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Aiyi Asnawi
Universitas Bhakti Kencana
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Kemitraan Asosiasi Profesi Kesehatan dalam Aplikasi Metode KESET untuk Menangani Stress di Masa Pandemi Covid-19 bagi Masyarakat Desa Cibiru Wetan dan Praktisi Apoteker Kabupaten Sumedang, Jawa Barat Aiyi Asnawi; Widhya Aligita; Soni Muhsinin; Nur Intan Hayati Husnul Khotimah; Eki Pratidina; Iceu Mulyati; Yulianti Anjayani; Ellin Febrina; Fauzan Z Muttaqin
Jurnal Pengabdian Pada Masyarakat Vol 6 No 1 (2021)
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/002.202161.671

Abstract

PARTNERSHIP OF THE HEALTH PROFESSIONAL ASSOCIATION IN THE APPLICATION OF THE KESET METHOD TO MANAGE STRESS DURING THE COVID-19 PANDEMIC FOR THE PEOPLE OF CIBIRU WETAN VILLAGE AND PHARMACIST PRACTITIONERS IN SUMEDANG REGENCY, WEST JAVA. EFT (Emotional Freedom Technique) is an alternative treatment method that offers healing from physical and emotional pain and disease. EFT works by tapping on acupressure meridians to release blockages. When these blockages are released, the problem feeling can be released and move through the body. Learning EFT also empowers the client to take charge of handling their emotional state/ controls stress. because they can tap on a feeling any time, they want to move out a painful feeling. Impact of quarantine or PSBB, the restriction of movement of people, is the mental health toll became even steeper including for community of Desa Cibiru Wetan and pharmacist of Kabupaten Sumedang, West Java. Therefore, the purpose of this community service activity was to transfer knowledge about the EFT method for stress management during the Covid-19 pandemic for the Desa Cibiru Wetan community and pharmacist in Kabupaten Sumedang, West Java. The stages of this activity began from education about stress and its prevention, and continues with the introduction of the KESET method in managing stress independently. The critical point in this activity is how to transfer knowledge and skills in preparing the participants who use this technique believe tapping the body can create a balance in their energy system and treat pain. The results of the activity showed that community participation could improve the knowledge and ability of participants in handling their emotional state/ controls stress by using KESET method. In conclusion, this activity could be an alternative healing from emotional pain for participants.
Peningkatan Potensi Ibu Rumah Tangga Peternak Sapi Perah dalam Membuat Yoghurt di Desa Cibiru Wetan, Kabupaten Bandung, Jawa Barat Aiyi Asnawi; Widhya Aligita; Soni Muhsinin; Eki Pratidina; Iceu Mulyati; Ika Kana Trisnawati; Ellin Febrina; Fauzan Zein Muttaqin
Jurnal Pengabdian Pada Masyarakat Vol 6 No 3 (2021)
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/002.202163.775

Abstract

INCREASING THE POTENTIAL OF DAIRY CATTLE HOUSEWIVES IN MAKING YOGHURT IN CIBIRU WETAN VILLAGE, BANDUNG REGENCY, WEST JAVA. Yogurt is the product of milk fermentation by Lactobacillus subspecies. The unique properties of yoghurt provided by its living bacteria and its nutrients have captured the interest of the community. The highest price of cow's milk in dairy farming centres of Cibiru Wetan Village, Kabupaten Bandung is purchased by the Milk Processing Industry (IPS) at around IDR 4,500 / litre. Therefore, the purpose of this community service activity was the utilization of fresh cow milk as yoghurt to increase the income of dairy cattle farmer. Yoghurt processing begins with the modification of the incoming milk composition. This process typically involves reducing the fat content and increasing the total solids in the milk by are Lactobacillus bulgaricus and Streptococcus thermophilus. The stages of this activity began from providing an understanding of milk and dairy products and training in making yoghurt from fresh cow milk. The critical point in this activity is how to transfer knowledge and skills in preparing the starter and sterile conditions of the cooking utensils. The results of the activity showed that community participation could improve the knowledge and ability of participants in the processing of fresh cow milk as yoghurt. In conclusion, this activity could be an alternative income for dairy cattle farmer.
ATR-FTIR Method for Detection of Cassava Impurities in Indonesian Commercial White Pepper (Piper nigrum L.) Based on Principal Component Analysis Aiyi Asnawi; Ajeng Fitriani; Ellin Febrina; Emma Emawati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 2 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i2.24664

Abstract

White pepper (Piper nigrum L.) is one of the most popular flavourings targeted for adulteration, i.e., cassava, resulting in quality loss and infringement on consumer rights and interests. Because it is easy and quick cleanup, minimal sample preparation, and excellent performance with strongly or thickly absorbed samples, the Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR) spectrum signal is widely used to measure commercial herbal products. Manipulation of the spectrum signal can be used to quantify a sample as well as reduce its dimensionality. As a result, there is a lot of interest in developing methods for detecting cassava in commercial white pepper (Piper nigrum L.). The aim of the research was to get an ATR-FTIR spectroscopic technique combined with chemometrics to detect cassava as an adulterant in commercial white pepper (Piper nigrum L.). The chemical profiles of white pepper (Piper nigrum L.) and cassava were compared using principal component analysis (PCA). Bangka, Sudu, and Pontianak were used to collect white pepper (Piper nigrum L.)  and cassava. White pepper (Piper nigrum L.) and cassava were macerated in 96 percent ethanol for 3×24 hours before being concentrated with a rotary evaporator until thick. Each extract's IR spectral was measured using ATR-FTIR spectroscopy in the 4000-650 cm-1range. In addition, the IR spectral was clustered using PCA in the R program. To obtain the appropriate PCA model, we applied two IR spectral manipulation procedures (normal and derivative IR spectra) of the pure material. The PCA chosen was of the normal IR spectral type, with PC1 and PC2 values of 82.3 percent and 7.5 percent, respectively.. The projection of three commercial samples from the markets revealed that samples A and B were negative for cassava adulterant, while Sample C was suspected to be positive. Finally, the ATR-FTIR spectroscopic method tandem PCA was successful in clustering the presence or absence of cassava content in the commercial of Indonesian White Pepper
Peningkatan Kesiapsiagaan Kader PKK Cibiru Wetan untuk Ketahanan Bencana di Masa Pandemi COVID-19 Nur Intan Hayati Husnul Khotimah; Fauzan Zein Mutaqin; Soni Muhsinin; Widhya Aligita; Eki Pratidina; Iceu Mulyati; Yulianti Anjayani; Untung Sudharmono; Etika Emaliyawati; Ellin Febrina; Aiyi Asnawi
Jurnal Pengabdian Pada Masyarakat Vol 7 No 2 (2022): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (588.082 KB) | DOI: 10.30653/002.202272.87

Abstract

IMPROVİNG THE PREPAREDNESS OF CİBİRU WETAN PKK CADRES FOR DİSASTER RESİLİENCE DURİNG THE COVİD-19 PANDEMİC. Cibiru is a high-risk area for natural and man-made disasters, so efforts must be made to reduce the risk of disaster impacts. One effort that can be made is to strengthen the Cibiru Wetan village's resilience by increasing preparedness to deal with emergency cases caused by disasters, such as cases of respiratory arrest, cardiac arrest, trauma, and respiratory emergencies caused by COVID-19. Community service is performed to improve the preparedness of Cibiru Wetan PKK cadres for disaster-resilient village resilience during the COVID-19 Pandemic. The method of implementing community service by simulating basic life support, trauma event handling, prevention and handling of COVID-19 emergencies, and the production of health drinks made from natural ingredients such as ginger, honey, lime, cardamom, and turmeric to boost immunity. As a result, the Cibiru Wetan PKK cadres were able to simulate basic life support, first aid in the event of trauma, and respiratory disorders caused by COVID-19, as well as process natural ingredients into healthy drinks to increase immunity, thereby increasing the Cibiru Wetan village's resilience.
KAJIAN PENAMBATAN MOLEKUL FITOKIMIA ASHITABA (Angelica keiskei Koidzumi) TERHADAP ENZIM α-GLUKOSIDASE SEBAGAI SENYAWA POTENSIAL ANTIDIABETES TIPE 2 Anne Yuliantini; Mitsly Fauziyah Jamil; Aiyi Asnawi
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 8, No 1 (2023)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v8i1.6600

Abstract

Diabetes Melitus (DM) adalah kumpulan gangguan metabolisme kronis yang ditandai dengan adanya peningkatan kadar glukosa dalam darah. DM merupakan permasalahan Kesehatan global abad ke-20 yang tiap tahunnya mengalami peningkatan kasus, terutama Diabetes Melitus Tipe 2 (DMT2). Salah satu pengobatan DMT2 dapat dilakukan dengan menghambat α-glukosidase. Akan tetapi, penggunaan obat anti-DM, seperti akarbosa, dalam jangka panjang dapat menimbulkan beberapa efek samping, yaitu gangguan pada sistem saluran pencernaan, fungsi hati, dan ginjal. Oleh karena itu, perlu adanya pengembangan obat anti-DM baru yang lebih efektif. Ekstrak ashitaba (Angelica keskei) diketahui memiliki efek antidiabetes sehingga pada penelitian ini dilakukan pencarian senyawa yang berpotensi sebagai inhibitor α-glukosidase. Metode yang digunakan secara in silico melalui metode penambatan molekul menggunakan perangkat lunak Autodock tools 1.5.6. Hasil penambatan molekul diperoleh tiga senyawa terbaik yaitu senyawa uji Xanthoangelol I (XAI), 8-geranylnaringenin (8GN), dan (2E)-1-[3,5-dihydroxy-2-methyl2-(4-methyl-3-penten-1-yl)-3,4-dihydro-2H-chromen-8-yl]-3-(4-hydroxyphenyl)-2-propen-1-one (3DM) dengan nilai energi bebas ikatan secara berturut-turut sebesar −8,61;−8,33; dan −8,26 kkal/mol. Senyawa XAI, 8GN, dan 3DM merupakan 3 senyawa terbaik yang memiliki interaksi yang mirip dengan ligan alami dan potensial untuk dikembangkan menjadi obat anti-DM yang baru.
Marine Sponge Xestospongia sp.: A Promising Source for Tuberculosis Drug Development - Computational Insights into Mycobactin Biosynthesis Inhibition Arfan Arfan; Aiyi Asnawi; La Ode Aman
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.5513

Abstract

Mycobacterium tuberculosis (MTB) remains the leading cause of infection, with a significant fatality rate, owing primarily to drug resistance. MTB contains the enzyme salicylate synthase, which regulates mycobactin production to bind iron ions from the host cell, facilitating the bacteria to grow and reproduce. This study investigates the potential of marine sponges to inhibit the MTB salicylate synthase by exploiting a computational approach combining molecular docking and dynamics simulations. Forty-six compounds from Xestospongia sp. were chosen from the Marine Natural Products database. The docking results selected four compounds (CMNPD15071, CMNPD7640, CMNPD26706, and CMNPD7639) from this sponge, which provide more negative binding energy than their inhibitors (RVE). After reclassifying their interactions, such as hydrophobic and hydrogen bonds, CMNPD15071 (Sulfuric acid mono-(8-methoxy-12b-methyl-6-oxo-2,3,6,12b-tetrahydro-1H-5-oxa-benzo[k]acephenanthrylen-11-yl) ester) and CMNPD7640 (secoadociaquinone B) performed molecular dynamics simulations to assess their stability. These two compounds show a promising stability profile compared to RVE based on RMSD, RMSF, SASA, and gyration analysis. Furthermore, the binding affinity prediction of these two compounds using the MM/GBSA calculation method reveals that CMNPD15071 (-38.48 kJ/mol) had the highest affinity for binding to MTB salicylate synthase compared to RVE (-35.36 kJ/mol) and CMNPD7640 (-26.03 kJ/mol). These findings demonstrate that compounds from Xestospongia sp. can block MTB mycobactin biosynthesis by inhibiting salicylate synthase.
Effect of Solvent Polarity on Antioxidant and Antidiabetic Activity of Kesambi Leaf Extract (Schleichera oleosa L.) Nursamsiar Nursamsiar; Marwati Marwati; Fitriyanti J. Sami; Syamsu Nur; Henny Kasmawati; Aiyi Asnawi
Jurnal Penelitian Pendidikan IPA Vol 11 No 1 (2025): January
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i1.9439

Abstract

Kesambi (Schleichera Oleosa (L.) is one of the beneficial plants in Indonesia which contains fenolic and flavonoids that exhibit antioxidant properties. The presence of antioxidants in plants could be associated with antidiabetic activity of these plants. This research was conducted to determine the antioxidant and antidiabetic activities of n-hexane, ethyl acetate, acetone and methanol extracts from Kesambi leaves. Extraction was carried out by the ultrasonic assisted extraction (UAE) method. The antioxidant activity was determined quantitatively by DPPH and ABTS method, while the antidiabetic activity was evaluated by using α-glukosidase inhibition method. The IC50 values from the determination of antioxidant and antidiabetic activities were obtained by using Microplate reader at the maximum wavelength. Results of the antioxidant determination DPPH method showed that IC50 values of n-hexane, ethyl acetate, acetone and methanol extracts were 414.1993; 57.7862; 6.33 dan 13.4558 µg/mL, respectively. And for ABTS method showed 162.679; 22.6684; 10.7975; dan 146.869 µg/mL. This indicates the acetone and methanol extracts give the best results in antioxidant activity. Meanwhile, IC50 values of in vitro antidiabetic activity of n-hexane, ethyl acetate, acetone and methanol extracts were 99.3235; 272.8723; 1.6799; dan 24.4653 µg/mL, respectively. Acetone and methanol extracts of kesambi leaf give the best results in antidiabetic activity.
Co-Authors Ajeng Fitriani Anne Yuliantini Arfan Arfan Eki Pratidina Ellin Febrina Ellin Febrina Emma Emawati, Emma Etika Emaliyawati Fauzan Z Muttaqin Fauzan Zein Mutaqin Fauzan Zein Muttaqin Fitriyanti J. Sami Iceu Mulyati Iceu Mulyati Ika Kana Trisnawati Kasmawati, Henny La Ode Aman Marwati Marwati Mitsly Fauziyah Jamil Nur Intan Hayati Husnul Khotimah Nur Intan Hayati Husnul Khotimah Nursamsiar Nursamsiar Soni Muhsinin Syamsu Nur Untung Sudharmono Widhya Aligita Widhya Aligita Yulianti Anjayani Yulianti Anjayani