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Hubungan Pengetahuan tentang Disabilitas Intelektual terhadap Tingkat Kecemasan Orang Tua yang Memiliki Anak dengan Disabilitas Intelektual Gini Marta Lestari; Tiar Masykuroh Pratamawati; Gara Samara Brajadenta
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 7, No 2 (2021): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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Latar Belakang: Disabilitas intelektual atau yang sebelumnya disebut dengan retardasi mental merupakan suatu gangguan perkembangan yang ditandai dengan kekurangan atau keterbatasan fungsi intelektual dan perilaku adaptif dengan skor IQ (intelligence quotient) di bawah 70. Onsetnya terjadi sebelum usia anak mencapai 18 tahun. Terdapat banyak faktor penyebab terkait dengan disabilitas intelektual yang telah diklasifikasikan menjadi genetik dan non genetik. Down syndrome dan Fragile-X syndrome (FXS) menjadi dua penyebab genetik paling sering pada disabilitas intelektual. Disabilitas intelektual pada anak menjadi masalah kesehatan yang serius di setiap negara. Di Indonesia, terdapat 38.545 anak dengan disabilitas intelektual yang terdaftar di sekolah luar biasa (SLB). Cirebon memiliki 15 SLB untuk anak-anak dengan disabilitas intelektual dengan jumlah total 975 siswa. Tujuan: Mengetahui hubungan pengetahuan tentang disabilitas intelektual terhadap tingkat kecemasan orang tua yang memiliki anak dengan disabilitas intelektual. Metode: Penelitian ini menggunakan metode analitik observasional dengan desain Cross sectional yang melibatkan 51 orang tua siswa disabilitas intelektual di SLB-C Pancaran Kasih dan SLBN Budi Utama Kota Cirebon yang didapatkan dengan teknik pengambilan Total Sampling. Data diperoleh dengan pengisian kuesioner kepada responden. Data di analisis dengan uji korelasi Spearman. Hasil: Mayoritas orang tua yang memiliki anak dengan disabilitas intelektual di SLB-C Pancaran Kasih dan SLBN Budi Utama Kota Cirebon (39,2%) memiliki pengetahuan kategori cukup mengenai disabilitas intelektual dan 37,3% memiliki kecemasan yang termasuk dalam kategori sedang. Hasil analisis data menunjukan P-value <0.001 dan nilai r 0,839 (sangat kuat). Arah korelasi menunjukkan nilai positif, maka hubungan kedua variabel adalah searah (semakin berkurang pengetahuan orang tua tentang disabilitas intelektual maka akan semakin berat tingkat kecemasan orang tua yang memiliki anak dengan disabilitas intelektual). Kesimpulan: Terdapat hubungan antara pengetahuan orang tua tentang disabilitas intelektual dengan tingkat kecemasan orang tua yang memiliki anak dengan disabilitas intelektual.Kata Kunci: Pengetahuan, Tingkat Kecemasan, Disabilitas Intelektual.ABSTRACTBackground:Intellectual disability or previously referred to asmental retardation is a developmental disorder characterized by lack or limitation of intellectual function and adaptive behavior with an IQ (intelligence quotient) score below 70.The onset occurs before the child reaches the age of 18 years.There are many causal factors associated with intellectual disabilities that have been classified into genetic and non-genetic.Down syndromeandFragile-X syndrome(FXS) are the two most common genetic causes of intellectual disabilities.Intellectual disability in children is a serious health problem in every country.In Indonesia, there are 38,545 children with intellectual disabilities enrolled in outstanding schools (SLB).Cirebon has 15 SLB for children with intellectual disabilities with a total of 975 students. Purpose:To know the relationship of knowledge about intellectual disabilities to the level of anxiety of parents who have children with intellectual disabilities. Method: This study uses observational analytics method withCross sectionaldesign involving 51 parents of intellectually disabled students at SLB-C Pancaran Kasih and SLBN Budi Utama Cirebon which were obtained bytotal sampling technique.The data was obtained by filling out questionnaires to respondents.The data in the analysis with Spearman correlationtest. Result:The majority ofparents who have children with intellectual disabilities in SLB-C Pancaran Kasih and SLBN Budi Utama Cirebon(39.2%)had sufficient category knowledge of intellectual disabilities and 37.3% had moderate anxiety.The data analysis results showedP-value<0.001 and r value 0.839 (very strong).The correlation direction indicates a positive value, so the relationship of the two variables is in the same direction (the less knowledge parents have about intellectual disabilities, the heavier the level of anxiety of parents who have children with intellectual disabilities). Conclusion: There isa relationshipbetweenparents' knowledge of intellectual disabilities and the level of anxiety of parents who have children with intellectual disabilities.Keywords: Knowledge, Anxiety Level, Intellectual Disability.

Hubungan Kebersihan Pribadi dan Kepadatan Hunian dengan Kejadian Kutu Kepala Santriwati di Pondok Pesantren Ma’hadut Tholabah Babakan Kabupaten Tegal Provinsi Jawa Tengah Tiar M Pratamawati; Ayu SM Hanif
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 1, No 4 (2014): Tunas Medika Jurnal Kedokteran & Kesehatan
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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ABSTRAK Pedikulosis merupakan penyakit yang dapat menyerang siapa saja. Kebersihan perorangan yang buruk dapat mempengaruhi timbulnya pedikulosis. Kelompok masyarakat yang berisiko tinggi dengan pedikulosis adalah pondok pesantren atau asrama. Cara penularan lewat benda seperti topi, bantal, dan kasur dapat menambah angka prevalensi pedikulosis. Penelitian ini dilaksanakan untuk mengetahui hubungan kebersihan pribadi dan kepadatan hunian terhadap kejadian kutu kepala pada santriwati di Pondok Pesantren Ma’hadut Tholabah Babakan Tegal.Disain penelitian yang digunakan adalah analitik dengan rancangan cross sectional, populasi adalah santriwati di asrama putri pondok pesantren Ma’hadut Tholabah Babakan, jumlah sampel 200 responden yang diambil dengan menggunakan teknik simple random sampling. Kuesioner dianalisis secara univariat dan bivariat dengan uji korelasi Rank Spearman. Hasil penelitian menunjukkan responden memiliki kebersihan pribadi kurang sebanyak 85 (42,5%) dan memiliki hunian yang padat 105 (52,5%). Terdapat hubungan antara kebersihan pribadi (p=0,018) dan kepadatan hunian (p=0,001) dengan kejadian kutu kepala di pondok pesantren Ma’hadut Tholabah Babakan. Dari hasil penelitian dapat disimpulkan terdapat hubungan antara kebersihan pribadi dan kepadatan hunian dengan kejadian kutu kepala di Pondok pesantren putri Ma’hadut Tholabah Babakan Tegal.Kata Kunci: Kebersihan pribadi, Kepadatan hunian dan Kutu kepala ABSTRACT Pediculosis is acommon disease and can attack anyone. Poor personal hygiene is one the main causes of pediculosis. People living in boarding school or dormitory have highe risk people of pediculosis. Mode of transmission through objects such as hats, pillows, and mattress can increase the prevalence of pediculosis. This study was done to determine the relationship of personal hygiene and residential density on the incidence of pediculosis on female students at Ma'hadut Tholabah boarding school in Babakan, Tegal. The study was designed using analytical cross sectional, and the sample population were 200 female students in the dormitory of Ma'hadut Tholabah Babakan boarding school. Samples were recruited using simple random sampling. The data were obtained using a questionnaire and analyzed with Spearman rank correlation test. The result showed the majority of respondents had less personal hygiene as many as 85 people (42.5%) and live in high density area for as many as 105 people (52.5%). There is a relationship between personal hygiene with pediculosis capitis (p-value=0.018) and the relationship between residential density with pediculosis capitis (p-value= 0.001) in dormitory in Babakan, Tegal. There was a relationship between personal hygiene and residential density with incidence of pediculosis capitis in Ma'hadut Tholabah boarding school in Babakan, Tegal.Key words: Personal hygiene, residential density, and Pediculosis capitis

THE EFFECT OF ORALLY ADMINISTERED CATFISH (Clarias gariepinus) SKIN AND MEAT ON EPITHELIALIZATION THICKNESS AND COLLAGEN DENSITY IN INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Muhammad Irsyad Baihaqi; Muhammad Duddy Satrianugraha; Tiar M Pratamawati; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Alternative medicine using animal is still rare whereas Indonesia have a lot of potential natural resources. Catfish is easily found animal in Indonesia and is common consumed as nutriment sources contains albumin, amino acid and fatty acids which plays an essential role of wound healing process. This study will determine effect of orally administered catfish (Clarias gariepinus) skin and meat on epithelialization thickness and collagen density in incision wound of white male rat (Rattus norvegicus). Methods: This experimental post-test only group design used 30 white male rat (Rattus norvegicus), that randomly divided into 4 tratment goup and one control group. The treatment group was given 12,5 mg/g W, 25 mg/g W, 37,5 mg/g W and 50 mg/g W dose of catfish (Clarias gariepinus) skin and meat flour, in the other hand the contol group were given aquades. Non-parametric analyses using Kruscall- Wallis and Mann Whitney test were used to compare epithelization thickness and collagen density. Result: The comparison results of epithelialization thickness between group C with TGI, C with TG2, C with TG3 and C with TG4 showed significant differences (p<0.05). TG4 was the thickest of all groups. Significant differences were also observed in collagen density result between C with TGI, C with TG2, C with TG3 and C with TG4 (p <0,05) TG4 showed the highest density of all groups. Conclusion: Catfish (Clarias gariepinus) skin and meat flour with 50 mg/200g W dose is effective for wound healing and increasing epithelial thickness and collagen density in Wistar rat (Rattus norvegicus) incision wounds. Keywords: Epithelial thickness, Collagen density, Wound, Catfish (Clarias gariepinus)

EFFECTIVENESS OF ORALLY USE TILAPIA (Oreochromis niloticus) ON WOUND LENGTH AND FIBROBLAST DENSITY ON INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Sayyidah Vina Syauqia; A. Fariz Malvi Zamzam Zein; Tiar M. Pratamawati; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: The incidence of a wound in Indonesia has increased from 7.5 percent in 2007 to 8.2 percent in 2013 according to Riskesdas. Wound care that widely used is povidone-iodine, but in case, it has a toxic effect on healthy cells around the wound. The albumin, amino acids, and fatty acids in Tilapia (Oreochromis niloticus) are the potential substances to accelerate the wound healing process. This study aims to investigate the efficacy of Tilapia (Oreochromis niloticus) on wound length and fibroblast density on the incision wound of Wistar rat (Rattus norvegicus). Methods: The study was conducted in the Food and Nutrition PAU Laboratory and Pathology Anatomy Laboratory of Universitas Gadjah Mada, Yogyakarta. This post-test only control group design experimental study used 30 male white rats that randomly divided into five groups, i.e. control group K, and treatment group P1, P2, P3 and P4 that were each given Tilapia with a dose of 12.5 mg/200gBW, 25 mg/200gBW, 37.5 mg/200gBW dan 50 mg/200gBW. The length of the wound was measured by a ruler each day. The rats were terminated on the 10th day to obtain wound tissue for H&E stained histopathological sections to observe fibroblast density. One Way ANOVA, Tamhane, Kruskal-Wallis and Mann Whitney tests were used to compare the wound length and fibroblasts density. Results: Incision wounds in this study showed the best wound healing on the 10th day. Based on the theory, on the 10th day, a proliferation and remodeling phase occurs. There is an effect of giving Tilapia (Oreochromis niloticus) orally at a different dose. Tilapia at dose 37.5mg/200gBW is more effective compared with the dose of 12.5mg/200gBW, 25mg/200gBW, and 50mg/200gBW to accelerate wound healing for wound length and fibroblast density in Wistar rat (Rattus norvegicus). Conclusion: Consuming Tilapia (Oreochromis niloticus) could be a new alternative for wound healing treatment. The antimicrobial ability of Tilapia should be analyzed. Keywords: wound healing, wound length, fibroblast density, Tilapia, Oreochromis niloticus

EFFECTIVENESS OF ORALLY USE CATFISH (Clarias gariepinus) SKIN AND MEAT ON WOUND LENGTH AND FIBROBLAST DENSITY IN INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Sri Utami Fauziah; Risnandya Primanagara; Tiar M. Pratamawati; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Treatment for wounds that are currently often given is use povidone-iodine. But, this antiseptics also kills fibroblast tissue which is useful for forming new tissue. One of the other ways to treatment for wounds is use catfish. The contents found in catfish (Clarias gariepinus) is albumin which is a globular protein that is useful in the formation of body tissues, such as postoperative wounds and burns. This study aims to determine the effect of skin and meat of catfish (Clarias gariepinus) on wound length and fibroblast density in incision wounds of Wistar rat (Rattus norvegicus). Methodology: This study is an experimental study with Post Test Only Control Group Design using Wistar rats which are divided into five groups. The control group (aquadest) and treatment groups 1, 2, 3 and 4 are given the skin and meat of catfish (Clarias gariepinus) orally at a dose of 12.5 mg / 200 g BW, 25 mg / 200 g BW, 37.5 mg / 200 g BW, and 50 mg / 200 g BW. After 10 days, the rats are killed to take the wound tissue for histological preparations to observe fibroblast density. Then, it is analyzed by ANOVA test or the alternative. Results: There is an effect of giving catfish skin and meat (Clarias gariepinus) orally at different dose. The administration of catfish skin and meat (Clarias gariepinus) at a dose of 37.5 mg / 200 g BW and 50 mg / 200 g BW is better than other doses assessed from wound length and fibroblast density in Wistar rat incision wounds (Rattus norvegicus). Conclusion: The use of catfish for wound healing can be applied. This method can reduce wound length and increase fibroblast density at certain doses. Keywords: Fibroblasts, incision wounds, catfish, Clarias gariepinus, wound healing

The Association Between the Pattern of Electronic Cigarette Smoking and Gastroesophageal Reflux Ahmad Fariz Malvi Zamzam Zein; Donny Nauphar; Uswatun Khasanah; Tiar M Pratamawati; Rama S Brajawikalpa; Eka Ayuningtyas; Alif Hamzah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 22, No 1 (2021): VOLUME 22, NUMBER 1, April 2021
Publisher : The Indonesian Society for Digestive Endoscopy

Background: This study was aimed to investigate the proportion of gastroesophageal reflux (GER) among electronic cigarette (e-cig) smokers and its association with the pattern of e-cig smoking.Method: This cross-sectional study underwent among e-cig smokers community in Cirebon City, Jawa Barat, ranged from March to August 2020. Subjects were enrolled through consecutive sampling method. The data collection used survey containing the pattern of e-cig smoking and GER. The pattern of e-cig smoking included the duration of e-cig smoking and the amount of e-cig smoking. Gastroesophageal reflux consisted of GER-related symptoms (heartburn, regurgitation, and nocturnal symptom) and gastroesophageal reflux disease (GERD). GERD was defined as GERD questionnaire score cut-off 8. Data analysis used chi square test. This study has been approved by The Medical Research Ethics Committee, Faculty of Medicine, Universitas Swadaya Gunung Jati.Results: There were 273 respondents in this study. The proportion of heartburn was 6.6%, 10.3% for regurgitation, 3.7% for nocturnal symptom, and 5.5% for GERD. There was no association between duration of e-cig smoking and heartburn (p 0.681), regurgitation (p 0.568), nocturnal symptom (p 0.764), and GERD (p 0.113). There was no association between amount of e-cig smoking and heartburn (p 0.062), regurgitation (p 0.770), nocturnal symptom (p 0.985), and GERD (p 0.605).Conclusion: There was relatively low proportion of GER among e-cig smokers. There was no association between the pattern of e-cig smoking and GER in this study.

The prevalence and habit-associated risk factors of gastroesophageal reflux disease among fishermen in Indonesia Ahmad Fariz Malvi Zamzam Zein; Catur Setiya Sulistiyana; Tissa Octavira Permatasari; Uswatun Khasanah; Tiar Masykuroh Pratamawati; Ismayanti Ismayanti; Dwi Listiany Corneli; Eni Suhaeni
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 22, No 3 (2021): VOLUME 22, NUMBER 3, December 2021
Publisher : The Indonesian Society for Digestive Endoscopy

Background. This study was aimed to investigate the prevalence and habit-associated risk factors of gastroesophageal reflux disease (GERD) among fishermen.Methods. A cross-sectional study was conducted among 168 adult fishermen in Cirebon Regency, West Java, Indonesia. A self-administered questionnaire was given. The questionnaire consisted of demographic characteristics and validated GERD questionnaire (GERDQ) in Indonesian language. Data were analyzed using descriptive statistics and chi-square test. The study has been approved by the Medical Research Ethic Comiittee.Results. The medan age of the participants was 39.0 (24-86) years old. They were predominanty (60.7%) female. The prevalence of GERD was 22.6%. According to bivariate analysis, there was association between smoking (PR 1.181; 95%CI 1.013-1.377;p 0.041), high-salt intake (PR 2.419;95%CI 1.079-5.424; p 0.029), herb consumption (PR 3.068; 95%CI 1.307-7.200; p 0.008), poor hand hygiene (PR 3.202; 95%ci 1.445-7.095; p 0.003), and non-steroidal anti-inflammatory drug (NSAID) consumption (PR 3.062; 95%CI 1.446-6.488; p 0.00) with GERD. Tea consumption, coffee consumption, and raw vegetable eating were not associated with GERD.Conclusions This population-based study showed that the prevalence of GERD among fishermen in Indonesia is high. Habits associated with GERD in this study were smoking, high-salt intake, herb consumption poor, hand hygiene,

IDENTIFIKASI POLIMORFISME A1298C GEN MTHFR PADA PASIEN HIPERTENSI ESENSIAL Tiar Masykuroh Pratamawati
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 8, No 1 (2022): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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Latar Belakang: Hipertensi adalah salah satu penyebab utama mortalitas dan morbiditas di Indonesia, termasuk di Jawa Barat, dan khususnya Cirebon. Seseorang yang memiliki riwayat keluarga menderita hipertensi akan memiliki kemungkinan yang lebih tinggi untuk menderita hipertensi juga. Hal ini salah satunya disebabkan oleh adanya pewarisan polimorfisme A1298C gen MTHFR. Beberapa penelitian juga menunjukkan bahwa adanya peran inflamasi dalam mekanisme terjadinya hipertensi.Tujuan: Penelitian ini bertujuan untuk mengetahui polimorfisme A1298C gen MTHFR pada pasien hipertensi esensial.Metode: Penelitian observasional dengan desain cross sectional yang dilakukan di Puskesmas Plumbon dan melibatkan 37 orang. Data diperoleh dengan cara pemeriksaan langsung menggunakan metode analisis gen, PCR-RFLP.Hasil: Terdapat 24 subjek (65%) dengan hasil polimorfisme positif dan 13 subjek (35%) dengan hasil polimorfisme negatif.Kesimpulan: Mayoritas subjek penelitian ini memiliki polimorfisme A1298C (65%). Kata Kunci: polimorfisme A1298C gen MTHFR, Hipertensi esensial, PCR-RFLP ABSTRACT Background: Hypertension is one of the main causes of mortality and morbidity in Indonesia, including in West Java, and especially in Cirebon. Person who has a family history of suffering from hypertension will have a higher chance of suffering from hypertension as well. This is partly due to the inheritance of the A1298C polymorphism of the MTHFR gene. Some research also shows that the role of inflammation in the mechanism of hypertension. Aim: This study aims to determine the polymorphism of the A1298C MTHFR gene with essential hypertension.Methods: An observational study with cross sectional design conducted at the Plumbon Primary Healthcare and involved 37 people. Data obtained by direct examination using the method of gene analysis, PCR-RFLP.Results: There were 24 subjects (65%) with positive polymorphism results and 13 subjects (35%) with negative polymorphism results.Conclusion: The majority of the subjects of this study had A1298C polymorphism (65%) Keywords: polymorphism A1298C MTHFR gene; essential hypertension, PCR-RFLP

Hubungan Polimorfisme M235T Gen AGT dengan Inflamasi Pembuluh Darah pada Pasien Hipertensi Esensial Apriliani Nur Puspita Sari; Tiar Masykuroh Pratamawati; Ahmad Fariz Malvi Zamzam Zein
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 8, No 2 (2022): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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Latar Belakang: Hipertensi menyebabkan 7,5 juta kematian per tahun dan menyumbang sekitar 12,8% dari total seluruh kematian di dunia. Salah satu patogenesis dari penyakit ini adalah gangguan regulasi sistem renin-angiotensin-aldosteron (RAAS) yang diduga diperantarai salah satunya oleh polimorfisme M235T di daerah promoter gen angiotensinogen (AGT). Beberapa penelitian juga menunjukkan bahwa peningkatan tekanan darah dapat terjadi melalui mekanisme inflamasi yang menyebabkan ketidakseimbangan vasokonstriktor dan vasodilator, trombogenesis, dan aktivasi trombosit. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan polimorfisme M235T gen AGT dengan inflamasi pembuluh darah pada pasien hipertensi esensial. Metode: Penelitian observasional analitik dengan desain potong lintang yang dilakukan di Puskesmas Plumbon dan melibatkan 50 orang. Data diperoleh dengan cara pemeriksaan menggunakan PCR-RFLP dan pemeriksaan hitung darah lengkap. Analisis data dilakukan dengan metode koefisien kontingensi dan perhitungan rasio prevalensi. Hasil: Mayoritas subjek penelitian ini memiliki polimorfisme M235T (94%) dan mengalami inflamasi pembuluh darah (66%). Hasil analisis menunjukkan bahwa secara statistik hubungan antara polimorfisme M235T gen AGT dengan inflamasi pembuluh darah tidak bermakna (p = 0,218), tetapi hasil perhitungan rasio prevalensi menunjukkan penderita hipertensi esensial dengan polimorfisme M235T gen AGT berisiko untuk mengalami inflamasi pembuluh darah. (PR = 2,06). Kesimpulan: Tidak didapatkan hasil yang bermakna pada hubungan polimorfisme M235T gen AGT dengan inflamasi pembuluh darah pada pasien hipertensi esensial.Â Kata Kunci: polimorfisme M235T gen AGT; inflamasi vaskular; PLR, hipertensi.Â ABSTRACTÂ Background: Hypertension causes 7.5 million deaths per year and accounts for around 12.8% of all world deaths. One of the pathogenesis of this disease is the disruption of the regulation of the renin-angiotensin-aldosterone system (RAAS) which is thought to be mediated one of them by the M235T polymorphism in the angiotensinogen gene promoter (AGT) region. Some studies also show that increased blood pressure can occur through inflammatory mechanisms that cause vasoconstrictor and vasodilator imbalances, thrombogenesis, and platelet activation. Aim: This study aims to determine the relationship of M235T polymorphism of AGT gene with vascular inflammation in patients with essential hypertension. Methods: An analytic observational study with cross sectional design conducted at Puskesmas Plumbon and involved 50 people. Data obtained by PCR-RFLP and complete blood count. Data analysis was performed using the contingency coefficient method and prevalence ratio calculations. Results: The majority of study subjects had M235T polymorphisms (94%) and had vascular inflammation (66%). The analysis showed that statistically, the relationship between M235T polymorphism of AGT gene with vascular inflammation was not significant (p = 0.218) but the prevalence ratio showed that patients with essential hypertension with M235T polymorphism of AGT gene haveÂ a risk of vascular inflammation (PR = 2,06). Conclusion: There is no relationship between M235T polymorphism of AGT gene with vascular inflammation.Â Keywords: M235T polymorphism of AGT gene; vascular inflammation; PLR; hypertension.

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