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All Journal Indonesian Journal of Rheumatology The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Bambang Setiyohadi
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Medicine & Pharmacology

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Correlation of matrix metalloproteinase-9 level, erythrocyte sedimentation rate, rheumatoid factor, and the duration of illness with radiological findings in rheumatoid arthritis patients Aji, G; Manuaba, Ida Ayu Ratih Wulansari; Ongkowijaya, Jeffrey A; Setiyohadi, Bambang; Sumariyono, Sumariyono
Indonesian Journal of Rheumatology Vol 2, No 2 (2010)
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.584 KB)

Abstract

Background: Rheumatoid arthritis (RA) is a common autoimmune disease of the joint indicated by chronic inflammation of synovium, cartilage destruction, and osteopenia. The end results of RA are joint deformity and disability that will decrease the quality of life ofthe patients. Until now there is not a specifi c marker to assess the process of joint and bone damage in RA. Available markers such as C-reactive protein and erythrocyte sedimentation rate (ESR) indicate more about the infl ammatory status of the patient. Thediscovery of matrix metalloproteinases (MMPs) enzyme overexpression in RA has brought a new hope for the discovery of more specifi c markers of joint damage.Objective: To study the correlation of MMP-9 level, ESR, rheumatoid factor (RF), and the duration of illness with joint damage in RA patients.Methods: A cross-sectional study was conducted on RA outpatients in rheumatology clinic at Cipto Mangunkusumo General Hospital, Jakarta from January to October 2009. From the patients who fulfilled the inclusion criteria and did not fulfi ll the exclusion criteria, blood sample was collected for MMP-9 level, RF, and ESR examinations; hand radiography (posterior-anterior view) was also taken. Results: From the study of 46 patients, we found a significant correlation between MMP-9 level and radiographic feature of bone erosion (r = 0.3, p = 0.02) and between the duration of illness and Sharp score (r = 0.36, p = 0.014). There was no correlation between ESR and radiological fi ndings nor between RF and radiological fi ndings. Linear regression analysis showed the duration of illness as the most infl uencing factor toradiological fi ndings in RA patients.Conclusion: We found a signifi cant correlation between MMP-9 level and radiographic feature of bone erosion, and between the duration of illness and radiological fi ndings in RA patients.
Profile of osteophyte location in different grades of functional status in patients with knee osteoarthritis Mesanti, O; SETIYOHADI, BAMBANG; Kasjmir, Yoga I; Budihusodo, U; Oemardi, M
Indonesian Journal of Rheumatology Vol 2, No 1 (2010)
Publisher : Indonesian Rheumatology Association

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Background. Osteophyte is a reparative response to cartilage breakdown in osteoarthritis (OA) and osteophyte formation is a knee stabilizing factor. Disability could be found in patients with knee OA. Objective. To identify the profile of osteophyte formation (location, size, and direction) based on knee radiograph and functional status examination in knee OA patients who presented to the Rheumatology Clinic, Cipto Mangunkusumo Central National General Hospital.Methods. Samples were taken by consecutive approach. Knee radiographs (weight bearing anteroposterior and30 degrees flexion skyline views) and functional status examinations were performed on 100 patients with knee OA (90 females and 10 males with ages ranging from 51 to 74 years old). A radiologist assessed films for osteophyte profile such as location, size, and direction according to standard atlas. One knee with the severe radiological assessment based on OA grade was selected from one patient to be the profile. LequesneAlgofunctional Index was also taken from the patients. Results. The site of osteophyte in patients with knee OA was mostly found at lateral femur (85/100 subjects). Based on specific location, grade 2 osteophyte at lateral femur was the most frequent size (49/100 subjects) and osteophyte extending toward the lower middle atlateral patella (65/100 subjects) was the most frequent direction of osteophyte. The most frequent profile for size and direction of osteophyte at specific location was the grade 2 osteophyte extending toward the lower middle at lateral patella (35/100 subjects). Severe functional status impairment was found in 53% of the patients. The most frequent functional status found according to specific location of osteophyte was severe functionalstatus impairment in patients with oste ophyte at lateral femur (46/100 subjects). The most frequent functional status of OA patients based on the size and direction of osteophyte at specific location was the severe functional impairment in the patients with grade 2  osteophyte at lateral femur (27/100 subjects) and the patients with osteophyte extending towards the lower middle at lateral patella (37/100 subjects) respectively.Conclusions. Osteophyte at lateral femur, osteophyte at lateral tibiofemoral compartment, grade 2 osteophyte at lateral femur, and osteophyte extending toward the lower middle at lateral patella were the profiles of osteophyte which mostly showed severe functional status impairment in patients with knee OA.
Esophageal Varices Bleeding in Portal Hypertension due to Portal Vein and Splenic Vein Obstruction David R.S. Samosir; Loli Simanjuntak; Bambang Setiyohadi; L. A. Lesmana; Aru W. Sudoyo; Marcellus Simandibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 3, NUMBER 1, April 2002
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/31200224-27

Abstract

Based on its relation to the liver sinusoid, increased pressure of portal vein can occur at three levels: presinusoid, sinusoid ,and postsinusoid. Obstruction of the presinusoid veins can be caused by extra- hepatic condition such as venous thrombosis. We reported a case of portal hypertension with esophageal varices bleeding was a result of obstruction due to thrombosis of the splenic vein and portal vein under hypercoagulant conditions due to thrombocytosis. The management of esophageal varices was sclerotherapy while for overcome the thrombosis the patient was given hydroxy urea.    Keywords: esophageal varices bleeding, portal hypertension, vein obstruction
Co-Authors A Harahap, A Abd. Rasyid Syamsuri Abdullah, A A Abdullah, M Aji, G Akil, Natsir Anggraini, N Aru W. Sudoyo Aru W. Sudoyo Aziza, L Azizi, M S Budihusodo, U Budiman Budiman Cleopas Martin Rumende David R.S. Samosir Dewi, Sumartini Djoerban, Z Fawziah, A Gunawan Gunawan Isbagio, H Kasjmir, Yoga I L. A. Lesmana L. A. Lesmana Laniyati Hamijoyo, Laniyati Loli Simanjuntak Lubis, A MT Lusiani Lusiani, Lusiani Marcellus Simandibrata Mesanti, O Mokoagow, M I Nasution, A R Nilasari, D Nufus, H Nyoman Suarjana Oemardi, M Oktaviana, F Ongkowijaya, Jeffrey A Pangestu, Y Rudy Hidayat Rumende, C Matin S Effendy, S Sandra, R Santosa, D Setiati, S Simadibrata, M Sinaga, A Sinto, R Sitorus, F Suhendro Suhendro Sukmana, N Sulaiman, A S Sumariyono Sumariyono Titis, Titis Umami, V Utari, A P Wahyuningsih, R Wardoyo, A Wijaya, Linda K Yudharto, M A Yuliani, Ika Wulan Zuljasri Albar