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All Journal Jurnal Kimia (Journal of Chemistry) Jurnal Sains Materi Indonesia Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) INDONESIAN JOURNAL OF PHARMACY JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) ISM (Intisari Sains Medis) : Jurnal Kedokteran Management Studies and Entrepreneurship Journal (MSEJ) Udayana Journal of Social Sciences and Humanities (UJoSSH) Journal of Health Sciences and Medicine Quantitative Economics and Management Studies JOURNAL SCIENTIFIC OF MANDALIKA (JSM) ProBisnis : Jurnal Manajemen Indonesian Journal of Multidisciplinary Science Journal Transformation of Mandalika Jurnal Indonesia Sosial Sains Jurnal Cendekia Ilmiah Jurnal Farmasi Sains dan Teknologi

I Gusti Ngurah Agung Dewantara Putra

Program Studi Farmasi, Fakultas MIPA, Universitas Udayana 80361, Indonesia

Author-ID : 4217789

Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Physical and Chemical Properties of Native and Fully Pregelatinized Cassava Starch (Manihot esculenta Crantz) Dewantara Putra, I Gusti Ngurah Agung; Murwanti, Retno; Rohman, Abdul; Sulaiman, T.N Saifullah
Indonesian Journal of Pharmacy Vol 29 No 3, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

StarchÂ is widely used as an excipient in pharmaceutical formulations because it is inert and it can be mixed with drugs without any chemical reactions. This study was aimed to develop and to characterize the physical and chemical properties of cassava starch fully pregelatinized (CSFP) and native cassava starch (Manihot esculentaÂ Crantz) (NCS). Organoleptic properties, pH, ash content, shrink drying, macroscopic and microscopic analyses, amylose and amylopectin content, bulk and tapped density, the angle of repose and flow rate were physically evaluated for both type of cassava starch. Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy-dispersive x-ray spectroscopy (EDS), and differential scanning calorimetry (DSC) were used to characterize and evaluate the chemical properties of the CSFP and NCS. The results of this study indicate that CSFP exhibited different values of those determined parameters compared to that of NCS organoleptic properties i.e, pH, viscosity, ash content, shrink drying, macroscopic and microscopic analyses, amylose and amylopectin content, bulk and tapped density, angle of repose and flow rate. The measurement results with DSC obtained Tg at NCS of 68.18oCÂ while in CSFP there is no Tg because cassava starch (CS) is fully gelatinized. In conclusion, CSFP as a good profile starch contained a higher amount of amylose with larger particle size and good particle density and viscosity than the natural starch and improve its flow properties andÂ compactibility. CSFP had a noticeable effect on fragility, hardness, disintegration time and percentage of drug release from the tablets produced, that can be developed as a pharmaceutical excipient in development of solid dosage forms Â (sustain release).Â

PENGEMBANGAN BASIS COLD CREAM EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) YANG MEMENUHI SIFAT FARMASETIS Dewantara, IGN Agung; Setyawan, Eka Indra
Media Farmasi: Jurnal Ilmu Farmasi Vol 11, No 2: September 2014
Publisher : Universitas Ahmad Dahlan

Ekstrak kulit buah manggis (Garcinia mangostana L.), telah diteliti memiliki aktivitas anti luka bakar. Formula cold cream dirancang dengan menggunakan ekstrak tersebut dan diharapkan dapat mempermudah pengaplikasian. Tujuan dari penelitian ini untuk mengetahui sifat fisik farmasetis sediaan cold cream. Pencampuran cold cream dilakukan pada suhu 60oC kemudian dilakukan pengujian sifat fisik farmasetis sediaan pada hari ke-0 sampai hari ke-28 setelah sediaan jadi. Pengujian sediaan meliputi uji homogenitas, distribusi ukuran droplet, tipe krim, rheologi, dan derajat pemisahan fase, secara deskriptif. Hasil penelitian menunjukkan sifat fisik yang baik, krim homogen, dengan ukuran droplet <10µm, tipe krim a/m, dengan rheologi tiksotropik dan derajat pemisahan 1. Kata kunci : Cold Cream, Sifat Fisik, Ekstrak Kulit Buah Manggis,

OPTIMASI FORMULA MATRIK PATCH MUKOADHESIF EKSTRAK DAUN SIRIH (Piper betle L.) MENGGUNAKAN MENTOL DAN PEG 400 SEBAGAI PERMEATION ENHANCER DAN PLASTICIZER Setyawan, Eka Indra; Dewantara, IGN Agung; Putra, IMD Dwi
Media Farmasi: Jurnal Ilmu Farmasi Vol 11, No 2: September 2014
Publisher : Universitas Ahmad Dahlan

Daun sirih (Piper betle L) adalah tanaman obat tradisional yang secara empirik dimanfaatkan masyarakat untuk pengobatan antiinflamasi gusi. Penelitian ini bertujuan untuk memformulasi ekstrak etanol daun sirih ke dalam sistem penghantaran obat baru yakni patch mukoadhesif. Ekstrak daun sirih sebagai bahan aktif dibuat dengan teknik maserasi sedangkan formulasi patch dibuat menggunakan sistem matrix controlled. Bahan tambahan yang dipergunakan dalam pembuatan patch antara lain; hidroksipropil metilselulosa, polietilenglikol 400, dan mentol. Komposisi pemakaian polietilenglikol 400 dan mentol dalam formula ditentukan dengan menggunakan metode simplex lattice design. Evaluasi matrik patch meliputi; bobot matrik patch, ketebalan matrik patch, folding endurance dan loss on drying. Hasil penelitian memperlihatkan bobot matrik berkisar antara 0,510 - 2,837 g, tebal matrik antara 0,28 – 1,00 mm, folding endurance antara 60 - > 500 lipatan dan loss on drying antara 0,063% - 0,099%. Formula optimal dihasilkan oleh kombinasi mentol dan PEG 400 dengan perbandingan 2:0 atau dengan nilai desirability 0,931. Kata kunci : ekstrak daun sirih, mentol, PEG 400, mukoadhesif matrik patch

STUDI KARAKTERISTIK FARMASETIS MIKRO KRISTALIN SELULOSA DARI JERAMI PADI VARIETAS LOKAL BALI Prasetia Prasetia; I G. N. Jemmy A; I G. N. A. Dewantara Putra
Jurnal Sains Materi Indonesia Vol 17, No 3: APRIL 2016
Publisher : Center for Science & Technology of Advanced Materials - National Nuclear Energy Agency

STUDI KARAKTERISTIK FARMASETIS MIKRO KRISTALIN SELULOSA DARI JERAMI PADI VARIETAS LOKAL BALI. Bali terkenal dengan sistemirigasi pertaniannya di Indonesia. Padimenjadi komoditas pertanian utama di Bali dengan pengembangan varietas lokal yaitu varietas Mansur. Namun, pemanfaatan limbah jerami padi sisa hasil pertanian kurang optimal. Kandungan selulosa yang sangat tinggi pada jerami padi menjadikannya berpotensi sebagai bahan baku Pembuatan Mikrokristalin Selulosa (MCC). Oleh karena itu, pada penelitian ini dilakukan pengujian karakteristik farmasetisMCC dari jerami padi varietas Mansur dengan tujuan meningkatkan pemanfaatan limbah padi sehingga dapat dimanfaatkan sebagai bahan tambahan dalam formulasi sediaan farmasi. Pembuatan MCC dilakukan melalui dua tahapan yaitu proses delignifikasi dan hidrolisis asam. Dalam proses delignifikasi, digunakan larutan NaOH pada berbagai konsentrasi (5%; 7,5%; 10%; 12,5%dan 15%) selama 24 jam. Tahap hidrolisis asamdilakukan dengan menggunakan larutan HCl 2,5 N. Hasil MCC pada berbagai konsentrasi NaOH selanjutnya dilakukan evaluasi karakteristik farmasetis yang meliputi penentuan kadar α-selulosa, pengamatan organoleptis, kelembaban, kelarutan dalam air, pH, bobot jenis nyata, bobot jenis mampat, Indeks Carr dan uji Scanning Electron Microscope (SEM). Pada penelitian ini, telah dihasilkan produk MCC dari jerami padi varietas Mansur (MCCMS).Adanya variasi konsentrasi NaOH pada proses delignifikasi menyebabkan adanya perbedaan kandungan α-selulosa. Dari karakteristik farmasetis, MCCMS-7,5% memiliki kandungan selulosa paling tinggi dan Indeks Carr yang cukup baik.

PERBEDAAN KARAKTERISASI DAN SKRINING FITOKIMIA EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangsotana Linn) YANG DIPEROLEH DARI KABUPATEN TABANAN DAN KABUPATEN KARANGASEM, PROVINSI BALI Ni Putu Chintya Sandra Bhuana; Ni Putu Ayu Dewi Wijayanti; I G. N. Agung Dewantara Putra
Jurnal Kimia (Journal of Chemistry) Vol. 7, No. 2 Juli 2013
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Mangosteen peel has been studied to contain many chemical constituents. However, differences in the geographical location of a plant can result in variations in the content of a plant metabolites. This study aimed to determine differences in the characteristics of the extract as well as content owned chemical peel ethanol extract of mangosteen (Garcinia mangostana L.) were obtained from Tabanan and Karangasem regency, Bali province. This study is experimental designed. Extraction process used the method of maceration with 70% ethanol. Organoleptic characterization of the extract was conducted. Water content, content of water-soluble extract and ethanol soluble extract were also determined. Phytochemical screening of the extract covered the content of alkaloids, glycosides, flavonoids, saponins, phenolic, and steroids / terpenoids. The results showed that the ethanol extract of mangosteen peel taken from Tabanan regency contain saponins, alkaloids, flavonoids, phenolics, terpenoids, and glycosides, while the ethanol extract of mangosteen rind taken from Karangasem regency contain saponins, alkaloids, flavonoids, phenolic, terpenoids. The ethanol extract of mangosteen peel taken from Tabanan regency has a different chemical content with ethanol extract of mangosteen peel taken from Karangasem regency.

OPTIMASI FORMULA MATRIK PATCH MUKOADHESIF EKSTRAK DAUN SIRIH (Piper betle L.) MENGGUNAKAN MENTOL DAN PEG 400 SEBAGAI PERMEATION ENHANCER DAN PLASTICIZER Eka Indra Setyawan; IGN Agung Dewantara; IMD Dwi Putra
Media Farmasi: Jurnal Ilmu Farmasi Vol 11, No 2: September 2014
Publisher : Universitas Ahmad Dahlan

Daun sirih (Piper betle L) adalah tanaman obat tradisional yang secara empirik dimanfaatkan masyarakat untuk pengobatan antiinflamasi gusi. Penelitian ini bertujuan untuk memformulasi ekstrak etanol daun sirih ke dalam sistem penghantaran obat baru yakni patch mukoadhesif. Ekstrak daun sirih sebagai bahan aktif dibuat dengan teknik maserasi sedangkan formulasi patch dibuat menggunakan sistem matrix controlled. Bahan tambahan yang dipergunakan dalam pembuatan patch antara lain; hidroksipropil metilselulosa, polietilenglikol 400, dan mentol. Komposisi pemakaian polietilenglikol 400 dan mentol dalam formula ditentukan dengan menggunakan metode simplex lattice design. Evaluasi matrik patch meliputi; bobot matrik patch, ketebalan matrik patch, folding endurance dan loss on drying. Hasil penelitian memperlihatkan bobot matrik berkisar antara 0,510 - 2,837 g, tebal matrik antara 0,28 - 1,00 mm, folding endurance antara 60 - > 500 lipatan dan loss on drying antara 0,063% - 0,099%. Formula optimal dihasilkan oleh kombinasi mentol dan PEG 400 dengan perbandingan 2:0 atau dengan nilai desirability 0,931.

PENGEMBANGAN BASIS COLD CREAM EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) YANG MEMENUHI SIFAT FARMASETIS IGN Agung Dewantara; Eka Indra Setyawan
Media Farmasi: Jurnal Ilmu Farmasi Vol 11, No 2: September 2014
Publisher : Universitas Ahmad Dahlan

Influence of Patient Characteristics on The Type of Insulin Therapy Obtained by Diabetes Type 2 Outpatient in Denpasar Municipality Luh Putu Febrayana Larasanty; I GNA. Dewantara Putra; Rhyce Dewata Sari; Komang Dede Saputra; I GA. Gede Minanjaya; I Made Arya Wiraguna; I Made Wiracana
Udayana Journal of Social Sciences and Humanities Vol 1 No 2 (2017): UJoSSH, September 2017
Publisher : Research and Community Services Institutes of Udayana University

This study aims to investigate the influence of patient characteristics on the choice of insulin therapy in type 2 diabetes mellitus outpatients in Denpasar municipality. This is a descriptive analysis study using the patient's medical records as research material. Patients who meet inclusion and exclusion criteria are being recorded based on their medical records. Characteristics that are taken are age, gender, fasting blood glucose level (FBG), 2-hour postprandial blood glucose level (2-hours PPG) and HbA1c values of patients. Types of insulin therapy gained from patient medical records and drug use report in pharmacy. Characteristics data and type of insulin analyzed using correlation test to determine the effect of the patient characteristics on the selection of insulin therapy. 43 patients became the research subject. Males gendered patients (72.09%) and the patients aged less than 65 years (90.70%) are the dominant characteristics of the research subjects. The average value of FBG of patients is 212 mg / dL; 2-hours PPG 280 mg / dL and HbA1c 10.1%. There is a correlation between sex, age, HbA1c value and FBG with the type of insulin obtained by patients (p <0.05). Based on the results of statistical tests, age and gender have a strong correlation on insulin choice, HbA1c and FBG level has a moderate influence and 2-hours PPG have a weak correlation. Patient characteristics had an influence on the type of insulin choice for diabetes mellitus type 2 outpatient in the Denpasar municipality.

Optimization Of Isolation Method Of Carrageenan From Kappaphycuss Alvarezii Doty Using Factorial Experimental Design Ketut Widyani Astuti; Ni Putu Ayu Dewi Wijayanti; I Gusti Ngurah Agung Dewantara Putra; Ni Putu Linda Laksmiani
Journal of Health Sciences and Medicine Vol 1 No 2 (2017): JHSM (September 2017)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (232.941 KB)

Kappaphycus alvarezii Doty is a species of red algae ( Rhodophyceae) producing kappa carrageenan. The value of carrageenan will increase if it is able to form thermoreversible gels. The quality of carrageenan is determined by the isolation method which includes several stages, namely soaking, extraction, purification, and drying. This study aims to obtain an optimum isolation method of carrageenan from seaweed Kappaphycus alvarezii Doty using the factorial experimental design software, Design Expert Version.7.0.0. with the characteristics that meet the standards set by FAO. The seaweed was collected from the sea in Nusa Lembongan, Bali Province. The carrageenan isolation method was optimized by varying three factors, namely the concentration of NaOH (4% and 8%), extraction time (0.5 hour and 3 hours), and precipitation time (0.25 hour and 0.5 hour) in order to obtain 8 formulae which then went through an evaluation of the physical and chemical characteristics of the carrageenan. The physical and chemical characteristics include the yield, viscosity, sulfate content, and ash content, analyzed using Design Expert Version 7.0.0 program to determine the optimum method of isolation. The analysis showed that the optimum method of carrageenan isolation was using NaOH with a concentration of 4.40%, the extraction time of 2.16 hours and the precipitation time of 0.29 hour. The physical and chemical characteristics of carrageenan with the optimum isolation method include the yield of 25.73%, the viscosity of 11.92 cPs, sulfate content of 31.95% and the ash content of 26.16% which have met the standards set by FAO.

TOTAL BIAYA TERAPI INSULIN PADA KASUS DIABETES MELLITUS TIPE 2 RAWAT JALAN DI KOTAMADYA DENPASAR Luh Putu Febryana Larasaty; I Gusti Ngurah Agung Dewantara Putra; Made Ary Sarasmita
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 7, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.361

Insulin merupakan salah satu terapi obat untuk pasien diabetes mellitus (DM) tipe 2. Terdapat 4 jenis insulin berdasarkan onset kerjanya. Tiap jenis insulin memiliki besaran biaya dan effektivitasnya masing - masing. Telah banyak penelitian dilakukan untuk menilai effektivitas penggunaan insulin, di lain pihak penelitian yang membandingkan biaya total tiap jenis insulin masih sangat sedikit. Tujuan penelitian ini adalah untuk mengetahui total biaya yang dibutuhkan untuk terapi insulin pada pasien DM tipe 2 rawat jalan di rumah sakit kotamadya Denpasar. Penelitian ini merupakan penelitian deskriptif yang dilakukan pada bulan Maret sampai dengan bulan Juni 2016 di rumah sakit pemerintah di Kotamadya Denpasar. Subyek penelitian adalah pasien DM tipe 2 rawat jalan. Data regimen terapi insulin dan biayanya diperoleh dari rekam medis pasien, data resep, lembar administrasi, laporan terapi pasien pada instalasi farmasi dan juga riwayat sosial pasien. Total biaya dihitung berdasarkan biaya medis langsung (jasa dokter, tes laboratorium, biaya obat dan biaya penyiapan obat serta alat kesehatan), biaya non medis langsung (biaya administrasi dan transportasi) serta biaya non medis tidak langsung (hilangnya gaji/upah karena tidak masuk kerja). Terdapat 8 nama dagang insulin yang diresepkan untuk pasien DM tipe 2, dengan masing – masing persentase penggunaannya adalah sebagai berikut : Apidra Solostar (12,50%), Humalog Mix (4,35%), Humalog Quickpen (3,80%), Humulin N (2,17%), Lantus Solostar (28,26%), Levemir (11,96%), Novomix (1,09%) and Novorapid (35,87%). Total biaya terendah regimen terapi insulin adalah penggunaan Lantus Solostar (Rp 528.480,-) dan total biaya tertinggi adalah Humalog Mix (Rp. 685.066,-). Rata – rata total biaya terapi insulin adalah sebesar Rp. 565.474,-

Co-Authors A. A. Yastawa Cakranegara, Pandu Adi Darmaputra, I Gusti Nyoman Eka Indra Setyawan Erlina, Ni Putu Natasha Ernianti Fachry Abda El Rahman Farida Akbarina Firstianty Wahyuhening Fibriany I G. N. Jemmy A I GA. Gede Minanjaya I Gusti Agus Tusan Wira Darma I Gusti Ayu Kusuma Dewi I Gusti Ngurah Jemmy Anton Prasetia I Made Arya Wiraguna I Made Wiracana I Nengah Sujaya IMD Dwi Putra Imron Hadi Tamim, Imron Hadi IRIANI SETYAWATI Julie Abdullah Kartini, Ni Komang Triayu Cita Ketut Widyani Astuti Komang Dede Saputra Kurniawan Arif Maspul Luh Ayu Putri Saraswati Luh Putu Febryana Larasanty Luh Putu Febryana Larasaty Made Krisna Adi Jaya Mekar Meilisa Amalia Muhammad Syafri N. P. A. D. Wijayanti Ni Gusti Ketut Roni Ni Made Ary Sarasmita Ni Putu Ayu Dewi Wijayanti Ni Putu Chintya Sandra Bhuana Ni Putu Linda Laksmiani Pangestu, Ade Winanda Pranatha, I Putu Adhi Prasetia Prasetia Raúl Eleazar Arias Sánchez Retno Murwanti Rhyce Dewata Sari Rohman, Abdul Sanita Dhakirah Sapitri, Putu Dian Saputra, Eka Kurnia Sasono, Heri Savitri, Anava Salsa Nur Shabrina Herawati Shan Amadeus Sugianto, Efendi Sulaiman, T.N Saifullah Sutardjo, Agus Syahril Hasan - Politeknik Sains dan Teknologi Wiratama Maluku Utara, Syahril Hasan Teguh Setiawan Wibowo Uli Wildan Nuryanto Umar, Ahmad Ulil Albab Al Yanti, Ni Made Frida

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