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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Tumbuhan Obat Indonesia Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Jurnal Kesehatan Masyarakat (JKM) CENDEKIA UTAMA Indonesian Journal of Biotechnology Majalah Obat Tradisional Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Jurnal Biologi Tropis JMM (Jurnal Masyarakat Mandiri) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM Journal of Fundamental and Applied Pharmaceutical Science Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Eko dan Bisnis: Riau Economic and Business Review
Siti Rofida
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Analisis Jejaring Farmakologi Metabolit Sekunder Tanaman Alang-Alang (Imperata cylindrica) Terhadap Penyakit Stroke Iskemik Syabana, Nada Laela; Rofida, Siti; Jamil, Ahmad Shobrun
Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Vol 11 No 1 (2025): Agustus 2025
Publisher : Fakultas Matematika & Ilmu Pengetahuan Alam - Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/ejbst.v11i1.601

Abstract

Stroke iskemik disebabkan oleh adanya plak aterosklerosis sehingga aliran darah menuju otak tersumbat. Hal ini terjadi karena adanya faktor risiko, yaitu hipertensi, diabetes melitus, dan kolesterol. Untuk mencegahnya, dilakukan penelitian menggunakan tanaman Imperata cylindrica yang sudah terbukti memiliki efek antihipertensi, antikolesterol, dan antidiabetes pada penelitian sebelumnya. Metode penelitian yang digunakan yaitu jejaring farmakologi menggunakan cytoscape dan analisis komputasi menggunakan molecular docking. Dilakukan analisis penunjang seperti, evaluasi farmakokinetik obat, kemiripan obat, prediksi dan validasi target. Didapatkan sebanyak 59 protein gen memiliki keterkaitan dengan tanaman Imperata cylindrica dan penyakit stroke iskemik dengan PTGS2 menjadi protein paling berpengaruh karena terhubung dengan hampir seluruh jalur persinyalan, seperti jalur metabolisme, resistensi insulin, AGE-RAGE pada komplikasi diabetes, biosintesis hormon steroid, dan kardiomiopati diabetes.
Cytotoxic Potential of Combination of Hibiscus sabdariffa L. Extract and Cisplatin against HeLa Cervical Cancer Cell Line: A Study of Antiproliferative Activity and Apoptosis Induction Nurani, Laela Hayu; Azzahra, Fara; Utami, Dwi; Edityaningrum, Citra Ariani; Guntarti, Any; Irham, Lalu Muhammad; Daud, Intan; Khairurrizki, Amanda; Putra, Ichsan Luqmana Indra; Ismiyati, Nur; Rofida, Siti; Sugiyanto, Sugiyanto
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.92440

Abstract

Cervical cancer is one of the most prevalent cancer types, making the development of effective anticancer agents critical. Cisplatin (CIS) is a drug that has been used to treat cancer, but it also affects normal cells. Hibiscus sabdariffa L. extract (HSE), which has the potential as an anticancer agent, can be developed as a co-chemotherapy with CIS. This study aimed to determine the potential of HSE as a co-chemotherapy with CIS against HeLa cervical cancer cells and determine specific and non-specific parameters of the studied extract. Hibiscus sabdariffa L. (HS) simplicia powder was macerated with 96% ethanol. An in vitro evaluation was carried out on antiproliferative activity by calculating the doubling time. Additionally, a selectivity test was conducted to calculate combination index (CI) values based on the microtetrazolium (MTT) method. Apoptosis mechanisms were explored based on immunocytochemical methods using p53, caspase, and Bax antibodies, followed by an observation of apoptotic induction using a flow cytometer. The HSE and CIS selectivity index values obtained for Vero cells and HeLa cells were 209 and 278, respectively. The antiproliferation test results showed that the combination of HSE and CIS could better extend the doubling time of cells compared to the negative control. This combination also demonstrated a strong synergistic effect, with a CI value of 0.001. The extract as a co-chemotherapy with CIS was capable of increasing the expression of p53, caspase-3, and Bax. The flow cytometry analysis results indicated that HSE could induce apoptosis. Based on the results on the IC50 and CI value of HSE, as well as on the doubling time and apoptosis induction of HSE-influenced HeLa cells, it is concluded that HSE has the potential as a co-chemotherapy against cervical cancer.
Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Annona squamosa L. Rofida, Siti; Firdiansyah, Ahmad; Fitriyastuti, Endah
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.693

Abstract

Cause of cardiovascular disease risk factors, one of which is a high cholesterol levels in serum. Mortality caused by cardiovascular disease as 17.3 million people. Annona squamosa L. or commonly referred custard apple is a plant from family Annonaceae and have been used for insecticide, antitumor, antidiabetic, antioxidant, anti-inflammatory, and antihyperlipidemia. The leaves of Annona squamosa L. contains acetogenin, diterpene, flavonoids, lignin, hydroxyl ketones, and benzoquinazolin. The aims of this study is to determine the optimum dose to reduce levels of LDL on hyperlipidemic rats. In this study, hyperlipidemic rats were divided into 5 groups, negative control group (normal feed), positive control group (normal feed and simvastatin at a dose of 0.9 mg/KgBW), treatment group 1 (normal feed and ethanol extract leaves of Annona squamosa L. at a dose of 0.25 mg/gBB, treatment groups 2 (normal feed and ethanol extract leaf of Annona squamosa L. at a dose of 0.75 mg/gBB, treatment groups 3 (normal feed and ethanol extract leaf of Annona squamosa L. at a dose of 1 mg/gBB). The results of identification by thin-layer chromatography on ethanol extract leaf of Annona squamosa L indicates the presence of flavonoids. The results showed that the ethanol extract leaves of Annona squamosa Linn. On hyperlipidemia rats, can lower LDL cholesterol levels at doses of 0.25 mg/gram BB.
Cytotoxicity of Zingiber officinale var. rubrum on HeLa cells and prediction of anti-proliferative activity via the jak2/stat3 and hedgehog pathways using a molecular docking approach Rofida, Siti; Nurani, Laela Hayu; Utami, Dwi; Edityaningrum, Citra Ariani
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27482

Abstract

Cervical cancer is one of the second-leading causes of death in women. The discovery of cancer drug candidates continues to be carried out due to the resistance that occurs in cervical cancer therapy. Plant metabolite compounds are one of the sources used to explore new drug candidates. Red ginger rhizome is a candidate plant that has anti-cervical cancer activity. This study aims to determine the cytotoxicity of an ethanol extract of red ginger rhizomes on the growth of HeLa cancer cells and predict anti-proliferative activity via the jak2/stat3 and hedgehog pathways. The sample (red ginger rhizome simplicia) was extracted by remaceration using 75% ethanol. The MTT assay method is used to test the cytotoxicity and anti-proliferation of metabolite compounds using Autodock 4.2 software. The receptors used in the jak2, stat3, and smo pathways were obtained from the Protein Data Bank with the codes 6VGL, 6NUQ, and 5L7I, respectively. The ethanol extract produced is a thick yellowish brown extract with an aromatic smell and spicy taste, with an extract yield of 18.63% w/w. 75% ethanol extract of red ginger rhizomes has cytotoxic activity in HeLa cancer with an IC50 of 104.22 ± 6.18 µg/mL and an IC50 of cisplatin of 38.61 ± 3.66. Prediction of antiproliferative activity via the jak2 pathway shows a binding energy and Ki value of -7.47 kcal/mol, -7.48 kcal/mol, and 3.33 uM, 3.27 uM, as shown by alpha-cedrol and beta-eudesmol compounds. The highest inhibition on the stat3 and smo pathways was shown by the beta compound eudesmol, with binding energy and Ki values of -6.05 kcal/mol, -7.57 kcal/mol, and 36.48 uM, respectively; 2.81 uM.
THE INFLUENCE OF EMPOWERMENT, BELIEF, AND REWARD TOWARD EMPLOYEE’S COMMITMENT AT MOTHER AND CHILD HOSPITAL OF ERIA BUNDA PEKANBARU Rofidah, Siti
Eko dan Bisnis: Riau Economic and Business Review Vol. 10 No. 1 (2019)
Publisher : Sekolah Tinggi Ilmu Ekonomi Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36975/jeb.v10i1.190

Abstract

The purposes of this research were to know the influence of empowerment, belief, and reward simultaneously and partially and to know which one the highest aspect influence employee’s commitment at mother and child hospital of Eria Bunda Pekanbaru. The method of this research used quantitative research and designed with correlational research. The population in this research was 164 employees. By using random sampling method, it can be calculated that the sample was 116 respondents. Then, the data collection technic used questionnaire and interview. In finding the quantity of an independent variable, influence with dependent variable used multiple linear regression analysis. This research concluded that empowerment, belief, and reward simultaneously gave significant influence toward employee’s commitment. Partially, empowerment had significant influence, which was dominated toward employee’s commitment. Meanwhile, belief and reward did not have influence toward employee’s commitment
Metabolomic Study of Andrographis paniculata Using Fourier Transform Infrared Spectroscopy and Gas Chromatography-Mass Spectrometry Yustawan, Dandy Arif; Apriliani, Firli Triayu; Farmasari, Novan Visia; Rofida, Siti
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 2 (2026): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i2.27055

Abstract

Andrographis paniculata contains bioactive compounds with anticancer, hepatoprotective, antibacterial, antidiabetic, antihypertensive, analgesic, and anti-inflammatory properties. Key compounds include andrographolide, paniculide, farnesol, flavonoids, saponins, alkaloids, phenols, and tannins. Environmental and geographic factors influence the composition of these compounds, thereby altering metabolite profiles. This study used FTIR and GC-MS methods in a non-targeted metabolomics approach to identify and analyze the metabolite diversity of Andrographis paniculata from different regions of Java Island. The FTIR analysis identified functional groups associated with secondary metabolites, including tannins, flavonoids, andrographolide, saponins, alkaloids, and triterpenoids. GC-MS profiling identified 43, 46, and 49 metabolites in West Java, Central Java, and East Java samples, respectively, with fatty acids and fatty acid esters as the dominant classes. PCA clearly separated Central Java samples from the other two regions, while ANOSIM confirmed significant differences in chemical composition among the groups. Overall, the findings demonstrate that geographical origin strongly influences the secondary metabolite composition of A. paniculata, with Central Java exhibiting the most distinct profile.
Co-Authors Ahmad Shobrun Jamil Amaliyah Dina Anggraeni Anak Agung Istri Sri Wiadnyani Any Guntarti Any Guntarti Apriliani, Firli Triayu Aufa Fadnurrahim Azzahra, Fara Citra Ariani Edityaningrum, Citra Daud, Intan Dian Yuliartha Lestari Dinda Farida Dwi Hartanti Dwi Retno Nur Syahida Dwi Utami Erfan Dani Septia Farmasari, Novan Visia Firdiansyah, Ahmad Firzannida Firzannida Fitriyastuti, Endah Ichsan Luqmana Indra Putra, Ichsan Luqmana Indra Ilham Niawan Saputra Khairurrizki, Amanda Laela Hayu Nurani Lalu Muhammad Irham Lely Mauliana Lilik Yusetyani Lilik Yusetyani Maftuchah Maftuchah Mohammad Saifur Rahman Moonike Era Wahyuningati Nur Ismiyati Nurul Amalia Azhari Nurwahdaniati Nurwahdaniati Nurwahdaniati Nurwahdaniati, Nurwahdaniati Rahman, Mohammad Saifur Refie Putri Madiyanti Sakti Bagaskara Saputra, Ilham Niawan Savana Sonia Savira Setyawati Soeharto Setyawati Soeharto, Setyawati Sofyan Arief Sugiyanto - Syabana, Nada Laela Tiara Aninditha Trimianti Hidahyatun Nazah Ulfiatul Jannah Yustawan, Dandy Arif Yustika Faradhiba Yustika Savira