, in this case, significantly related to diarrhea incidence, and the latter substantially defines self-medication measures taken for acute diarrhea treatment. The research was intended to determine the extent to which socioeconomic conditions and diarrheal knowledge formed comprehension of such treatment. For this purpose, it employed a cross-sectional study with 504 research subjects, namely, mothers of children under five in the Special Region of Yogyakarta, Indonesia. Data were collected using a validated questionnaire consisting of items on socioeconomic details (education, employment, income), diarrheal knowledge, and relevant self-medication knowledge. Afterward, education and post-test were conducted using the same list of questions. Analytical techniques were carried out to identify how significant socioeconomic characteristics determined knowledge of diarrheal disease and self-medication.Results showed that, socioeconomically, a large proportion of research subjects attained secondary to tertiary education (76%), were unemployed (71%), and earned low income (62%). Educational attainment was found to be significantly related to levels of knowledge of diarrheal disease and self-medication (p < 0.005), but employment status and income were not (p > 0.005). Analysis results also indicate a significant relationship (p = 0.000) between the level of knowledge of diarrheal disease and that of diarrheal self-medication. Overall, socioeconomic status (i.e., level of education) and diarrheal knowledge is significantly related to diarrheal self-medication knowledge.

Kerinci Cinnamon Leaf (Cinnamomum burmanii) and Tangkit Pineapple Core (Ananas comosus) Extracts in Mouthwash Formulation: Potential for Preventing Dental Plaque Growth in Special Needs Childre Fitria, Karin Tika; Handayatun, Naning Nur; Baroroh, Faridah; Pertiwi, Deasy Vanda
Jurnal Kesehatan Gigi Vol 11, No 2 (2024): Desember 2024
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v11i2.12021

Dental plaque is a significant factor in developing oral diseases, particularly in children with special needs who may face challenges maintaining oral hygiene. This study explores the potential of a mouthwash formulation incorporating Kerinci cinnamon leaf (Cinnamomum burmanii) and Tangkit pineapple core (Ananas comosus) extracts in preventing dental plaque growth. Both extracts were chosen due to their known antibacterial properties and natural origin, making them suitable for children with sensitivities to synthetic chemicals. The formulation was tested in varying ratios to determine the most effective combination for inhibiting the growth of Streptococcus mutans, a primary bacterium responsible for dental plaque. The results indicated that a 50:50 ratio of cinnamon leaf and pineapple core extracts exhibited the highest antibacterial activity (p-value 0,034), outperforming other ratios such as 75:25 and 25:75. This suggests a synergistic interaction between the two extracts, enhancing their combined efficacy. Further research is recommended to optimize the formulation and evaluate its long-term effectiveness and safety in clinical settings

KUALITAS HIDUP PASIEN HIPERTENSI RAWAT JALAN RUMAH SAKIT SWASTA DI YOGYAKARTA YANG MENDAPATKAN TERAPI ANGIOTENSIN RECEPTOR BLOCKERS (ARB) DAN KOMBINASI OBAT LAIN Baroroh, Faridah; Nurul Ichwan, Willy; Sari, Andriana
Media Farmasi: Jurnal Ilmu Farmasi Vol. 18 No. 1: Maret 2021
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v18i1.16762

Kualitas hidup yang buruk pada seseorang dapat diakibatkan karena perasaan tidak nyaman, terapi dengan obat antihipertensi sering berhubungan dengan munculnya efek samping yang tidak nyaman. Tujuan penelitian ini adalah untuk mengetahui apakah ada perbedaan kualitas hidup pasien hipertensi yang diberi terapi angiotensin receptor blockers (ARB) dan kombinasi obat lain. Metode penelitian ini adalah observasional analitik melalui pendekatan cross sectional. Teknik pengambilan sampel purposive sampling, lokasi penelitian di rumah sakit swasta di Yogyakarta. Analisis data dengan skoring kuesioner EQ5D dimensi menjadi EQ5D indeks, dilanjutkan uji Mann-Whitney. Hasil penelitian dari 55 pasien yang memenuhi kriteria inklusi dan eksklusi, kualitas hidup tertinggi dengan nilai indeks EQ5D 0,933 dan kualitas hidup terendah dengan nilai indeks EQ5D 0,243. Kualitas hidup yang sangat bermasalah dari empat dimensi yaitu perawatan diri, kegiatan yang biasa dilakukan, rasa sakit/tidak nyaman, rasa cemas/depresi. Kualitas hidup yang paling banyak mempunyai masalah yaitu pada dimensi rasa kesakitan/tidak nyaman (50,9%). Terdapat hubungan signifikan usia (p=0,008) dengan kualitas hidup, dan tidak terdapat hubungan signifikan jenis kelamin (p=0,857), pendidikan (p=0,079), pekerjaan (p=0,507) dengan kualitas hidup. Tidak ada perbedaan signifikan (p=0,317) kualitas hidup pasien hipertensi yang mendapatkan terapi angiotensin receptor blockers (ARB) dan kombinasi obat lain. Kesimpulan penelitian, tidak ada perbedaan signifikan (p=0,317) kualitas hidup pasien hipertensi yang mendapatkan terapi angiotensin receptor blockers (ARB) dan kombinasi obat lain.

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