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All Journal Media Penelitian dan Pengembangan Kesehatan Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Biopropal Industri BERITA BIOLOGI Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Biosaintifika: Journal of Biology & Biology Education Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Kefarmasian Indonesia
ERIS SEPTIANA
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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PENGHAMBATAN AKTIVITAS ENZIM α-GLUKOSIDASE DARI EKSTRAK AIR TANAMAN RARU (Vatica pauciflora) SECARA IN VITRO septiana, eris; winarti, wiwi; simanjuntak, partomuan
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 4 No. 1 (2017)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v4i1.96

Abstract

Diabetes mellitus is a metabolic disorder that leading the blood sugar levels become higher than normal. In Indonesia, one of the plants that traditionally used to cure hyperglycemic is raru plant (Vatica pauciflora). The objectives of this research was to investigate α-glucosidase inhibitory activity from stem bark, root, and leaf of raru plant. Extraction of stem bark, root, and leaf was conducted with reflux at 70 °C by using water as a solvent. In vitro anti-diabetic activity was tested using the method of α-glucosidase inhibition. The results show that water extracts of raru's stem bark, root, and leaf have α-glucosidase inhibitory activity. The stem bark water extract has the highest activity than leaf and root with IC50 values were 13.53, 16.96, and 41.91 ppm respectively. All extracts is categorized as active in inhibiting the activity of α-glucosidase enzyme by having IC50≤100 ppm. The results obtain in this research clearly indicate a promising potential as anti-diabetic properties of raru plant.
Co-Authors Andriyaningsih, Fitri Ayu Purnamasari Bustanussalam Bustanussalam, Bustanussalam Fauzy Rachman Gianny, Demitra Lekatompessy, Sylvia J.R. Mawadah, Nursifa Mutia Hardhiyuna, Mutia Pamungkas, Riska Andriani Partomuan Simanjuntak Rahmawati, Siti Irma Sukiman, Harmastini I. Untari, Febriana Wiwi Winarti Yadi, Yadi