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Optimasi Formula dan Uji Antibakteri Terhadap Staphylococcus aureus dan Propionibacterium acne Pada Sediaan Emulgel Kombinasi Minyak Atsiri Cinnamomum Zeylanicum dan Citrus hystrix dengan Desain Faktorial 2^2 Anggraeni, Amaliyah Dina
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 1 No 02 (2020): HERCLIPS VOL 01 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v1i02.1410

Cinnamon and lime essential oils are known as antibacterial activity. It contains citronellol, geraniol, cinnamaldehyde, and Eugenol. This study aims to determine the concentration of combination Cinnamomum zeylanicum and Citrus hystrix essential oils in emulgel preparations as an antibacterial against Staphylococcus aureus and Propionibacterium acnes. Dosage formulation of emulgel made in various concentrations of combinations of C. Zeylanicum And C. Hystric Essential Oil that 0.5: 2 (FI); 0.5: 4 (FII); 1: 2 (FIII); 1: 4 (FIV) respectively. Further preparation of the emulgel evaluated physical, chemical characteristics, stability during storage, and antibacterial activity. Factorial design 2^2 used to analyze data on the test characteristics of emulgel preparations. The result showed that all formulations have the characteristics of soft, white, and smells of lime and cinnamon. Viscosity, pH, spreadability, freeze-thaw, and real-time temperature stability did not differ significantly. The F3 showed the highest antibacterial activity against Staphylococcus aureus and Propionibacterium acne with a zone of inhibition of 19.10 mm and 19.10 mm, respectively. Variation of C. zeylanicum and C. hystrix essential oils had a significant pH change in the one-month real-time stability test at various temperatures. The antibacterial activity there was no synergistic effect as an antibacterial, which is shown by the absence of interaction between the two active ingredients. Keywords: Cinnamomum zeylanicum, Citrus hystrix, Factorial design, Formulation, Antibacterial

ANALISIS KUALITATIF OBAT TRADISIONAL SEBAGAI AGEN PENINGKATAN IMUNITAS TUBUH DALAM MELAWAN COVID-19 DI SURAT KABAR ONLINE INDONESIA Amaliyah Dina Anggraeni; Salahudin Salahudin; Ahmad Shobrun Jamil; Siti Rofida
JKM (Jurnal Kesehatan Masyarakat) Cendekia Utama Vol 8, No 2 (2021): JKM (Jurnal Kesehatan Masyarakat) Cendekia Utama
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/jkm.v8i2.684

COVID-19 menjadi pandemic di seluruh dunia saat ini. Pengobatan dan vaksin yang spesifik untuk penanganannya juga belum ditemukan. Namun, beberapa peneliti dunia tengah melakukan studi potensi pengobatan tradisional untuk menjadi alternative penanganan COVID-19. Pemberitaan media online termasuk di Indonesia juga tidak sedikit yang memberitakan potensi obat tradisional dalam melawan COVID-19. Penelitian ini bertujuan untuk mengetahui pengobatan tradisional yang dapat digunakan sebagai peningkatan imunitas tubuh untuk melawan COVID- 19. Penelitian ini merupakan penelitian kualitatif analisis konten terhadap konten media online nasional yang berkaitan langsung dengan pemberitaan dan pengkajian tentang obat tradisional sebagai obat untuk meningkatkan kekebalan tubuh menghadapi wabah Covid-19 di Indonesia. Analisis data menerapkan teknik coding berbuka, yaitu proses analisis data yang dilakukan berdasarkan pada konsep abstrak yang kemudian dijadikan sebagai dasar pengklasifikasian data yang berkaitan dengan topik penelitian ini. Analisis koding berbuka menggunakan software Nvivo 12 plus melalui fitur auto code, crosstab, hirarchy chart, dan word frequency. Penelitian ini menemukan bahwa penggunaan herbal dapat meningkatkan fungsi kekebalan tubuh. Kekebalan tubuh yang optimal dapat mencegah tubuh dari infeksi COVID-19 (penyakit Coronavirus-19). Keterbatasan penelitian ini adalah validitas data yang perlu dilakukan melalui triangulasi konten media online dan laporan ilmiah yang dibuat oleh para ahli dari berbagai laboratorium terkemuka. Oleh karena itu, penelitian selanjutnya perlu meninjau topik penelitian ini menggunakan teknik analisis triangulasi media online dan laporan penelitian yang dikeluarkan oleh laboratorium terkemuka di Indonesia.

Pelatihan Pembuatan Minuman Herbal Modern dalam Kemasan Siap Minum di Puskesmas Mojolangu Amaliyah Dina Anggraeni; Kurnia Putri Utami; Nungki Marlian Yuliadarwati
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 5 No 3 (2020): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Training on making new herbal drinks in containers has been carried out at the Mojolangu Health Center, Malang city. The aim of the training on making new herbal drinks is to provide skills to partners in order to help improve the family economy through the creative economy. So the products produced can be marketed in public facilities such as schools and food stalls and grocery stores. The output of the training activities is to provide solutions to problems faced by the community in partner villages in an integrated manner to increase the economic value of the local community. Besides that, there is a noble value to be conveyed by the author, namely that herbal medicine is better known globally by not reducing its usefulness. Training on making new herbal drinks can be used as product ingredients/industrial development by partners as entrepreneurs. Issuance of certificates given to residents who took part in training as a form of appreciation, they have participated in training in making new herbal drinks, increased knowledge, skills, and confidence of health center cadres in the field of traditional medicine in tackling health in the community quickly and accurately. These community service activities will include experiences that are not only useful for the partner community but also the immediate family and the surrounding environment.

Pemberdayaan Dan Pendampingan Kader Binaan Puskesmas Mojolangu Dalam Pembuatan Obat Tradisional Yang Baik Amaliyah Dina Anggraeni; Siti Rofida
JURNAL KREATIVITAS PENGABDIAN KEPADA MASYARAKAT (PKM) Volume 4 Nomor 3 Juni 2021
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v4i3.3563

ABSTRAK Pemanfaatan obat tradisional untuk menunjang kualitas kesehatan, sangat diperlukan keseimbangan dari upaya – upaya dalam peningkatan mutunya. Hal ini berkaitan pula dengan adanya dampak – dampak dari penggunaan obat tradisional pada umumnya. Sehingga untuk melindungi konsumen dari akibat penggunaan obat tradisional yang tidak memenuhi persyaratan, maka produk obat tradisional harus memenuhi persyaratan mutu, keAmanan, dan kemanfaatan untuk dapat diedarkan di Indonesia maupun ekspor ke luar negeri. Puskesmas Mojolangu merupakan fasilitas kesehatan yang memiliki bidang pengembangan dan pemberdayaan masyarakat khususnya departemen kesehatan pengobatan tradisional. Banyaknya masyarakat daerah sekitar mitra yang berprofesi sebagai produsen obat tradisional tetapi belum adanya pemberian informasi terkait cara pembuatan obat tradisional yang baik dan benar. Higenitas dan keamanan jamu atau minuman herbal yang diproduksi oleh produsen jamu di lingkungan puskesmas mojolangu belum terstandarisasi sesuai dengan CPOTB. Sehingga berpotensi dihasilkan produk jamu yang tidak berkhasiat optimal serta keamanan produk tidak tercapai. Kegiatan pengabdian ini menggunakan metode Contextual Teaching and Learning (CTL) untuk mengatasi permasalahan yang dialami oleh masyarakat di kelurahan Mojolangu. Setelah edukasi dan pendampingan produsen jamu atau obat tradisional dapat memproduksi jamu temulawak dan jahe instan yang berkhasiat dan aman untuk dikonsumsi. Kata kunci : Jamu, Obat Tradisional, Kader binaan, produsen jamu, CPOTB ABSTRACT The use of traditional medicines to support health quality requires a balance of efforts to improve its quality. It is also related to the effects of using traditional medicines in general. It protects consumers from the consequences of using traditional medicines that do not meet the requirements. Traditional medicinal products must meet the quality, safety, and benefit requirements circulated in Indonesia and exported abroad. The Mojolangu Health Center is a health facility with community development and empowerment sector, especially the traditional medicine health department. There are many local communities around the partners who work as producers of traditional medicines, but there is no information regarding how to manufacture traditional medicines correctly and adequately. The hygiene and safety of jamu or herbal drinks produced by herbal medicine producers in the Mojolangu Community Health Center have not standard according to the CPOTB. The potential to produce herbal products that do not have optimal efficacy and product safety does not achieve. This service activity uses the Contextual Teaching and Learning (CTL) method to overcome the community's problems in Mojolangu village. After education and assistance, producers of herbal medicine or traditional medicine can produce herbal ginger and instant ginger, which are efficacious and safe for consumption. Keywords: Jamu, Traditional medicine, construction cadres, herbal medicine manufacturer, CPOTB

PEMANFAATAN TANAMAN OBAT KELUARGA SEBAGAI MINUMAN KESEHATAN DAN HAND SANITIZER PADA MASA PANDEMI COVID-19 DI KOTA MALANG Siti Rofida; Amaliyah Dina Anggraeni; Ulfiatul Jannah; Moonike Era Wahyuningati; Yustika Faradhiba; Refie Putri Madiyanti; Yustika Savira
JMM (Jurnal Masyarakat Mandiri) Vol 6, No 5 (2022): Oktober
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v6i5.9912

Abstrak: Pandemi COVID-19 menyebabkan perubahan perilaku untuk selalu menggunakan masker dan hand sanitizer. Upaya preventif yang dilakukan untuk penanggulangan penyebaran covid-19 adalah dengan memberikan edukasi tentang pemanfaatan tanaman obat keluarga (TOGA) yang dapat meningkatkan imunitas tubuh dan sebagai antiseptic. Tujuan kegiatan pengabdian ini adalah meningkatan pengetahuan dan ketrampilan masyarakat melalui transfer ipteks tentang pemanfataan TOGA sebagai minuman kesehatan dan hand sanitizer. Pelaksanaan pengabdian menggunakan 2 metode yaitu penyuluhan dan pelatihan. Mitra yang dilibatkan pada kegiatan ini adalah kelompok Ibu PKK RT 01 RW 10 Kelurahan Bandungrejosari. Jumlah peserta kegiatan sebanyak 20 orang. Monitoring kegiatan dilakukan melalui teknik wawancara sedangkan evaluasi kegiatan melalui penyebaran kuisioner kepada mitra. Kuisioner ini berisi pertanyaan yang berhubungan dengan tingkat pemahaman mitra untuk memanfaatkan TOGA sebagai minuman kesehatan dan hand sanitizer. Kesimpulan hasil kegiatan pengabdian ini adalah Mitra pengabdian memiliki pengetahuan yang baik tentang pembuatan minuman kesehatan bentuk larutan, serbuk effervescent, dan serbuk instan serta pembuatan hand sanitizer. Mitra pengabdian mampu membuat minuman kesehatan bentuk larutan, serbuk effervescent, dan serbuk instan serta hand sanitizer dari tanaman hasil budidaya TOGA yang telah dimiliki sebelumnya. Saran dari kegiatan ini adalah Mitra pengabdian diharapkan tetap menerapkan 5 M dan mengkonsumsi minuman kesehatan untuk mencegah penyebaran COVID-19.Abstract: The COVID-19 pandemic has caused behavioral changes to always use masks and hand sanitizers. Preventive efforts are being taken to prevent the spread of COVID-19 by providing education about the use of TOGA (”Tanaman Obat Keluarga”, Family Medicinal Plants) which can increase the body's immunity and act as antiseptics. The purpose of this service activity is to increase the knowledge and skills of the community through the transfer of science and technology regarding the use of TOGA as a health drink and hand sanitizer. The implementation of service uses 2 methods, namely counseling and training. The partners involved in this activity were the PKK group of RT 01 RW 10, Bandungrejosari Village. The number of participants in the activity was 20 people. Monitoring of activities is carried out through interview techniques, while evaluation of activities is carried out by distributing questionnaires to partners. This questionnaire contains questions about the level of understanding of partners to utilize TOGA as a health drink and hand sanitizer. This service activity concludes that service partners have good knowledge about making health drinks in the form of solutions, effervescent powders, and instant powders as well as making hand sanitizers. Service partners can make health drinks in the form of solutions, effervescent powders, and instant powders as well as hand sanitizers from plants that are the result of TOGA cultivation which has been owned by previous partners. The suggestion from this activity is that service partners are expected to continue to apply the 5 M and consume health drinks to prevent the spread of COVID-19.

BIOAVAILABILITY AND MOLECULAR DOCKING PREDICTION OF SECONDARY METABOLITE OF Curcuma zedoaria AS POTENTIAL MPRO SARS COV-2 INHIBITOR Amaliyah Dina Anggraeni; Nia Yuniar Fitriana Putri; Septia Devi Amalia; M. Artabah Muchlisin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023): Forthcoming Issue
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.805

Almost all countries worldwide have been exposed to the COVID-19 pandemic, which can cause respiratory diseases. Therefore, it is necessary to identify and develop drugs for the treatment of COVID-19. White turmeric (Curcuma zedoaria) is very popular because it is effective as an anticancer and antiviral agent. This study used the in silico method to predict the secondary metabolite compounds contained in C. zedoaria as inhibitors of Mpro (main protease) SARS-CoV-2. Of the 30 secondary metabolite compounds identified, 26 compounds had good bioavailability prediction, and three compounds (curcumadiol, curcumin, and desmethoxycurcumin) were predicted to have potential as SARS-COV-2 Mpro inhibitors because they have low inhibition constants and numerous ligand-protein interactions. Curcumadiol have binding energy: -8.34 kcal/mol; pKi: 0.77 µM; hydrogen bond: Glu166, Thr190, and Gln192; and hydrophobic bond: Met165 and Gln189. Curcumin have binding energy: -8.28 kcal/mol; pKi: 0.85 µM; hydrogen bond: Leu141, Gly143, Ser144, and Thr190; and hydrophobic bond: Cys145, Met165, and Gln189. Desmethoxycurcumin have binding energy: -7.83 kcal/mol; pKi: 1.84 µM; hydrogen bond: Asp187, Thr190, and Gln192; and hydrophobic bond: Met165. Keywords: Curcuma zedoaria, SARS-CoV-2, bioavailability, molecular docking

Phytochemical and Cytotoxic Test of Durio kutejensis Root Bark on MCF-7 Cells Muhammad Priyadi; Haryoto Haryoto; Amaliyah Dina Anggraeni; Heng Yen Khong
Borneo Journal of Pharmacy Vol. 4 No. 1 (2021): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v4i1.1443

Durio kutejensis has known potential as herbal medicine in Kalimantan. Many things can be explored from D. kutejensis related pharmacological activity in every part of the plant included root bark. This study investigated the phytochemical content with a qualitative test and tested cytotoxic activities of D. kutejensis root bark on MCF-7 cell lines. Cytotoxic activity tested on MCF-7 cells with MTT assay method. The result showed that D. kutejensis root bark contains flavonoid, tannin, terpenoid, phenol, and saponin. IC50 value for ethanol extracts of root bark, n-hexane fractions, ethyl acetate fractions, and doxorubicin on MCF-7 cells were 761.29; 280.5; 207.08; and 0.25 μg/mL, respectively. In conclusion, D. kutejensis root bark has some secondary metabolites but no cytotoxic activity on MCF-7 cells. Further research is needed to explore the anticancer activity of secondary metabolites on some other cancer cells and other pharmacological activities.

Analysis Of The Relationship Of Covid-19 Symptoms Which Receive Favipiravir And Length Of Treatment In The Inpatition Of Dr. Iskak Tulungagung Aghnia Fuadatul Inayah; Ghassani Shabrina Putri; Amaliyah Dina Anggraeni
Eduvest - Journal of Universal Studies Vol. 4 No. 5 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i5.1277

Coronavirus disease 2019 or commonly called COVID-19 is an infectious disease caused by SARS-CoV-2. Favipiravir is a broad-spectrum antiviral drug so it has potential antiviral action against SARS-CoV-2 which is an RNA virus. This research aims to find out the relationship between Covid-19 symptoms when receiving favipiravir and the length of treatment of patients hospitalized at RSUD Dr. Iskak Tulungagung. Observational research with descriptive retrospective methods in COVID-19 patients' moderate symptoms with Favipiravir therapy at RSUD dr. Iskak Tungagung period July - September 2021. Data collection using the calculation of the Slovin formula to determine the number of patient samples. Analysis analysis using SPSS by carrying out the Chi-square test. The results of the study were obtained from 146 patients, the pattern of using Favipiravir was given at a dose (2x1600mg) on the first day followed by (2x600mg) on the second day and so on with the most giving range of 1-7 days .

BIOAVAILABILITY AND MOLECULAR DOCKING PREDICTION OF SECONDARY METABOLITE OF Curcuma zedoaria AS POTENTIAL MPRO SARS COV-2 INHIBITOR Amaliyah Dina Anggraeni; Nia Yuniar Fitriana Putri; Septia Devi Amalia; M. Artabah Muchlisin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.805

Almost all countries worldwide have been exposed to the COVID-19 pandemic, which can cause respiratory diseases. Therefore, it is necessary to identify and develop drugs for the treatment of COVID-19. White turmeric (Curcuma zedoaria) is very popular because it is effective as an anticancer and antiviral agent. This study used the in silico method to predict the secondary metabolite compounds contained in C. zedoaria as inhibitors of Mpro (main protease) SARS-CoV-2. Of the 30 secondary metabolite compounds identified, 26 compounds had good bioavailability prediction, and three compounds (curcumadiol, curcumin, and desmethoxycurcumin) were predicted to have potential as SARS-COV-2 Mpro inhibitors because they have low inhibition constants and numerous ligand-protein interactions. Curcumadiol have binding energy: -8.34 kcal/mol; pKi: 0.77 µM; hydrogen bond: Glu166, Thr190, and Gln192; and hydrophobic bond: Met165 and Gln189. Curcumin have binding energy: -8.28 kcal/mol; pKi: 0.85 µM; hydrogen bond: Leu141, Gly143, Ser144, and Thr190; and hydrophobic bond: Cys145, Met165, and Gln189. Desmethoxycurcumin have binding energy: -7.83 kcal/mol; pKi: 1.84 µM; hydrogen bond: Asp187, Thr190, and Gln192; and hydrophobic bond: Met165. Keywords: Curcuma zedoaria, SARS-CoV-2, bioavailability, molecular docking

Knowledge of the Madurese Community-Indonesia Regarding Bioprospection of the Traditional Herb Kamandin Saebo (Glossocardia leschenaultii [Cass.] Veldkamp) Purwanti, Elly; Nuryady, Moh. Mirza; Permana, Tutut Indria; Rachmawati, Hidajah; Anggraeni, Amaliyah Dina
Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika Vol. 7 No. 3: November 2023
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/esaintika.v7i3.1403

The purpose of this study was to describe the knowledge of the Sumenep Madura community (village elders and gatherers) about the Kamandin Saebo (Glossocardia leschenaultii) plant and its utilization. This study uses observational research that aims to observe a fact at a certain time using a descriptional approach model. The research was conducted in the Sumenep-Madura area, East Java Province. The research was conducted in July 2023-August 2023 by observational method. We discussed the results of information regarding the knowledge of the Sumenep people about the existence and growing areas of Kamandin saebo, a literature search regarding the morphological characterization, benefits, or uses of Kamandin saebo in medicine as conveyed by the gatherers. We also found that Kamandin Saebo is of great value. There are 14 healing functions associated with Kamandin Saebo. The Madurese people believe this plant to have many benefits or even cure all diseases.

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