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All Journal Journal of Food and Pharmaceutical Science Jurnal Ilmiah Farmasi Jurnal Kimia (Journal of Chemistry) Jurnal Farmasi Udayana Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Sains dan Komunitas Journal of Health Sciences and Medicine Jurnal Farmasi Sains dan Praktis Innovation in Health for Society Eduvest - Journal of Universal Studies Journal of Food and Pharmaceutical Sciences
Eka Indra Setyawan
Program Studi Farmasi Fakultas MIPA Universitas Udayana Bali
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Pengaruh Pemakaian PEG 400 Dan Mentol Dalam Patch Mukoadhesif Ekstrak Etanol Daun Sirih (Piper betle L.) Terhadap Transpor Senyawa Polifenol Setyawan E I; P O Samirana; I G A. Indyayani
Media Farmasi: Jurnal Ilmu Farmasi Vol 13, No 1: Maret 2016
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.586 KB) | DOI: 10.12928/mf.v13i1.5738

Abstract

Patch bukal merupakan sediaan obat dengan sistem penghantaran transmukosa. Kemampuan absorpsi zat aktif sediaan Patch bukal dapat dimodifikasi dengan penambahan suatu plasticizers dan permeation enhancer.Penelitian ini dilakukan untuk mengetahui pengaruh pemakaian PEG 400 dan mentol terhadap transpor serta mengetahui proporsi PEG 400 dan mentol yang dapat memberikan transpor optimum senyawa polifenol ekstrak daun sirih (Piper bitle L.) dari patch bukal secara in vitro. Metode yang digunakan untuk menentukan perbandingan jumlah PEG 400 dan mentol adalah dengan metode Simplex Lattice Design (SLD). Uji transpor senyawa polifenol dari patch dilakukan selama 23 jam dengan menggunakan sel difusi Franz dengan membran Whatmann No. 1. Jumlah senyawa yang tertranspor ditetapkan kadarnya dengan instrumen Spektrofotometer-UV. Verifikasi formula optimum dilakukan sebanyak 3 kali dengan Single Simple Test. Hasil penelitian menunjukkan bahwa penggunaan PEG 400 dan mentol dapat meningkatkan jumlah polifenol yang tertranspor. Hubungan pengaruh PEG 400 dan mentol dapat digambarkan melalui persamaan special cubic, y =  3,26071 (A) + 4,31372 (B) + 2,80876 (A)(B) + 0,64912 (A)(B) (A-B). Verifikasi formula optimum menghasilkan p-value 0,503(>0,05). Permodelan transpor polifenol melalui membran dapat digambarkan dengan model 4 kompartemen dan menghasilkan kecepatan masing-masing L(2,1) sebesar 0,013 mgEAG/cm2/jam, L(3,2) sebesar 0,050 mgEAG/cm2/jam, L(4,1) sebesar 0,089 mgEAG/cm2/jam, dan L(3,4) sebesar 0,027 mgEAG/cm2/jam. Kata kunci: Piper betle, mentol, Patch bukal, PEG 400, polifenol.
Occurrence of Hypoglycemia, Hypokalemia and Hyperkalemia in Diabetic Hypertensive Patients Using Insulin and Diuretics Sarasmita M A; Setyawan E. I.; Hendra Jaya A.
Journal of Health Sciences and Medicine Vol 1 No 2 (2017): JHSM (September 2017)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (173.67 KB) | DOI: 10.24843/JHSM.2017.v01.i02.p04

Abstract

Diabetes Mellitus (DM) is a metabolic disease with characteristics of hyperglycemia that occurs due to insulin secretion abnormalities, insulin work or both. DM can cause macrovascular complications such as hypertension. Administration of therapy may lead to hypoglycemic and hypokalemia that may increase the risk of impaired brain and heart. Objective: The purpose of this study to analyze the incidence of hypoglycemia and hypokalemia side effects in patients with diabetic hypertension using antidiabetes and antihypertensives. Method: The study was conducted retrospectively with retrospective patient medical records from January to December 2016. Blood and potassium blood glucose levels were measured as long as the patient was treated. Random and potassium blood glucose levels prior to therapy were compared with after therapy using paired t-test. Result : From the results of the study found 27 patients suffering from diabetic hypertension and get therapy. The value of changes in the patient's random blood glucose level averaged 280.89 mg/dl to 189.15 mg/dl, which met the target of antidiabetic drug therapy, and no patients had hypoglycemia. From 27 patients, as many as 7 people did not get antihypertensive therapy. Three patients had hyperkalemia (serum potassium level > 5 mEq/L). The value of changes in blood potassium levels of patients averaged 4.74 mEq/L to 4.46 mEq/L, where no patients had hypokalemia. Conclusion : the occurrence of hypoglycemia and hyperkalemia were suspected due to side effect of insulin and antihypertensive drugs.
APPLICATION D-OPTIMAL METHOD ON THE OPTIMIZATION OF FORMULATION OF KINTAMANI ARABICA COFFEE GEL (Coffea arabica L.) Hendra Wijaya; I Putu Rizki Karisma Parta Wiratama; Pande Ketut Pramita Desna Putri; Kadek Sutri Ariyanthini; Elisabeth Angelina; Ni Kadek Devi Pradnya Andina; Putu Saradevi Naripradnya; Eka Indra Setyawan
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.6115

Abstract

Arabica coffee (Coffea arabica L.) kintamani is a superior agricultural product from Bali. Arabica coffee (Coffea arabica L.) contains many compounds, one of which is caffeine which is beneficial for health and beauty. This study aims to formulate kintamani arabica coffee beans into a gel dosage form. The optimization formula of kintamani arabica coffee bean gel was made using the D-Optimal method using a combination of HPMC and propylene glycol as observation variables and spreadability, pH, and viscosity of the gel preparation as experimental responses. The study of caffeine from the gel preparation was carried out using a Franz diffusion cell. Caffeine content in the gel preparation and its release are determined by spectrophotometric method. The results showed that the amount of HPMC used would increase the viscosity value (+14113.92) and decrease the spreadability (-0.29) and pH (-6.59167E-003) of the gel. The greater the amount of propylene glycol used will decrease the viscosity value (-2484.54) and increase the spreadability value (+0.30) and pH (+0.31802) of the gel. The conclusion of this study is the use of a combination of HPMC and propylene glycol (6%:17%) resulted in the optimum formula with a viscosity value of 44,070 cps, a spreadability value of 3.6 cm, and a pH value of 5.32. The caffeine content obtained in the gel preparation was 188.47 g and the amount of caffeine released from the gel preparation for 6 hours of testing was 4.95%.
Application Simplex Lattice Design on Optimizing Formula of Ketoprofen Matrix Patch Transdermal Eka Indra Setyawan; Akhmad Kharis Nugroho; Achmad Fudholi
Journal of Food and Pharmaceutical Sciences Vol 7, No 2 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.722

Abstract

Ketoprofen is a propionic acid derivative that has anti-inflammatory, analgesic, and antipyretic activity. Transdermal patch dosage form is the right choice for ketoprofen in an effort to minimize side effects, improving patient compliance and ensure the achievement of therapeutic targets. This study aimed to optimize the formulation of ketoprofen matrix patch transdermal. The optimizing process was analyzed by simplex lattice model. Determination of the level of ketoprofen released was carried out by spectrophotometer UV-Vis. Interpretation of the dissolution profile can be seen visually fit between the model constructed from the zero-order approximation, first-order, Higuchi, Korsmeyer-Peppas, Weibull, Hixson-Crowell and Baker-Lonsdale. The results provide information that a combination of MC and HPMC polymers have a significant influence on increasing the patch weight, patch thickness, loss on drying and dissolution efficiency and insignificant effect against folding endurance. The optimal formula is generated by a combination of HPMC:MC (0.1:0.9) and produces a patch matrix with weight, thickness, drying loss, and DE were 0.68 g, 0.36 mm, 12.42%, and 23.21%, respectively. The release kinetic of ketoprofen followed Korsmeyer-Peppas model through the mechanism of non-Fickian diffusion.
A Decade of Research about Honey as an Antioxidant in the Scopus Database: Bibliometric Analysis Setyawan, Eka Indra; Putra, Komang Dian Aditya; Ishfahan, Izzul; Lingling, Gek Niken Tasya
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007378

Abstract

Honeybees transform flowers' delicious, aromatic, and viscous nectar into the naturally occurring, antioxidant-rich honey. A growing scientific study increasingly supports honey's use in complementary and alternative medicine. No bibliometric analysis of published data on honey antioxidants has been conducted to ascertain the state of the research. Using VOSviewer and RStudio, we conducted a bibliometric analysis of the scholarly articles about honey's antioxidants in the Scopus database. Honey's antioxidant properties were covered in 765 papers between 2013 and 2023. Most publications (309 articles) are attributed to Malaysian researchers, with Universiti Sains Malaysia being the most productive, with 53 articles produced. Food Chemistry is the most productive source, with an average of 64.8 citations per article and 24 documents. Having the highest H-index of 10, Battino M significantly influenced the honey's antioxidant properties studies. "Honey" and "antioxidant activity" were the most frequent keywords. We can learn about the novelty of honey as an antioxidant research from this results.
Application D-Optimal method on the optimization of green tea (Camellia sinensis L.) formulation Andina, Ni Kadek Devi Pradnya; Darmawan, Fiki Dwi; Dewi, Ni Putu Intan Satya; Naripradnya, Putu Saradevi; Wijaya, Hendra; Parta, I Putu Rizki Karisma; Sutri, Wiratama Kadek; Angelina, Ariyanthini Elisabeth; Setyawan, Eka Indra
Innovation in Health for Society Vol 1 No 2 (2021): July - December
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ihs.6331

Abstract

Green tea leaves contain many polyphenols and antioxidants that can reduce cell damage and prevent premature ageing. Green tea extract is made in gel preparation to make it easier to use and increase convenience. HPMC base with propylene glycol additives can increase drug release and penetration into the skin. This study aims to optimize HPMC and propylene glycol levels in green tea extract gel formulations using the D-optimal method and calculate the total release of polyphenols using the Franz diffusion cell method. The extract is produced by infundation. The gel preparation was formulated by varying HPMC and propylene glycol levels in the manufacturing process. Each gel was evaluated for its physical properties, namely viscosity test, pH test, and dispersion test. The physical properties data obtained were then analyzed using Design-Expert software in the mixture design program to get the optimum formula. The optimum procedure brought was HPMC with a concentration of 6% and propylene glycol with a concentration of 17%, resulting in the best correlation between viscosity, dispersion, and pH, with a desirability value of 0.921. In the green tea gel preparation, the resulting concentration was 8.00 GAE/g sample, and the gel content was released at 360 min. was 3.30 GAE/g sample. Keywords: D-Optional mixture design; green tea; HPMC; polyphenols; pharmacy care
OPTIMASI FORMULA MATRIK PATCH MUKOADHESIF EKSTRAK DAUN SIRIH (Piper betle L.) MENGGUNAKAN MENTOL DAN PEG 400 SEBAGAI PERMEATION ENHANCER DAN PLASTICIZER Setyawan, Eka Indra; Dewantara, IGN Agung; Putra, IMD Dwi
Media Farmasi: Jurnal Ilmu Farmasi Vol. 11 No. 2: September 2014
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v11i2.1872

Abstract

Daun sirih (Piper betle L) adalah tanaman obat tradisional yang secara empirik dimanfaatkan masyarakat untuk pengobatan antiinflamasi gusi. Penelitian ini bertujuan untuk memformulasi ekstrak etanol daun sirih ke dalam sistem penghantaran obat baru yakni patch mukoadhesif. Ekstrak daun sirih sebagai bahan aktif dibuat dengan teknik maserasi sedangkan formulasi patch dibuat menggunakan sistem matrix controlled. Bahan tambahan yang dipergunakan dalam pembuatan patch antara lain; hidroksipropil metilselulosa, polietilenglikol 400, dan mentol. Komposisi pemakaian polietilenglikol 400 dan mentol dalam formula ditentukan dengan menggunakan metode simplex lattice design. Evaluasi matrik patch meliputi; bobot matrik patch, ketebalan matrik patch, folding endurance dan loss on drying. Hasil penelitian memperlihatkan bobot matrik berkisar antara 0,510 - 2,837 g, tebal matrik antara 0,28 - 1,00 mm, folding endurance antara 60 - > 500 lipatan dan loss on drying antara 0,063% - 0,099%. Formula optimal dihasilkan oleh kombinasi mentol dan PEG 400 dengan perbandingan 2:0 atau dengan nilai desirability 0,931.   
PENGEMBANGAN BASIS COLD CREAM EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) YANG MEMENUHI SIFAT FARMASETIS Dewantara, IGN Agung; Setyawan, Eka Indra
Media Farmasi: Jurnal Ilmu Farmasi Vol. 11 No. 2: September 2014
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v11i2.1873

Abstract

Ekstrak kulit buah manggis (Garcinia mangostana L.), telah diteliti memiliki aktivitas anti luka bakar. Formula cold cream dirancang dengan menggunakan ekstrak tersebut dan diharapkan dapat mempermudah pengaplikasian. Tujuan dari penelitian ini untuk mengetahui sifat fisik farmasetis sediaan cold cream.  Pencampuran cold cream dilakukan pada suhu 60oC kemudian dilakukan pengujian sifat fisik farmasetis sediaan pada hari ke-0 sampai hari ke-28 setelah sediaan jadi. Pengujian sediaan meliputi uji homogenitas, distribusi ukuran droplet, tipe krim, rheologi, dan derajat pemisahan fase, secara deskriptif. Hasil penelitian menunjukkan sifat fisik yang baik, krim homogen, dengan ukuran droplet  <10µm, tipe krim a/m, dengan rheologi tiksotropik dan derajat pemisahan 1.  
Optimization of Non-Effervescet Floating Tablets Ranitidine HCL Formula Using Durian Seed Matrix (Durio Zibethinus Murr) Fully Gelatinized Modified Using Simplex Lattice Design Method Agung Dewantara Putra, I Gusti Ngurah; Setyawan, Eka Indra; Ninditha, Ni Putu Maya; Diva, Made Tresia Pramasta
Eduvest - Journal of Universal Studies Vol. 3 No. 12 (2023): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v3i12.964

Abstract

This study investigated the use of fully gelatinated durian seed starch as an excipient in Ranitidine HCl Non-Effervescent Buoyancy Tablets (NEFT). The simplex lattice design method was used to formulate the optimum composition of the formula, including fully gelatinated durian seed starch, PVP K30, and magnesium stearate. Physically modified durian seed starch is expected to increase the release time of active substances in the body. The experiment was conducted for six months by measuring the physical properties of the granule, tablet hardness, solubility, and friability. Results showed that the optimum formula (27.74 mg durian seed starch, 1.5 mg PVP K30, 0.76 mg magnesium stearate) produced ranitidine HCl NEFT tablets with optimal properties. This research may contribute to the development of effective tablet formulations.
Co-Authors A. Indyayani, I G Achmad Fudholi Agung Dewantara Putra, I Gusti Ngurah Akhmad Kharis Nugroho Andina, Ni Kadek Devi Pradnya Angelina, Ariyanthini Elisabeth Cokorda Istri Sri Arisanti Darmawan, Fiki Dwi Dewi, Ni Putu Intan Satya Diva, Made Tresia Pramasta Elisabeth Angelina Hendra Jaya A. Hendra Wijaya Hendra Wijaya I G A. Indyayani I Gusti Ngurah Agung D.P. I Gusti Ngurah Agung Dewantara Putra I Made Agus Gelgel Wirasuta I Putu Rizki Karisma Parta Wiratama I. G. N. A. Dewantara, IMD Dwi Putra Ishfahan, Izzul Kadek Sutri Ariyanthini Komang Ayu Mariyani Lingling, Gek Niken Tasya M. A. Ningtyas Naripradnya, Putu Saradevi Ni Kadek Devi Pradnya Andina Ni Made Ary Sarasmita Ninditha, Ni Putu Maya P. A. R. W. Pertiwi, Pande Ketut Pramita Desna Putri Parta, I Putu Rizki Karisma Putra, Komang Dian Aditya Putu Eka Masmita U.D. Putu Oka Samirana Putu Saradevi Naripradnya Sutri, Wiratama Kadek