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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Tumbuhan Obat Indonesia Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Jurnal Kesehatan Masyarakat (JKM) CENDEKIA UTAMA Indonesian Journal of Biotechnology Majalah Obat Tradisional Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Caraka Tani: Journal of Sustainable Agriculture Jurnal Biologi Tropis JMM (Jurnal Masyarakat Mandiri) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Eko dan Bisnis: Riau Economic and Business Review
Siti Rofida
Universitas Muhammadiyah Malang
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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THE APOPTOSIS INDUCTION OF Zingiber oficinale ETHANOLIC EXTRACT-Treated HeLa (HUMAN CERVICAL CANCER) CELLS AND ACTIVE COMPOUND PROFILING USING GAS CHROMATOGRAPHY/MASS SPECTROMETRY Laela Hayu Nurani; Siti Rofida; Dwi Utami; Citra Ariani Edityaningrum; Any Guntarti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1059

Abstract

Cervical cancer accounts for the highest percentage of cancer-related deaths in Indonesia, accounting for nearly 60% of all cancer cases.  Therefore, research into the anticancer mechanisms needs to be conducted.  The ethanolic extract of Zingiber officinale (EEZO) contains zingiberene, a chemical known for its anticancer activity. Understanding the mechanism underlying the apoptosis-inducing effects is crucial. This study aimed to elucidate the apoptotic pathway and analyze the gas chromatography/mass spectrometry (GC/MS) profile of EEZO cells. The research commenced with the maceration of Zingiber officinale rhizomes using 75% ethanol to obtain EEZO. Apoptosis assays were conducted on both a negative control group and an EEZO-treated group of HeLa cells (cervical cancer cells). The apoptotic mechanism was evaluated using forward scattered light-side scattered light (FSC-SSC), fluorescein isothiocyanate (FTIC), and phycoerythrin (PE) flow cytometry. Apoptotic results were analyzed by comparing the control and EEZO samples, which revealed the number of viable cells, apoptotic cells, and cells in the sub-G1 phase. The major constituent of EEZO, which is expected to be a potent apoptosis inducer, was detected using GC/MS. The FSC-SSC results indicated a lower number of viable cells in the EEZO-exposed group than in the control group. FTIC results demonstrated that EEZO significantly increased apoptotic cell death, increasing from 68 to 1537 cells. PE flow cytometry revealed an elevated sub-G1 cell population, indicating the induction of apoptosis by EEZO. GC/MS analysis revealed five dominant components in EEZO, which had the potential to induce apoptosis: L-borneol, zingiberene, farnesol, beta-sesquiphellandrene, and alpha-curcumene ...  
Analisis Jejaring Farmakologi Metabolit Sekunder Tanaman Alang-Alang (Imperata cylindrica) Terhadap Penyakit Stroke Iskemik Syabana, Nada Laela; Rofida, Siti; Jamil, Ahmad Shobrun
Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Vol 11 No 1 (2025): Agustus 2025
Publisher : Fakultas Matematika & Ilmu Pengetahuan Alam - Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/ejbst.v11i1.601

Abstract

Stroke iskemik disebabkan oleh adanya plak aterosklerosis sehingga aliran darah menuju otak tersumbat. Hal ini terjadi karena adanya faktor risiko, yaitu hipertensi, diabetes melitus, dan kolesterol. Untuk mencegahnya, dilakukan penelitian menggunakan tanaman Imperata cylindrica yang sudah terbukti memiliki efek antihipertensi, antikolesterol, dan antidiabetes pada penelitian sebelumnya. Metode penelitian yang digunakan yaitu jejaring farmakologi menggunakan cytoscape dan analisis komputasi menggunakan molecular docking. Dilakukan analisis penunjang seperti, evaluasi farmakokinetik obat, kemiripan obat, prediksi dan validasi target. Didapatkan sebanyak 59 protein gen memiliki keterkaitan dengan tanaman Imperata cylindrica dan penyakit stroke iskemik dengan PTGS2 menjadi protein paling berpengaruh karena terhubung dengan hampir seluruh jalur persinyalan, seperti jalur metabolisme, resistensi insulin, AGE-RAGE pada komplikasi diabetes, biosintesis hormon steroid, dan kardiomiopati diabetes.
Cytotoxic Potential of Combination of Hibiscus sabdariffa L. Extract and Cisplatin against HeLa Cervical Cancer Cell Line: A Study of Antiproliferative Activity and Apoptosis Induction Nurani, Laela Hayu; Azzahra, Fara; Utami, Dwi; Edityaningrum, Citra Ariani; Guntarti, Any; Irham, Lalu Muhammad; Daud, Intan; Khairurrizki, Amanda; Putra, Ichsan Luqmana Indra; Ismiyati, Nur; Rofida, Siti; Sugiyanto, Sugiyanto
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.92440

Abstract

Cervical cancer is one of the most prevalent cancer types, making the development of effective anticancer agents critical. Cisplatin (CIS) is a drug that has been used to treat cancer, but it also affects normal cells. Hibiscus sabdariffa L. extract (HSE), which has the potential as an anticancer agent, can be developed as a co-chemotherapy with CIS. This study aimed to determine the potential of HSE as a co-chemotherapy with CIS against HeLa cervical cancer cells and determine specific and non-specific parameters of the studied extract. Hibiscus sabdariffa L. (HS) simplicia powder was macerated with 96% ethanol. An in vitro evaluation was carried out on antiproliferative activity by calculating the doubling time. Additionally, a selectivity test was conducted to calculate combination index (CI) values based on the microtetrazolium (MTT) method. Apoptosis mechanisms were explored based on immunocytochemical methods using p53, caspase, and Bax antibodies, followed by an observation of apoptotic induction using a flow cytometer. The HSE and CIS selectivity index values obtained for Vero cells and HeLa cells were 209 and 278, respectively. The antiproliferation test results showed that the combination of HSE and CIS could better extend the doubling time of cells compared to the negative control. This combination also demonstrated a strong synergistic effect, with a CI value of 0.001. The extract as a co-chemotherapy with CIS was capable of increasing the expression of p53, caspase-3, and Bax. The flow cytometry analysis results indicated that HSE could induce apoptosis. Based on the results on the IC50 and CI value of HSE, as well as on the doubling time and apoptosis induction of HSE-influenced HeLa cells, it is concluded that HSE has the potential as a co-chemotherapy against cervical cancer.
Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Annona squamosa L. Rofida, Siti; Firdiansyah, Ahmad; Fitriyastuti, Endah
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.693

Abstract

Cause of cardiovascular disease risk factors, one of which is a high cholesterol levels in serum. Mortality caused by cardiovascular disease as 17.3 million people. Annona squamosa L. or commonly referred custard apple is a plant from family Annonaceae and have been used for insecticide, antitumor, antidiabetic, antioxidant, anti-inflammatory, and antihyperlipidemia. The leaves of Annona squamosa L. contains acetogenin, diterpene, flavonoids, lignin, hydroxyl ketones, and benzoquinazolin. The aims of this study is to determine the optimum dose to reduce levels of LDL on hyperlipidemic rats. In this study, hyperlipidemic rats were divided into 5 groups, negative control group (normal feed), positive control group (normal feed and simvastatin at a dose of 0.9 mg/KgBW), treatment group 1 (normal feed and ethanol extract leaves of Annona squamosa L. at a dose of 0.25 mg/gBB, treatment groups 2 (normal feed and ethanol extract leaf of Annona squamosa L. at a dose of 0.75 mg/gBB, treatment groups 3 (normal feed and ethanol extract leaf of Annona squamosa L. at a dose of 1 mg/gBB). The results of identification by thin-layer chromatography on ethanol extract leaf of Annona squamosa L indicates the presence of flavonoids. The results showed that the ethanol extract leaves of Annona squamosa Linn. On hyperlipidemia rats, can lower LDL cholesterol levels at doses of 0.25 mg/gram BB.
Cytotoxicity of Zingiber officinale var. rubrum on HeLa cells and prediction of anti-proliferative activity via the jak2/stat3 and hedgehog pathways using a molecular docking approach Rofida, Siti; Nurani, Laela Hayu; Utami, Dwi; Edityaningrum, Citra Ariani
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27482

Abstract

Cervical cancer is one of the second-leading causes of death in women. The discovery of cancer drug candidates continues to be carried out due to the resistance that occurs in cervical cancer therapy. Plant metabolite compounds are one of the sources used to explore new drug candidates. Red ginger rhizome is a candidate plant that has anti-cervical cancer activity. This study aims to determine the cytotoxicity of an ethanol extract of red ginger rhizomes on the growth of HeLa cancer cells and predict anti-proliferative activity via the jak2/stat3 and hedgehog pathways. The sample (red ginger rhizome simplicia) was extracted by remaceration using 75% ethanol. The MTT assay method is used to test the cytotoxicity and anti-proliferation of metabolite compounds using Autodock 4.2 software. The receptors used in the jak2, stat3, and smo pathways were obtained from the Protein Data Bank with the codes 6VGL, 6NUQ, and 5L7I, respectively. The ethanol extract produced is a thick yellowish brown extract with an aromatic smell and spicy taste, with an extract yield of 18.63% w/w. 75% ethanol extract of red ginger rhizomes has cytotoxic activity in HeLa cancer with an IC50 of 104.22 ± 6.18 µg/mL and an IC50 of cisplatin of 38.61 ± 3.66. Prediction of antiproliferative activity via the jak2 pathway shows a binding energy and Ki value of -7.47 kcal/mol, -7.48 kcal/mol, and 3.33 uM, 3.27 uM, as shown by alpha-cedrol and beta-eudesmol compounds. The highest inhibition on the stat3 and smo pathways was shown by the beta compound eudesmol, with binding energy and Ki values of -6.05 kcal/mol, -7.57 kcal/mol, and 36.48 uM, respectively; 2.81 uM.
THE INFLUENCE OF EMPOWERMENT, BELIEF, AND REWARD TOWARD EMPLOYEE’S COMMITMENT AT MOTHER AND CHILD HOSPITAL OF ERIA BUNDA PEKANBARU Rofidah, Siti
Eko dan Bisnis: Riau Economic and Business Review Vol. 10 No. 1 (2019)
Publisher : Sekolah Tinggi Ilmu Ekonomi Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36975/jeb.v10i1.190

Abstract

The purposes of this research were to know the influence of empowerment, belief, and reward simultaneously and partially and to know which one the highest aspect influence employee’s commitment at mother and child hospital of Eria Bunda Pekanbaru. The method of this research used quantitative research and designed with correlational research. The population in this research was 164 employees. By using random sampling method, it can be calculated that the sample was 116 respondents. Then, the data collection technic used questionnaire and interview. In finding the quantity of an independent variable, influence with dependent variable used multiple linear regression analysis. This research concluded that empowerment, belief, and reward simultaneously gave significant influence toward employee’s commitment. Partially, empowerment had significant influence, which was dominated toward employee’s commitment. Meanwhile, belief and reward did not have influence toward employee’s commitment
Pengaruh Kompensasi Terhadap Kinerja Karyawan Pada PT. Surya Pilar Perkasa Pekanbaru Rofidah, Siti
Eko dan Bisnis: Riau Economic and Business Review Vol. 14 No. 1 (2023): Determinasi Kinerja, Kepatuhan, dan Perilaku Konsumen dalam Beragam Sektor Ind
Publisher : Sekolah Tinggi Ilmu Ekonomi Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36975/jeb.v14i1.411

Abstract

The purpose of this study was to determine the effect of compensation on employee performance at PT. Surya Pilar Perkasa Pekanbaru. The population in this study were all employees of PT. Surya Pilar Perkasa Pekanbaru, totaling 89 people.Data analysis used simple linear regression method using validity test, reliability test, normality test, R² and t test. The test was conducted to determine the relationship between the independent variable (independent variable) and the dependent variable (dependent variable).Based on the results of the research analysis, it was found that t count was greater than t table (10,846 > 1,988). Thus it can be concluded that the compensation variable (X) has an effect on employee performance. The simple regression results show Y = a + bX, namely: Y = 15.341 + 0.904 X. From the regression equation, it is concluded that the regression coefficient of bX is positive. This shows that if the independent variable is increased the equation will cause an increase in the dependent variable. The result of R Square of 0.558 explains that performance is influenced by compensation of 55.8%.
Pengaruh Pengawasan Terhadap Disiplin Kerja Pegawai Non PNS Pada Rumah Sakit Jiwa Tampan Provinsi Riau Rofidah, Siti
Eko dan Bisnis: Riau Economic and Business Review Vol. 14 No. 3 (2023): Kualitas Pelayanan, Kompetensi, dan Kinerja: Perspektif Manajemen Sumber Daya
Publisher : Sekolah Tinggi Ilmu Ekonomi Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36975/jeb.v14i3.434

Abstract

This research was conducted at Taman Mental Hospital, Riau Province, which is located at Jl. HR. Soebrantas Km. 12.5 New Intersection, Handsome District, Pekanbaru City. Samples were taken as many as 64 people. Data analysis in this study used descriptive and quantitative analysis methods. Descriptive is comparing actual facts with theories related to the problem in order to draw a conclusion and tabulate it in the form of frequency distribution tables. While the quantitative research method is based on data that can be calculated to produce a solid assessment. The results of a simple linear regression study in this study were Y = 14.833 + 0.627 X. By using the t test, a ttable value of 1.998 was obtained and a tcount value of 6.313 means that tcount = 6.313> ttable = 1.998 which means that supervision influences work discipline in mental hospitals Riau Provincial Park with a large influence of 39.1%
Pengaruh Kualitas Produk Terhadap Keputusan Pembelian Produk Cireng Frozen Food Pada CV. “XY” Fakhri, Rizqi; Rofidah, Siti
Eko dan Bisnis: Riau Economic and Business Review Vol. 14 No. 4 (2023): Dinamika Kinerja, Kepuasan, dan Perilaku Konsumen: Perspektif Ekonomi, Pendidi
Publisher : Sekolah Tinggi Ilmu Ekonomi Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36975/ekobis.v14i4.446

Abstract

This research was conducted on CV. XY, the purpose of this study was to determine the effect of product quality on purchasing decisions at CV. XY, with the population in this study were 780 people and a sample of 89 people. Data collection was carried out through questionnaires and data analysis techniques used with a significant level of 0.05 were validity test, reliability test with Cronbach alpha, t test, and simple linear regression analysis and analysis of determination R Square (R^2). The results of the analysis and the data of this study using SPSS version 21, the results of the simple linear regression equation are Y = 13,121 + 0,775 X. Based on the results of research on the t test, the value of t_count> t_table (8,272> 1,987) then the results of this study indicate that product quality has a significant effect on purchasing decisions. Based on the data obtained from the results of the correlation analysis between variables X and Y variables obtained R Square (R²) of 0.440 or 44.0%, this shows that the percentage of the contribution of the influence of the independent variable on the dependent variable is 44.0% while the remaining 56, 0% is influenced by other variables not examined in this study
Pengaruh Motivasi Kerja Terhadap Kinerja Guru Sekolah Dasar “ XYZ” Pekabaru Rofidah, Siti; Putra, Eka
Eko dan Bisnis: Riau Economic and Business Review Vol. 15 No. 1 (2024): Faktor Internal dan Eksternal terhadap Kinerja, Kepuasan, dan Keputusan Ekonom
Publisher : Sekolah Tinggi Ilmu Ekonomi Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36975/ekobis.v15i1.473

Abstract

The research conducted at XYZ analyzed data using descriptive and quantitative methods to compare actual reality with theories. The data was tabulated and analyzed according to research objectives. The results showed that respondents strongly agreed with the motivation variable (X) and agreed with the performance variable (Y). The regression equation derived from the research indicated that when the motivation value is 0, teacher performance is positive at 9.829. The motivation coefficient value of 0.734 suggested that a unit increase in motivation led to a 73.4% change in teacher performance. The R Square (R2) value of 0.520 indicated that 52.0% of the teacher performance at SD XYZ in Pekanbaru can be explained by motivation, while the remaining 48.0% is influenced by other factors not examined in the research.
Co-Authors Ahmad Shobrun Jamil Amaliyah Dina Anggraeni Anak Agung Istri Sri Wiadnyani Any Guntarti Any Guntarti Aufa Fadnurrahim Azzahra, Fara Bishri, Hasanul Citra Ariani Edityaningrum, Citra Daud, Intan Dian Yuliartha Lestari Dinda Farida Dwi Hartanti Dwi Retno Nur Syahida Dwi Utami Eka Putra Erfan Dani Septia Fadillah, Sonia Wati Fakhri, Rizqi Firdiansyah, Ahmad Firzannida Firzannida Fitriyastuti, Endah Herman Ichsan Luqmana Indra Putra, Ichsan Luqmana Indra Ilham Niawan Saputra Irawan, Mhd.Sahreza Khairurrizki, Amanda Kurniawan, Teuku Reza Laela Hayu Nurani Lalu Muhammad Irham Lely Mauliana Lilik Yusetyani Lilik Yusetyani Maftuchah Maftuchah Mohammad Saifur Rahman Moonike Era Wahyuningati Muhammad Yusron Maulana El-Yunusi Nur Ismiyati Nurul Amalia Azhari Nurwahdaniati Nurwahdaniati Nurwahdaniati Nurwahdaniati, Nurwahdaniati Rahman, Mohammad Saifur Refie Putri Madiyanti Sakti Bagaskara Saputra, Ilham Niawan Savana Sonia Savira Setyawati Soeharto Setyawati Soeharto, Setyawati Sofyan Arief Solly Aryza Sugiyanto - Syabana, Nada Laela Trimianti Hidahyatun Nazah Ulfiatul Jannah Warman, Defi Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yustika Faradhiba Yustika Savira