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All Journal Jurnal Sains dan Teknologi Farmasi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JPK: Jurnal Proteksi Kesehatan Journal of Pharmaceutical and Sciences.

Regina Handayani Handayani, Regina Handayani

Fakultas Farmasi, Universitas Andalas, Padang, Sumatera Barat, Indonesia.

Author-ID : 3802067

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Published : 8 Documents Claim Missing Document

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Articles

Analisis Î±-Mangostin Dalam Minuman Herbal Kulit Buah Manggis (Garcinia mangostana L.) dengan Metode Kromatografi Lapis Tipis-Densitometri Andayani, Regina; Friardi, Friardi
Jurnal Sains dan Teknologi Farmasi Vol 19 No Supl1 (2017): Vol 19 Supplement 1, December 2017
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar

Saat ini, jus manggis menjadi âminuman herbalâ yang populer. Beberapa produsen mengklaim bahwa jus manggis dapat mengobati diare, masalah menstruasi, infeksi saluran kemih, tuberkulosis, dan berbagai kondisi lainnya. Namun, tidak ada bukti ilmiah yang dapat diandalkan untuk mendukung klaim ini. Penelitian ini bertujuan untuk menganalisis Î±-mangostin dalam minuman herbal kulit buah manggis yang terdapat di pasaran dengan metode kromatografi lapis tipis densitometri. Analisis dilakukan dengan TLC Scanner menggunakan Camag TLC Scanner 4 dengan software Wincats, panjang gelombang maksimum Î±-mangostin adalah 316 nm, dilihat menggunakan lampu UV Camag 254 nm dan 366 nm, Camag Nanomat 4, Camag pipet kapiler ukuran 2 ÂµL, Camag Twin Chamber, plat silika gel 60 F254 (Merck) ukuran 20 x 20 cm. Fase gerak yang digunakan adalah kloroform dan etil asetat (9:1). Setelah dilihat di bawah lampu UV 254 nm, standar Î±-mangostin, sampel B dan C memiliki nilai Rf yang sama yaitu 0,48. Deret konsentrasi yang digunakan 50, 100, 150, 300 dan 400 ppm menghasilkan persamaan regresi y = 1326,1658 + 19,7647x dengan koefisien korelasi (r) = 0,99415. Koefisien korelasi ini menunjukkan hasil yang linear. Batas deteksi (LOD) dan batas kuantifikasi (LOQ) yang diperoleh 54,38 Âµg/mL dan 181,28 Âµg/mL. Persentase Recovery yang diperoleh dari analisis sebesar 90,04 %, metode validasi ini memberikan hasil yang akurat dan tepat (nilai intraday presisi RSD/Relatif Standar Deviasi adalah ï£ 1,28 %, sedangkan uji presisi interday adalah ï£ 2,39 %). Hasil kadar rata-rata yang diperoleh untuk sampel B dan C berturut-turut adalah 0,040% b/v dan 0,118% b/v. Penelitian ini murah, akurat, tepat, linier dan cepat. Metode KLT densitometri memenuhi kriteria validasi untuk penetapan kuantitatif Î±-mangostin dalam minuman herbal kulit buah manggis.

Analisis Logam Kromium (Cr) Pada Sediaan Perona Pipi (Blush On) Secara Spektrofotometri Serapan Atom Regina Andayani; Siti Yulia Rahma; Martinus Martinus
Jurnal Sains Farmasi & Klinis Vol 5, No 3 (2018): J Sains Farm Klin 5(3), Desember 2018
Publisher : Fakultas Farmasi Universitas Andalas

ABSTRAKKromium merupakan logam berat yang dilarang penggunaannya dalam sediaan kosmetik. Efek logam kromium apabila terpapar pada kulit dapat menyebabkan dermatitis, oedema dan borok yang dapat meluas pada kulit. Analisis logam kromium (Cr) pada sediaan perona pipi (Blush On) secara Spektrofotometri Serapan Atom telah dilakukan. Masing-masing sampel didestruksi terlebih dahulu dengan cara destruksi kering, kemudian sampel dilarutkan dengan asam nitrat 6 N, larutan sampel diukur serapannya dengan alat Spektrofotometer Serapan Atom menggunakan lampu katoda berongga kromium pada panjang gelombang 357,9 nm. Hasil dari penelitian ini adalah sampel merek IZ, VV, KS, MC terdeteksi mengandung logam kromium dengan kadar berturut-turut adalah 10,05 ± 0,05 µg/g; 6,74 ± 0,02 µg/g; 28,95 ± 0,19 µg/g; 13,52 ± 0,63 µg/g. Data menunjukan bahwa adanya kromium pada semua sampel.Kata kunci: logam; kromium; perona pipi; spektrofotometri serapan atom ABSTRACTChromium is a heavy metal which is prohibited from using it in cosmetic preparations. Effects of chromium metal, when exposed to the skin, can cause dermatitis, oedema and ulcers that can extend to the skin. Analysis of chromium (Cr) metal in blush preparations by Atomic Absorption Spectrophotometry was carried out. Each sample was first destructed by dry destruction, then the sample was dissolved with 6 N nitric acid, the absorption of the sample solution was measured by an atomic absorption spectrophotometer using a chromium hollow cathode lamp at a wavelength of 357.9 nm. The results showed that all samples under the IZ, VV, KS and MC brands were detected containing chromium metal with levels of 10.05 ± 0.05 μg/g respectively; 6.74 ± 0.02 µg/g; 28.95 ± 0.19 µg/g; 13.52 ± 0.63 µg/g. Data shows that the presence of chromium in all samples.Keywords: metal; chromium; blush; atomic absorption spectrophotometry.

Analisis α-Mangostin dalam Minuman Herbal Kulit Buah Manggis (Garcinia mangostana L.) dengan Metode Kromatografi Lapis Tipis-Densitometri Regina Andayani; Friardi Ismed
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Some herbal formulation containing α-mangostin as a marker compound in the pericarp of the mangosteen (Garcinia mangostana L.) are marketed now in Indonesia. The determination of the component of preparation both qualitatively and quantitatively is essential to ensure quality of the product. This research is aimed to develop a TLC (Thin Layer Chromatography)-densitometry method to analyze α-mangostin in the herbal drinks of mangosteen rind. The analysis was performed with TLC Scanner using Camag TLC Scanner 4 with Wincats software. Silica gel 60 F254 (Merck) plates (20x20 cm: 200 μm thickness) were used as stationary phase and mixture of chloroform and ethyl acetate (9:1,v/v) as a mobile phase. The developed chromatogram was scanned at 316 nm, the wavelength of maximum absorption for α-mangostin. At this condition, the Rf value of α-mangostin is 0.48. Regression analysis of the calibration data showed an excellent linear relationship between peak-area vs drug concentration. Linearity was found to be in the range of 50-400 µg/mL. The suitability of developed TLC densitometry method for estimation of α-mangostin was established by validating it as per the ICH guidelines. The limits of detection (LOD) and quantification (LOQ) for α-mangostin were found to be 54.38 μg/mL and 181.28 μg/mL. The developed method was found to be linear (r=0,99415), precise (RSD <1.28 % and < 2.39 % for intra-day and inter-day precision) and accurate (mean recovery of 90.04%). Results of the samples analysis showed that sample A does not contain α-mangostin, whereas sample B and C contain α-mangostin. The average concentrations obtained for samples B and C were 0.040% w/v and 0.118% w/v, respectively. The developed method has been successfully applied for the determination of α-mangostin in the herbal drinks of mangosteen rind.

Analisis Rhodamin B pada Lipstik Impor yang Beredar di Kota Batam secara Kromatografi Lapis Tipis dan Spektrofotometri UV-Vis Trie Yuni Elfasyari; Mutia Amelia Putri; Regina Andayani
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 01 Juli 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i1.5066

Zat warna rhodamin B adalah bahan pewarna yang dilarang penggunaannya dalam sediaan lipstik karena memiliki potensi karsinogenik dan merusak organ hati. Penelitian ini bertujuan untuk mengetahui secara kualitatif dan kuantitatif zat rhodamin B dalam sediaan lipstik impor yang beredar di Pasar Kota Batam. Metode yang digunakan adalah kromatografi lapis tipis untuk mengidentifikasi senyawa rhodamin B dengan menghitung nilai Rf dari fluoresensi bercak di bawah sinar ultraviolet. Penentuan kadar rhodamin B dilakukan dengan alat spektrofotometer UV-visibel dengan mengukur absorban pada panjang gelombang maksimum 548,5 nm. Konsentrasi larutan baku standar rhodamin B adalah 0,8; 1,2; 1,6; 2,0; dan 2,4 µg/mL. Didapatkan persamaan kurva y=0,0128+0,276x dengan r=0,9999. Hasil analisis kualitatif dari 15 merek sampel lipstik didapatkan dua merek lipstik yang teridentifikasi positif rhodamin B yaitu lipstik I dengan Rf 0,78 dan lipstik L dengan nilai Rf 0,77. Penentuan kadar rhodamin B dari masing-masing lipstik didapatkan kadar sebesar 73,225 µg/g pada lipstik I dan 92,61 µg/g pada lipstik L.

ANALISIS MERKURI (Hg) PADA LOTION PEMUTIH YANG BEREDAR DI PASAR RAYA KOTA PADANG MENGGUNAKAN SPEKTROFOTOMETER SERAPAN ATOM Afdhil Arel; Regina Andayani; Aulia Rahmi; Wida Ningsih
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 16, No 02 (2019): Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 02 Desember 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Whitening lotion is a mixture of chemicals or other ingredients with properties that can whiten the skin or blemish black (brown) on the skin. The use of mercury in whitening lotions can cause a variety of things, ranging from skin discoloration which can ultimately cause black spots on the skin, allergies and skin irritation. The using of mercury in high dose can cause permanent brain damageand cancer. An analysis of mercury content in the whitening lotion brands A, B and C circulating at market in Padang city has been conducted. Extraction of mercury in the whitening lotion was done by wet destruction with a concentrated HNO3 solution and concentrated H2SO4 for 2 hours at a temperature of ± 95°C until a clear solution is obtained. The clear solution was measured by absorption with an Atomic Absorption Spectrophotometer using a mercury hollow cathode lamp at a wavelength of 253.7 nm. The results of this study were samples of brands A, B and C detected containing mercury metals with successive levels of 0.3347 μg /g; 0,7917 μg /g and 0,7981 μg/ g. The whitening lotions that circulate in market do not meet the Head of BPOM RI Regulation No.18 of 2015 whose contents prohibit the use of mercury in cosmetics preparations. Keywords: mercury, whitening lotion, Atomic Absorption Spectrophotometer

Analisis Rendang Daging Sapi dan Daging Babi Hutan Menggunakan Metode Spektroskopi FTIR Kombinasi Kemometrik untuk Autentikasi Halal Regina Andayani; Ditya Kesumaningrum; Tadzkia Nisa; Elidahanum Husni; Suryati Suryati; Syofyan Syofyan; Dachriyanus Dachriyanus
Jurnal Sains Farmasi & Klinis Vol 10, No 1 (2023): J Sains Farm Klin 10(1), April 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.1.78-88.2023

ABSTRAKRendang merupakan salah satu makanan tradisional Sumatra Barat dari olahan daging sapi. Harga daging sapi yang mahal, mendorong pemalsuan menggunakan daging babi hutan. Penelitian ini bertujuan untuk mengembangkan metode analisis autentikasi rendang sapi menggunakan spektroskopi FTIR kombinasi kemometrik. Sampel yang digunakan adalah campuran daging sapi dan babi hutan yang dibuat dalam 11 konsentrasi (training data set) serta rendang rumah makan (testing data set). Komponen lemak rendang diekstraksi menggunakan metode Folch dan Bligh Dyer kemudian dianalisis dengan spektroskopi FTIR. Spektra FTIR yang dihasilkan digunakan sebagai variabel pemodelan kemometrik. Untuk kuantifikasi, model PLS di bilangan gelombang 1250-950 cm-1 memberikan model terbaik pada metode Folch dengan nilai R2 kalibrasi 0,9946, R2 prediksi 0,9954, RMSEC 0,0328, RMSEP 0,0402 dan pada metode Bligh Dyer, model PCR di bilangan gelombang 1800-500 cm-1 memberikan model terbaik dengan nilai R2 kalibrasi 0,9940, R2 prediksi 0,9919, RMSEC 0,0345, RMSEP 0,0457. Untuk klasifikasi, model DA di daerah gabungan bilangan gelombang 1800-1600 cm-1 dan 1250-950 cm-1 dengan metode Folch dan bilangan gelombang 1800-650 cm-1 dengan metode Bligh Dyer, berhasil mengelompokkan training data set menjadi beberapa kelas dan mengelompokkan testing data set ke dalam kelas sapi. Dengan demikian disimpulkan bahwa analisis spektroskopi FTIR kombinasi kemometrik merupakan metode screening yang cepat, sederhana dan murah untuk autentikasi rendang sapi dan babi hutan.Kata kunci: autentikasi, rendang sapi, babi hutan, FTIR, kemometrik ABSTRACTRendang is one of West Sumatra's traditional foods made from processed beef. The high price of beef encourages counterfeiting using wild boar meat. This study aims to develop a method of authentication analysis of beef rendang using FTIR spectroscopy in combination with chemometrics. The sample used is a mixture of beef and boar meat made in 11 concentrations (training data set) and restaurant rendang (testing data set). The rendang fat component was extracted using the Folch and Bligh Dyer methods and then analyzed by FTIR spectroscopy. The resulting FTIR spectra are used as a chemometric modelling variable. For quantification, the PLS model at wave number 1250-950 cm-1 gives the best model in the Folch method with a calibration R2 value of 0.9946, prediction R2 of 0.9954, RMSEC 0.0328, RMSEP 0.0402 and in the Bligh Dyer method, the model PCR at wavenumber 1800-500 cm-1 gave the best model with a calibration R2 value of 0.9940, prediction R2 of 0.9919, RMSEC 0.0345, RMSEP 0.0457. For classification, the DA model in the combined area of wave numbers 1800-1600 cm-1 and 1250-950 cm-1 with the Folch method and wave numbers 1800-650 cm-1 with the Bligh Dyer method, successfully grouped the training data set into several classes and grouped testing data set into cow class. Thus it was concluded that FTIR spectroscopic analysis combined with chemometrics is a fast, simple, and inexpensive screening method for the authentication of beef rendang and wild boar.Keywords: authentication, beef rendang, wild boar, FTIR, chemometrics

Literatur Review: Prospects of Stem Cell Secretomes for the Treatment of Hair Loss/Alopecia Nella Novita; Marlina Marlina; Regina Andayani
JURNAL PROTEKSI KESEHATAN Vol 12 No 1 (2023): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v12i1.666

The goal of this literature review is to find out the role of MSC in stimulating hair growth, particularly in people who suffer from hair loss/alopecia. Literature reviews were conducted using an electronic database such as Researchgate, PubMed, GoogleScholar, and ScienceDirect. MSC secretome for hair growth, secretome for hair growth, ADSC-Exosome for hair growth, ADSC-CM for alopecia, secretome conditioned medium for baldness, and formulation of hair tonic preparations to stimulate hair growth were the keywords used. From these keywords, 13 relevant research articles were found, 11 of which used patients with alopecia as research subjects in randomized clinical trials to examine hair growth. MSC therapy for alopecia has been shown to stimulate hair growth, density, and thickness.

Nanotope™ sebagai Sistem penghantaran Cosmeceutical untuk Meningkatkan Intensitas Efek pada Kulit Ulma Sintia; Regina Andayani; Henny Lucida
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Nanotope™ as a monolayer nanoencapsulated vesicular delivery system, consisting of a membrane formed by phospholipids (lecithin) and cosurfactants. Nanotope™ is an Ultra-small Unilamellar Carrier (USUC) having an average globule size of 0-40 nm. The diameter of the globule size which is smaller than the size of the skin pores allows the active ingredients to penetrate the stratum corneum to reach the target. Natural active compounds such as catechin, alpha mangostin, quercetin, and ascorbic acid have great potential as active ingredients to be formulated in cosmetic preparations. However, these compounds have limited penetration into the skin. Therefore, the Nanotope™ delivery system is the best solution for encapsulating these active ingredients without reducing their effectiveness. Cosmetic serums, creams and emulgel are preparations that are most likely to be formulated with the Nanotope™ delivery system. This review article presents Nanotope™ preparation techniques along with their evaluations, as well as active compounds from natural ingredients that have the potential for cosmetic applications with the Nanotope™ delivery system.

Co-Authors Afdhil Arel Aulia Rahmi Dachriyanus Ditya Kesumaningrum Elfasyari, Trie Yuni Friardi Ismed Henny Lucida Marlina . Martinus Martinus Mutia Amelia Putri Nella Novita Sintia, Ulma Siti Yulia Rahma Suryati Suryati Syofyan Syofyan Tadzkia Nisa Wida Ningsih

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